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Protein

La-related protein 7

Gene

Larp7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.By similarity

GO - Molecular functioni

GO - Biological processi

  • germ cell proliferation Source: MGI
  • negative regulation of chromatin binding Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of G1/S transition of mitotic cell cycle Source: MGI
  • RNA processing Source: InterPro

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
La-related protein 7
Alternative name(s):
La ribonucleoprotein domain family member 7
Gene namesi
Name:Larp7
Synonyms:D3Wsu161e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:107634 Larp7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002811441 – 570La-related protein 7Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Cross-linki231Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei251PhosphothreonineCombined sources1
Modified residuei253PhosphoserineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Modified residuei260PhosphothreonineCombined sources1
Modified residuei294PhosphoserineBy similarity1
Modified residuei334PhosphoserineCombined sources1
Modified residuei335PhosphothreonineCombined sources1
Modified residuei347PhosphoserineBy similarity1
Cross-linki406Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ05CL8
MaxQBiQ05CL8
PaxDbiQ05CL8
PeptideAtlasiQ05CL8
PRIDEiQ05CL8

PTM databases

iPTMnetiQ05CL8
PhosphoSitePlusiQ05CL8

Expressioni

Developmental stagei

Ubiquitously expressed in the embryo.1 Publication

Gene expression databases

BgeeiENSMUSG00000027968
CleanExiMM_LARP7
ExpressionAtlasiQ05CL8 baseline and differential
GenevisibleiQ05CL8 MM

Interactioni

Subunit structurei

Integral part of the 7SK RNP complex. Specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA. On stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. Interacts with METTL16.By similarity

Protein-protein interaction databases

IntActiQ05CL8, 6 interactors
MINTiQ05CL8
STRINGi10090.ENSMUSP00000029588

Structurei

3D structure databases

ProteinModelPortaliQ05CL8
SMRiQ05CL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 116HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST95
Domaini119 – 197RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi196 – 364Lys-richAdd BLAST169

Phylogenomic databases

eggNOGiENOG410IQXQ Eukaryota
COG5193 LUCA
GeneTreeiENSGT00830000128323
HOVERGENiHBG081891
InParanoidiQ05CL8
KOiK15191
OMAiNMNFYGA
OrthoDBiEOG091G0E47
PhylomeDBiQ05CL8
TreeFamiTF314476

Family and domain databases

CDDicd08032 LARP_7, 1 hit
cd12290 RRM1_LARP7, 1 hit
cd12542 RRM2_LARP7, 1 hit
Gene3Di1.10.10.10, 1 hit
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR006630 La_HTH
IPR014886 La_RRM
IPR034946 LARP7_La
IPR034887 LARP7_RRM1
IPR034910 LARP7_RRM2
IPR002344 Lupus_La
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
PF00076 RRM_1, 1 hit
PF08777 RRM_3, 1 hit
PRINTSiPR00302 LUPUSLA
SMARTiView protein in SMART
SM00715 LA, 1 hit
SM00360 RRM, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit
PS50102 RRM, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q05CL8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METENQKTME ESTKRKEEKK KRSRVKQVLA DIAKQVDFWF GDANLHKDKF
60 70 80 90 100
LREQIEKSRD GYVDISLLVS FNKMKKLTTD GKLIARALKS SSVVELDLEG
110 120 130 140 150
TRIRRKKPLG ERPKDEEERT VYVELLPKNV THSWIERVFG KCGNVVYISI
160 170 180 190 200
PHYKSTGDPK GFAFVEFETK EQAAKAIEFL NNPPEEAPRK PGIFPKTVKN
210 220 230 240 250
KPIPSLRVAE EKKKKKKKKG RIKKEESVQA KESAVDSSSS GVCKATKRPR
260 270 280 290 300
TASEGSEAET PEAPKQPAKK KKKRDKVEAS SLPEARAGKR ERCSAEDEDC
310 320 330 340 350
LPPRPKAKKR AQKDGVGQAA SEVSKESRDL EFCSTEEEKE TDRKGDSLSK
360 370 380 390 400
VKRKHKKKHK ERHKMGEEVI PLRVLSKTEW MDLKKEYLAL QKASMASLKK
410 420 430 440 450
TISQIKLESE METDCKAPTA GSGQECSTQE KVSAQGPQFV TGVIVKIVSG
460 470 480 490 500
EPLPGRKQVK DILATISEVV YIDLLEGDTE CHARFKTPED AQAVMNAQTE
510 520 530 540 550
IRKKHSWNLE VLSGDHEQRY WQKILVDRQA KLNQPREKKR GTEKLITKAE
560 570
KIRLAKTQQA SQHIRFSEYD
Length:570
Mass (Da):64,802
Last modified:March 20, 2007 - v2
Checksum:i025EB8EC3CA58F22
GO
Isoform 2 (identifier: Q05CL8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-185: FLNNPPE → VRTSVGP
     186-570: Missing.

Show »
Length:185
Mass (Da):21,334
Checksum:iA158BB9C4FA710EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13T → TE in BC020127 (PubMed:15489334).Curated1
Sequence conflicti202P → L in AAH23165 (PubMed:15489334).Curated1
Sequence conflicti214K → R in BAB28459 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024022179 – 185FLNNPPE → VRTSVGP in isoform 2. 1 Publication7
Alternative sequenceiVSP_024023186 – 570Missing in isoform 2. 1 PublicationAdd BLAST385

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC113952 Genomic DNA No translation available.
BC020127 mRNA No translation available.
BC023165 mRNA Translation: AAH23165.1 Different termination.
BC029178 mRNA Translation: AAH29178.2
AK012726 mRNA Translation: BAB28435.1
AK012772 mRNA Translation: BAB28459.1
AK015041 mRNA Translation: BAB29687.1
AK162147 mRNA Translation: BAE36753.1
CCDSiCCDS38626.1 [Q05CL8-1]
RefSeqiNP_613059.2, NM_138593.2 [Q05CL8-1]
UniGeneiMm.291032

Genome annotation databases

EnsembliENSMUST00000029588; ENSMUSP00000029588; ENSMUSG00000027968 [Q05CL8-1]
GeneIDi28036
KEGGimmu:28036
UCSCiuc008rhd.1 mouse [Q05CL8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiLARP7_MOUSE
AccessioniPrimary (citable) accession number: Q05CL8
Secondary accession number(s): Q3TSC2
, Q8K2Y6, Q8VDW3, Q9CSI2, Q9CSI9, Q9CUQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: June 20, 2018
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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