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Protein

CTD small phosphatase-like protein 2

Gene

CTDSPL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Probable phosphatase.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
CTD small phosphatase-like protein 2 (EC:3.1.3.-)
Short name:
CTDSP-like 2
Gene namesi
Name:CTDSPL2
ORF Names:HSPC058, HSPC129
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:26936. CTDSPL2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672063.

Polymorphism and mutation databases

BioMutaiCTDSPL2.
DMDMi187471086.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466CTD small phosphatase-like protein 2PRO_0000331464Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei26 – 261N6-acetyllysineCombined sources
Modified residuei28 – 281PhosphoserineCombined sources
Modified residuei51 – 511PhosphoserineCombined sources
Modified residuei57 – 571N6-acetyllysineCombined sources
Modified residuei85 – 851PhosphoserineCombined sources
Modified residuei86 – 861PhosphothreonineCombined sources
Modified residuei104 – 1041PhosphoserineCombined sources
Modified residuei134 – 1341PhosphoserineCombined sources
Modified residuei165 – 1651PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ05D32.
MaxQBiQ05D32.
PaxDbiQ05D32.
PeptideAtlasiQ05D32.
PRIDEiQ05D32.

PTM databases

DEPODiQ05D32.
iPTMnetiQ05D32.
PhosphoSiteiQ05D32.

Expressioni

Gene expression databases

BgeeiENSG00000137770.
CleanExiHS_CTDSPL2.
ExpressionAtlasiQ05D32. baseline and differential.
GenevisibleiQ05D32. HS.

Organism-specific databases

HPAiHPA040763.
HPA062198.

Interactioni

Protein-protein interaction databases

BioGridi119571. 16 interactions.
IntActiQ05D32. 14 interactions.
MINTiMINT-5009084.
STRINGi9606.ENSP00000260327.

Structurei

3D structure databases

ProteinModelPortaliQ05D32.
SMRiQ05D32. Positions 290-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini283 – 442160FCP1 homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CTDSPL2 family.Curated
Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1605. Eukaryota.
COG5190. LUCA.
GeneTreeiENSGT00390000017194.
HOVERGENiHBG107781.
InParanoidiQ05D32.
KOiK17616.
OMAiYTSQAVQ.
OrthoDBiEOG091G0GO9.
PhylomeDBiQ05D32.
TreeFamiTF354278.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q05D32-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRLRTRKASQ QSNQIQTQRT ARAKRKYSEV DDSLPSGGEK PSKNETGLLS
60 70 80 90 100
SIKKFIKGST PKEERENPSK RSRIERDIDN NLITSTPRAG EKPNKQISRV
110 120 130 140 150
RRKSQVNGEA GSYEMTNQHV KQNGKLEDNP SSGSPPRTTL LGTIFSPVFN
160 170 180 190 200
FFSPANKNGT SGSDSPGQAV EAEEIVKQLD MEQVDEITTS TTTSTNGAAY
210 220 230 240 250
SNQAVQVRPS LNNGLEEAEE TVNRDIPPLT APVTPDSGYS SAHAEATYEE
260 270 280 290 300
DWEVFDPYYF IKHVPPLTEE QLNRKPALPL KTRSTPEFSL VLDLDETLVH
310 320 330 340 350
CSLNELEDAA LTFPVLFQDV IYQVYVRLRP FFREFLERMS QMYEIILFTA
360 370 380 390 400
SKKVYADKLL NILDPKKQLV RHRLFREHCV CVQGNYIKDL NILGRDLSKT
410 420 430 440 450
IIIDNSPQAF AYQLSNGIPI ESWFMDKNDN ELLKLIPFLE KLVELNEDVR
460
PHIRDRFRLH DLLPPD
Length:466
Mass (Da):52,999
Last modified:April 29, 2008 - v2
Checksum:iE8BA6911EBD4B332
GO
Isoform 2 (identifier: Q05D32-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-230: Missing.

Show »
Length:394
Mass (Da):45,424
Checksum:iA1E6F3A0FBFCD13B
GO

Sequence cautioni

The sequence AAF29030 differs from that shown. Reason: Frameshift at positions 84 and 95. Curated
The sequence AAH18623 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAA91664 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti107 – 1104NGEA → MEKL in AAF29093 (PubMed:11042152).Curated
Sequence conflicti228 – 2281P → T in AAF29030 (PubMed:11042152).Curated
Sequence conflicti321 – 3211I → V in AAQ76796 (PubMed:16533400).Curated
Sequence conflicti321 – 3211I → V in BAA91664 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti244 – 2441A → V.
Corresponds to variant rs871923 [ dbSNP | Ensembl ].
VAR_042886

