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Submitted name:

ANXA1 protein



Homo sapiens (Human)
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli


GO - Molecular functioni

  1. annealing helicase activity Source: Ensembl
  2. calcium-dependent phospholipid binding Source: InterPro
  3. calcium ion binding Source: InterPro
  4. double-stranded DNA-dependent ATPase activity Source: Ensembl
  5. helicase activity Source: Ensembl
  6. phospholipase A2 inhibitor activity Source: Ensembl
  7. single-stranded DNA binding Source: Ensembl
  8. single-stranded RNA binding Source: Ensembl

GO - Biological processi

  1. alpha-beta T cell differentiation Source: Ensembl
  2. arachidonic acid secretion Source: Ensembl
  3. cell surface receptor signaling pathway Source: Ensembl
  4. cellular response to glucocorticoid stimulus Source: Ensembl
  5. cellular response to hydrogen peroxide Source: Ensembl
  6. DNA duplex unwinding Source: Ensembl
  7. DNA rewinding Source: Ensembl
  8. endocrine pancreas development Source: Ensembl
  9. gliogenesis Source: Ensembl
  10. hepatocyte differentiation Source: Ensembl
  11. insulin secretion Source: Ensembl
  12. negative regulation of phospholipase A2 activity Source: Ensembl
  13. negative regulation of protein secretion Source: Ensembl
  14. neutrophil homeostasis Source: Ensembl
  15. positive regulation of G1/S transition of mitotic cell cycle Source: Ensembl
  16. positive regulation of neutrophil apoptotic process Source: Ensembl
  17. positive regulation of prostaglandin biosynthetic process Source: Ensembl
  18. prolactin secretion Source: Ensembl
  19. prostate gland development Source: Ensembl
  20. regulation of cell proliferation Source: Ensembl
  21. response to drug Source: Ensembl
  22. response to estradiol Source: Ensembl
  23. response to interleukin-1 Source: Ensembl
  24. response to peptide hormone Source: Ensembl
  25. response to X-ray Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
ANXA1 proteinImported
Gene namesi
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. mast cell granule Source: Ensembl
  3. mitochondrial membrane Source: Ensembl
  4. nucleus Source: Ensembl
  5. protein complex Source: Ensembl
  6. sarcolemma Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases



Gene expression databases

ExpressionAtlasiQ05BR2. baseline and differential.


3D structure databases

SMRiQ05BR2. Positions 1-45.

Family & Domainsi

Keywords - Domaini

AnnexinSAAS annotation

Family and domain databases

Gene3Di1.10.220.10. 1 hit.
InterProiIPR018502. Annexin_repeat.
IPR002388. AnnexinI.
[Graphical view]
PANTHERiPTHR10502:SF17. PTHR10502:SF17. 1 hit.
PfamiPF00191. Annexin. 1 hit.
[Graphical view]
SMARTiSM00335. ANX. 1 hit.
[Graphical view]


Sequence statusi: Complete.

Q05BR2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40 
Mass (Da):5,276
Last modified:November 14, 2006 - v1

Sequence databases

Select the link destinations:
Links Updated
BC034157 mRNA. Translation: AAH34157.1.


Sequence databases

Select the link destinations:
Links Updated
BC034157 mRNA. Translation: AAH34157.1 .
UniGenei Hs.494173.

3D structure databases

ProteinModelPortali Q05BR2.
SMRi Q05BR2. Positions 1-45.
ModBasei Search...
MobiDBi Search...

Proteomic databases


Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

ChiTaRSi ANXA1. human.

Gene expression databases

Bgeei Q05BR2.
ExpressionAtlasi Q05BR2. baseline and differential.

Family and domain databases

Gene3Di 1 hit.
InterProi IPR018502. Annexin_repeat.
IPR002388. AnnexinI.
[Graphical view ]
PANTHERi PTHR10502:SF17. PTHR10502:SF17. 1 hit.
Pfami PF00191. Annexin. 1 hit.
[Graphical view ]
SMARTi SM00335. ANX. 1 hit.
[Graphical view ]
ProtoNeti Search...


  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Tissue: PlacentaImported.

Entry informationi

Entry nameiQ05BR2_HUMAN
AccessioniPrimary (citable) accession number: Q05BR2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: January 7, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.