UniProtKB - Q05D26 (Q05D26_HUMAN)
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Protein
Tyrosine-protein kinase
Gene
BLK
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
Keywordsi
Molecular function | Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation |
Ligand | ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding |
Enzyme and pathway databases
SignaLinki | Q05D26. |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:BLKImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 118 | SH3InterPro annotationAdd BLAST | 61 | |
Domaini | 124 – 220 | SH2InterPro annotationAdd BLAST | 97 | |
Domaini | 241 – 500 | Protein kinaseInterPro annotationAdd BLAST | 260 |
Sequence similaritiesi
Keywords - Domaini
SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotationPhylogenomic databases
eggNOGi | KOG0197. Eukaryota. COG0515. LUCA. |
HOGENOMi | HOG000233858. |
HOVERGENi | HBG008761. |
KOi | K08890. |
Family and domain databases
CDDi | cd10371. SH2_Src_Blk. 1 hit. |
Gene3Di | 3.30.505.10. 1 hit. |
InterProi | View protein in InterPro IPR035853. Blk_SH2. IPR011009. Kinase-like_dom_sf. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR036860. SH2_dom_sf. IPR036028. SH3-like_dom_sf. IPR001452. SH3_domain. IPR020635. Tyr_kinase_cat_dom. |
Pfami | View protein in Pfam PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit. |
PRINTSi | PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. PR00109. TYRKINASE. |
SMARTi | View protein in SMART SM00252. SH2. 1 hit. SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit. |
SUPFAMi | SSF50044. SSF50044. 1 hit. SSF55550. SSF55550. 1 hit. SSF56112. SSF56112. 1 hit. |
PROSITEi | View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. |
i Sequence
Sequence statusi: Fragment.
Q05D26-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDAPPLPP LVVFNHLTPP
60 70 80 90 100
PPDEHLDEDK HFVVALYDYT AMNDRDLQML KGEKLQVLKG TGDWWLARSL
110 120 130 140 150
VTGREGYVPS NFVARVESLE MERWFFRSQG RKEAERQLLA PINKAGSFLI
160 170 180 190 200
RESETNKGAF SLSVKDVTTQ GELIKHYKIR CLDEGGYYIS PRITFPSLQA
210 220 230 240 250
LVQHYSKKGD GLCQRLTLPC VRPAPQNPWA QDEWEIPRQS LRLVRKLGSG
260 270 280 290 300
QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY
310 320 330 340 350
AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY
360 370 380 390 400
IERMNSIHRD LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK
410 420 430 440 450
WTAPEAIHFG VFTIKADVWS FGVLLMEVVT YGRVPYPGMS NPEVIRNLER
460 470 480 490 500
GYRMPRPDTC PPELYRGVIA ECWRSRPEER PTFDCTPGRV TRPLCAASFV
510 520 530 540 550
EGCNSDLARS SGVLSPSKVF RTGKRLSSSK APVLGTPRAG RVPASAPCVD
560 570 580 590
PALPRYRSQT GSRGRQQGQP QPRLRSSTAG LFCNKVTSVR KKKKKKKKK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 599 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC018703 mRNA. Translation: AAH18703.1. |
RefSeqi | NP_001706.2. NM_001715.2. |
UniGenei | Hs.146591. |
Genome annotation databases
GeneIDi | 640. |
KEGGi | hsa:640. |
Similar proteinsi
Entry informationi
Entry namei | Q05D26_HUMAN | |
Accessioni | Q05D26Primary (citable) accession number: Q05D26 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 14, 2006 |
Last sequence update: | November 14, 2006 | |
Last modified: | February 28, 2018 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |