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Protein

Protein turtle homolog A

Gene

Igsf9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions in dendrite outgrowth and synapse maturation.2 Publications

GO - Molecular functioni

  • protein binding involved in cell-cell adhesion Source: MGI

GO - Biological processi

  • dendrite development Source: MGI
  • homophilic cell adhesion via plasma membrane adhesion molecules Source: MGI
  • regulation of synapse organization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein turtle homolog A
Alternative name(s):
Dendrite arborization and synapse maturation protein 1
Immunoglobulin superfamily member 9A
Short name:
IgSF9A
Gene namesi
Name:Igsf9
Synonyms:Dasm1, Igsf9a, Nrt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2135283. Igsf9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 734ExtracellularSequence analysisAdd BLAST714
Transmembranei735 – 755HelicalSequence analysisAdd BLAST21
Topological domaini756 – 1179CytoplasmicSequence analysisAdd BLAST424

GO - Cellular componenti

  • axon Source: MGI
  • cell junction Source: UniProtKB-KW
  • dendrite Source: MGI
  • inhibitory synapse Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1177T → A: Loss of interaction with MAGI2 and SHANK1 and loss of function. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000030610821 – 1179Protein turtle homolog AAdd BLAST1159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 108PROSITE-ProRule annotation
Disulfide bondi158 ↔ 206PROSITE-ProRule annotation
Glycosylationi188N-linked (GlcNAc...)Sequence analysis1
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi248 ↔ 301PROSITE-ProRule annotation
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi344 ↔ 395PROSITE-ProRule annotation
Disulfide bondi440 ↔ 486PROSITE-ProRule annotation
Glycosylationi513N-linked (GlcNAc...)Sequence analysis1
Glycosylationi524N-linked (GlcNAc...)Sequence analysis1
Modified residuei809PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ05BQ1.
PRIDEiQ05BQ1.

PTM databases

iPTMnetiQ05BQ1.
PhosphoSitePlusiQ05BQ1.

Expressioni

Tissue specificityi

Expressed in both cell bodies and dendrites of cortical and hippocampal neurons and also cerebellar Purkinje cells (at protein level).1 Publication

Developmental stagei

Detected in brain during embryonic development at least from E7.5 until E16.5. Mainly expressed within the dorsal root glanglia, trigeminal glanglia and olfactory epithelium of E10.5 embryos. Expressed to a lower extent in neuroepithelium, retina and hindgut.2 Publications

Gene expression databases

BgeeiENSMUSG00000037995.
CleanExiMM_IGSF9.
ExpressionAtlasiQ05BQ1. baseline and differential.
GenevisibleiQ05BQ1. MM.

Interactioni

Subunit structurei

Interacts with MAGI2 and SHANK1.1 Publication

GO - Molecular functioni

  • protein binding involved in cell-cell adhesion Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058275.

Structurei

3D structure databases

ProteinModelPortaliQ05BQ1.
SMRiQ05BQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 124Ig-like 1Add BLAST101
Domaini136 – 216Ig-like 2Add BLAST81
Domaini226 – 318Ig-like 3Add BLAST93
Domaini322 – 410Ig-like 4Add BLAST89
Domaini418 – 502Ig-like 5Add BLAST85
Domaini507 – 611Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST105
Domaini623 – 718Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1177 – 1179PDZ-binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi823 – 974Pro-richAdd BLAST152

Domaini

The PDZ-binding motif mediates interactions with MAGI2 and SHANK1.

