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Q05DD2 (Q05DD2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Nefl EMBL AAH16436.1 MGI 97313
OrganismMus musculus (Mouse) EMBL AAH16436.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length510 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the intermediate filament family. RuleBase RU000685

Ontologies

Keywords
   Cellular componentIntermediate filament RuleBase RU000685 SAAS SAAS006821
   DomainCoiled coil SAAS SAAS006821
Gene Ontology (GO)
   Biological_processintermediate filament bundle assembly

Inferred from genetic interaction PubMed 10461886. Source: MGI

intermediate filament organization

Inferred from mutant phenotype PubMed 2121744PubMed 7946341. Source: MGI

locomotion

Inferred from mutant phenotype PubMed 15132161. Source: MGI

microtubule cytoskeleton organization

Inferred from mutant phenotype PubMed 11487626. Source: MGI

negative regulation of neuron apoptotic process

Inferred from mutant phenotype PubMed 10884316PubMed 7946341. Source: MGI

neurofilament cytoskeleton organization

Inferred from mutant phenotype PubMed 11487626PubMed 14561875PubMed 15132161PubMed 16920084PubMed 9398473. Source: MGI

neuromuscular process controlling balance

Inferred from mutant phenotype PubMed 15884021. Source: MGI

neuron projection morphogenesis

Inferred from mutant phenotype PubMed 10884316. Source: MGI

peripheral nervous system axon regeneration

Inferred from mutant phenotype PubMed 9398473. Source: MGI

positive regulation of axonogenesis

Inferred from mutant phenotype PubMed 7946341. Source: MGI

regulation of axon diameter

Inferred from mutant phenotype PubMed 11343650PubMed 9398473. Source: MGI

   Cellular_componentaxon

Inferred from direct assay PubMed 8110465PubMed 8821035. Source: MGI

intermediate filament

Inferred from direct assay PubMed 2493000. Source: MGI

neurofilament

Inferred from direct assay PubMed 10221457PubMed 15242779PubMed 8821035. Source: MGI

neuron projection

Inferred from direct assay PubMed 11834298PubMed 19646951. Source: MGI

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue5101 EMBL AAH16436.1

Sequences

Sequence LengthMass (Da)Tools
Q05DD2 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 592FD43AC735ABD4

FASTA51057,826
        10         20         30         40         50         60 
MSSFGYDPYF STSYKRRYVE TPRVHISSVR SGYSTARSAY SSYSAPVSSS LSVRRSYSSS 

        70         80         90        100        110        120 
SGSLMPSLEN LDLSQVAAIS NDLKSIRTQE KAQLQDLNDR FASFIERVHE LEQQNKVLEA 

       130        140        150        160        170        180 
ELLVLRQKHS EPSRFRALYE QEIRDLRLAA EDATNEKQAL QGEREGLEET LRNLQARYEE 

       190        200        210        220        230        240 
EVLSREDAEG RLMEARKGAD EAALARAELE KRIDSLMDEI AFLKKVHEEE IAELQAQIQY 

       250        260        270        280        290        300 
AQISVEMDVS SKPDLSAALK DIRAQYEKLA AKNMQNAEEW FKSRFTVLTE SAAKNTDAVR 

       310        320        330        340        350        360 
AAKDEVSESR RLLKAKTLEI EACRGMNEAL EKQLQELEDK QNADISAMQD TINKLENELR 

       370        380        390        400        410        420 
STKSEMARYL KEYQDLLNVK MALDIEIAAY RKLLEGEETR LSFTSVGSIT SGYSQSSQVF 

       430        440        450        460        470        480 
GRSAYSGLQS SSYLMSARSF PAYYTSHVQE EQTEVEETIE ATKAEEAKDE PPSEGEAEEE 

       490        500        510 
EKEKEEGEEE EGAEEEEAAK DESEDTKKKK 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye EMBL AAH16436.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC016436 mRNA. Translation: AAH16436.1.
UniGeneMm.1956.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ05DD2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:97313. Nefl.

Phylogenomic databases

HOVERGENHBG013015.
InParanoidQ05DD2.

Gene expression databases

GenevestigatorQ05DD2.

Family and domain databases

InterProIPR001664. IF.
IPR006821. Intermed_filament_DNA-bd.
IPR018039. Intermediate_filament_CS.
IPR027692. NF-L.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PTHR23239:SF22. PTHR23239:SF22. 1 hit.
PfamPF00038. Filament. 1 hit.
PF04732. Filament_head. 1 hit.
[Graphical view]
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNEFL. mouse.
SOURCESearch...

Entry information

Entry nameQ05DD2_MOUSE
AccessionPrimary (citable) accession number: Q05DD2
Entry history
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)