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Protein
Submitted name:

MRE11A protein

Gene

MRE11A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

EndonucleaseUniRule annotation, ExonucleaseUniRule annotation, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repairUniRule annotation, MeiosisUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
MRE11A proteinImported
Gene namesi
Name:MRE11AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30934.

PTM / Processingi

Proteomic databases

PaxDbiQ05D78.
PeptideAtlasiQ05D78.

Expressioni

Gene expression databases

GenevisibleiQ05D78. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000325863.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini294 – 461Mre11_DNA_bindInterPro annotationAdd BLAST168

Sequence similaritiesi

Belongs to the MRE11/RAD32 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2310. Eukaryota.
COG0420. LUCA.
HOGENOMiHOG000216581.
HOVERGENiHBG052508.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR003701. Mre11.
IPR007281. Mre11_DNA-bd.
[Graphical view]
PANTHERiPTHR10139:SF1. PTHR10139:SF1. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
PF04152. Mre11_DNA_bind. 1 hit.
[Graphical view]
SMARTiSM01347. Mre11_DNA_bind. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
TIGRFAMsiTIGR00583. mre11. 1 hit.

Sequencei

Sequence statusi: Fragment.

Q05D78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTADALDDE NTFKILVATD IHLGFMEKDA VRGNDTFVTL DEILRLAQEN
60 70 80 90 100
EVDFILLGGD LFHENKPSRK TLHTCLELLR KYCMGDRPVQ FEILSDQSVN
110 120 130 140 150
FGFSKFPWVN YQDGNLNISI PVFSIHGNHD DPTGADALCA LDILSCAGFV
160 170 180 190 200
NHFGRSMSVE KIDISPVLLQ KGSTKIALYG LGSIPDERLY RMFVNKKVTM
210 220 230 240 250
LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL VIWGHEHECK
260 270 280 290 300
IAPTKNEQQL FYISQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMHKIP
310 320 330 340 350
LHTVRQFFME DIVLANHPDI FNPDNPKVTQ AIQSFCLEKI EEMLENAERE
360 370 380 390 400
RLGNSHQPEK PLVRLRVDYS GGFEPFSVLR FSQKFVDRVA NPKDIIHFFR
410 420 430 440 450
HREQKEKTGE EINFGKLITK PSEGTTLRVE DLVKQYFQTA EKNVQLSLLT
460 470 480 490 500
ERGMGEAVQE FVDKEEKDAI EELVKYQLEK TQRFLKERHI DALEDKIDEE
510
VRRFRETRKK KKKKKKK
Length:517
Mass (Da):59,724
Last modified:November 14, 2006 - v1
Checksum:iC9D454197D1B334B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei517Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC017823 mRNA. Translation: AAH17823.1.
RefSeqiNP_005581.2. NM_005590.3.
UniGeneiHs.192649.

Genome annotation databases

GeneIDi4361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC017823 mRNA. Translation: AAH17823.1.
RefSeqiNP_005581.2. NM_005590.3.
UniGeneiHs.192649.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000325863.

Proteomic databases

PaxDbiQ05D78.
PeptideAtlasiQ05D78.

Protocols and materials databases

DNASUi4361.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4361.

Organism-specific databases

CTDi4361.
PharmGKBiPA30934.

Phylogenomic databases

eggNOGiKOG2310. Eukaryota.
COG0420. LUCA.
HOGENOMiHOG000216581.
HOVERGENiHBG052508.

Miscellaneous databases

ChiTaRSiMRE11A. human.
GenomeRNAii4361.

Gene expression databases

GenevisibleiQ05D78. HS.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR003701. Mre11.
IPR007281. Mre11_DNA-bd.
[Graphical view]
PANTHERiPTHR10139:SF1. PTHR10139:SF1. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
PF04152. Mre11_DNA_bind. 1 hit.
[Graphical view]
SMARTiSM01347. Mre11_DNA_bind. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
TIGRFAMsiTIGR00583. mre11. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ05D78_HUMAN
AccessioniPrimary (citable) accession number: Q05D78
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: November 30, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.