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Q05B60 (NUD14_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Uridine diphosphate glucose pyrophosphatase

Short name=UDPG pyrophosphatase
Short name=UGPPase
EC=3.6.1.45
Alternative name(s):
Nucleoside diphosphate-linked moiety X motif 14
Short name=Nudix motif 14
Gene names
Name:NUDT14
Synonyms:UGPP
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose By similarity.

Catalytic activity

UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the Nudix hydrolase family.

Contains 1 nudix hydrolase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMagnesium
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionADP-ribose diphosphatase activity

Inferred from electronic annotation. Source: Ensembl

UDP-sugar diphosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 222222Uridine diphosphate glucose pyrophosphatase
PRO_0000282602

Regions

Domain38 – 206169Nudix hydrolase
Motif111 – 12919Nudix box

Sequences

Sequence LengthMass (Da)Tools
Q05B60 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 961622E27E0562D9

FASTA22223,901
        10         20         30         40         50         60 
MERIEGVAVG RCAASPYLVP LTLHYRQNGA QKSWDFMKTH DSVTILMFNS SRRSLVLVKQ 

        70         80         90        100        110        120 
FRPAVYAGEV ERLFPGSLAA AEQDRPQALQ AALPGSAGVT YELCAGLLDQ PGLSLEEVAC 

       130        140        150        160        170        180 
KEAWEECGYR LAPSDLRRVT SYKSGVGLTG SSQTMFYAEV TDAQRGSPGG GLAEEGELIE 

       190        200        210        220 
VVHLPLDGAR TFADDPDVPK TLGVIFGISW FFSCVAPGLG LQ 

« Hide

References

[1]NIH - Mammalian Gene Collection (MGC) project
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Hereford.
Tissue: Hypothalamus.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC122769 mRNA. Translation: AAI22770.1.
RefSeqNP_001099122.1. NM_001105652.2.
UniGeneBt.97205.

3D structure databases

ProteinModelPortalQ05B60.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000063951; ENSBTAP00000055697; ENSBTAG00000048010.
GeneID100126049.
KEGGbta:100126049.

Organism-specific databases

CTD256281.

Phylogenomic databases

GeneTreeENSGT00410000025889.
HOVERGENHBG052689.
KOK08077.
OMAYTYELCA.
OrthoDBEOG7JHM6K.
TreeFamTF313661.

Family and domain databases

Gene3D3.90.79.10. 1 hit.
InterProIPR004385. NDP_pyrophosphatase.
IPR000086. NUDIX_hydrolase_dom.
IPR015797. NUDIX_hydrolase_dom-like.
[Graphical view]
PfamPF00293. NUDIX. 1 hit.
[Graphical view]
SUPFAMSSF55811. SSF55811. 1 hit.
TIGRFAMsTIGR00052. TIGR00052. 1 hit.
PROSITEPS51462. NUDIX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20788934.

Entry information

Entry nameNUD14_BOVIN
AccessionPrimary (citable) accession number: Q05B60
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 14, 2006
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families