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Q05C92

- Q05C92_HUMAN

UniProt

Q05C92 - Q05C92_HUMAN

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Protein
Submitted name:

TBXA2R protein

Gene

TBXA2R

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. thromboxane receptor activity Source: Ensembl

GO - Biological processi

  1. inflammatory response Source: Ensembl
  2. positive regulation of angiogenesis Source: Ensembl
  3. positive regulation of blood pressure Source: Ensembl
  4. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  5. positive regulation of smooth muscle contraction Source: Ensembl
  6. positive regulation of vasoconstriction Source: Ensembl
  7. response to drug Source: Ensembl
  8. response to lipopolysaccharide Source: Ensembl
  9. response to nutrient Source: Ensembl
  10. second-messenger-mediated signaling Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
TBXA2R proteinImported
Gene namesi
Name:TBXA2RImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA348.

Expressioni

Gene expression databases

BgeeiQ05C92.
ExpressionAtlasiQ05C92. baseline and differential.

Interactioni

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

HOGENOMiHOG000015238.
HOVERGENiHBG082876.
KOiK04264.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q05C92-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWPNGSSLGP CFRPTNITLE ERRLIASPWF AASFCVVGLA SNLLALSVLA
60 70 80 90 100
GARQGGSHTR SSFLTFLCGL VLTDFLGLLV TGTIVVSQHA ALFEWHAVDP
110 120 130 140 150
GCRLCRFMGV VMIFFGLSPL LLGAAMASER YLGITRPFSR PAVASQRRAW

ATVGLV
Length:156
Mass (Da):16,772
Last modified:November 14, 2006 - v1
Checksum:i30C541B7BC25706E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei156 – 1561Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC028027 mRNA. Translation: AAH28027.1.
RefSeqiNP_001051.1. NM_001060.5.
NP_963998.2. NM_201636.2.
UniGeneiHs.442530.

Genome annotation databases

GeneIDi6915.
KEGGihsa:6915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC028027 mRNA. Translation: AAH28027.1 .
RefSeqi NP_001051.1. NM_001060.5.
NP_963998.2. NM_201636.2.
UniGenei Hs.442530.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q05C92.

Protein family/group databases

GPCRDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6915.
KEGGi hsa:6915.

Organism-specific databases

CTDi 6915.
PharmGKBi PA348.

Phylogenomic databases

HOGENOMi HOG000015238.
HOVERGENi HBG082876.
KOi K04264.

Miscellaneous databases

ChiTaRSi TBXA2R. human.
GenomeRNAii 6915.
NextBioi 27045.

Gene expression databases

Bgeei Q05C92.
ExpressionAtlasi Q05C92. baseline and differential.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001105. Thbox_rcpt.
[Graphical view ]
PANTHERi PTHR11866. PTHR11866. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01788. PROSTANOIDR.
PR00429. THROMBOXANER.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BloodImported.

Entry informationi

Entry nameiQ05C92_HUMAN
AccessioniPrimary (citable) accession number: Q05C92
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.