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Protein
Submitted name:

Smad3 protein

Gene

Smad3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • activin receptor signaling pathway Source: MGI
  • cell-cell junction organization Source: MGI
  • cell cycle arrest Source: MGI
  • developmental growth Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • embryonic foregut morphogenesis Source: MGI
  • embryonic pattern specification Source: MGI
  • endoderm development Source: MGI
  • evasion or tolerance of host defenses by virus Source: MGI
  • extrinsic apoptotic signaling pathway Source: MGI
  • gastrulation Source: MGI
  • heart looping Source: MGI
  • immune response Source: MGI
  • immune system development Source: MGI
  • intracellular signal transduction Source: MGI
  • in utero embryonic development Source: MGI
  • lens fiber cell differentiation Source: MGI
  • liver development Source: MGI
  • mesoderm formation Source: MGI
  • negative regulation of cell growth Source: MGI
  • negative regulation of mitotic cell cycle Source: MGI
  • negative regulation of osteoblast differentiation Source: MGI
  • negative regulation of protein catabolic process Source: MGI
  • negative regulation of protein phosphorylation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • nodal signaling pathway Source: MGI
  • osteoblast development Source: MGI
  • paraxial mesoderm morphogenesis Source: MGI
  • pericardium development Source: MGI
  • positive regulation of canonical Wnt signaling pathway Source: MGI
  • positive regulation of catenin import into nucleus Source: MGI
  • positive regulation of epithelial to mesenchymal transition Source: MGI
  • positive regulation of extracellular matrix assembly Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • positive regulation of transcription factor import into nucleus Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • protein stabilization Source: MGI
  • regulation of binding Source: MGI
  • regulation of epithelial cell proliferation Source: MGI
  • regulation of striated muscle tissue development Source: MGI
  • regulation of transcription from RNA polymerase II promoter Source: MGI
  • regulation of transforming growth factor beta2 production Source: MGI
  • regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  • response to hypoxia Source: MGI
  • skeletal system development Source: MGI
  • SMAD protein complex assembly Source: MGI
  • SMAD protein signal transduction Source: MGI
  • somitogenesis Source: MGI
  • thyroid gland development Source: MGI
  • transcription from RNA polymerase II promoter Source: GOC
  • transforming growth factor beta receptor signaling pathway Source: MGI
  • transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Smad3 proteinImported
Gene namesi
Name:Smad3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1201674. Smad3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ05CN3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034973.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG053353.

Family and domain databases

Gene3Di3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
[Graphical view]
SUPFAMiSSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q05CN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE
60 70 80 90 100
LEKAITTQNV NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH
110 120 130 140 150
HELRAMELCE FAFNMKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF
160 170 180 190 200
PPLDDYSHSI PENTNFPAGI EPQSNIPETP IKSVSSVLHK KKKKKKKKKK

KKKKKKKKK
Length:209
Mass (Da):24,278
Last modified:November 14, 2006 - v1
Checksum:iE24A97053C9B116E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei209 – 2091Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC022904 mRNA. Translation: AAH22904.1.
UniGeneiMm.7320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC022904 mRNA. Translation: AAH22904.1.
UniGeneiMm.7320.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034973.

Chemistry

BindingDBiQ05CN3.

Proteomic databases

PRIDEiQ05CN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1201674. Smad3.

Phylogenomic databases

HOVERGENiHBG053353.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
[Graphical view]
SUPFAMiSSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Mix FVB/NImported.
    Tissue: Mammary tumor. WAP-TGF alpha model. 7 months oldImported.

Entry informationi

Entry nameiQ05CN3_MOUSE
AccessioniPrimary (citable) accession number: Q05CN3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: June 24, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.