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Q05CN3

- Q05CN3_MOUSE

UniProt

Q05CN3 - Q05CN3_MOUSE

Protein
Submitted name:

Smad3 protein

Gene

Smad3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. collagen binding Source: MGI
    3. double-stranded DNA binding Source: MGI
    4. protein binding Source: MGI
    5. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. developmental growth Source: MGI
    2. embryonic cranial skeleton morphogenesis Source: MGI
    3. embryonic foregut morphogenesis Source: MGI
    4. embryonic pattern specification Source: MGI
    5. endoderm development Source: MGI
    6. gastrulation Source: MGI
    7. heart looping Source: MGI
    8. immune system development Source: MGI
    9. in utero embryonic development Source: MGI
    10. lens fiber cell differentiation Source: MGI
    11. liver development Source: MGI
    12. mesoderm formation Source: MGI
    13. negative regulation of osteoblast differentiation Source: MGI
    14. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    15. osteoblast development Source: MGI
    16. paraxial mesoderm morphogenesis Source: MGI
    17. pericardium development Source: MGI
    18. positive regulation of transcription, DNA-templated Source: MGI
    19. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    20. regulation of binding Source: MGI
    21. regulation of epithelial cell proliferation Source: MGI
    22. regulation of striated muscle tissue development Source: MGI
    23. regulation of transforming growth factor beta receptor signaling pathway Source: MGI
    24. skeletal system development Source: MGI
    25. somitogenesis Source: MGI
    26. thyroid gland development Source: MGI
    27. transcription, DNA-templated Source: UniProtKB-KW
    28. transforming growth factor beta receptor signaling pathway Source: MGI

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Smad3 proteinImported
    Gene namesi
    Name:Smad3Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1201674. Smad3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI
    2. plasma membrane Source: MGI
    3. transcription factor complex Source: InterPro

    Keywords - Cellular componenti

    NucleusSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiQ05CN3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ05CN3.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG053353.

    Family and domain databases

    Gene3Di3.90.520.10. 1 hit.
    InterProiIPR013790. Dwarfin.
    IPR003619. MAD_homology1_Dwarfin-type.
    IPR013019. MAD_homology_MH1.
    [Graphical view]
    PANTHERiPTHR13703. PTHR13703. 1 hit.
    PfamiPF03165. MH1. 1 hit.
    [Graphical view]
    SMARTiSM00523. DWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF56366. SSF56366. 1 hit.
    PROSITEiPS51075. MH1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q05CN3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE    50
    LEKAITTQNV NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH 100
    HELRAMELCE FAFNMKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF 150
    PPLDDYSHSI PENTNFPAGI EPQSNIPETP IKSVSSVLHK KKKKKKKKKK 200
    KKKKKKKKK 209
    Length:209
    Mass (Da):24,278
    Last modified:November 14, 2006 - v1
    Checksum:iE24A97053C9B116E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei209 – 2091Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC022904 mRNA. Translation: AAH22904.1.
    UniGeneiMm.7320.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC022904 mRNA. Translation: AAH22904.1 .
    UniGenei Mm.7320.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q05CN3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1201674. Smad3.

    Phylogenomic databases

    HOVERGENi HBG053353.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q05CN3.

    Family and domain databases

    Gene3Di 3.90.520.10. 1 hit.
    InterProi IPR013790. Dwarfin.
    IPR003619. MAD_homology1_Dwarfin-type.
    IPR013019. MAD_homology_MH1.
    [Graphical view ]
    PANTHERi PTHR13703. PTHR13703. 1 hit.
    Pfami PF03165. MH1. 1 hit.
    [Graphical view ]
    SMARTi SM00523. DWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56366. SSF56366. 1 hit.
    PROSITEi PS51075. MH1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Mix FVB/NImported.
      Tissue: Mammary tumor. WAP-TGF alpha model. 7 months oldImported.

    Entry informationi

    Entry nameiQ05CN3_MOUSE
    AccessioniPrimary (citable) accession number: Q05CN3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 14, 2006
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)