Reviewed, UniProtKB/Swiss-Prot Q05B60 (NUD14_BOVIN)

Names and origin

Protein names

Recommended name:
    Uridine diphosphate glucose pyrophosphatase
      Short name=UDPG pyrophosphatase
      Short name=UGPPase
    EC=3.6.1.45
Alternative name(s):
    Nucleoside diphosphate-linked moiety X motif 14
      Short name=Nudix motif 14

Gene names

Name:	NUDT14
Synonyms:	UGPP

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	222 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and ADP-ribose to ribose 5-phosphate and AMP. The physiological substrate is probably UDP-glucose. Poor activity on other substrates such as ADP-glucose, CDP-glucose, GDP-glucose and GDP-mannose By similarity.
Catalytic activity	UDP-sugar + H2O = UMP + alpha-D-aldose 1-phosphate.
Cofactor	Magnesium By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. Contains 1 nudix hydrolase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Magnesium
Molecular function	Hydrolase
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-sugar diphosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 222	222	Uridine diphosphate glucose pyrophosphatase		PRO_0000282602
Regions
	Domain	38 – 206	169	Nudix hydrolase
	Motif	111 – 129	19	Nudix box

Sequences

	Sequence		Length	Mass (Da)
	Q05B60-1 [UniParc]. Last modified November 14, 2006. Version 1. Checksum: 961622E27E0562D9	FASTA	222	23,901
	10 20 30 40 50 60 MERIEGVAVG RCAASPYLVP LTLHYRQNGA QKSWDFMKTH DSVTILMFNS SRRSLVLVKQ 70 80 90 100 110 120 FRPAVYAGEV ERLFPGSLAA AEQDRPQALQ AALPGSAGVT YELCAGLLDQ PGLSLEEVAC 130 140 150 160 170 180 KEAWEECGYR LAPSDLRRVT SYKSGVGLTG SSQTMFYAEV TDAQRGSPGG GLAEEGELIE 190 200 210 220 VVHLPLDGAR TFADDPDVPK TLGVIFGISW FFSCVAPGLG LQ

References

[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Hypothalamus.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC122769 mRNA. Translation: AAI22770.1.
IPI	IPI00705126.
RefSeq	NP_001099122.1.
UniGene	Bt.97205
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	100126049.
KEGG	bta:100126049.
Organism-specific databases
CTD	100126049.
Phylogenomic databases
HOVERGEN	Q05B60.
Enzyme and pathway databases
BRENDA	3.6.1.45. 251.
Family and domain databases
InterPro	IPR004385. NDP_pyrophosphatase. IPR020084. NUDIX_hydrolase_CS. IPR000086. NUDIX_hydrolase_dom. [Graphical view]
Gene3D	G3DSA:3.90.79.10. NUDIX_hydrolase. 1 hit.
Pfam	PF00293. NUDIX. 1 hit. [Graphical view]
TIGRFAMs	TIGR00052. NDP_pyrophos. 1 hit.
PROSITE	PS51462. NUDIX. 1 hit. PS00893. NUDIX_BOX. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NUD14_BOVIN

Accession

Primary (citable) accession number: Q05B60

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	November 14, 2006
Last modified:	October 13, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)