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Protein

Nuclear receptor coactivator

Gene

Ncoa3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivatorUniRule annotation, ReceptorImported
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-5687128 MAPK6/MAPK4 signaling
R-MMU-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor coactivatorUniRule annotation
Gene namesi
Name:Ncoa3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1276535 Ncoa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1293301

Expressioni

Gene expression databases

BgeeiENSMUSG00000027678

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ05BA5, 2 interactors

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 83BHLHInterPro annotationAdd BLAST58
Domaini118 – 181PASInterPro annotationAdd BLAST64

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili963 – 991Sequence analysisAdd BLAST29

Sequence similaritiesi

Belongs to the SRC/p160 nuclear receptor coactivator family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG3561 Eukaryota
ENOG410XRJI LUCA
GeneTreeiENSGT00530000063109
HOGENOMiHOG000230947
HOVERGENiHBG052583
KOiK11256
OMAiMQCFALS
OrthoDBiEOG091G152H
TreeFamiTF332652

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 1 hit
Gene3Di1.10.287.1070, 1 hit
4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR010011 DUF1518
IPR032565 DUF4927
IPR036638 HLH_DNA-bd_sf
IPR028818 NCOA3
IPR009110 Nuc_rcpt_coact
IPR014920 Nuc_rcpt_coact_Ncoa-typ
IPR037077 Nuc_rcpt_coact_Ncoa_int_sf
IPR017426 Nuclear_rcpt_coactivator
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
IPR014935 SRC/p160_LXXLL
PANTHERiPTHR10684 PTHR10684, 1 hit
PTHR10684:SF3 PTHR10684:SF3, 1 hit
PfamiView protein in Pfam
PF07469 DUF1518, 1 hit
PF16279 DUF4927, 1 hit
PF08815 Nuc_rec_co-act, 1 hit
PF00989 PAS, 1 hit
PF08832 SRC-1, 1 hit
PIRSFiPIRSF038181 Nuclear_receptor_coactivator, 2 hits
SMARTiView protein in SMART
SM01151 DUF1518, 1 hit
SM00353 HLH, 1 hit
SM00091 PAS, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
SSF69125 SSF69125, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 1 hit

Sequencei

Sequence statusi: Complete.

Q05BA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLGESSLD PLAAESRKRK LPCDAPGQGL VYSGEKWRRE QESKYIEELA
60 70 80 90 100
ELISANLSDI DNFNVKPDKC AILKETVRQI RQIKEQGKTI SSDDDVQKAD
110 120 130 140 150
VSSTGQGVID KDSLGPLLLQ ALDGFLFVVN RDGNIVFVSE NVTQYLQYKQ
160 170 180 190 200
EDLVNTSVYS ILHEQDRKDF LKHLPKSTVN GVSWTNENQR QKSHTFNCRM
210 220 230 240 250
LMKTHDILED VNASPETRQR YETMQCFALS QPRAMLEEGE DLQCCMICVA
260 270 280 290 300
RRVTAPFPSS PESFITRHDL SGKVVNIDTN SLRSSMRPGF EDIIRRCIQR
310 320 330 340 350
FFSLNDGQSW SQKRHYQEAY VHGHAETPVY RFSLADGTIV SAQTKSKLFR
360 370 380 390 400
NPVTNDRHGF ISTHFLQREQ NGYRPNPNPA GQGIRPPAAG CGVSMSPNQN
410 420 430 440 450
VQMMGSRTYG VPDPSNTGQM GGARYGASSS VASLTPGQSL QSPSSYQNSS
460 470 480 490 500
YGLSMSSPPH GSPGLGPNQQ NIMISPRNRG SPKMASHQFS PAAGAHSPMG
510 520 530 540 550
PSGNTGSHSF SSSSLSALQA ISEGVGTSLL STLSSPGPKL DNSPNMNISQ
560 570 580 590 600
PSKVSGQDSK SPLGLYCEQN PVESSVCQSN SRDHPSEKES KESSGEVSET
610 620 630 640 650
PRGPLESKGH KKLLQLLTCS SDDRGHSSLT NSPLDPNCKD SSVSVTSPSG
660 670 680 690 700
VSSSTSGTVS STSNVHGSLL QEKHRILHKL LQNGNSPAEV AKITAEATGK
710 720 730 740 750
DTSSTASCGE GTTRQEQLSP KKKENNALLR YLLDRDDPSD VLAKELQPQA
760 770 780 790 800
DSGDSKLSQC SCSTNPSSGQ EKDPKIKTET NEEVSGDLDN LDAILGDLTS
810 820 830 840 850
SDFYNNPTNG GHPGAKQQMF AGPSSLGLRS PQPVQSVRPP YNRAVSLDSP
860 870 880 890 900
VSVGSGPPVK NVSAFPGLPK QPILAGNPRM MDSQENYGAN MGPNRNVPVN
910 920 930 940 950
PTSSPGDWGL ANSRASRMEP LASSPLGRTG ADYSATLPRP AMGGSVPTLP
960 970 980 990 1000
LRSNRLPGAR PSLQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QMLQMRTGEI
1010 1020 1030 1040 1050
PMGMGVNPYS PAVPSNQPGS WPEGMLSMEQ GPHGSQNRPL LRNSLDDLLG
1060 1070 1080 1090 1100
PPSNAEGQSD ERALLDQLHT LLSNTDATGL EEIDRALGIP ELVNQGQALE
1110 1120 1130 1140 1150
SKQDVFQGQE AAVMMDQKAA LYGQTYPAQG PPLQGGFNLQ GQSPSFNSMM
1160 1170 1180 1190 1200
GQISQQGSFP LQGMHPRAGL VRPRTNTPKQ LRMQLQQRLQ GQQFLNQSRQ
1210 1220 1230 1240 1250
ALEMKMENPA GTAVMRPMMP QQAFFNAQMA AQQKRELMSH HLQQQRMAMM
1260 1270 1280 1290 1300
MSQPQPQAFS PPPNVTASPS MDGVLAGSAM PQAPPQQFPY PANYGMGQPP
1310 1320 1330 1340 1350
EPAFGRGSSP PSAMMSSRMG PSQNAMVQHP QPTPMYQPSD MKGWPSGNLA
1360 1370 1380 1390 1400
RNGSFPQQQF APQGNPAAYN MVHMNSSGGH LGQMAMTPMP MSGMPMGPDQ

KYC
Length:1,403
Mass (Da):151,953
Last modified:November 14, 2006 - v1
Checksum:i6DFF2E276EF47BAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL589873 Genomic DNA No translation available.
AL589902 Genomic DNA No translation available.
BC086482 mRNA Translation: AAH86482.1
RefSeqiNP_032705.2, NM_008679.3
UniGeneiMm.469663

Genome annotation databases

EnsembliENSMUST00000088095; ENSMUSP00000085416; ENSMUSG00000027678
GeneIDi17979
KEGGimmu:17979
UCSCiuc008nyi.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ05BA5_MOUSE
AccessioniPrimary (citable) accession number: Q05BA5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 14, 2006
Last sequence update: November 14, 2006
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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