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Q05B60

- NUD14_BOVIN

UniProt

Q05B60 - NUD14_BOVIN

Protein

Uridine diphosphate glucose pyrophosphatase

Gene

NUDT14

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose By similarity.By similarity

    Catalytic activityi

    UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. ADP-ribose diphosphatase activity Source: Ensembl
    2. metal ion binding Source: InterPro
    3. UDP-sugar diphosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Uridine diphosphate glucose pyrophosphatase (EC:3.6.1.45)
    Short name:
    UDPG pyrophosphatase
    Short name:
    UGPPase
    Alternative name(s):
    Nucleoside diphosphate-linked moiety X motif 14
    Short name:
    Nudix motif 14
    Gene namesi
    Name:NUDT14
    Synonyms:UGPP
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 21

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 222222Uridine diphosphate glucose pyrophosphatasePRO_0000282602Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ05B60.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 206169Nudix hydrolasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi111 – 12919Nudix boxAdd
    BLAST

    Sequence similaritiesi

    Belongs to the Nudix hydrolase family.Curated
    Contains 1 nudix hydrolase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00410000025889.
    HOVERGENiHBG052689.
    KOiK08077.
    OMAiIYARHFH.
    OrthoDBiEOG7JHM6K.
    TreeFamiTF313661.

    Family and domain databases

    Gene3Di3.90.79.10. 1 hit.
    InterProiIPR004385. NDP_pyrophosphatase.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    [Graphical view]
    PfamiPF00293. NUDIX. 1 hit.
    [Graphical view]
    SUPFAMiSSF55811. SSF55811. 1 hit.
    TIGRFAMsiTIGR00052. TIGR00052. 1 hit.
    PROSITEiPS51462. NUDIX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05B60-1 [UniParc]FASTAAdd to Basket

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    MERIEGVAVG RCAASPYLVP LTLHYRQNGA QKSWDFMKTH DSVTILMFNS    50
    SRRSLVLVKQ FRPAVYAGEV ERLFPGSLAA AEQDRPQALQ AALPGSAGVT 100
    YELCAGLLDQ PGLSLEEVAC KEAWEECGYR LAPSDLRRVT SYKSGVGLTG 150
    SSQTMFYAEV TDAQRGSPGG GLAEEGELIE VVHLPLDGAR TFADDPDVPK 200
    TLGVIFGISW FFSCVAPGLG LQ 222
    Length:222
    Mass (Da):23,901
    Last modified:November 14, 2006 - v1
    Checksum:i961622E27E0562D9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC122769 mRNA. Translation: AAI22770.1.
    RefSeqiNP_001099122.1. NM_001105652.2.
    UniGeneiBt.97205.

    Genome annotation databases

    EnsembliENSBTAT00000063951; ENSBTAP00000055697; ENSBTAG00000048010.
    GeneIDi100126049.
    KEGGibta:100126049.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC122769 mRNA. Translation: AAI22770.1 .
    RefSeqi NP_001099122.1. NM_001105652.2.
    UniGenei Bt.97205.

    3D structure databases

    ProteinModelPortali Q05B60.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000063951 ; ENSBTAP00000055697 ; ENSBTAG00000048010 .
    GeneIDi 100126049.
    KEGGi bta:100126049.

    Organism-specific databases

    CTDi 256281.

    Phylogenomic databases

    GeneTreei ENSGT00410000025889.
    HOVERGENi HBG052689.
    KOi K08077.
    OMAi IYARHFH.
    OrthoDBi EOG7JHM6K.
    TreeFami TF313661.

    Miscellaneous databases

    NextBioi 20788934.

    Family and domain databases

    Gene3Di 3.90.79.10. 1 hit.
    InterProi IPR004385. NDP_pyrophosphatase.
    IPR000086. NUDIX_hydrolase_dom.
    IPR015797. NUDIX_hydrolase_dom-like.
    [Graphical view ]
    Pfami PF00293. NUDIX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55811. SSF55811. 1 hit.
    TIGRFAMsi TIGR00052. TIGR00052. 1 hit.
    PROSITEi PS51462. NUDIX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Mammalian Gene Collection (MGC) project
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Hypothalamus.

    Entry informationi

    Entry nameiNUD14_BOVIN
    AccessioniPrimary (citable) accession number: Q05B60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3