Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q05B60

- NUD14_BOVIN

UniProt

Q05B60 - NUD14_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Uridine diphosphate glucose pyrophosphatase

Gene

NUDT14

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose (By similarity).By similarity

Catalytic activityi

UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

  1. ADP-ribose diphosphatase activity Source: Ensembl
  2. metal ion binding Source: InterPro
  3. UDP-sugar diphosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Uridine diphosphate glucose pyrophosphatase (EC:3.6.1.45)
Short name:
UDPG pyrophosphatase
Short name:
UGPPase
Alternative name(s):
Nucleoside diphosphate-linked moiety X motif 14
Short name:
Nudix motif 14
Gene namesi
Name:NUDT14
Synonyms:UGPP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 21

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Uridine diphosphate glucose pyrophosphatasePRO_0000282602Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ05B60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 206169Nudix hydrolasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi111 – 12919Nudix boxAdd
BLAST

Sequence similaritiesi

Belongs to the Nudix hydrolase family.Curated
Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00410000025889.
HOVERGENiHBG052689.
InParanoidiQ05B60.
KOiK08077.
OMAiIYARHFH.
OrthoDBiEOG7JHM6K.
TreeFamiTF313661.

Family and domain databases

Gene3Di3.90.79.10. 1 hit.
InterProiIPR004385. NDP_pyrophosphatase.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamiPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMiSSF55811. SSF55811. 1 hit.
TIGRFAMsiTIGR00052. TIGR00052. 1 hit.
PROSITEiPS51462. NUDIX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05B60-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERIEGVAVG RCAASPYLVP LTLHYRQNGA QKSWDFMKTH DSVTILMFNS
60 70 80 90 100
SRRSLVLVKQ FRPAVYAGEV ERLFPGSLAA AEQDRPQALQ AALPGSAGVT
110 120 130 140 150
YELCAGLLDQ PGLSLEEVAC KEAWEECGYR LAPSDLRRVT SYKSGVGLTG
160 170 180 190 200
SSQTMFYAEV TDAQRGSPGG GLAEEGELIE VVHLPLDGAR TFADDPDVPK
210 220
TLGVIFGISW FFSCVAPGLG LQ
Length:222
Mass (Da):23,901
Last modified:November 14, 2006 - v1
Checksum:i961622E27E0562D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122769 mRNA. Translation: AAI22770.1.
RefSeqiNP_001099122.1. NM_001105652.2.
UniGeneiBt.97205.

Genome annotation databases

EnsembliENSBTAT00000063951; ENSBTAP00000055697; ENSBTAG00000048010.
GeneIDi100126049.
KEGGibta:100126049.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122769 mRNA. Translation: AAI22770.1 .
RefSeqi NP_001099122.1. NM_001105652.2.
UniGenei Bt.97205.

3D structure databases

ProteinModelPortali Q05B60.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000063951 ; ENSBTAP00000055697 ; ENSBTAG00000048010 .
GeneIDi 100126049.
KEGGi bta:100126049.

Organism-specific databases

CTDi 256281.

Phylogenomic databases

GeneTreei ENSGT00410000025889.
HOVERGENi HBG052689.
InParanoidi Q05B60.
KOi K08077.
OMAi IYARHFH.
OrthoDBi EOG7JHM6K.
TreeFami TF313661.

Miscellaneous databases

NextBioi 20788934.

Family and domain databases

Gene3Di 3.90.79.10. 1 hit.
InterProi IPR004385. NDP_pyrophosphatase.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view ]
Pfami PF00293. NUDIX. 1 hit.
[Graphical view ]
SUPFAMi SSF55811. SSF55811. 1 hit.
TIGRFAMsi TIGR00052. TIGR00052. 1 hit.
PROSITEi PS51462. NUDIX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Hypothalamus.

Entry informationi

Entry nameiNUD14_BOVIN
AccessioniPrimary (citable) accession number: Q05B60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 14, 2006
Last modified: November 26, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3