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Q05CN3 (Q05CN3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Smad3 EMBL AAH22904.1 MGI 1201674
OrganismMus musculus (Mouse) EMBL AAH22904.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length209 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Biological processTranscription
Transcription regulation SAAS SAAS003619
   Cellular componentNucleus SAAS SAAS003619
Gene Ontology (GO)
   Biological_processdevelopmental growth

Inferred from genetic interaction PubMed 15183723. Source: MGI

embryonic cranial skeleton morphogenesis

Inferred from genetic interaction PubMed 15183723. Source: MGI

embryonic foregut morphogenesis

Inferred from genetic interaction PubMed 15183723. Source: MGI

embryonic pattern specification

Inferred from genetic interaction PubMed 15183723. Source: MGI

endoderm development

Inferred from genetic interaction PubMed 15183723. Source: MGI

gastrulation

Inferred from genetic interaction PubMed 15183723. Source: MGI

heart looping

Inferred from genetic interaction PubMed 15183723. Source: MGI

immune system development

Inferred from genetic interaction PubMed 15183723. Source: MGI

in utero embryonic development

Inferred from genetic interaction PubMed 15183723. Source: MGI

lens fiber cell differentiation

Inferred from mutant phenotype PubMed 17215516. Source: MGI

liver development

Inferred from genetic interaction PubMed 15183723. Source: MGI

mesoderm formation

Inferred from mutant phenotype PubMed 15084457. Source: MGI

negative regulation of osteoblast differentiation

Inferred from genetic interaction PubMed 15150273. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 11711431PubMed 9702197. Source: MGI

osteoblast development

Inferred from genetic interaction PubMed 15150273. Source: MGI

paraxial mesoderm morphogenesis

Inferred from mutant phenotype PubMed 15084457. Source: MGI

pericardium development

Inferred from genetic interaction PubMed 15183723. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 12943993PubMed 15150273PubMed 16619037. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from direct assay PubMed 15282343PubMed 15464984. Source: MGI

regulation of binding

Inferred from direct assay PubMed 15282343. Source: MGI

regulation of epithelial cell proliferation

Inferred from mutant phenotype PubMed 12845704. Source: MGI

regulation of striated muscle tissue development

Inferred from direct assay PubMed 11711431. Source: MGI

regulation of transforming growth factor beta receptor signaling pathway

Inferred from direct assay PubMed 11711431. Source: MGI

skeletal system development

Inferred from genetic interaction PubMed 15183723. Source: MGI

somitogenesis

Inferred from mutant phenotype PubMed 15183723. Source: MGI

thyroid gland development

Inferred from genetic interaction PubMed 15183723. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transforming growth factor beta receptor signaling pathway

Inferred from direct assay PubMed 16619037PubMed 21937600. Source: MGI

   Cellular_componentnucleus

Inferred from direct assay PubMed 12943993PubMed 15282343. Source: MGI

plasma membrane

Inferred from direct assay PubMed 12543979. Source: MGI

transcription factor complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionchromatin binding

Inferred from direct assay PubMed 16619037. Source: MGI

collagen binding

Inferred from physical interaction PubMed 14559231. Source: MGI

double-stranded DNA binding

Inferred from direct assay PubMed 15282343. Source: MGI

protein binding

Inferred from physical interaction PubMed 11711431PubMed 12543979PubMed 14764653PubMed 15150273PubMed 15282343PubMed 15464984PubMed 15990875PubMed 16601693PubMed 17467076PubMed 21937600. Source: MGI

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 12943993. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue2091 EMBL AAH22904.1

Sequences

Sequence LengthMass (Da)Tools
Q05CN3 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: E24A97053C9B116E

FASTA20924,278
        10         20         30         40         50         60 
MSSILPFTPP IVKRLLGWKK GEQNGQEEKW CEKAVKSLVK KLKKTGQLDE LEKAITTQNV 

        70         80         90        100        110        120 
NTKCITIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELRAMELCE FAFNMKKDEV 

       130        140        150        160        170        180 
CVNPYHYQRV ETPVLPPVLV PRHTEIPAEF PPLDDYSHSI PENTNFPAGI EPQSNIPETP 

       190        200 
IKSVSSVLHK KKKKKKKKKK KKKKKKKKK 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Mix FVB/N EMBL AAH22904.1.
Tissue: Mammary tumor. WAP-TGF alpha model. 7 months old EMBL AAH22904.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC022904 mRNA. Translation: AAH22904.1.
UniGeneMm.7320.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ05CN3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1201674. Smad3.

Phylogenomic databases

HOVERGENHBG053353.

Gene expression databases

GenevestigatorQ05CN3.

Family and domain databases

Gene3D3.90.520.10. 1 hit.
InterProIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
[Graphical view]
PANTHERPTHR13703. PTHR13703. 1 hit.
PfamPF03165. MH1. 1 hit.
[Graphical view]
SMARTSM00523. DWA. 1 hit.
[Graphical view]
SUPFAMSSF56366. SSF56366. 1 hit.
PROSITEPS51075. MH1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ05CN3_MOUSE
AccessionPrimary (citable) accession number: Q05CN3
Entry history
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)