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Q05B87 (FRDA_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Frataxin, mitochondrial

Short name=Fxn
EC=1.16.3.1

Cleaved into the following 2 chains:

  1. Frataxin intermediate form
  2. Frataxin mature form
Gene names
Name:FXN
Synonyms:FRDA
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1 By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Monomer (probable predominant form). Oligomer. Interacts with LYRM4 AND HSPA9. Interacts with ACO1. Interacts with ISCU. Interacts with FECH; one iron-bound FXN monomer seems to interact with a FECH homodimer. Interacts with SDHA and SDHB. Interacts with ACO2; the interaction is dependent on citrate By similarity.

Subcellular location

Cytoplasm By similarity. Mitochondrion By similarity.

Post-translational modification

Processed in two steps by mitochondrial processing peptidase (MPP). MPP first cleaves the precursor to intermediate form and subsequently converts the intermediate to yield frataxin mature form By similarity.

Sequence similarities

Belongs to the frataxin family.

Ontologies

Keywords
   Biological processHeme biosynthesis
Ion transport
Iron storage
Iron transport
Transport
   Cellular componentCytoplasm
Mitochondrion
   DomainTransit peptide
   LigandIron
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processadult walking behavior

Inferred from electronic annotation. Source: Ensembl

aerobic respiration

Inferred from electronic annotation. Source: Ensembl

cellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

cellular response to hydrogen peroxide

Inferred from electronic annotation. Source: Ensembl

embryo development ending in birth or egg hatching

Inferred from electronic annotation. Source: Ensembl

heme biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

iron incorporation into metallo-sulfur cluster

Inferred from electronic annotation. Source: Ensembl

mitochondrion organization

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of multicellular organism growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of organ growth

Inferred from electronic annotation. Source: Ensembl

negative regulation of release of cytochrome c from mitochondria

Inferred from electronic annotation. Source: Ensembl

oxidative phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell growth

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of lyase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of metalloenzyme activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of oxidoreductase activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of transferase activity

Inferred from electronic annotation. Source: Ensembl

proprioception

Inferred from electronic annotation. Source: Ensembl

protein autoprocessing

Inferred from electronic annotation. Source: Ensembl

regulation of ferrochelatase activity

Inferred from electronic annotation. Source: Ensembl

response to iron ion

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytosol

Inferred from electronic annotation. Source: Ensembl

mitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function2 iron, 2 sulfur cluster binding

Inferred from electronic annotation. Source: Ensembl

ferric iron binding

Inferred from electronic annotation. Source: InterPro

ferrous iron binding

Inferred from electronic annotation. Source: Ensembl

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

iron chaperone activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 4242Mitochondrion By similarity
Chain43 – 217175Frataxin intermediate form
PRO_0000289330
Chain82 – 217136Frataxin mature form By similarity
PRO_0000399387

Sequences

Sequence LengthMass (Da)Tools
Q05B87 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: AF8AB00650CD9ACC

FASTA21723,567
        10         20         30         40         50         60 
MWTLGRRSVA SFLPRSALPG FAPTRAGAPR PAKDLSLSGL PGLRIGTAKA PARSQSSLSL 

        70         80         90        100        110        120 
RCLNQTLDVK KQSVCWINLR TAGTLGDAGT LDDTTYERLA EETLDSLAEF FEDLADKPYT 

       130        140        150        160        170        180 
FEDYDVSFGS GVLTVKLGGD LGTYVINKQT PNKQIWLSSP SSGPKRYDWT GRNWVYSHDG 

       190        200        210 
VSLHELLATE LTQALKTKLD LSALAYSGKD TCCPAQC 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Thalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC122620 mRNA. Translation: AAI22621.1.
RefSeqNP_001074196.1. NM_001080727.1.
UniGeneBt.17029.

3D structure databases

ProteinModelPortalQ05B87.
SMRQ05B87. Positions 91-210.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000001725.

Proteomic databases

PRIDEQ05B87.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000001725; ENSBTAP00000001725; ENSBTAG00000001306.
GeneID505694.
KEGGbta:505694.

Organism-specific databases

CTD2395.

Phylogenomic databases

eggNOGCOG1965.
GeneTreeENSGT00390000005811.
HOGENOMHOG000190729.
HOVERGENHBG005745.
InParanoidQ05B87.
OMAKQSVCLM.
OrthoDBEOG7HHWVD.
TreeFamTF318958.

Family and domain databases

Gene3D3.30.920.10. 1 hit.
InterProIPR017789. Frataxin.
IPR002908. Frataxin/CyaY.
IPR020895. Frataxin_CS.
[Graphical view]
PANTHERPTHR16821. PTHR16821. 1 hit.
PfamPF01491. Frataxin_Cyay. 1 hit.
[Graphical view]
PRINTSPR00904. FRATAXIN.
SUPFAMSSF55387. SSF55387. 1 hit.
TIGRFAMsTIGR03421. FeS_CyaY. 1 hit.
TIGR03422. mito_frataxin. 1 hit.
PROSITEPS01344. FRATAXIN_1. 1 hit.
PS50810. FRATAXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20867270.

Entry information

Entry nameFRDA_BOVIN
AccessionPrimary (citable) accession number: Q05B87
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: November 14, 2006
Last modified: February 19, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families