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Protein

Transcription factor E3

Gene

TFE3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Adaptive immunity, Immunity, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor E3
Gene namesi
Name:TFE3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 573573Transcription factor E3PRO_0000270142Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei540 – 5401PhosphoserineBy similarity
Modified residuei546 – 5461PhosphoserineBy similarity
Modified residuei552 – 5521PhosphoserineBy similarity
Modified residuei554 – 5541PhosphoserineBy similarity
Modified residuei558 – 5581PhosphoserineBy similarity
Modified residuei566 – 5661PhosphoserineBy similarity

Post-translational modificationi

Sumoylated; does not affect dimerization with MITF.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ05B92.

Expressioni

Gene expression databases

ExpressionAtlasiQ05B92. baseline and differential.

Interactioni

Subunit structurei

Homodimer and heterodimer; with TFEB or MITF.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011237.

Structurei

3D structure databases

ProteinModelPortaliQ05B92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini344 – 39754bHLHPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni258 – 26912Strong transcription activation domainSequence analysisAdd
BLAST
Regioni407 – 42822Leucine-zipperAdd
BLAST

Sequence similaritiesi

Belongs to the MiT/TFE family.Curated
Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1318. Eukaryota.
ENOG410ZYYV. LUCA.
GeneTreeiENSGT00390000004402.
HOGENOMiHOG000231368.
HOVERGENiHBG006768.
InParanoidiQ05B92.
KOiK09105.
OMAiPGTATFH.
OrthoDBiEOG72G182.
TreeFamiTF317174.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR021802. MiT/TFE_C.
IPR031867. MiT/TFE_N.
IPR024100. TFE3.
[Graphical view]
PANTHERiPTHR12565:SF163. PTHR12565:SF163. 2 hits.
PfamiPF11851. DUF3371. 1 hit.
PF00010. HLH. 1 hit.
PF15951. MITF_TFEB_C_3_N. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05B92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHAAEPAQD GVEASAEGPR AVFLLLEDRR PADSAQLLSL NSLLPESGIV
60 70 80 90 100
ADIELENVLD PDSFYELKSP PLSLRSSLPI SLQATPATPA TLSASSSAEG
110 120 130 140 150
SRTPAMSSSS SSRVLLRQQL MRAQAQEQER RERREQASSF PSPAPASPAI
160 170 180 190 200
SVVGVSAGGH TLGRPPPAQV PREVLKVQTH LENPTRYHLQ QARRQQVKQY
210 220 230 240 250
LSTTLGPKLA SQALTPPPGG ASVQPLPTPE AAHAPGPTSS APNSPMALLT
260 270 280 290 300
IGSSSEKEID DVIDEIISLE SSYNDEMLSY LPGGNTGLQL PSTLPVSGNL
310 320 330 340 350
LDVYNNQGVA TPAITVSNSC PAELPNIKRE ISETEAKALL KERQKKDNHN
360 370 380 390 400
LIERRRRFNI NDRIKELGTL IPKSSDPEMR WNKGTILKAS VDYIRKLQKE
410 420 430 440 450
QQRSKDLESR QRSLEQANRS LQLRIQELEL QAQIHGLPVP PTPGLLSLAA
460 470 480 490 500
TSASDSLKPE QLDVEEEGRP GTAIFHATGG LAQSAPHQQP PPPPSDALLD
510 520 530 540 550
LHFPSDHLGD LGDPFHLGLE DILMEEEEGV VGGLSGGTLS PLRAASDPLL
560 570
SSVSPAVSKA SSRRSSFSME EES
Length:573
Mass (Da):61,498
Last modified:November 14, 2006 - v1
Checksum:iECAF75544180277D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122581 mRNA. Translation: AAI22582.1.
RefSeqiNP_001069279.2. NM_001075811.2.
UniGeneiBt.20221.

Genome annotation databases

EnsembliENSBTAT00000011237; ENSBTAP00000011237; ENSBTAG00000008523.
GeneIDi520800.
KEGGibta:520800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122581 mRNA. Translation: AAI22582.1.
RefSeqiNP_001069279.2. NM_001075811.2.
UniGeneiBt.20221.

3D structure databases

ProteinModelPortaliQ05B92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011237.

Proteomic databases

PaxDbiQ05B92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000011237; ENSBTAP00000011237; ENSBTAG00000008523.
GeneIDi520800.
KEGGibta:520800.

Organism-specific databases

CTDi7030.

Phylogenomic databases

eggNOGiKOG1318. Eukaryota.
ENOG410ZYYV. LUCA.
GeneTreeiENSGT00390000004402.
HOGENOMiHOG000231368.
HOVERGENiHBG006768.
InParanoidiQ05B92.
KOiK09105.
OMAiPGTATFH.
OrthoDBiEOG72G182.
TreeFamiTF317174.

Miscellaneous databases

NextBioi20873184.

Gene expression databases

ExpressionAtlasiQ05B92. baseline and differential.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
IPR021802. MiT/TFE_C.
IPR031867. MiT/TFE_N.
IPR024100. TFE3.
[Graphical view]
PANTHERiPTHR12565:SF163. PTHR12565:SF163. 2 hits.
PfamiPF11851. DUF3371. 1 hit.
PF00010. HLH. 1 hit.
PF15951. MITF_TFEB_C_3_N. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hippocampus.

Entry informationi

Entry nameiTFE3_BOVIN
AccessioniPrimary (citable) accession number: Q05B92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 14, 2006
Last modified: May 11, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.