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Q05DD2

- Q05DD2_MOUSE

UniProt

Q05DD2 - Q05DD2_MOUSE

Protein
Submitted name:

Nefl protein

Gene

Nefl

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. intermediate filament bundle assembly Source: MGI
    2. intermediate filament organization Source: MGI
    3. locomotion Source: MGI
    4. microtubule cytoskeleton organization Source: MGI
    5. negative regulation of neuron apoptotic process Source: MGI
    6. neurofilament cytoskeleton organization Source: MGI
    7. neuromuscular process controlling balance Source: MGI
    8. neuron projection morphogenesis Source: MGI
    9. peripheral nervous system axon regeneration Source: MGI
    10. positive regulation of axonogenesis Source: MGI
    11. regulation of axon diameter Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Nefl proteinImported
    Gene namesi
    Name:NeflImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:97313. Nefl.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. intermediate filament Source: MGI
    3. neurofilament Source: MGI
    4. neuron projection Source: MGI

    Keywords - Cellular componenti

    Intermediate filamentUniRule annotationSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiQ05DD2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ05DD2.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the intermediate filament family.UniRule annotation

    Keywords - Domaini

    Coiled coilSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG013015.
    InParanoidiQ05DD2.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR006821. Intermed_filament_DNA-bd.
    IPR018039. Intermediate_filament_CS.
    IPR027692. NF-L.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PTHR23239:SF22. PTHR23239:SF22. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    PF04732. Filament_head. 1 hit.
    [Graphical view]
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q05DD2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSFGYDPYF STSYKRRYVE TPRVHISSVR SGYSTARSAY SSYSAPVSSS    50
    LSVRRSYSSS SGSLMPSLEN LDLSQVAAIS NDLKSIRTQE KAQLQDLNDR 100
    FASFIERVHE LEQQNKVLEA ELLVLRQKHS EPSRFRALYE QEIRDLRLAA 150
    EDATNEKQAL QGEREGLEET LRNLQARYEE EVLSREDAEG RLMEARKGAD 200
    EAALARAELE KRIDSLMDEI AFLKKVHEEE IAELQAQIQY AQISVEMDVS 250
    SKPDLSAALK DIRAQYEKLA AKNMQNAEEW FKSRFTVLTE SAAKNTDAVR 300
    AAKDEVSESR RLLKAKTLEI EACRGMNEAL EKQLQELEDK QNADISAMQD 350
    TINKLENELR STKSEMARYL KEYQDLLNVK MALDIEIAAY RKLLEGEETR 400
    LSFTSVGSIT SGYSQSSQVF GRSAYSGLQS SSYLMSARSF PAYYTSHVQE 450
    EQTEVEETIE ATKAEEAKDE PPSEGEAEEE EKEKEEGEEE EGAEEEEAAK 500
    DESEDTKKKK 510
    Length:510
    Mass (Da):57,826
    Last modified:November 14, 2006 - v1
    Checksum:i592FD43AC735ABD4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei510 – 5101Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC016436 mRNA. Translation: AAH16436.1.
    UniGeneiMm.1956.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC016436 mRNA. Translation: AAH16436.1 .
    UniGenei Mm.1956.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q05DD2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97313. Nefl.

    Phylogenomic databases

    HOVERGENi HBG013015.
    InParanoidi Q05DD2.

    Miscellaneous databases

    ChiTaRSi NEFL. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q05DD2.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR006821. Intermed_filament_DNA-bd.
    IPR018039. Intermediate_filament_CS.
    IPR027692. NF-L.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    PTHR23239:SF22. PTHR23239:SF22. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    PF04732. Filament_head. 1 hit.
    [Graphical view ]
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: EyeImported.

    Entry informationi

    Entry nameiQ05DD2_MOUSE
    AccessioniPrimary (citable) accession number: Q05DD2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 14, 2006
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)