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQJK. Eukaryota.
ENOG410XNZS. LUCA.
GeneTreeiENSGT00530000063887.
HOGENOMiHOG000154716.
HOVERGENiHBG079460.
InParanoidiQ05BQ1.
OMAiRVEDQGW.
OrthoDBiEOG091G02TX.
PhylomeDBiQ05BQ1.
TreeFamiTF326128.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q05BQ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIWCLRLTVL SLIISQGADG RRKPEVVSVV GRAGESAVLG CDLLPPAGHP
60 70 80 90 100
PLHVIEWLRF GFLLPIFIQF GLYSPRIDPD YVGRVRLQTG ASLQIEGLRV
110 120 130 140 150
EDQGWYECRV LFLDQHSPEQ DFANGSWVHL TVNSPPQFQE TPPLVLEVKE
160 170 180 190 200
LEAVTLRCVA RGSPQPYVTW KFRGQDLGKG QGQVQVQNGT LWIRRVERGS
210 220 230 240 250
AGDYTCQASS SEGSITHATQ LLVLGPPVIV VPPSNSTVNS SQDVSLACRA
260 270 280 290 300
EAYPANLTYS WFQDGVNVFH ISRLQSRVRI LVDGSLWLQA TQPDDAGHYT
310 320 330 340 350
CVPSNGFLHP PSASAYLTVL YPAQVTVMPP ETPLPTGMRG VIRCPVRANP
360 370 380 390 400
PLLFVTWTKD GQALQLDKFP GWSLGPEGSL IIALGNENAL GEYSCTPYNS
410 420 430 440 450
LGTAGPSPVT QVLLKAPPAF IDQPKEEYFQ EVGRELLIPC SARGDPPPIV
460 470 480 490 500
SWAKVGRGLQ GQAQVDSNNS LVLRPLTKEA QGRWECSASN AVARVTTSTN
510 520 530 540 550
VYVLGTSPHV VTNVSVVPLP KGANVSWEPG FDGGYLQRFS VWYTPLAKRP
560 570 580 590 600
DRAHHDWVSL AVPIGATHLL VPGLQAHAQY QFSVLAQNKL GSGPFSEIVL
610 620 630 640 650
SIPEGLPTTP AAPGLPPTEI PPPLSPPRGL VAVRTPRGVL LHWDPPELIP
660 670 680 690 700
GRLDGYILEG RQGSQGWEIL DQGVAGTEIQ LLVPGLIKDV LYEFRLVAFA
710 720 730 740 750
DSYVSDPSNV ANISTSGLEV YPSRTQLPGL LPQPVLAGVV GGVCFLGVAV
760 770 780 790 800
LVSILAACLM NRRRAARRHR KRLRQDPPLI FSPRGKSGSH SAPGSGSPDS
810 820 830 840 850
VTKFKLQGSP VPSLRQSLLW GEPARPPSPH PDSPLGRGPL PLEPICRGPD
860 870 880 890 900
GRFVMGPTVA PSQEKLCLER SEPRTSAKRL AQSFDCSSSS PSGVPQPLCI
910 920 930 940 950
TDISPVGQPL AAVPSPLPGP GPLLQYLSLP FFREMNVDGD WPPLEEPTPA
960 970 980 990 1000
PPPDFMDSQP CPTSSFLPPP DSPPANLRAV LPGTLMGVGV SSEPPYTALA
1010 1020 1030 1040 1050
DWTLRERVLP GLLSAAPRGS LTSQSSGRGS ASFLRPPSTA PSAGGSYLSP
1060 1070 1080 1090 1100
APGDTSSWAS GPERWPRREH VVTVSKRRNT SVDENYEWDS EFPGDMELLE
1110 1120 1130 1140 1150
TWHPGLASSR THPELEPELG VKTPEESCLL NPTHAAGPEA RCAALREEFL
1160 1170
AFRRRRDATR ARLPAYQQSI SYPEQATLL
Length:1,179
Mass (Da):127,330
Last modified:October 2, 2007 - v2
Checksum:i8CD76F4D1B32A2DF
GO
Isoform 2 (identifier: Q05BQ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     505-528: GTSPHVVTNVSVVPLPKGANVSWE → EPSVLTEPTMTGYLWLCLSGLHTS
     529-1179: Missing.

