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Protein

Deuterosome assembly protein 1

Gene

DEUP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Deuterosome assembly protein 1Imported
Alternative name(s):
Coiled-coil domain-containing protein 67
Gene namesi
Name:DEUP1Imported
Synonyms:CCDC67
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:26344. DEUP1.

Subcellular locationi

  • Cytoplasm By similarity

  • Note: Localizes to the deuterosome.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi159989.
OpenTargetsiENSG00000165325.
PharmGKBiPA143485419.

Polymorphism and mutation databases

BioMutaiCCDC67.
DMDMi156630476.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002978291 – 604Deuterosome assembly protein 1Add BLAST604

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei547PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ05D60.
MaxQBiQ05D60.
PaxDbiQ05D60.
PeptideAtlasiQ05D60.
PRIDEiQ05D60.

PTM databases

iPTMnetiQ05D60.
PhosphoSitePlusiQ05D60.

Expressioni

Gene expression databases

BgeeiENSG00000165325.
CleanExiHS_CCDC67.
ExpressionAtlasiQ05D60. baseline and differential.
GenevisibleiQ05D60. HS.

Organism-specific databases

HPAiHPA010986.

Interactioni

Subunit structurei

Interacts with CEP152; the interaction is mutually exclusive with CEP63.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AMPHP494183EBI-748597,EBI-7121510
CCDC67E9PJR53EBI-748597,EBI-10177066
DGCR6LQ9BY273EBI-748597,EBI-742953
DKFZp451B226Q5HYH73EBI-748597,EBI-10173842
ESRRGP625083EBI-748597,EBI-2834260
EXOC5Q8IW243EBI-748597,EBI-10171392
FBF1Q8TES7-63EBI-748597,EBI-10244131
GEMP550403EBI-748597,EBI-744104
GOLGA2Q083793EBI-748597,EBI-618309
IFIT3O148794EBI-748597,EBI-745127
KIFC3Q9BVG83EBI-748597,EBI-2125614
KRT15P190123EBI-748597,EBI-739566
SUMO1P631653EBI-748597,EBI-80140
TFPTG5E9B53EBI-748597,EBI-10178002
TRIM54Q9BYV23EBI-748597,EBI-2130429
TXLNAP402223EBI-748597,EBI-359793
ZNF460Q145923EBI-748597,EBI-2555738
ZNF572A1L4E93EBI-748597,EBI-10172590
ZNF572Q7Z3I73EBI-748597,EBI-10257016

Protein-protein interaction databases

BioGridi127746. 54 interactors.
IntActiQ05D60. 21 interactors.
MINTiMINT-1448213.
STRINGi9606.ENSP00000298050.

Structurei

3D structure databases

ProteinModelPortaliQ05D60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili14 – 59Sequence analysisAdd BLAST46
Coiled coili85 – 197Sequence analysisAdd BLAST113
Coiled coili226 – 278Sequence analysisAdd BLAST53
Coiled coili336 – 399Sequence analysisAdd BLAST64
Coiled coili558 – 601Sequence analysisAdd BLAST44

Sequence similaritiesi

Belongs to the CEP63 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IIW9. Eukaryota.
ENOG4111S30. LUCA.
GeneTreeiENSGT00530000063797.
HOGENOMiHOG000111430.
HOVERGENiHBG107618.
InParanoidiQ05D60.
OMAiRYAYQSQ.
OrthoDBiEOG091G0LBG.
PhylomeDBiQ05D60.
TreeFamiTF330595.

Family and domain databases

InterProiIPR031470. Cep63/Deup1_N.
IPR029611. Deup1.
[Graphical view]
PANTHERiPTHR18875:SF5. PTHR18875:SF5. 1 hit.
PfamiPF17045. CEP63. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q05D60-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENQAHNTMG TSPCEAELQE LMEQIDIMVS NKKMDWERKM RALETRLDLR
60 70 80 90 100
DQELANAQTC LDQKGQEVGL LRQKLDSLEK CNLAMTQNYE GQLQSLKAQF
110 120 130 140 150
SKLTNNFEKL RLHQMKQNKV PRKELPHLKE EIPFELSNLN QKLEEFRAKS
160 170 180 190 200
REWDKQEILY QTHLISLDAQ QKLLSEKCNQ FQKQAQSYQT QLNGKKQCLE
210 220 230 240 250
DSSSEIPRLI CDPDPNCEIN ERDEFIIEKL KSAVNEIALS RNKLQDENQK
260 270 280 290 300
LLQELKMYQR QCQAMEAGLS EVKSELQSRD DLLRIIEMER LQLHRELLKI
310 320 330 340 350
GECQNAQGNK TRLESSYLPS IKEPERKIKE LFSVMQDQPN HEKELNKIRS
360 370 380 390 400
QLQQVEEYHN SEQERMRNEI SDLTEELHQK EITIATVTKK AALLEKQLKM
410 420 430 440 450
ELEIKEKMLA KQKVSDMKYK AVRTENTHLK GMMGDLDPGE YMSMDFTNRE
460 470 480 490 500
QSRHTSINKL QYENERLRND LAKLHVNGKS TWTNQNTYEE TGRYAYQSQI
510 520 530 540 550
KVEQNEERLS HDCEPNRSTM PPLPPSTFQA KEMTSPLVSD DDVFPLSPPD
560 570 580 590 600
MSFPASLAAQ HFLLEEEKRA KELEKLLNTH IDELQRHTEF TLNKYSKLKQ

