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Protein

Echinoderm microtubule-associated protein-like 5

Gene

EML5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.By similarity

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ05BV3.

Names & Taxonomyi

Protein namesi
Recommended name:
Echinoderm microtubule-associated protein-like 5
Short name:
EMAP-5
Gene namesi
Name:EML5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:18197. EML5.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • microtubule Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Organism-specific databases

DisGeNETi161436.
OpenTargetsiENSG00000165521.
PharmGKBiPA134894613.

Polymorphism and mutation databases

BioMutaiEML5.
DMDMi215274143.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002843951 – 1969Echinoderm microtubule-associated protein-like 5Add BLAST1969

Proteomic databases

EPDiQ05BV3.
MaxQBiQ05BV3.
PaxDbiQ05BV3.
PeptideAtlasiQ05BV3.
PRIDEiQ05BV3.

PTM databases

iPTMnetiQ05BV3.
PhosphoSitePlusiQ05BV3.

Expressioni

Gene expression databases

BgeeiENSG00000165521.
CleanExiHS_EML5.
ExpressionAtlasiQ05BV3. baseline and differential.
GenevisibleiQ05BV3. HS.

Organism-specific databases

HPAiHPA054019.
HPA055379.

Interactioni

Protein-protein interaction databases

BioGridi127791. 5 interactors.
STRINGi9606.ENSP00000451998.

Structurei

3D structure databases

ProteinModelPortaliQ05BV3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati59 – 100WD 1Add BLAST42
Repeati104 – 145WD 2Add BLAST42
Repeati148 – 187WD 3Add BLAST40
Repeati195 – 233WD 4Add BLAST39
Repeati235 – 273WD 5Add BLAST39
Repeati280 – 321WD 6Add BLAST42
Repeati323 – 362WD 7Add BLAST40
Repeati406 – 445WD 8Add BLAST40
Repeati449 – 488WD 9Add BLAST40
Repeati561 – 601WD 10Add BLAST41
Repeati725 – 766WD 11Add BLAST42
Repeati770 – 811WD 12Add BLAST42
Repeati814 – 853WD 13Add BLAST40
Repeati861 – 900WD 14Add BLAST40
Repeati901 – 940WD 15Add BLAST40
Repeati996 – 1035WD 16Add BLAST40
Repeati1038 – 1077WD 17Add BLAST40
Repeati1080 – 1120WD 18Add BLAST41
Repeati1236 – 1276WD 19Add BLAST41
Repeati1412 – 1463WD 20Add BLAST52
Repeati1467 – 1508WD 21Add BLAST42
Repeati1511 – 1550WD 22Add BLAST40
Repeati1560 – 1598WD 23Add BLAST39
Repeati1600 – 1646WD 24Add BLAST47
Repeati1691 – 1731WD 25Add BLAST41
Repeati1733 – 1774WD 26Add BLAST42
Repeati1775 – 1814WD 27Add BLAST40
Repeati1887 – 1926WD 28Add BLAST40
Repeati1932 – 1969WD 29Add BLAST38

Sequence similaritiesi

Belongs to the WD repeat EMAP family.Curated
Contains 29 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2106. Eukaryota.
ENOG410XNTQ. LUCA.
GeneTreeiENSGT00550000074369.
HOGENOMiHOG000031037.
HOVERGENiHBG107846.
InParanoidiQ05BV3.
KOiK18597.
OMAiPEKLQTN.
OrthoDBiEOG091G00FB.
PhylomeDBiQ05BV3.
TreeFamiTF317832.