Note: No experimental confirmation available.
Show »
Length:528
Mass (Da):57,608
Checksum:i5D74ADA7C166B951
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49H → R in AAK49447 (PubMed:11401431).Curated1
Sequence conflicti1161A → V in AAH24487 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_028408505 – 528GTSPH…NVSWE → EPSVLTEPTMTGYLWLCLSG LHTS in isoform 2. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_028409529 – 1179Missing in isoform 2. 1 PublicationAdd BLAST651

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121551 Genomic DNA. No translation available.
BC024487 mRNA. Translation: AAH24487.1.
BC034594 mRNA. Translation: AAH34594.1.
AF284775 Genomic DNA. Translation: AAK49447.1.
CCDSiCCDS15515.1. [Q05BQ1-1]
RefSeqiNP_001139272.1. NM_001145800.1. [Q05BQ1-1]
NP_291086.2. NM_033608.3. [Q05BQ1-1]
XP_006497119.1. XM_006497056.3. [Q05BQ1-1]
UniGeneiMm.214530.

Genome annotation databases

EnsembliENSMUST00000052629; ENSMUSP00000058275; ENSMUSG00000037995. [Q05BQ1-1]
ENSMUST00000111235; ENSMUSP00000106866; ENSMUSG00000037995. [Q05BQ1-1]
ENSMUST00000127482; ENSMUSP00000117854; ENSMUSG00000037995. [Q05BQ1-2]
GeneIDi93842.
KEGGimmu:93842.
UCSCiuc007dqn.2. mouse. [Q05BQ1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121551 Genomic DNA. No translation available.
BC024487 mRNA. Translation: AAH24487.1.
BC034594 mRNA. Translation: AAH34594.1.
AF284775 Genomic DNA. Translation: AAK49447.1.
CCDSiCCDS15515.1. [Q05BQ1-1]
RefSeqiNP_001139272.1. NM_001145800.1. [Q05BQ1-1]
NP_291086.2. NM_033608.3. [Q05BQ1-1]
XP_006497119.1. XM_006497056.3. [Q05BQ1-1]
UniGeneiMm.214530.

3D structure databases

ProteinModelPortaliQ05BQ1.
SMRiQ05BQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058275.

PTM databases

iPTMnetiQ05BQ1.
PhosphoSitePlusiQ05BQ1.

Proteomic databases

PaxDbiQ05BQ1.
PRIDEiQ05BQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052629; ENSMUSP00000058275; ENSMUSG00000037995. [Q05BQ1-1]
ENSMUST00000111235; ENSMUSP00000106866; ENSMUSG00000037995. [Q05BQ1-1]
ENSMUST00000127482; ENSMUSP00000117854; ENSMUSG00000037995. [Q05BQ1-2]
GeneIDi93842.
KEGGimmu:93842.
UCSCiuc007dqn.2. mouse. [Q05BQ1-1]

Organism-specific databases

CTDi57549.
MGIiMGI:2135283. Igsf9.

Phylogenomic databases

eggNOGiENOG410IQJK. Eukaryota.
ENOG410XNZS. LUCA.
GeneTreeiENSGT00530000063887.
HOGENOMiHOG000154716.
HOVERGENiHBG079460.
InParanoidiQ05BQ1.
OMAiRVEDQGW.
OrthoDBiEOG091G02TX.
PhylomeDBiQ05BQ1.
TreeFamiTF326128.

Miscellaneous databases

ChiTaRSiIgsf9. mouse.
PROiQ05BQ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037995.
CleanExiMM_IGSF9.
ExpressionAtlasiQ05BQ1. baseline and differential.
GenevisibleiQ05BQ1. MM.

Family and domain databases

CDDicd00063. FN3. 2 hits.
Gene3Di2.60.40.10. 7 hits.
InterProiIPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
SSF49265. SSF49265. 1 hit.
PROSITEiPS50853. FN3. 2 hits.
PS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTUTLA_MOUSE
AccessioniPrimary (citable) accession number: Q05BQ1
Secondary accession number(s): Q8R1J8, Q925P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 30, 2016
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.