Echinoderm microtubule-associated protein-like 1

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Q05BC3 (EMAL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 52. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Echinoderm microtubule-associated protein-like 1
Short name=EMAP-1

Gene names

Name:

Eml1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	814 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic By similarity.

Subcellular location

Cytoplasm › cytoskeleton Potential.

Sequence similarities

Belongs to the WD repeat EMAP family.

Contains 11 WD repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton Microtubule
Coding sequence diversity	Alternative splicing
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW microtubule Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q05BC3-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q05BC3-2) The sequence of this isoform differs from the canonical sequence as follows: 1-31: Missing.
Note: No experimental confirmation available.

Isoform 3 (identifier: Q05BC3-3) The sequence of this isoform differs from the canonical sequence as follows: 181-181: P → PALQSPKPQGKRRVTHCK
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 814

814

Echinoderm microtubule-associated protein-like 1

PRO_0000284386

Regions

Repeat

268 – 317

WD 1

Repeat

322 – 365

WD 2

Repeat

368 – 407

WD 3

Repeat

415 – 453

WD 4

Repeat

457 – 496

WD 5

Repeat

540 – 579

WD 6

Repeat

581 – 620

WD 7

Repeat

623 – 662

WD 8

Repeat

669 – 708

WD 9

Repeat

736 – 775

WD 10

Repeat

781 – 814

WD 11

Compositional bias

159 – 165

Poly-Ser

Natural variations

Alternative sequence

1 – 31

Missing in isoform 2.

VSP_024477

Alternative sequence

181

P → PALQSPKPQGKRRVTHCK in isoform 3.

