BLK

Functionⁱ

Catalytic activityⁱ

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC

Keywordsⁱ

Molecular function	Kinase, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
Ligand	ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q05D26.

SignaLinkⁱ

Q05D26.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tyrosine-protein kinaseUniRule annotation (EC:2.7.10.2UniRule annotation)
Gene namesⁱ	Name:BLKImported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA25368.

PharmGKBⁱ

PA25368.

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q05D26.
PaxDbⁱ	Q05D26.
PRIDEⁱ	Q05D26.

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q05D26. HS.

Genevisibleⁱ

Q05D26. HS.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q05D26.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	58 – 118	SH3InterPro annotationAdd BLAST	61
Domainⁱ	124 – 220	SH2InterPro annotationAdd BLAST	97
Domainⁱ	241 – 500	Protein kinaseInterPro annotationAdd BLAST	260

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family.UniRule annotation

Keywords - Domainⁱ

SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGⁱ	KOG0197. Eukaryota. COG0515. LUCA.
HOGENOMⁱ	HOG000233858.
HOVERGENⁱ	HBG008761.
KEGG Orthology (KO) More...KOⁱ	K08890.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10371. SH2_Src_Blk. 1 hit.
Gene3Dⁱ	3.30.505.10. 1 hit.
InterProⁱ	View protein in InterPro IPR035853. Blk_SH2. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR001452. SH3_domain. IPR020635. Tyr_kinase_cat_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit.
PRINTSⁱ	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. PR00109. TYRKINASE.
SMARTⁱ	View protein in SMART SM00252. SH2. 1 hit. SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit.
SUPFAMⁱ	SSF50044. SSF50044. 1 hit. SSF55550. SSF55550. 1 hit. SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Q05D26-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDAPPLPP LVVFNHLTPP 
        60         70         80         90        100
PPDEHLDEDK HFVVALYDYT AMNDRDLQML KGEKLQVLKG TGDWWLARSL 
       110        120        130        140        150
VTGREGYVPS NFVARVESLE MERWFFRSQG RKEAERQLLA PINKAGSFLI 
       160        170        180        190        200
RESETNKGAF SLSVKDVTTQ GELIKHYKIR CLDEGGYYIS PRITFPSLQA 
       210        220        230        240        250
LVQHYSKKGD GLCQRLTLPC VRPAPQNPWA QDEWEIPRQS LRLVRKLGSG 
       260        270        280        290        300
QFGEVWMGYY KNNMKVAIKT LKEGTMSPEA FLGEANVMKA LQHERLVRLY 
       310        320        330        340        350
AVVTKEPIYI VTEYMARGCL LDFLKTDEGS RLSLPRLIDM SAQIAEGMAY 
       360        370        380        390        400
IERMNSIHRD LRAANILVSE ALCCKIADFG LARIIDSEYT AQEGAKFPIK 
       410        420        430        440        450
WTAPEAIHFG VFTIKADVWS FGVLLMEVVT YGRVPYPGMS NPEVIRNLER 
       460        470        480        490        500
GYRMPRPDTC PPELYRGVIA ECWRSRPEER PTFDCTPGRV TRPLCAASFV 
       510        520        530        540        550
EGCNSDLARS SGVLSPSKVF RTGKRLSSSK APVLGTPRAG RVPASAPCVD 
       560        570        580        590 
PALPRYRSQT GSRGRQQGQP QPRLRSSTAG LFCNKVTSVR KKKKKKKKK

Length:599

Mass (Da):67,424

Last modified:November 14, 2006 - v1

Checksum:ⁱ37DBDC410DB63823

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	599	Imported		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC018703 mRNA. Translation: AAH18703.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001706.2. NM_001715.2.
UniGeneⁱ	Hs.146591.

Genome annotation databases

GeneIDⁱ	640.
KEGGⁱ	hsa:640.

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q05D26	P51451 E9PJX5 H2R5W0 G3QQZ5 UPI0007DBCA12 UPI000274312B A0A0D9RWI1 UPI000533556D H9ZC88 F6QQC0 +7	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Gorilla gorilla gorilla (Western lowland gorilla) Pan paniscus (Pygmy chimpanzee) (Bonobo) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana) Macaca mulatta (Rhesus macaque) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) And more	505	UniRef90_P51451	Cluster: Tyrosine-protein kinase Blk	18

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q05D26	P08631 F6SF04 UPI0000111AFB P08631-2 F1PSI2 W5NXU9 G1M4J6 G3QK47 UPI00029D96FA J3KPD6 +567	Homo sapiens (Human) Canis lupus familiaris (Dog) (Canis familiaris) Ovis aries (Sheep) Ailuropoda melanoleuca (Giant panda) Gorilla gorilla gorilla (Western lowland gorilla) Bos taurus (Bovine) Bison bison bison Bos mutus (wild yak) Felis catus (Cat) (Felis silvestris catus) Equus caballus (Horse) And more	526	UniRef50_P08631	Cluster: Tyrosine-protein kinase HCK	578

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC018703 mRNA. Translation: AAH18703.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001706.2. NM_001715.2.
UniGeneⁱ	Hs.146591.

3D structure databases

ProteinModelPortalⁱ	Q05D26.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q05D26.
PaxDbⁱ	Q05D26.
PRIDEⁱ	Q05D26.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	640.
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	640.
KEGGⁱ	hsa:640.

Organism-specific databases

CTDⁱ	640.
PharmGKBⁱ	PA25368.

Phylogenomic databases

eggNOGⁱ	KOG0197. Eukaryota. COG0515. LUCA.
HOGENOMⁱ	HOG000233858.
HOVERGENⁱ	HBG008761.
KEGG Orthology (KO) More...KOⁱ	K08890.

Enzyme and pathway databases

SignaLinkⁱ	Q05D26.

SignaLinkⁱ

Q05D26.

Miscellaneous databases

ChiTaRSⁱ	BLK. human.
GenomeRNAiⁱ	640.

Gene expression databases

Genevisibleⁱ	Q05D26. HS.

Genevisibleⁱ

Q05D26. HS.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10371. SH2_Src_Blk. 1 hit.
Gene3Dⁱ	3.30.505.10. 1 hit.
InterProⁱ	View protein in InterPro IPR035853. Blk_SH2. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR000980. SH2. IPR001452. SH3_domain. IPR020635. Tyr_kinase_cat_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07714. Pkinase_Tyr. 1 hit. PF00017. SH2. 1 hit. PF00018. SH3_1. 1 hit.
PRINTSⁱ	PR00401. SH2DOMAIN. PR00452. SH3DOMAIN. PR00109. TYRKINASE.
SMARTⁱ	View protein in SMART SM00252. SH2. 1 hit. SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit.
SUPFAMⁱ	SSF50044. SSF50044. 1 hit. SSF55550. SSF55550. 1 hit. SSF56112. SSF56112. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q05D26_HUMAN
Accessionⁱ	Q05D26Primary (citable) accession number: Q05D26
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 14, 2006
	Last sequence update:	November 14, 2006
	Last modified:	September 27, 2017
	This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - Q05D26 (Q05D26_HUMAN)

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Tyrosine-protein kinase

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