Q05FR8 (CLPP_CARRP) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit
EC=3.4.21.92

Alternative name(s):
Endopeptidase Clp

Gene names

Name:	clpP
Ordered Locus Names:	CRP_072

Organism

Carsonella ruddii (strain PV) [Complete proteome] [HAMAP]

Taxonomic identifier

387662 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Candidatus Carsonella

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	ATP-dependent Clp protease proteolytic subunit HAMAP MF_00444		PRO_1000206143
Sites
	Active site	97	1	By similarity
	Active site	122	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q05FR8 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: BFC7ED144BD88C79	FASTA	194	21,827
	10 20 30 40 50 60 MIFLPTVIDK NIKGDRFLDL YSKMLKERVI YLNGAIEDTM ASLIVSQLMF LDSENSKDII 70 80 90 100 110 120 LYINSPGGVV SSGLSIYDTI QFLKSDVSTI CIGQAASMAA VLLAAGKKGK RFCFPNSRIM 130 140 150 160 170 180 IHQPLGYAQG QASDVEIHAR EMINIKQILC EILSSHTNNS IFQIFKDTDR DNFMNCKQTL 190 KYGIIDNVLY KKWI

References

[1]	"The 160-kilobase genome of the bacterial endosymbiont Carsonella." Nakabachi A., Yamashita A., Toh H., Ishikawa H., Dunbar H.E., Moran N.A., Hattori M. Science 314:267-267(2006) [PubMed: 17038615] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PV.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP009180 Genomic DNA. Translation: BAF35103.1.
RefSeq	YP_802469.1. NC_008512.1.
3D structure databases
ProteinModelPortal	Q05FR8.
SMR	Q05FR8. Positions 13-189.
ModBase	Search...
Protein-protein interaction databases
STRING	Q05FR8.
Protein family/group databases
MEROPS	S14.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4415004.
GenomeReviews	Gene locus CRP_072 in contig AP009180_GR.
KEGG	crp:CRP_072.
PATRIC	31966434. VBICanCar121052_0073.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG558421.
OMA	QTICMGQ.
Enzyme and pathway databases
BioCyc	CCAR387662:CRP_072-MONOMER.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. PS00381. CLP_PROTEASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CLPP_CARRP

Accession

Primary (citable) accession number: Q05FR8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	November 14, 2006
Last modified:	January 25, 2012
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program