Family and domain databases

Gene3Di2.130.10.10. 9 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR005108. HELP.
IPR011041. Quinoprot_gluc/sorb_DH.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 2 hits.
PF03451. HELP. 3 hits.
PF00400. WD40. 8 hits.
[Graphical view]
SMARTiSM00320. WD40. 28 hits.
[Graphical view]
SUPFAMiSSF50952. SSF50952. 1 hit.
SSF50978. SSF50978. 5 hits.
SSF50998. SSF50998. 5 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 4 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q05BV3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARSAPSCH LRLEWVYGYR GHQCRNNLYY TAAKEIVYFV AGVGVVYSPR
60 70 80 90 100
EHRQKFYRGH SDDIISLALH PERVLVATGQ VGKEPYICIW DSYTVQTISV
110 120 130 140 150
LKDVHTHGIA CLAFDLDGQR LVSVGLDSKN AVCVWDWKRG KMLSMAPGHT
160 170 180 190 200
DRIFDISWDL YQPNKLVSCG VKHIKFWSLC GNALTPKRGV FGKTGDLQTI
210 220 230 240 250
LCLACARDEL TYSGALNGDI YVWKGINLIR TIQGAHAAGI FSMNACEEGF
260 270 280 290 300
ATGGRDGCIR LWDLTFKPIT VIDLRETDQG YKGLSVRSVC WRGDHILVGT
310 320 330 340 350
QDSEIFEIVV QERNKPFLIM QGHCEGELWA LAVHPTKPLA VTGSDDRSVR
360 370 380 390 400
IWSLVDHALI ARCNMEEPIR CAAVNADGIH LALGMKDGSF TVLRVRDMTE
410 420 430 440 450
VVHIKDRKEA IHELKYSPDG TYLAVGCNDS SVDIYGVAQR YKKVGECLGS
460 470 480 490 500
LSFITHLDWS SDSRYLQTND GNGKRLFYRM PGGKEVTSTE EIKGVHWASW
510 520 530 540 550
TCVSGLEVNG IWPKYSDIND INSVDGNYIG QVLVTADDYG IIKLFRYPCL
560 570 580 590 600
RKGAKFRKYI GHSAHVTNVR WSHDYQWVIS IGGADHSVFQ WKFIPERKLK
610 620 630 640 650
DAVHIAPQES LADSHSDESD SDLSDVPELD SEIEQETQLT YRRQVYKEDL
660 670 680 690 700
PQLKEQCKEK QKSATSKRRE RAPGNSIRLH FVHGYRGYDC RSNLFYTQIG
710 720 730 740 750
EIVYHVAAVG VIYNRQQNTQ RFYLGHDDDI LCLTIHPLKD YVATGQVGRD
760 770 780 790 800
PSIHIWDTET IKPLSILKGH HQYGVSAVDF SADGKRLASV GIDDSHTVVL
810 820 830 840 850
WDWKKGEKLS IARGSKDKIF VVKMNPYVPD KLITAGIKHM KFWRKAGGGL
860 870 880 890 900
IGRKGYIGTL GKNDTMMCAV YGWTEEMAFS GTSTGDVCIW RDIFLVKTVK
910 920 930 940 950
AHDGPVFSMH ALEKGFVTGG KDGIVALWDD SFERCLKTYA IKRAALAPGS
960 970 980 990 1000
KGLLLEDNPS IRAISLGHGH ILVGTKNGEI LEVDKSGPIT LLVQGHMEGE
1010 1020 1030 1040 1050
VWGLATHPYL PICATVSDDK TLRIWDLSPS HCMLAVRKLK KGGRCCCFSP
1060 1070 1080 1090 1100
DGKALAVGLN DGSFLMANAD TLEDLVSFHH RKDMISDIRF SPGSGKYLAV
1110 1120 1130 1140 1150
ASHDSFIDIY NVMSSKRVGI CKGATSYITH IDWDIRGKLL QVNTGAKEQL
1160 1170 1180 1190 1200
FFEAPRGKKQ TIPSVEVEKI AWASWTSVLG LCCEGIWPVI GEVTDVTASC
1210 1220 1230 1240 1250
LTSDKMVLAT GDDLGFVKLF RYPTKGKFGK FKRYVAHSTH VTNVRWTYDD
1260 1270 1280 1290 1300
SMLVTLGGTD MSLMVWTNEM EGYREKRPCD SEESDIDSEE DGGYDSDVTR
1310 1320 1330 1340 1350
ENEISYTIRA LSTNIRPMLG IKPHLQQKEP SIDERPPVSR APPQPEKLQT
1360 1370 1380 1390 1400
NNVGKKKRPI EDLVLELIFG YRGRDCRNNV HYLNDGDDII YHTASVGILH
1410 1420 1430 1440 1450
NVATGSQSFY QEHNDDILCL TVNQHPKFIN IVATGQVGDS ADMSATAPSI
1460 1470 1480 1490 1500
HIWDAMNKQT LSILRCYHSK GVCSVSFSAT GKLLLSVGLD PEHTITIWRW
1510 1520 1530 1540 1550
QEGAKIASRA GHNQRIFVAE FRPDSDTQFV SVGVKHVKFW TLAGRALLSK
1560 1570 1580 1590 1600
KGLLSTLEDA RMQTMLAIAF GANNLTFTGT ISGDVCVWKD HILCRIVARA
1610 1620 1630 1640 1650
HNGPVFAMYT TLRDGLIVTG GKERPSKEGG AVKLWDQELR RCRAFRLETG
1660 1670 1680 1690 1700
QATDCVRSVC RGKGKILVGT RNAEIIEVGE KNAACNILVN GHVDGPIWGL
1710 1720 1730 1740 1750
ATHPSRDFFL SAAEDGTVRL WDIADKKMLN KVNLGHAART VCYSPEGDMV
1760 1770 1780 1790 1800
AIGMKNGEFI ILLVSSLKIW GKKRDRRCAI HDIRFSPDSR YLAVGSSENS
1810 1820 1830 1840 1850
VDFYDLTLGP TLNRISYCKD IPSFVIQMDF SADSSYLQVS SGCYKRHVYE
1860 1870 1880 1890 1900
VPSGKHLMDH AAIDRITWAT WTSILGDEVL GIWSRHAEKA DVNCACVSHS
1910 1920 1930 1940 1950
GISLVTGDDF GMVKLFDFPC PEKFAKHKRF LGHSPHVTNI RFTSGDRHVV
1960
SAGGDDCSLF VWKCVHTPH
Length:1,969
Mass (Da):219,427
Last modified:November 25, 2008 - v3
Checksum:iB105BD33557F500D
GO
Isoform 2 (identifier: Q05BV3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1137-1144: GKLLQVNT → AFTGQHWC
     1145-1969: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:1,144
Mass (Da):127,821
Checksum:iF882D3A33FB66378
GO
Isoform 4 (identifier: Q05BV3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     609-622: ESLADSHSDESDSD → GYIHLYLHRHLNLM
     623-1969: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:622
Mass (Da):70,003
Checksum:iECEFB08803C581CE
GO
Isoform 5 (identifier: Q05BV3-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1334-1334: E → ERQGVVRGS

