Q05B60 (NUD14_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uridine diphosphate glucose pyrophosphatase
Short name=UDPG pyrophosphatase
Short name=UGPPase
EC=3.6.1.45

Alternative name(s):
Nucleoside diphosphate-linked moiety X motif 14
Short name=Nudix motif 14

Gene names

Name:	NUDT14
Synonyms:	UGPP

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose By similarity.
Catalytic activity	UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.
Cofactor	Magnesium By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. Contains 1 nudix hydrolase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ADP-ribose diphosphatase activity Inferred from electronic annotation. Source: Compara UDP-sugar diphosphatase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Uridine diphosphate glucose pyrophosphatase		PRO_0000282602
Regions
	Domain	38 – 206	169	Nudix hydrolase
	Motif	111 – 129	19	Nudix box

Sequences

	Sequence		Length	Mass (Da)
	Q05B60 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 961622E27E0562D9	FASTA	222	23,901
	10 20 30 40 50 60 MERIEGVAVG RCAASPYLVP LTLHYRQNGA QKSWDFMKTH DSVTILMFNS SRRSLVLVKQ 70 80 90 100 110 120 FRPAVYAGEV ERLFPGSLAA AEQDRPQALQ AALPGSAGVT YELCAGLLDQ PGLSLEEVAC 130 140 150 160 170 180 KEAWEECGYR LAPSDLRRVT SYKSGVGLTG SSQTMFYAEV TDAQRGSPGG GLAEEGELIE 190 200 210 220 VVHLPLDGAR TFADDPDVPK TLGVIFGISW FFSCVAPGLG LQ

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC122769 mRNA. Translation: AAI22770.1.
IPI	IPI00705126.
RefSeq	NP_001099122.1. NM_001105652.2.
UniGene	Bt.97205.
3D structure databases
ProteinModelPortal	Q05B60.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000063951; ENSBTAP00000055697; ENSBTAG00000048010.
GeneID	100126049.
KEGG	bta:100126049.
Organism-specific databases
CTD	256281.
Phylogenomic databases
GeneTree	ENSGT00410000025889.
HOVERGEN	HBG052689.
KO	K08077.
OMA	YTYELCA.
Family and domain databases
Gene3D	3.90.79.10. 1 hit.
InterPro	IPR004385. NDP_pyrophosphatase. IPR000086. NUDIX_hydrolase_dom. IPR015797. NUDIX_hydrolase_dom-like. [Graphical view]
Pfam	PF00293. NUDIX. 1 hit. [Graphical view]
SUPFAM	SSF55811. NUDIX_hydrolase. 1 hit.
TIGRFAMs	TIGR00052. TIGR00052. 1 hit.
PROSITE	PS51462. NUDIX. 1 hit. PS00893. NUDIX_BOX. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	20788934.

Entry information

Entry name

NUD14_BOVIN

Accession

Primary (citable) accession number: Q05B60

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	November 14, 2006
Last modified:	April 3, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program