VSP_024478

Experimental info

Sequence conflict

113

A → S in AAI25290. Ref.1

Sequence conflict

669

G → C in AAH59839. Ref.1

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 9881D29F4C2899D5 Show »	FASTA	814	89,680
10 20 30 40 50 60 MEDGFSSYSS LYDTSSLLQF CNDDSASAAS SMEVSDRIAS LEQRVQMQED DIQLLKSALA 70 80 90 100 110 120 DVVRRLNITE EQQAVLNRKG PTKARPLGQT LPLRTTVNNG TVLPKKPSAS LPAPSGARKE 130 140 150 160 170 180 VVVPVTKSIN RTSSSERVSP GGRRESSGDS KGSRNRTGST SSSSSGKKNS ESKPKEPAFS 190 200 210 220 230 240 PEEGYVKMFL RGRPVTMYMP KDQVDSYSLE AKAELPTKRL KLEWVYGYRG RDCRNNLYLL 250 260 270 280 290 300 PTGETVYFIA SVVVLYNVEE QLQRHYAGHN DDVKCLAVHP DRITIATGQV AGTSKDGKQL 310 320 330 340 350 360 PPHVRIWDSV TLNTLHVIGI GFFDRAVTCI AFSKSNGGGH LCAVDDSNDH VLSVWDWQKE 370 380 390 400 410 420 ERLADVKCSN EAVFAADFHP TDTNIIVTCG KSHLYFWTLE GNSLNKKQGL FEKQEKPKFV 430 440 450 460 470 480 LCVTFSENGD TITGDSSGNI LVWGKGTNRI SYAVQGAHEG GIFALCMLRD GTLVSGGGKD 490 500 510 520 530 540 RRLISWNGNY QKLHKAEIPE QFGPIRTVAE GKGNVILIGT TRNFVLQGTL SGDFTPITQG 550 560 570 580 590 600 HTDELWGLAI HASKPQFLTC GHDKHATLWD AVGHRPVWDK IIEDPAQSSG FHPSGSVVAV 610 620 630 640 650 660 GTLTGRWFVF DTETKDLVTV HTDGNEQLSV MRYSPDGNFL AIGSHDNCIY IYGVTDNGRK 670 680 690 700 710 720 YTRVGKCSGH SSFITHLDWS VNSQFLVSNS GDYEILYWVP SACKQVVSVE TTRDIEWATY 730 740 750 760 770 780 TCTLGFHVFG VWPEGSDGTD INAVCRAHER KLLCTGDDFG KVHLFSYPCS QFRAPSHIYS 790 800 810 GHSSHVTNVD FLCEDSHLIS TGGKDTSIMQ WRVI « Hide
Isoform 2 [UniParc]. Checksum: 47F0B22EA6BE7E2E Show »	FASTA	783	86,411
10 20 30 40 50 60 MEVSDRIASL EQRVQMQEDD IQLLKSALAD VVRRLNITEE QQAVLNRKGP TKARPLGQTL 70 80 90 100 110 120 PLRTTVNNGT VLPKKPSASL PAPSGARKEV VVPVTKSINR TSSSERVSPG GRRESSGDSK 130 140 150 160 170 180 GSRNRTGSTS SSSSGKKNSE SKPKEPAFSP EEGYVKMFLR GRPVTMYMPK DQVDSYSLEA 190 200 210 220 230 240 KAELPTKRLK LEWVYGYRGR DCRNNLYLLP TGETVYFIAS VVVLYNVEEQ LQRHYAGHND 250 260 270 280 290 300 DVKCLAVHPD RITIATGQVA GTSKDGKQLP PHVRIWDSVT LNTLHVIGIG FFDRAVTCIA 310 320 330 340 350 360 FSKSNGGGHL CAVDDSNDHV LSVWDWQKEE RLADVKCSNE AVFAADFHPT DTNIIVTCGK 370 380 390 400 410 420 SHLYFWTLEG NSLNKKQGLF EKQEKPKFVL CVTFSENGDT ITGDSSGNIL VWGKGTNRIS 430 440 450 460 470 480 YAVQGAHEGG IFALCMLRDG TLVSGGGKDR RLISWNGNYQ KLHKAEIPEQ FGPIRTVAEG 490 500 510 520 530 540 KGNVILIGTT RNFVLQGTLS GDFTPITQGH TDELWGLAIH ASKPQFLTCG HDKHATLWDA 550 560 570 580 590 600 VGHRPVWDKI IEDPAQSSGF HPSGSVVAVG TLTGRWFVFD TETKDLVTVH TDGNEQLSVM 610 620 630 640 650 660 RYSPDGNFLA IGSHDNCIYI YGVTDNGRKY TRVGKCSGHS SFITHLDWSV NSQFLVSNSG 670 680 690 700 710 720 DYEILYWVPS ACKQVVSVET TRDIEWATYT CTLGFHVFGV WPEGSDGTDI NAVCRAHERK 730 740 750 760 770 780 LLCTGDDFGK VHLFSYPCSQ FRAPSHIYSG HSSHVTNVDF LCEDSHLIST GGKDTSIMQW RVI « Hide
Isoform 3 [UniParc]. Checksum: 8DA3147067A18828 Show »	FASTA	831	91,596
10 20 30 40 50 60 MEDGFSSYSS LYDTSSLLQF CNDDSASAAS SMEVSDRIAS LEQRVQMQED DIQLLKSALA 70 80 90 100 110 120 DVVRRLNITE EQQAVLNRKG PTKARPLGQT LPLRTTVNNG TVLPKKPSAS LPAPSGARKE 130 140 150 160 170 180 VVVPVTKSIN RTSSSERVSP GGRRESSGDS KGSRNRTGST SSSSSGKKNS ESKPKEPAFS 190 200 210 220 230 240 PALQSPKPQG KRRVTHCKEE GYVKMFLRGR PVTMYMPKDQ VDSYSLEAKA ELPTKRLKLE 250 260 270 280 290 300 WVYGYRGRDC RNNLYLLPTG ETVYFIASVV VLYNVEEQLQ RHYAGHNDDV KCLAVHPDRI 310 320 330 340 350 360 TIATGQVAGT SKDGKQLPPH VRIWDSVTLN TLHVIGIGFF DRAVTCIAFS KSNGGGHLCA 370 380 390 400 410 420 VDDSNDHVLS VWDWQKEERL ADVKCSNEAV FAADFHPTDT NIIVTCGKSH LYFWTLEGNS 430 440 450 460 470 480 LNKKQGLFEK QEKPKFVLCV TFSENGDTIT GDSSGNILVW GKGTNRISYA VQGAHEGGIF 490 500 510 520 530 540 ALCMLRDGTL VSGGGKDRRL ISWNGNYQKL HKAEIPEQFG PIRTVAEGKG NVILIGTTRN 550 560 570 580 590 600 FVLQGTLSGD FTPITQGHTD ELWGLAIHAS KPQFLTCGHD KHATLWDAVG HRPVWDKIIE 610 620 630 640 650 660 DPAQSSGFHP SGSVVAVGTL TGRWFVFDTE TKDLVTVHTD GNEQLSVMRY SPDGNFLAIG 670 680 690 700 710 720 SHDNCIYIYG VTDNGRKYTR VGKCSGHSSF ITHLDWSVNS QFLVSNSGDY EILYWVPSAC 730 740 750 760 770 780 KQVVSVETTR DIEWATYTCT LGFHVFGVWP EGSDGTDINA VCRAHERKLL CTGDDFGKVH 790 800 810 820 830 LFSYPCSQFR APSHIYSGHS SHVTNVDFLC EDSHLISTGG KDTSIMQWRV I « Hide