NRHI
Length:604
Mass (Da):70,977
Last modified:August 21, 2007 - v2
Checksum:i0BC0B1C207D2EA2A
GO
Isoform 2 (identifier: Q05D60-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-262: Missing.
     263-263: Q → M

Note: No experimental confirmation available.
Show »
Length:342
Mass (Da):40,111
Checksum:iEA6CD8113D15980E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti440E → R in BAB71673 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050759175S → F.Corresponds to variant rs34205920dbSNPEnsembl.1
Natural variantiVAR_059601440E → G.Corresponds to variant rs12282288dbSNPEnsembl.1
Natural variantiVAR_050760440E → Q.Corresponds to variant rs12288277dbSNPEnsembl.1
Natural variantiVAR_050761504Q → K.1 PublicationCorresponds to variant rs2259633dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0273671 – 262Missing in isoform 2. 1 PublicationAdd BLAST262
Alternative sequenceiVSP_027368263Q → M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003969 Genomic DNA. No translation available.
AP004242 Genomic DNA. No translation available.
BC017929 mRNA. Translation: AAH17929.1. Sequence problems.
BC031247 mRNA. Translation: AAH31247.2.
AK058122 mRNA. Translation: BAB71673.1. Sequence problems.
CCDSiCCDS44707.1. [Q05D60-1]
RefSeqiNP_857596.2. NM_181645.3. [Q05D60-1]
XP_005273859.1. XM_005273802.1. [Q05D60-1]
UniGeneiHs.436625.

Genome annotation databases

EnsembliENST00000298050; ENSP00000298050; ENSG00000165325. [Q05D60-1]
GeneIDi159989.
KEGGihsa:159989.
UCSCiuc001pdq.5. human. [Q05D60-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003969 Genomic DNA. No translation available.
AP004242 Genomic DNA. No translation available.
BC017929 mRNA. Translation: AAH17929.1. Sequence problems.
BC031247 mRNA. Translation: AAH31247.2.
AK058122 mRNA. Translation: BAB71673.1. Sequence problems.
CCDSiCCDS44707.1. [Q05D60-1]
RefSeqiNP_857596.2. NM_181645.3. [Q05D60-1]
XP_005273859.1. XM_005273802.1. [Q05D60-1]
UniGeneiHs.436625.

3D structure databases

ProteinModelPortaliQ05D60.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127746. 54 interactors.
IntActiQ05D60. 21 interactors.
MINTiMINT-1448213.
STRINGi9606.ENSP00000298050.

PTM databases

iPTMnetiQ05D60.
PhosphoSitePlusiQ05D60.

Polymorphism and mutation databases

BioMutaiCCDC67.
DMDMi156630476.

Proteomic databases

EPDiQ05D60.
MaxQBiQ05D60.
PaxDbiQ05D60.
PeptideAtlasiQ05D60.
PRIDEiQ05D60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298050; ENSP00000298050; ENSG00000165325. [Q05D60-1]
GeneIDi159989.
KEGGihsa:159989.
UCSCiuc001pdq.5. human. [Q05D60-1]

Organism-specific databases

CTDi159989.
DisGeNETi159989.
GeneCardsiCCDC67.
HGNCiHGNC:26344. DEUP1.
HPAiHPA010986.
neXtProtiNX_Q05D60.
OpenTargetsiENSG00000165325.
PharmGKBiPA143485419.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIW9. Eukaryota.
ENOG4111S30. LUCA.
GeneTreeiENSGT00530000063797.
HOGENOMiHOG000111430.
HOVERGENiHBG107618.
InParanoidiQ05D60.
OMAiRYAYQSQ.
OrthoDBiEOG091G0LBG.
PhylomeDBiQ05D60.
TreeFamiTF330595.

Miscellaneous databases

GenomeRNAii159989.
PROiQ05D60.

Gene expression databases

BgeeiENSG00000165325.
CleanExiHS_CCDC67.
ExpressionAtlasiQ05D60. baseline and differential.
GenevisibleiQ05D60. HS.

Family and domain databases

InterProiIPR031470. Cep63/Deup1_N.
IPR029611. Deup1.
[Graphical view]
PANTHERiPTHR18875:SF5. PTHR18875:SF5. 1 hit.
PfamiPF17045. CEP63. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDEUP1_HUMAN
AccessioniPrimary (citable) accession number: Q05D60
Secondary accession number(s): Q8NEF1, Q96LL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: November 30, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

CEP63 and DEUP1 paralogs are both involved in centriole amplification: while CEP63 mediates mother-centriole-dependent centriole duplication, DEUP1 mediates de novo centriole amplification in multiciliated cells.

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.