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Protein

Mitogen-activated protein kinase kinase kinase kinase

Gene

Map4k5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei73 – 731Proton acceptorUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase kinase kinase kinaseUniRule annotation (EC:2.7.11.1UniRule annotation)
Gene namesi
Name:Map4k5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1925503. Map4k5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiQ05BG3.
PRIDEiQ05BG3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034761.
GenevisibleiQ05BG3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047812.

Structurei

3D structure databases

ProteinModelPortaliQ05BG3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 210210Protein kinaseInterPro annotationAdd
BLAST
Domaini440 – 753314CNHInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0576. Eukaryota.
ENOG410XP9G. LUCA.
HOVERGENiHBG036702.
KOiK08833.

Family and domain databases

InterProiIPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR021160. MAPKKKK.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF038172. MAPKKKK. 1 hit.
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05BG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKECKHCNI VAYFGSYLSR EKLWICMEYC GGGSLQDIYH VTGPLSEMQI
60 70 80 90 100
AYVCRETLQG LAYLHTKGKM HRDIKGANIL LTDHGDVKLA DFGVAAKITA
110 120 130 140 150
TIAKRKSFIG TPYWMAPEVA AVEKNGGYNQ LCDIWAVGIT AIELGELQPP
160 170 180 190 200
MFDLHPMRAL FLMSKSNFQP PKLKDKTKWS STFHNFVKIA LTKNPKKRPT
210 220 230 240 250
AERLLTHTFV GQPGLSRALA VELLDKVSNP DNHAPYSEGD EDDLEPHAII
260 270 280 290 300
RHTIRSTNRN SRAERTASEI NFDKLQFEPP LRKETEARDE MGLSSEPNFI
310 320 330 340 350
LHWNPFVDGA NTGRSTSKRA IPPPLPPKPR VNTYPEDSLP DEEKSSTIKR
360 370 380 390 400
CPDLEARAPQ VLRRQSSPSC VPVAETSSSI GNGDGISKLI SENTEGSAQA
410 420 430 440 450
PQLPRKKDKR DFPKPTINGL PPTPKVLMGA CFSKVFDGCP LKINCATSWI
460 470 480 490 500
HPDTKDQYII FGTEDGIYTL NLNELHEATM EQLFPRKCTW LYVINNTLMS
510 520 530 540 550
LSEGKTFQLY SHNLIALFEQ AKKPGLAAHI QTHRFPDRIL PRKFALTTKI
560 570 580 590 600
PDTKGCHKCC IVRNPYTGHK YLCGALQSGI VLLQWYEPMQ KFMLIKHFDF
610 620 630 640 650
PLPSPLNVFE MLVIPEQEYP MVCVAISKGS DSSQVVQFET INLNSASSWF
660 670 680 690 700
TEIGAGSQQL DSIHVTQLER DTVLVCLDKF VKIVNLQGKL KSSKKLASEL
710 720 730 740 750
SFDFRIESVV CLQDSVLAFW KHGMQGKSFK SDEVTQEISD ETRVFRLLGS
760 770 780
DRVVVLESRP TENPAAHSNL YILAGHENSY
Length:780
Mass (Da):87,511
Last modified:November 14, 2006 - v1
Checksum:i574C93D10D3BFC48
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048173 mRNA. Translation: AAH48173.1.
RefSeqiNP_958927.2. NM_201519.2.
UniGeneiMm.291936.

Genome annotation databases

GeneIDi399510.
KEGGimmu:399510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC048173 mRNA. Translation: AAH48173.1.
RefSeqiNP_958927.2. NM_201519.2.
UniGeneiMm.291936.

3D structure databases

ProteinModelPortaliQ05BG3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047812.

Proteomic databases

PaxDbiQ05BG3.
PRIDEiQ05BG3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399510.
KEGGimmu:399510.

Organism-specific databases

CTDi11183.
MGIiMGI:1925503. Map4k5.

Phylogenomic databases

eggNOGiKOG0576. Eukaryota.
ENOG410XP9G. LUCA.
HOVERGENiHBG036702.
KOiK08833.

Miscellaneous databases

ChiTaRSiMap4k5. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034761.
GenevisibleiQ05BG3. MM.

Family and domain databases

InterProiIPR001180. CNH_dom.
IPR011009. Kinase-like_dom.
IPR021160. MAPKKKK.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00780. CNH. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF038172. MAPKKKK. 1 hit.
SMARTiSM00036. CNH. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50219. CNH. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ05BG3_MOUSE
AccessioniPrimary (citable) accession number: Q05BG3
Entry historyi
Integrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.