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Protein

Transcription factor E3

Gene

TFE3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processAdaptive immunity, Immunity, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor E3
Gene namesi
Name:TFE3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Organism-specific databases

VGNCiVGNC:35787 TFE3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002701421 – 573Transcription factor E3Add BLAST573

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei186Asymmetric dimethylarginineBy similarity1
Cross-linki337Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei540PhosphoserineBy similarity1
Modified residuei546PhosphoserineBy similarity1
Modified residuei552PhosphoserineBy similarity1
Modified residuei554PhosphoserineBy similarity1
Modified residuei558PhosphoserineBy similarity1
Modified residuei566PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated; does not affect dimerization with MITF.By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ05B92
PRIDEiQ05B92

Expressioni

Gene expression databases

BgeeiENSBTAG00000008523
ExpressionAtlasiQ05B92 baseline and differential

Interactioni

Subunit structurei

Homodimer and heterodimer; with TFEB or MITF.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000011237

Structurei

3D structure databases

ProteinModelPortaliQ05B92
SMRiQ05B92
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini344 – 397bHLHPROSITE-ProRule annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni258 – 269Strong transcription activation domainSequence analysisAdd BLAST12
Regioni407 – 428Leucine-zipperAdd BLAST22

Sequence similaritiesi

Belongs to the MiT/TFE family.Curated

Phylogenomic databases

eggNOGiKOG1318 Eukaryota
ENOG410ZYYV LUCA
GeneTreeiENSGT00390000004402
HOGENOMiHOG000231368
HOVERGENiHBG006768
InParanoidiQ05B92
KOiK09105
OMAiPGTATFH
OrthoDBiEOG091G0QCO
TreeFamiTF317174

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR021802 MiT/TFE_C
IPR031867 MiT/TFE_N
IPR024100 TFE3
PANTHERiPTHR12565:SF163 PTHR12565:SF163, 1 hit
PfamiView protein in Pfam
PF11851 DUF3371, 1 hit
PF00010 HLH, 1 hit
PF15951 MITF_TFEB_C_3_N, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q05B92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHAAEPAQD GVEASAEGPR AVFLLLEDRR PADSAQLLSL NSLLPESGIV
60 70 80 90 100
ADIELENVLD PDSFYELKSP PLSLRSSLPI SLQATPATPA TLSASSSAEG
110 120 130 140 150
SRTPAMSSSS SSRVLLRQQL MRAQAQEQER RERREQASSF PSPAPASPAI
160 170 180 190 200
SVVGVSAGGH TLGRPPPAQV PREVLKVQTH LENPTRYHLQ QARRQQVKQY
210 220 230 240 250
LSTTLGPKLA SQALTPPPGG ASVQPLPTPE AAHAPGPTSS APNSPMALLT
260 270 280 290 300
IGSSSEKEID DVIDEIISLE SSYNDEMLSY LPGGNTGLQL PSTLPVSGNL
310 320 330 340 350
LDVYNNQGVA TPAITVSNSC PAELPNIKRE ISETEAKALL KERQKKDNHN
360 370 380 390 400
LIERRRRFNI NDRIKELGTL IPKSSDPEMR WNKGTILKAS VDYIRKLQKE
410 420 430 440 450
QQRSKDLESR QRSLEQANRS LQLRIQELEL QAQIHGLPVP PTPGLLSLAA
460 470 480 490 500
TSASDSLKPE QLDVEEEGRP GTAIFHATGG LAQSAPHQQP PPPPSDALLD
510 520 530 540 550
LHFPSDHLGD LGDPFHLGLE DILMEEEEGV VGGLSGGTLS PLRAASDPLL
560 570
SSVSPAVSKA SSRRSSFSME EES
Length:573
Mass (Da):61,498
Last modified:November 14, 2006 - v1
Checksum:iECAF75544180277D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122581 mRNA Translation: AAI22582.1
RefSeqiNP_001069279.2, NM_001075811.2
UniGeneiBt.20221

Genome annotation databases

EnsembliENSBTAT00000011237; ENSBTAP00000011237; ENSBTAG00000008523
GeneIDi520800
KEGGibta:520800

Similar proteinsi

Entry informationi

Entry nameiTFE3_BOVIN
AccessioniPrimary (citable) accession number: Q05B92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 14, 2006
Last modified: March 28, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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