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Q05FN6

- ASSY_CARRP

UniProt

Q05FN6 - ASSY_CARRP

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Protein
Argininosuccinate synthase
Gene
argG, CRP_104
Organism
Carsonella ruddii (strain PV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei88 – 881Citrulline By similarity
Binding sitei118 – 1181ATP; via amide nitrogen By similarity
Binding sitei120 – 1201Aspartate By similarity
Binding sitei124 – 1241Aspartate By similarity
Binding sitei124 – 1241Citrulline By similarity
Binding sitei125 – 1251Aspartate By similarity
Binding sitei128 – 1281Citrulline By similarity
Binding sitei176 – 1761Citrulline By similarity
Binding sitei185 – 1851Citrulline By similarity
Binding sitei261 – 2611Citrulline By similarity
Binding sitei273 – 2731Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. argininosuccinate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCCAR387662:GBZ4-123-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:CRP_104
OrganismiCarsonella ruddii (strain PV)
Taxonomic identifieri387662 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaOceanospirillalesHalomonadaceaeZymobacter groupCandidatus Carsonella
ProteomesiUP000000777: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Argininosuccinate synthaseUniRule annotation
PRO_1000000390Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi387662.CRP_104.

Structurei

3D structure databases

ProteinModelPortaliQ05FN6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiPECEYIR.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05FN6-1 [UniParc]FASTAAdd to Basket

« Hide

MKIKEKIVLA YSGGLDTSVI VKWLQNELNF EVITFTADLG QGEEILLAKK    50
KAKLLNIKNI FVKNLKKEFI KNFVFPFLRS SSTYENNYLL GTAIARPLIV 100
KELMKISYYL NTNYVSHGAT GKGNDQIRFE LGFKYFNPKI KIIAPWRIWN 150
LNSRNSLLNF CIKNNIKFDS KTKKYSIDKN LFHNSYEGGN LDNINYEPDE 200
PMWEHTLSNY NSLDYPIYIS LTFKNGDPIK INNKNYNVEE LFLKLNNLGS 250
IAGIGRLDII ENRLIGIKSR GCYESPGASI IMYARKKLES LILDKEIYSF 300
KEEIALKYSK LVYNGYWWSP ERILLQKIID YTQTSINGII KLKIFKGQIN 350
IASINSINSL FNSKNSSFDE ISNLFNQSDS SGFINIKSLR LII 393
Length:393
Mass (Da):45,320
Last modified:November 14, 2006 - v1
Checksum:i1FDB21D282CD12F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009180 Genomic DNA. Translation: BAF35135.1.
RefSeqiYP_802501.1. NC_008512.1.

Genome annotation databases

EnsemblBacteriaiBAF35135; BAF35135; CRP_104.
GeneIDi4414925.
KEGGicrp:CRP_104.
PATRICi31966500. VBICanCar121052_0103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP009180 Genomic DNA. Translation: BAF35135.1 .
RefSeqi YP_802501.1. NC_008512.1.

3D structure databases

ProteinModelPortali Q05FN6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 387662.CRP_104.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAF35135 ; BAF35135 ; CRP_104 .
GeneIDi 4414925.
KEGGi crp:CRP_104.
PATRICi 31966500. VBICanCar121052_0103.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi PECEYIR.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci CCAR387662:GBZ4-123-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The 160-kilobase genome of the bacterial endosymbiont Carsonella."
    Nakabachi A., Yamashita A., Toh H., Ishikawa H., Dunbar H.E., Moran N.A., Hattori M.
    Science 314:267-267(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PV.

Entry informationi

Entry nameiASSY_CARRP
AccessioniPrimary (citable) accession number: Q05FN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 14, 2006
Last modified: July 9, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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