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Protein
Submitted name:

DENND4A protein

Gene

DENND4A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Submitted name:
DENND4A proteinImported
Gene namesi
Name:DENND4AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887513.

PTM / Processingi

Proteomic databases

PaxDbiQ05C90.
PRIDEiQ05C90.

Expressioni

Gene expression databases

GenevisibleiQ05C90. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000391167.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 200159MABPInterPro annotationAdd
BLAST
Domaini203 – 27674UDENNInterPro annotationAdd
BLAST
Domaini308 – 492185DENNInterPro annotationAdd
BLAST
Domaini558 – 63275DDENNInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG2127. Eukaryota.
ENOG410XQMX. LUCA.
HOVERGENiHBG058313.

Family and domain databases

InterProiIPR005112. dDENN_dom.
IPR001194. DENN_dom.
IPR023341. MABP.
IPR002885. Pentatricopeptide_repeat.
IPR005113. uDENN_dom.
[Graphical view]
PfamiPF03455. dDENN. 1 hit.
PF02141. DENN. 1 hit.
PF03456. uDENN. 1 hit.
[Graphical view]
SMARTiSM00801. dDENN. 1 hit.
SM00799. DENN. 1 hit.
SM00800. uDENN. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00756. PPR. 1 hit.
PROSITEiPS50947. DDENN. 1 hit.
PS50211. DENN. 1 hit.
PS51498. MABP. 1 hit.
PS51375. PPR. 1 hit.
PS50946. UDENN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q05C90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEDKGPRVA DYFVVAGLTD VSKPLEEEIH FNDACHKVAK PKEPITDVSV
60 70 80 90 100
IIKSLGEEVP QDYICIDVTP TGLSADLNNG SLVGPQIYLC YRRGRDKPPL
110 120 130 140 150
TDLGVLYDWK ERLKQGCEII QSTPYGRPAN ISGSTSSQRI YITYRRASEN
160 170 180 190 200
MTQNTLAVTD ICIIIPSKGE SPPHTFCKVD KNLNNSMWGS AVYLCYKKSV
210 220 230 240 250
AKTNTVSYKA GLICRYPQED YESFSLPESV PLFCLPMGAT IECWPSNSKY
260 270 280 290 300
PLPVFSTFVL TGASAEKVYG AAIQFYEPYS EENLTEKQRL LLGLTSADGK
310 320 330 340 350
SDSSKTIHTN KCICLLSHWP FFDAFRKFLT FLYRYSISGP HVLPIEKHIS
360 370 380 390 400
HFMHKVPFPS PQRPRILVQL SPHDNLILSQ PVSSPLPLSG GKFSTLLQNL
410 420 430 440 450
GPENAVTLLV FAVTEHKILI HSLRPSVLTS VTEALVSMIF PFHWPCPYVP
460 470 480 490 500
LCPLALADVL SAPCPFIVGI DSRYFDLYDP PPDVSCVDVD TNTISQIGDK
510 520 530 540 550
KNVAWKILPK KPCKNLMNTL NNLHQQLAKL QQRPRDDGLM DLAINDYDFN
560 570 580 590 600
SGKRLHMIDL EIQEAFLFFM ASILKGYRSY LRPITQAPSE TATDAASLFA
610 620 630 640 650
LQAFLRSRDR SHQKFYNMMT KTQMFIRFIE ECSFVSDKDA SLAFFDDCVD
660 670 680 690 700
KVDMDKSGEV RLIELDESFK SEHTVFVTPP EIPHLPNGEE PPLQYSYNGF
710 720 730 740 750
PVLRNNLFER PEGFLQAKKN KLPSKSSSPN SPLPMFRRTK QEIKSAHKIA
760 770 780 790 800
KRYSSIPQMW SRCLLRHCYG LWFICLPAYV KVCHSKVRAL KTAYDVLKKM
810 820 830 840 850
QSKKMDPPDE VCYRILMQLC GQYDQPVLAV RVLFEMQKAG IDPNAITYGY
860 870 880 890 900
YNKAVLESTW PSRSRSGYFL WTKVRNVVLG VTQFKRALKK HAHLSQTTLS
910 920 930
GGQSDLGYNS LSKDEVRRGD TSTEDIQEEK KKK
Length:933
Mass (Da):105,607
Last modified:November 14, 2006 - v1
Checksum:i1EB75548645ACAD5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei933 – 9331Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC028057 mRNA. Translation: AAH28057.1.
UniGeneiHs.654567.

Genome annotation databases

KEGGihsa:10260.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC028057 mRNA. Translation: AAH28057.1.
UniGeneiHs.654567.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000391167.

Proteomic databases

PaxDbiQ05C90.
PRIDEiQ05C90.

Protocols and materials databases

DNASUi10260.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

KEGGihsa:10260.

Organism-specific databases

CTDi10260.
PharmGKBiPA134887513.

Phylogenomic databases

eggNOGiKOG2127. Eukaryota.
ENOG410XQMX. LUCA.
HOVERGENiHBG058313.

Miscellaneous databases

ChiTaRSiDENND4A. human.
GenomeRNAii10260.
NextBioi38872.

Gene expression databases

GenevisibleiQ05C90. HS.

Family and domain databases

InterProiIPR005112. dDENN_dom.
IPR001194. DENN_dom.
IPR023341. MABP.
IPR002885. Pentatricopeptide_repeat.
IPR005113. uDENN_dom.
[Graphical view]
PfamiPF03455. dDENN. 1 hit.
PF02141. DENN. 1 hit.
PF03456. uDENN. 1 hit.
[Graphical view]
SMARTiSM00801. dDENN. 1 hit.
SM00799. DENN. 1 hit.
SM00800. uDENN. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00756. PPR. 1 hit.
PROSITEiPS50947. DDENN. 1 hit.
PS50211. DENN. 1 hit.
PS51498. MABP. 1 hit.
PS51375. PPR. 1 hit.
PS50946. UDENN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: CervixImported.

Entry informationi

Entry nameiQ05C90_HUMAN
AccessioniPrimary (citable) accession number: Q05C90
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: May 11, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.