Show »
Length:1,977
Mass (Da):220,267
Checksum:iD928D4A079974647
GO

Sequence cautioni

The sequence AAH32685 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC86793 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence BAC87266 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence CAI46257 differs from that shown. The sequence differs from that shown in N-terminus because it seems to be derived from a pre-mRNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317F → S in AAH32685 (PubMed:15489334).Curated1
Sequence conflicti1402V → A in BAC86793 (PubMed:14702039).Curated1
Sequence conflicti1804Y → C in AAI50640 (PubMed:15489334).Curated1
Sequence conflicti1814R → G in AAI50640 (PubMed:15489334).Curated1
Sequence conflicti1823S → G in AAI50640 (PubMed:15489334).Curated1
Sequence conflicti1827Q → R in AAI50640 (PubMed:15489334).Curated1
Sequence conflicti1928K → R in AAI50640 (PubMed:15489334).Curated1
Sequence conflicti1940I → V in AAI50640 (PubMed:15489334).Curated1
Sequence conflicti1963K → R in AAI50640 (PubMed:15489334).Curated1
Sequence conflicti1967T → A in AAI50640 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031730269I → V.Corresponds to variant rs17188228dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_041258609 – 622ESLAD…ESDSD → GYIHLYLHRHLNLM in isoform 4. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_041259623 – 1969Missing in isoform 4. 1 PublicationAdd BLAST1347
Alternative sequenceiVSP_0412601137 – 1144GKLLQVNT → AFTGQHWC in isoform 2. 1 Publication8
Alternative sequenceiVSP_0412611145 – 1969Missing in isoform 2. 1 PublicationAdd BLAST825
Alternative sequenceiVSP_0406451334E → ERQGVVRGS in isoform 5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127024 mRNA. Translation: BAC86793.1. Sequence problems.
AK128086 mRNA. Translation: BAC87266.1. Sequence problems.
AL121768 Genomic DNA. No translation available.
AL162171 Genomic DNA. No translation available.
BC032685 mRNA. Translation: AAH32685.1. Sequence problems.
BC150639 mRNA. Translation: AAI50640.1.
AY357725 mRNA. Translation: AAQ62653.1.
CR933726 Transcribed RNA. Translation: CAI46257.1. Sequence problems.
CCDSiCCDS45148.1. [Q05BV3-5]
RefSeqiNP_899243.1. NM_183387.2. [Q05BV3-5]
XP_006720133.1. XM_006720070.3. [Q05BV3-1]
UniGeneiHs.325846.

