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Q05CN3

- Q05CN3_MOUSE

UniProt

Q05CN3 - Q05CN3_MOUSE

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Protein
Submitted name:

Smad3 protein

Gene

Smad3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. collagen binding Source: MGI
  3. double-stranded DNA binding Source: MGI
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. developmental growth Source: MGI
  2. embryonic cranial skeleton morphogenesis Source: MGI
  3. embryonic foregut morphogenesis Source: MGI
  4. embryonic pattern specification Source: MGI
  5. endoderm development Source: MGI
  6. gastrulation Source: MGI
  7. heart looping Source: MGI
  8. immune system development Source: MGI
  9. in utero embryonic development Source: MGI
  10. lens fiber cell differentiation Source: MGI
  11. liver development Source: MGI
  12. mesoderm formation Source: MGI
  13. negative regulation of osteoblast differentiation Source: MGI
  14. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  15. osteoblast development Source: MGI
  16. paraxial mesoderm morphogenesis Source: MGI
  17. pericardium development Source: MGI
  18. positive regulation of transcription, DNA-templated Source: MGI
  19. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  20. regulation of binding Source: MGI
  21. regulation of epithelial cell proliferation Source: MGI
  22. regulation of striated muscle tissue development Source: MGI
  23. regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  24. skeletal system development Source: MGI
  25. SMAD protein signal transduction Source: MGI
  26. somitogenesis Source: MGI
  27. thyroid gland development Source: MGI
  28. transcription, DNA-templated Source: UniProtKB-KW
  29. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Smad3 proteinImported
Gene namesi
Name:Smad3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1201674. Smad3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
  2. plasma membrane Source: MGI
  3. transcription factor complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ05CN3.

Expressioni

Gene expression databases

GenevestigatoriQ05CN3.

Interactioni

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG053353.

Family and domain databases

Gene3Di3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
[Graphical view]
SUPFAMiSSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q05CN3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE
60 70 80 90 100
LEKAITTQNV NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH
110 120 130 140 150
HELRAMELCE FAFNMKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF
160 170 180 190 200
PPLDDYSHSI PENTNFPAGI EPQSNIPETP IKSVSSVLHK KKKKKKKKKK

KKKKKKKKK
Length:209
Mass (Da):24,278
Last modified:November 14, 2006 - v1
Checksum:iE24A97053C9B116E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei209 – 2091Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC022904 mRNA. Translation: AAH22904.1.
UniGeneiMm.7320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC022904 mRNA. Translation: AAH22904.1 .
UniGenei Mm.7320.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q05CN3.

Proteomic databases

PRIDEi Q05CN3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1201674. Smad3.

Phylogenomic databases

HOVERGENi HBG053353.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Genevestigatori Q05CN3.

Family and domain databases

Gene3Di 3.90.520.10. 1 hit.
InterProi IPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
[Graphical view ]
PANTHERi PTHR13703. PTHR13703. 1 hit.
Pfami PF03165. MH1. 1 hit.
[Graphical view ]
SMARTi SM00523. DWA. 1 hit.
[Graphical view ]
SUPFAMi SSF56366. SSF56366. 1 hit.
PROSITEi PS51075. MH1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Mix FVB/NImported.
    Tissue: Mammary tumor. WAP-TGF alpha model. 7 months oldImported.

Entry informationi

Entry nameiQ05CN3_MOUSE
AccessioniPrimary (citable) accession number: Q05CN3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)