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Protein

NIF3-like protein 1

Gene

NIF3L1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
NIF3-like protein 1Curated
Gene namesi
Name:NIF3L1By similarity
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Interaction with COPS2 may regulate localization to the nucleus.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377NIF3-like protein 1PRO_0000330908Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091N6-acetyllysineBy similarity
Modified residuei255 – 2551PhosphothreonineBy similarity
Modified residuei259 – 2591PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ05B89.
PRIDEiQ05B89.

Expressioni

Gene expression databases

BgeeiENSBTAG00000018282.

Interactioni

Subunit structurei

Homodimer. Interacts with COPS2. Interacts with THOC7.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024331.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni244 – 377134Mediates interaction with COPS2By similarityAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4131. Eukaryota.
COG0327. LUCA.
GeneTreeiENSGT00390000003590.
HOGENOMiHOG000014260.
HOVERGENiHBG029337.
InParanoidiQ05B89.
OMAiTNDLTEP.
OrthoDBiEOG091G0AAM.
TreeFamiTF324125.

Family and domain databases

InterProiIPR002678. GTP_cyclohydrolase_I/Nif3.
IPR017222. NIF3L1_animal.
[Graphical view]
PANTHERiPTHR13799. PTHR13799. 1 hit.
PfamiPF01784. NIF3. 1 hit.
[Graphical view]
PIRSFiPIRSF037490. UCP037490_NIF3_euk. 1 hit.
SUPFAMiSSF102705. SSF102705. 1 hit.
TIGRFAMsiTIGR00486. YbgI_SA1388. 1 hit.

Sequencei

Sequence statusi: Complete.

Q05B89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLSSRVRLVA TTARLVHSLI YSSSRSFMDL KALLSSLNDF ASLSFAESWD
60 70 80 90 100
NVGLLVEPSP PHTVNTLFLT NDLTEEVMEE ALQKKADLIL SYHPPIFRPM
110 120 130 140 150
KRITWKTWKE RLVIRALENR VGIYSPHTAY DAAPQGVNNW LAKGLGVCTS
160 170 180 190 200
RPIHPSKAPD YPTEGTHRVE FSVTHTQDPD KVISALKEIA GVSVTSFSAR
210 220 230 240 250
TDDEEQTRLS LNCTQQALMQ VVAFLSQNRQ FYQKTEILSL EKPLLLYTGM
260 270 280 290 300
GRLCTLDESV SLETMIERIK SHLKLSHVRL ALGIGKTLES PVKVVALCAG
310 320 330 340 350
SGSSVLQGTD ADLYLTGEMS HHDVLDAASQ GISVILCEHS NTERGFLSDL
360 370
RDMLDAHLEN KINIILSETD RDPLHVI
Length:377
Mass (Da):41,906
Last modified:November 14, 2006 - v1
Checksum:i33205D86C93D92CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122596 mRNA. Translation: AAI22597.1.
RefSeqiNP_001073718.1. NM_001080249.2.
XP_005202674.1. XM_005202617.3.
UniGeneiBt.89946.

Genome annotation databases

EnsembliENSBTAT00000024331; ENSBTAP00000024331; ENSBTAG00000018282.
GeneIDi509473.
KEGGibta:509473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122596 mRNA. Translation: AAI22597.1.
RefSeqiNP_001073718.1. NM_001080249.2.
XP_005202674.1. XM_005202617.3.
UniGeneiBt.89946.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024331.

Proteomic databases

PaxDbiQ05B89.
PRIDEiQ05B89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000024331; ENSBTAP00000024331; ENSBTAG00000018282.
GeneIDi509473.
KEGGibta:509473.

Organism-specific databases

CTDi60491.

Phylogenomic databases

eggNOGiKOG4131. Eukaryota.
COG0327. LUCA.
GeneTreeiENSGT00390000003590.
HOGENOMiHOG000014260.
HOVERGENiHBG029337.
InParanoidiQ05B89.
OMAiTNDLTEP.
OrthoDBiEOG091G0AAM.
TreeFamiTF324125.

Gene expression databases

BgeeiENSBTAG00000018282.

Family and domain databases

InterProiIPR002678. GTP_cyclohydrolase_I/Nif3.
IPR017222. NIF3L1_animal.
[Graphical view]
PANTHERiPTHR13799. PTHR13799. 1 hit.
PfamiPF01784. NIF3. 1 hit.
[Graphical view]
PIRSFiPIRSF037490. UCP037490_NIF3_euk. 1 hit.
SUPFAMiSSF102705. SSF102705. 1 hit.
TIGRFAMsiTIGR00486. YbgI_SA1388. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNIF3L_BOVIN
AccessioniPrimary (citable) accession number: Q05B89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 14, 2006
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.