Genome annotation databases

EnsembliENST00000380664; ENSP00000370039; ENSG00000165521. [Q05BV3-1]
ENST00000554922; ENSP00000451998; ENSG00000165521. [Q05BV3-5]
GeneIDi161436.
KEGGihsa:161436.
UCSCiuc059edd.1. human. [Q05BV3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK127024 mRNA. Translation: BAC86793.1. Sequence problems.
AK128086 mRNA. Translation: BAC87266.1. Sequence problems.
AL121768 Genomic DNA. No translation available.
AL162171 Genomic DNA. No translation available.
BC032685 mRNA. Translation: AAH32685.1. Sequence problems.
BC150639 mRNA. Translation: AAI50640.1.
AY357725 mRNA. Translation: AAQ62653.1.
CR933726 Transcribed RNA. Translation: CAI46257.1. Sequence problems.
CCDSiCCDS45148.1. [Q05BV3-5]
RefSeqiNP_899243.1. NM_183387.2. [Q05BV3-5]
XP_006720133.1. XM_006720070.3. [Q05BV3-1]
UniGeneiHs.325846.

3D structure databases

ProteinModelPortaliQ05BV3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127791. 5 interactors.
STRINGi9606.ENSP00000451998.

PTM databases

iPTMnetiQ05BV3.
PhosphoSitePlusiQ05BV3.

Polymorphism and mutation databases

BioMutaiEML5.
DMDMi215274143.

Proteomic databases

EPDiQ05BV3.
MaxQBiQ05BV3.
PaxDbiQ05BV3.
PeptideAtlasiQ05BV3.
PRIDEiQ05BV3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380664; ENSP00000370039; ENSG00000165521. [Q05BV3-1]
ENST00000554922; ENSP00000451998; ENSG00000165521. [Q05BV3-5]
GeneIDi161436.
KEGGihsa:161436.
UCSCiuc059edd.1. human. [Q05BV3-1]

Organism-specific databases

CTDi161436.
DisGeNETi161436.
GeneCardsiEML5.
H-InvDBHIX0026633.
HIX0172351.
HGNCiHGNC:18197. EML5.
HPAiHPA054019.
HPA055379.
neXtProtiNX_Q05BV3.
OpenTargetsiENSG00000165521.
PharmGKBiPA134894613.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2106. Eukaryota.
ENOG410XNTQ. LUCA.
GeneTreeiENSGT00550000074369.
HOGENOMiHOG000031037.
HOVERGENiHBG107846.
InParanoidiQ05BV3.
KOiK18597.
OMAiPEKLQTN.
OrthoDBiEOG091G00FB.
PhylomeDBiQ05BV3.
TreeFamiTF317832.

Enzyme and pathway databases

SignaLinkiQ05BV3.

Miscellaneous databases

ChiTaRSiEML5. human.
GenomeRNAii161436.
PROiQ05BV3.

Gene expression databases

BgeeiENSG00000165521.
CleanExiHS_EML5.
ExpressionAtlasiQ05BV3. baseline and differential.
GenevisibleiQ05BV3. HS.

Family and domain databases

Gene3Di2.130.10.10. 9 hits.
InterProiIPR024977. Apc4_WD40_dom.
IPR005108. HELP.
IPR011041. Quinoprot_gluc/sorb_DH.
IPR011047. Quinoprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF12894. ANAPC4_WD40. 2 hits.
PF03451. HELP. 3 hits.
PF00400. WD40. 8 hits.
[Graphical view]
SMARTiSM00320. WD40. 28 hits.
[Graphical view]
SUPFAMiSSF50952. SSF50952. 1 hit.
SSF50978. SSF50978. 5 hits.
SSF50998. SSF50998. 5 hits.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEMAL5_HUMAN
AccessioniPrimary (citable) accession number: Q05BV3
Secondary accession number(s): B9EK59
, Q5H9N6, Q6UYC9, Q6ZRP3, Q6ZT03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 25, 2008
Last modified: November 2, 2016
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.