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Protein
Submitted name:

Breast cancer anti-estrogen resistance 2

Gene

BCAR2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Breast cancer anti-estrogen resistance 2Imported
Submitted name:
Transcriptional-regulating factor 1Imported
Gene namesi
Name:BCAR2Imported
Synonyms:TRERF1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18273. TRERF1.

Subcellular locationi

  • Nucleus SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiQ05GC8.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000362013.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini512 – 53928C2H2-typeInterPro annotationAdd
BLAST
Domaini799 – 89092ELM2InterPro annotationAdd
BLAST
Domaini905 – 95652SANTInterPro annotationAdd
BLAST
Domaini1033 – 106230C2H2-typeInterPro annotationAdd
BLAST
Domaini1106 – 113328C2H2-typeInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG4167. Eukaryota.
ENOG4110BKZ. LUCA.
GeneTreeiENSGT00530000063277.
HOGENOMiHOG000154675.
HOVERGENiHBG082398.
OMAiQMHLQPP.

Family and domain databases

InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05GC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDQQLYKTN HVAHGSENLF YQQPPLGVHS GLNHNYGNAV TGGGMDAPQA
60 70 80 90 100
SPISPHFPQD TRDGLGLPVG SKNLGQMDTS RQGGWGSHAG PGNHVQLRGN
110 120 130 140 150
LANSNMMWGA PAQAEPTDGY QYTYSQASEI RTQKLTSGVL HKLDSFTQVF
160 170 180 190 200
ANQNLRIQVN NMAQVLHTQS AVMDGAPDSA LRQLLSQKPM EPPAPAIPSR
210 220 230 240 250
YQQVPQQPHP GFTGGLSKPA LQVGQHPTQG HLYYDYQQPL AQVPVQGGQP
260 270 280 290 300
LQAPQMLSQH MQQMQQHQYY PPQQQQQAGQ QRISMQEIQT QPQQIRPSQP
310 320 330 340 350
QPPPQQQQPQ QLQLQQRQGS MQIPQYYQPQ PMMQHLQEQQ QQQMHLQPPS
360 370 380 390 400
YHRDPHQYTP EQAHTVQLIP LGSMSQYYYQ EPQQPYSHPL YQQSHLSQHQ
410 420 430 440 450
QREDSQLKTY SSDRQAQAML SSHGDLGPPD TGMGDPASSD LTRVSSTLPH
460 470 480 490 500
RPLLSPSGIH LNNMGPQHQQ LSPSAMWPQM HLPDGRAQPG SPESSGQPKG
510 520 530 540 550
AFGEQFDAKN KLTCSICLKE FKNLPALNGH MRSHGGMRAS PNLKQEEGEK
560 570 580 590 600
VLPPQPQPPL PPPPPPPPPP QLPPEAESLT PMVMPVSVPV KLLPPKPSSQ
610 620 630 640 650
GFTNSTVAAP SARDKPASSM SDDEMPVLVR MTLSPPHSPQ GAAPRTPAEI
660 670 680 690 700
PRKHQPSVPK AEEPLKTVQE KKKFRHRPEP LFIPPPPSYN PNPAASYSGA
710 720 730 740 750
TLYQSQLRSP RVLGDHLLLD PTHELPPYTP PPMLSPVRQG SGLFSNVLIS
760 770 780 790 800
GHGPGAHPQL PLTPLTPTPR VLLCRSNSID GSNVTVTPGP GEQTVDVEPR
810 820 830 840 850
INIGLRFQAE IPELQDISAL AQDTHKATLV WKPWPELENH DLQQRVENLL
860 870 880 890 900
NLCCSSALPG GGTNSEFALH SLFEAKGDVM VALEMLLLRK PVRLKCHPLA
910 920 930 940 950
NYHYAGSDKW TSLERKLFNK ALATYSKDFI FVQKMVKSKT VAQCVEYYYT
960 970 980 990 1000
WKKIMRLGRK HRTRLAEIID DCVTSEEEEE LEEEEEEDPE EDRKSTKEEE
1010 1020 1030 1040 1050
SEVPKSPEPP PVPVLAPTEG PPLQALGQPS GSFICEMPNC GAVFSSRQAL
1060 1070 1080 1090 1100
NGHARIHGGT NQVTKARGAI PSGKQKPGGT QSGYCSVKSS PSHSTTSGET
1110 1120 1130 1140 1150
DPTTIFPCKE CGKVFFKIKS RNAHMKTHRQ QEEQQRQKAQ KAAFAAEMAA
1160 1170 1180 1190 1200
TIERTTGPVG APGLLPLDQL SLIKPIKDVD ILDDDVVQQL GGVMEEAEVV
1210 1220
DTDLLLDDQD SVLLQGDAEL
Length:1,220
Mass (Da):134,309
Last modified:November 14, 2006 - v1
Checksum:i87F3C83E7799EE0C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096814 Genomic DNA. No translation available.
AL138735 Genomic DNA. No translation available.
AL450325 Genomic DNA. No translation available.
KF458150 Genomic DNA. No translation available.
KF458152 Genomic DNA. No translation available.
AM404182 mRNA. Translation: CAL49296.1.
RefSeqiNP_001284502.1. NM_001297573.1.
NP_277037.1. NM_033502.3.
XP_011513052.1. XM_011514750.1.
UniGeneiHs.485392.

Genome annotation databases

EnsembliENST00000541110; ENSP00000439689; ENSG00000124496.
GeneIDi55809.
KEGGihsa:55809.
UCSCiuc003ose.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096814 Genomic DNA. No translation available.
AL138735 Genomic DNA. No translation available.
AL450325 Genomic DNA. No translation available.
KF458150 Genomic DNA. No translation available.
KF458152 Genomic DNA. No translation available.
AM404182 mRNA. Translation: CAL49296.1.
RefSeqiNP_001284502.1. NM_001297573.1.
NP_277037.1. NM_033502.3.
XP_011513052.1. XM_011514750.1.
UniGeneiHs.485392.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000362013.

Proteomic databases

PeptideAtlasiQ05GC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000541110; ENSP00000439689; ENSG00000124496.
GeneIDi55809.
KEGGihsa:55809.
UCSCiuc003ose.3. human.

Organism-specific databases

CTDi55809.
HGNCiHGNC:18273. TRERF1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4167. Eukaryota.
ENOG4110BKZ. LUCA.
GeneTreeiENSGT00530000063277.
HOGENOMiHOG000154675.
HOVERGENiHBG082398.
OMAiQMHLQPP.

Miscellaneous databases

ChiTaRSiTRERF1. human.
GenomeRNAii55809.

Family and domain databases

InterProiIPR000949. ELM2_dom.
IPR009057. Homeodomain-like.
IPR001005. SANT/Myb.
IPR017884. SANT_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
PfamiPF01448. ELM2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM01189. ELM2. 1 hit.
SM00717. SANT. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS51156. ELM2. 1 hit.
PS51293. SANT. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Breast cancer resistance genes, methods for their detection and uses thereof."
    Dorssers L.C.J.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Insertion mutagenesis in human breast cancer cells in vitro: Functional identification of genes causing estrogen independence."
    Van Agthoven T., Veldscholte J., Smid M., Van Agthoven T., Dorssers L.C.J.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  10. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiQ05GC8_HUMAN
AccessioniPrimary (citable) accession number: Q05GC8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: July 6, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.