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Protein
Submitted name:

Smad3 protein

Gene

Smad3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. beta-catenin binding Source: MGI
  2. bHLH transcription factor binding Source: MGI
  3. chromatin binding Source: MGI
  4. collagen binding Source: MGI
  5. core promoter proximal region sequence-specific DNA binding Source: MGI
  6. co-SMAD binding Source: MGI
  7. double-stranded DNA binding Source: MGI
  8. identical protein binding Source: MGI
  9. phosphatase binding Source: MGI
  10. protein heterodimerization activity Source: MGI
  11. protein homodimerization activity Source: MGI
  12. protein kinase binding Source: MGI
  13. RNA polymerase II activating transcription factor binding Source: MGI
  14. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: MGI
  15. RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity Source: MGI
  16. R-SMAD binding Source: MGI
  17. sequence-specific DNA binding Source: MGI
  18. sequence-specific DNA binding transcription factor activity Source: MGI
  19. transcription factor binding Source: MGI
  20. transcription regulatory region DNA binding Source: MGI
  21. transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity Source: MGI
  22. transforming growth factor beta receptor binding Source: MGI
  23. ubiquitin binding Source: MGI
  24. ubiquitin protein ligase binding Source: MGI
  25. zinc ion binding Source: MGI

GO - Biological processi

  1. activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  2. activin receptor signaling pathway Source: MGI
  3. cell-cell junction organization Source: MGI
  4. cell cycle arrest Source: MGI
  5. developmental growth Source: MGI
  6. embryonic cranial skeleton morphogenesis Source: MGI
  7. embryonic foregut morphogenesis Source: MGI
  8. embryonic pattern specification Source: MGI
  9. endoderm development Source: MGI
  10. evasion or tolerance of host defenses by virus Source: MGI
  11. extrinsic apoptotic signaling pathway Source: MGI
  12. gastrulation Source: MGI
  13. heart looping Source: MGI
  14. immune response Source: MGI
  15. immune system development Source: MGI
  16. intracellular signal transduction Source: MGI
  17. in utero embryonic development Source: MGI
  18. lens fiber cell differentiation Source: MGI
  19. liver development Source: MGI
  20. mesoderm formation Source: MGI
  21. negative regulation of cell growth Source: MGI
  22. negative regulation of mitotic cell cycle Source: MGI
  23. negative regulation of osteoblast differentiation Source: MGI
  24. negative regulation of protein catabolic process Source: MGI
  25. negative regulation of protein phosphorylation Source: MGI
  26. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  27. nodal signaling pathway Source: MGI
  28. osteoblast development Source: MGI
  29. paraxial mesoderm morphogenesis Source: MGI
  30. pericardium development Source: MGI
  31. positive regulation of canonical Wnt signaling pathway Source: MGI
  32. positive regulation of catenin import into nucleus Source: MGI
  33. positive regulation of epithelial to mesenchymal transition Source: MGI
  34. positive regulation of gene expression Source: MGI
  35. positive regulation of transcription, DNA-templated Source: MGI
  36. positive regulation of transcription factor import into nucleus Source: MGI
  37. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  38. protein stabilization Source: MGI
  39. regulation of binding Source: MGI
  40. regulation of epithelial cell proliferation Source: MGI
  41. regulation of striated muscle tissue development Source: MGI
  42. regulation of transcription from RNA polymerase II promoter Source: MGI
  43. regulation of transforming growth factor beta2 production Source: MGI
  44. regulation of transforming growth factor beta receptor signaling pathway Source: MGI
  45. response to hypoxia Source: MGI
  46. skeletal system development Source: MGI
  47. SMAD protein complex assembly Source: MGI
  48. SMAD protein signal transduction Source: MGI
  49. somitogenesis Source: MGI
  50. thyroid gland development Source: MGI
  51. transcription from RNA polymerase II promoter Source: GOC
  52. transforming growth factor beta receptor signaling pathway Source: MGI
  53. transport Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Smad3 proteinImported
Gene namesi
Name:Smad3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1201674. Smad3.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nuclear chromatin Source: MGI
  3. nuclear inner membrane Source: MGI
  4. nucleoplasm Source: MGI
  5. nucleus Source: MGI
  6. plasma membrane Source: MGI
  7. receptor complex Source: MGI
  8. SMAD2-SMAD3 protein complex Source: MGI
  9. SMAD protein complex Source: MGI
  10. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ05CN3.

Expressioni

Gene expression databases

GenevestigatoriQ05CN3.

Interactioni

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG053353.

Family and domain databases

Gene3Di3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
[Graphical view]
SUPFAMiSSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q05CN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE
60 70 80 90 100
LEKAITTQNV NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH
110 120 130 140 150
HELRAMELCE FAFNMKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF
160 170 180 190 200
PPLDDYSHSI PENTNFPAGI EPQSNIPETP IKSVSSVLHK KKKKKKKKKK

KKKKKKKKK
Length:209
Mass (Da):24,278
Last modified:November 14, 2006 - v1
Checksum:iE24A97053C9B116E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei209 – 2091Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC022904 mRNA. Translation: AAH22904.1.
UniGeneiMm.7320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC022904 mRNA. Translation: AAH22904.1.
UniGeneiMm.7320.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ05CN3.

Proteomic databases

PRIDEiQ05CN3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1201674. Smad3.

Phylogenomic databases

HOVERGENiHBG053353.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

GenevestigatoriQ05CN3.

Family and domain databases

Gene3Di3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
[Graphical view]
SUPFAMiSSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Mix FVB/NImported.
    Tissue: Mammary tumor. WAP-TGF alpha model. 7 months oldImported.

Entry informationi

Entry nameiQ05CN3_MOUSE
AccessioniPrimary (citable) accession number: Q05CN3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: March 4, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.