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Protein

Uridine diphosphate glucose pyrophosphatase

Gene

NUDT14

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose (By similarity).By similarity

Catalytic activityi

UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandMagnesium

Enzyme and pathway databases

ReactomeiR-BTA-480985 Synthesis of dolichyl-phosphate-glucose

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine diphosphate glucose pyrophosphatase (EC:3.6.1.45)
Short name:
UDPG pyrophosphatase
Short name:
UGPPase
Alternative name(s):
Nucleoside diphosphate-linked moiety X motif 14
Short name:
Nudix motif 14
Gene namesi
Name:NUDT14
Synonyms:UGPP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 21

Organism-specific databases

VGNCiVGNC:32328 NUDT14

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002826021 – 222Uridine diphosphate glucose pyrophosphataseAdd BLAST222

Proteomic databases

PaxDbiQ05B60
PRIDEiQ05B60

Expressioni

Gene expression databases

BgeeiENSBTAG00000048010

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055697

Structurei

3D structure databases

ProteinModelPortaliQ05B60
SMRiQ05B60
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 206Nudix hydrolasePROSITE-ProRule annotationAdd BLAST169

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi111 – 129Nudix boxAdd BLAST19

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated

Phylogenomic databases

eggNOGiKOG4432 Eukaryota
COG0494 LUCA
GeneTreeiENSGT00410000025889
HOVERGENiHBG052689
InParanoidiQ05B60
KOiK08077
OMAiYTYELCA
OrthoDBiEOG091G0Q7M
TreeFamiTF313661

Family and domain databases

InterProiView protein in InterPro
IPR004385 NDP_pyrophosphatase
IPR015797 NUDIX_hydrolase-like_dom_sf
IPR000086 NUDIX_hydrolase_dom
SUPFAMiSSF55811 SSF55811, 1 hit
TIGRFAMsiTIGR00052 TIGR00052, 1 hit
PROSITEiView protein in PROSITE
PS51462 NUDIX, 1 hit

Sequencei

Sequence statusi: Complete.

Q05B60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERIEGVAVG RCAASPYLVP LTLHYRQNGA QKSWDFMKTH DSVTILMFNS
60 70 80 90 100
SRRSLVLVKQ FRPAVYAGEV ERLFPGSLAA AEQDRPQALQ AALPGSAGVT
110 120 130 140 150
YELCAGLLDQ PGLSLEEVAC KEAWEECGYR LAPSDLRRVT SYKSGVGLTG
160 170 180 190 200
SSQTMFYAEV TDAQRGSPGG GLAEEGELIE VVHLPLDGAR TFADDPDVPK
210 220
TLGVIFGISW FFSCVAPGLG LQ
Length:222
Mass (Da):23,901
Last modified:November 14, 2006 - v1
Checksum:i961622E27E0562D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122769 mRNA Translation: AAI22770.1
RefSeqiNP_001099122.1, NM_001105652.2
UniGeneiBt.97205

Genome annotation databases

EnsembliENSBTAT00000063951; ENSBTAP00000055697; ENSBTAG00000048010
GeneIDi100126049
KEGGibta:100126049

Similar proteinsi

Entry informationi

Entry nameiNUD14_BOVIN
AccessioniPrimary (citable) accession number: Q05B60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 14, 2006
Last modified: March 28, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health