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC053094 mRNA. Translation: AAH53094.2. BC059839 mRNA. Translation: AAH59839.1. BC079582 mRNA. Translation: AAH79582.1. BC125289 mRNA. Translation: AAI25290.1.
IPI	IPI00354624. IPI00785320. IPI00844646.
RefSeq	NP_001036800.1. NM_001043335.1. NP_001036801.1. NM_001043336.1.
UniGene	Mm.236645.
3D structure databases
ProteinModelPortal	Q05BC3.
SMR	Q05BC3. Positions 209-791.
ModBase	Search...
PTM databases
PhosphoSite	Q05BC3.
Proteomic databases
PaxDb	Q05BC3.
PRIDE	Q05BC3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000054955; ENSMUSP00000057209; ENSMUSG00000058070. ENSMUST00000109860; ENSMUSP00000105486; ENSMUSG00000058070.
GeneID	68519.
KEGG	mmu:68519.
UCSC	uc007ozq.1. mouse. uc007ozs.1. mouse.
Organism-specific databases
CTD	2009.
MGI	MGI:1915769. Eml1.
Phylogenomic databases
eggNOG	COG2319.
GeneTree	ENSGT00550000074369.
HOGENOM	HOG000294061.
HOVERGEN	HBG051470.
OMA	HPDKITI.
OrthoDB	EOG4CC40Q.
Gene expression databases
ArrayExpress	Q05BC3.
Bgee	Q05BC3.
CleanEx	MM_EML1.
Genevestigator	Q05BC3.
Family and domain databases
Gene3D	2.130.10.10. 3 hits.
InterPro	IPR005108. HELP. IPR011047. Quinonprotein_ADH-like_supfam. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR019775. WD40_repeat_CS. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF03451. HELP. 1 hit. PF00400. WD40. 5 hits. [Graphical view]
SMART	SM00320. WD40. 10 hits. [Graphical view]
SUPFAM	SSF50998. Quin_alc_DH_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. 1 hit. PS50082. WD_REPEATS_2. 3 hits. PS50294. WD_REPEATS_REGION. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	327362.
SOURCE	Search...

Entry information

Entry name

EMAL1_MOUSE

Accession

Primary (citable) accession number: Q05BC3
Secondary accession number(s): Q05AF8, Q0P5V3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	November 14, 2006
Last modified:	May 1, 2013
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents