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Protein

Solute carrier organic anion transporter family member

Gene

SLCO1B1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family memberUniRule annotation
Gene namesi
Name:SLCO1B1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei29 – 48HelicalUniRule annotationAdd BLAST20
Transmembranei68 – 89HelicalUniRule annotationAdd BLAST22
Transmembranei96 – 117HelicalUniRule annotationAdd BLAST22
Transmembranei170 – 195HelicalUniRule annotationAdd BLAST26
Transmembranei207 – 230HelicalUniRule annotationAdd BLAST24
Transmembranei258 – 279HelicalUniRule annotationAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134865839.

PTM / Processingi

Proteomic databases

PaxDbiQ05CV5.
PeptideAtlasiQ05CV5.

Expressioni

Gene expression databases

GenevisibleiQ05CV5. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000256958.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 296MFSInterPro annotationAdd BLAST267

Sequence similaritiesi

Belongs to the organo anion transporter (TC 2.A.60) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOVERGENiHBG063896.
KOiK05043.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q05CV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQNQHLNKT AEAQPSENKK TRYCNGLKMF LAALSLSFIA KTLGAIIMKS
60 70 80 90 100
SIIHIERRFE ISSSLVGFID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG
110 120 130 140 150
CFIMGIGGVL TALPHFFMGY YRYSKETNIN SSENSTSTLS TCLINQILSL
160 170 180 190 200
NRASPEIVGK GCLKESGSYM WIYVFMGNML RGIGETPIVP LGLSYIDDFA
210 220 230 240 250
KEGHSSLYLG ILNAIAMIGP IIGFTLGSLF SKMYVDIGYV DLSTIRITPT
260 270 280 290
DSRWVGAWWL NFLVSGLFSI ISSIPFFFLP QTPNKPQKKK KKKKKK
Length:296
Mass (Da):32,903
Last modified:November 14, 2006 - v1
Checksum:i31DD44FCCB6A0912
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei296Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020696 mRNA. Translation: AAH20696.1.
RefSeqiNP_006437.3. NM_006446.4.
UniGeneiHs.449738.

Genome annotation databases

GeneIDi10599.
KEGGihsa:10599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC020696 mRNA. Translation: AAH20696.1.
RefSeqiNP_006437.3. NM_006446.4.
UniGeneiHs.449738.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000256958.

Proteomic databases

PaxDbiQ05CV5.
PeptideAtlasiQ05CV5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10599.
KEGGihsa:10599.

Organism-specific databases

CTDi10599.
PharmGKBiPA134865839.

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
HOVERGENiHBG063896.
KOiK05043.

Miscellaneous databases

ChiTaRSiSLCO1B1. human.
GenomeRNAii10599.

Gene expression databases

GenevisibleiQ05CV5. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ05CV5_HUMAN
AccessioniPrimary (citable) accession number: Q05CV5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: September 7, 2016
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.