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei159 – 23072Missing in isoform 2. 1 PublicationVSP_033218Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY364237 mRNA. Translation: AAQ76796.1.
DQ128104 mRNA. Translation: AAZ42188.1.
AF161543 mRNA. Translation: AAF29030.1. Frameshift.
AF161478 mRNA. Translation: AAF29093.1.
AK001385 mRNA. Translation: BAA91664.1. Different initiation.
AK291230 mRNA. Translation: BAF83919.1.
CR627421 mRNA. Translation: CAH10508.1.
CH471082 Genomic DNA. Translation: EAW77265.1.
BC018623 mRNA. Translation: AAH18623.1. Sequence problems.
BC035744 mRNA. Translation: AAH35744.1.
CCDSiCCDS10110.1. [Q05D32-1]
RefSeqiNP_057480.2. NM_016396.2. [Q05D32-1]
XP_005254498.1. XM_005254441.2. [Q05D32-1]
XP_006720628.1. XM_006720565.2. [Q05D32-1]
UniGeneiHs.497967.

Genome annotation databases

EnsembliENST00000260327; ENSP00000260327; ENSG00000137770. [Q05D32-1]
ENST00000558373; ENSP00000453051; ENSG00000137770. [Q05D32-2]
ENST00000558966; ENSP00000452837; ENSG00000137770. [Q05D32-1]
GeneIDi51496.
KEGGihsa:51496.
UCSCiuc001ztr.4. human. [Q05D32-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY364237 mRNA. Translation: AAQ76796.1.
DQ128104 mRNA. Translation: AAZ42188.1.
AF161543 mRNA. Translation: AAF29030.1. Frameshift.
AF161478 mRNA. Translation: AAF29093.1.
AK001385 mRNA. Translation: BAA91664.1. Different initiation.
AK291230 mRNA. Translation: BAF83919.1.
CR627421 mRNA. Translation: CAH10508.1.
CH471082 Genomic DNA. Translation: EAW77265.1.
BC018623 mRNA. Translation: AAH18623.1. Sequence problems.
BC035744 mRNA. Translation: AAH35744.1.
CCDSiCCDS10110.1. [Q05D32-1]
RefSeqiNP_057480.2. NM_016396.2. [Q05D32-1]
XP_005254498.1. XM_005254441.2. [Q05D32-1]
XP_006720628.1. XM_006720565.2. [Q05D32-1]
UniGeneiHs.497967.

3D structure databases

ProteinModelPortaliQ05D32.
SMRiQ05D32. Positions 290-442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119571. 16 interactions.
IntActiQ05D32. 14 interactions.
MINTiMINT-5009084.
STRINGi9606.ENSP00000260327.

PTM databases

DEPODiQ05D32.
iPTMnetiQ05D32.
PhosphoSiteiQ05D32.

Polymorphism and mutation databases

BioMutaiCTDSPL2.
DMDMi187471086.

Proteomic databases

EPDiQ05D32.
MaxQBiQ05D32.
PaxDbiQ05D32.
PeptideAtlasiQ05D32.
PRIDEiQ05D32.

Protocols and materials databases

DNASUi51496.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000260327; ENSP00000260327; ENSG00000137770. [Q05D32-1]
ENST00000558373; ENSP00000453051; ENSG00000137770. [Q05D32-2]
ENST00000558966; ENSP00000452837; ENSG00000137770. [Q05D32-1]
GeneIDi51496.
KEGGihsa:51496.
UCSCiuc001ztr.4. human. [Q05D32-1]

Organism-specific databases

CTDi51496.
GeneCardsiCTDSPL2.
HGNCiHGNC:26936. CTDSPL2.
HPAiHPA040763.
HPA062198.
neXtProtiNX_Q05D32.
PharmGKBiPA142672063.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1605. Eukaryota.
COG5190. LUCA.
GeneTreeiENSGT00390000017194.
HOVERGENiHBG107781.
InParanoidiQ05D32.
KOiK17616.
OMAiYTSQAVQ.
OrthoDBiEOG091G0GO9.
PhylomeDBiQ05D32.
TreeFamiTF354278.

Miscellaneous databases

ChiTaRSiCTDSPL2. human.
GenomeRNAii51496.
PROiQ05D32.

Gene expression databases

BgeeiENSG00000137770.
CleanExiHS_CTDSPL2.
ExpressionAtlasiQ05D32. baseline and differential.
GenevisibleiQ05D32. HS.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiIPR011948. Dullard_phosphatase.
IPR004274. FCP1_dom.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF03031. NIF. 1 hit.
[Graphical view]
SMARTiSM00577. CPDc. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02251. HIF-SF_euk. 1 hit.
PROSITEiPS50969. FCP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCTSL2_HUMAN
AccessioniPrimary (citable) accession number: Q05D32
Secondary accession number(s): Q3ZTU1
, Q6AI06, Q8IYI9, Q9NVT2, Q9NZX8, Q9P030
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 7, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.