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Q05FN6

- ASSY_CARRP

UniProt

Q05FN6 - ASSY_CARRP

Protein

Argininosuccinate synthase

Gene

argG

Organism
Carsonella ruddii (strain PV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygenUniRule annotation
    Binding sitei88 – 881CitrullineUniRule annotation
    Binding sitei118 – 1181ATP; via amide nitrogenUniRule annotation
    Binding sitei120 – 1201AspartateUniRule annotation
    Binding sitei124 – 1241AspartateUniRule annotation
    Binding sitei124 – 1241CitrullineUniRule annotation
    Binding sitei125 – 1251AspartateUniRule annotation
    Binding sitei128 – 1281CitrullineUniRule annotation
    Binding sitei176 – 1761CitrullineUniRule annotation
    Binding sitei185 – 1851CitrullineUniRule annotation
    Binding sitei261 – 2611CitrullineUniRule annotation
    Binding sitei273 – 2731CitrullineUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPUniRule annotation

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
    2. ATP binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCCAR387662:GBZ4-123-MONOMER.
    UniPathwayiUPA00068; UER00113.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthaseUniRule annotation (EC:6.3.4.5UniRule annotation)
    Alternative name(s):
    Citrulline--aspartate ligaseUniRule annotation
    Gene namesi
    Name:argGUniRule annotation
    Ordered Locus Names:CRP_104
    OrganismiCarsonella ruddii (strain PV)
    Taxonomic identifieri387662 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeZymobacter groupCandidatus Carsonella
    ProteomesiUP000000777: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393Argininosuccinate synthasePRO_1000000390Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi387662.CRP_104.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05FN6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    KOiK01940.
    OMAiPECEYIR.
    OrthoDBiEOG6K9QCV.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05FN6-1 [UniParc]FASTAAdd to Basket

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    MKIKEKIVLA YSGGLDTSVI VKWLQNELNF EVITFTADLG QGEEILLAKK    50
    KAKLLNIKNI FVKNLKKEFI KNFVFPFLRS SSTYENNYLL GTAIARPLIV 100
    KELMKISYYL NTNYVSHGAT GKGNDQIRFE LGFKYFNPKI KIIAPWRIWN 150
    LNSRNSLLNF CIKNNIKFDS KTKKYSIDKN LFHNSYEGGN LDNINYEPDE 200
    PMWEHTLSNY NSLDYPIYIS LTFKNGDPIK INNKNYNVEE LFLKLNNLGS 250
    IAGIGRLDII ENRLIGIKSR GCYESPGASI IMYARKKLES LILDKEIYSF 300
    KEEIALKYSK LVYNGYWWSP ERILLQKIID YTQTSINGII KLKIFKGQIN 350
    IASINSINSL FNSKNSSFDE ISNLFNQSDS SGFINIKSLR LII 393
    Length:393
    Mass (Da):45,320
    Last modified:November 14, 2006 - v1
    Checksum:i1FDB21D282CD12F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009180 Genomic DNA. Translation: BAF35135.1.
    RefSeqiYP_802501.1. NC_008512.1.

    Genome annotation databases

    EnsemblBacteriaiBAF35135; BAF35135; CRP_104.
    GeneIDi4414925.
    KEGGicrp:CRP_104.
    PATRICi31966500. VBICanCar121052_0103.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP009180 Genomic DNA. Translation: BAF35135.1 .
    RefSeqi YP_802501.1. NC_008512.1.

    3D structure databases

    ProteinModelPortali Q05FN6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 387662.CRP_104.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAF35135 ; BAF35135 ; CRP_104 .
    GeneIDi 4414925.
    KEGGi crp:CRP_104.
    PATRICi 31966500. VBICanCar121052_0103.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    KOi K01940.
    OMAi PECEYIR.
    OrthoDBi EOG6K9QCV.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    BioCyci CCAR387662:GBZ4-123-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The 160-kilobase genome of the bacterial endosymbiont Carsonella."
      Nakabachi A., Yamashita A., Toh H., Ishikawa H., Dunbar H.E., Moran N.A., Hattori M.
      Science 314:267-267(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PV.

    Entry informationi

    Entry nameiASSY_CARRP
    AccessioniPrimary (citable) accession number: Q05FN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3