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Protein

NIF3-like protein 1

Gene

NIF3L1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
NIF3-like protein 1Curated
Gene namesi
Name:NIF3L1By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Organism-specific databases

VGNCiVGNC:32075 NIF3L1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003309081 – 377NIF3-like protein 1Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei109N6-acetyllysineBy similarity1
Modified residuei255PhosphothreonineBy similarity1
Modified residuei259PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ05B89
PRIDEiQ05B89

Expressioni

Gene expression databases

BgeeiENSBTAG00000018282

Interactioni

Subunit structurei

Homodimer. Interacts with COPS2. Interacts with THOC7.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024331

Structurei

3D structure databases

SMRiQ05B89
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni244 – 377Mediates interaction with COPS2By similarityAdd BLAST134

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4131 Eukaryota
COG0327 LUCA
GeneTreeiENSGT00390000003590
HOGENOMiHOG000014260
HOVERGENiHBG029337
InParanoidiQ05B89
OMAiEVAYDIY
OrthoDBiEOG091G0AAM
TreeFamiTF324125

Family and domain databases

InterProiView protein in InterPro
IPR002678 GTP_cyclohydrolase_I/Nif3
IPR036069 GTP_cyclohydrolase_I/Nif3_sf
IPR017222 NIF3L1_animal
PANTHERiPTHR13799 PTHR13799, 1 hit
PfamiView protein in Pfam
PF01784 NIF3, 1 hit
PIRSFiPIRSF037490 UCP037490_NIF3_euk, 1 hit
SUPFAMiSSF102705 SSF102705, 1 hit
TIGRFAMsiTIGR00486 YbgI_SA1388, 1 hit

Sequencei

Sequence statusi: Complete.

Q05B89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSRVRLVA TTARLVHSLI YSSSRSFMDL KALLSSLNDF ASLSFAESWD
60 70 80 90 100
NVGLLVEPSP PHTVNTLFLT NDLTEEVMEE ALQKKADLIL SYHPPIFRPM
110 120 130 140 150
KRITWKTWKE RLVIRALENR VGIYSPHTAY DAAPQGVNNW LAKGLGVCTS
160 170 180 190 200
RPIHPSKAPD YPTEGTHRVE FSVTHTQDPD KVISALKEIA GVSVTSFSAR
210 220 230 240 250
TDDEEQTRLS LNCTQQALMQ VVAFLSQNRQ FYQKTEILSL EKPLLLYTGM
260 270 280 290 300
GRLCTLDESV SLETMIERIK SHLKLSHVRL ALGIGKTLES PVKVVALCAG
310 320 330 340 350
SGSSVLQGTD ADLYLTGEMS HHDVLDAASQ GISVILCEHS NTERGFLSDL
360 370
RDMLDAHLEN KINIILSETD RDPLHVI
Length:377
Mass (Da):41,906
Last modified:November 14, 2006 - v1
Checksum:i33205D86C93D92CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122596 mRNA Translation: AAI22597.1
RefSeqiNP_001073718.1, NM_001080249.2
XP_005202674.1, XM_005202617.3
UniGeneiBt.89946

Genome annotation databases

EnsembliENSBTAT00000024331; ENSBTAP00000024331; ENSBTAG00000018282
GeneIDi509473
KEGGibta:509473

Similar proteinsi

Entry informationi

Entry nameiNIF3L_BOVIN
AccessioniPrimary (citable) accession number: Q05B89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 14, 2006
Last modified: March 28, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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