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Q05BC3 (EMAL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Echinoderm microtubule-associated protein-like 1

Short name=EMAP-1
Gene names
Name:Eml1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length814 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic By similarity.

Subcellular location

Cytoplasmcytoskeleton Potential.

Sequence similarities

Belongs to the WD repeat EMAP family.

Contains 11 WD repeats.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Microtubule
   Coding sequence diversityAlternative splicing
   DomainRepeat
WD repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processhematopoietic progenitor cell differentiation

Inferred from genetic interaction PubMed 24029230. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q05BC3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q05BC3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-31: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q05BC3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     181-181: P → PALQSPKPQGKRRVTHCK
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 814814Echinoderm microtubule-associated protein-like 1
PRO_0000284386

Regions

Repeat268 – 31750WD 1
Repeat322 – 36544WD 2
Repeat368 – 40740WD 3
Repeat415 – 45339WD 4
Repeat457 – 49640WD 5
Repeat540 – 57940WD 6
Repeat581 – 62040WD 7
Repeat623 – 66240WD 8
Repeat669 – 70840WD 9
Repeat736 – 77540WD 10
Repeat781 – 81434WD 11
Compositional bias159 – 1657Poly-Ser

Natural variations

Alternative sequence1 – 3131Missing in isoform 2.
VSP_024477
Alternative sequence1811P → PALQSPKPQGKRRVTHCK in isoform 3.
VSP_024478

Experimental info

Sequence conflict1131A → S in AAI25290. Ref.1
Sequence conflict6691G → C in AAH59839. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 9881D29F4C2899D5

FASTA81489,680
        10         20         30         40         50         60 
MEDGFSSYSS LYDTSSLLQF CNDDSASAAS SMEVSDRIAS LEQRVQMQED DIQLLKSALA 

        70         80         90        100        110        120 
DVVRRLNITE EQQAVLNRKG PTKARPLGQT LPLRTTVNNG TVLPKKPSAS LPAPSGARKE 

       130        140        150        160        170        180 
VVVPVTKSIN RTSSSERVSP GGRRESSGDS KGSRNRTGST SSSSSGKKNS ESKPKEPAFS 

       190        200        210        220        230        240 
PEEGYVKMFL RGRPVTMYMP KDQVDSYSLE AKAELPTKRL KLEWVYGYRG RDCRNNLYLL 

       250        260        270        280        290        300 
PTGETVYFIA SVVVLYNVEE QLQRHYAGHN DDVKCLAVHP DRITIATGQV AGTSKDGKQL 

       310        320        330        340        350        360 
PPHVRIWDSV TLNTLHVIGI GFFDRAVTCI AFSKSNGGGH LCAVDDSNDH VLSVWDWQKE 

       370        380        390        400        410        420 
ERLADVKCSN EAVFAADFHP TDTNIIVTCG KSHLYFWTLE GNSLNKKQGL FEKQEKPKFV 

       430        440        450        460        470        480 
LCVTFSENGD TITGDSSGNI LVWGKGTNRI SYAVQGAHEG GIFALCMLRD GTLVSGGGKD 

       490        500        510        520        530        540 
RRLISWNGNY QKLHKAEIPE QFGPIRTVAE GKGNVILIGT TRNFVLQGTL SGDFTPITQG 

       550        560        570        580        590        600 
HTDELWGLAI HASKPQFLTC GHDKHATLWD AVGHRPVWDK IIEDPAQSSG FHPSGSVVAV 

       610        620        630        640        650        660 
GTLTGRWFVF DTETKDLVTV HTDGNEQLSV MRYSPDGNFL AIGSHDNCIY IYGVTDNGRK 

       670        680        690        700        710        720 
YTRVGKCSGH SSFITHLDWS VNSQFLVSNS GDYEILYWVP SACKQVVSVE TTRDIEWATY 

       730        740        750        760        770        780 
TCTLGFHVFG VWPEGSDGTD INAVCRAHER KLLCTGDDFG KVHLFSYPCS QFRAPSHIYS 

       790        800        810 
GHSSHVTNVD FLCEDSHLIS TGGKDTSIMQ WRVI 

« Hide

Isoform 2 [UniParc].

Checksum: 47F0B22EA6BE7E2E
Show »

FASTA78386,411
Isoform 3 [UniParc].

Checksum: 8DA3147067A18828
Show »

FASTA83191,596

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC053094 mRNA. Translation: AAH53094.2.
BC059839 mRNA. Translation: AAH59839.1.
BC079582 mRNA. Translation: AAH79582.1.
BC125289 mRNA. Translation: AAI25290.1.
CCDSCCDS36555.1. [Q05BC3-1]
CCDS36556.1. [Q05BC3-2]
RefSeqNP_001036800.1. NM_001043335.1. [Q05BC3-1]
NP_001036801.1. NM_001043336.2. [Q05BC3-2]
NP_001273275.1. NM_001286346.1.
NP_001273276.1. NM_001286347.1.
UniGeneMm.236645.

3D structure databases

ProteinModelPortalQ05BC3.
SMRQ05BC3. Positions 209-791.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ05BC3.

Proteomic databases

MaxQBQ05BC3.
PaxDbQ05BC3.
PRIDEQ05BC3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000054955; ENSMUSP00000057209; ENSMUSG00000058070. [Q05BC3-2]
ENSMUST00000109860; ENSMUSP00000105486; ENSMUSG00000058070. [Q05BC3-1]
GeneID68519.
KEGGmmu:68519.
UCSCuc007ozq.1. mouse. [Q05BC3-1]

Organism-specific databases

CTD2009.
MGIMGI:1915769. Eml1.

Phylogenomic databases

eggNOGCOG2319.
GeneTreeENSGT00550000074369.
HOGENOMHOG000294061.
HOVERGENHBG051470.
OMAFRAPSHV.
OrthoDBEOG7XWPMW.
PhylomeDBQ05BC3.
TreeFamTF317832.

Gene expression databases

ArrayExpressQ05BC3.
BgeeQ05BC3.
CleanExMM_EML1.
GenevestigatorQ05BC3.

Family and domain databases

Gene3D2.130.10.10. 3 hits.
InterProIPR005108. HELP.
IPR011047. Quinonprotein_ADH-like_supfam.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF03451. HELP. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
SMARTSM00320. WD40. 10 hits.
[Graphical view]
SUPFAMSSF50998. SSF50998. 1 hit.
PROSITEPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio327362.
PROQ05BC3.
SOURCESearch...

Entry information

Entry nameEMAL1_MOUSE
AccessionPrimary (citable) accession number: Q05BC3
Secondary accession number(s): Q05AF8, Q0P5V3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 14, 2006
Last modified: July 9, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot