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Protein

Transmembrane protein 120A

Gene

TMEM120A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Necessary for efficient adipogenesis.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 120A
Gene namesi
Name:TMEM120A
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 25

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 135ExtracellularSequence analysisAdd BLAST135
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Topological domaini157 – 162CytoplasmicSequence analysis6
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 190ExtracellularSequence analysis7
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Topological domaini212 – 273CytoplasmicSequence analysisAdd BLAST62
Transmembranei274 – 294HelicalSequence analysisAdd BLAST21
Topological domaini295 – 305ExtracellularSequence analysisAdd BLAST11
Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 343CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003093381 – 343Transmembrane protein 120AAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ05B45.
PRIDEiQ05B45.

Expressioni

Gene expression databases

BgeeiENSBTAG00000016139.

Interactioni

Subunit structurei

Homooligomer and heterooligomer with TMEM120B.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021482.

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM120 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4758. Eukaryota.
ENOG410XT6G. LUCA.
GeneTreeiENSGT00390000007848.
HOGENOMiHOG000267032.
HOVERGENiHBG108532.
InParanoidiQ05B45.
OMAiSEWQASI.
OrthoDBiEOG091G0BVA.
TreeFamiTF313552.

Family and domain databases

InterProiIPR012926. TMPIT.
[Graphical view]
PANTHERiPTHR21433. PTHR21433. 1 hit.
PfamiPF07851. TMPIT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05B45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPPPPGPLG DCLRDWEELQ QDFHGIQETH RLYRLKLEEL TKLQNSCTSS
60 70 80 90 100
ITRQKKRLQE LALVLRKCKP SLPSEAEEAA RELENQIKER QGLFFDMEAY
110 120 130 140 150
LPKKNGLYLS LVLGNVNVTL LSKQAKFAYK DEYEKFKLYL TIILILISFT
160 170 180 190 200
CRFLLNSRVT DAAFNFLLVW YYCTLTIRES ILINNGSRIK GWWVFHHYVS
210 220 230 240 250
TFLSGVMLTW PDGLMYQKFR NQFLSFSMYQ SFVQFLQYYY QSGCLYRLRA
260 270 280 290 300
LGERHTMDLT VEGFQSWMWR GLTFLLPFLF FGHFWQLFNA LTLFNLARDP
310 320 330 340
ECKEWQVLMC GFPFLLLFLG NFFTTLRVVH QKFHNQLHGS KKE
Length:343
Mass (Da):40,730
Last modified:November 14, 2006 - v1
Checksum:i97952D5F590D4E91
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122849 mRNA. Translation: AAI22850.1.
RefSeqiNP_001073068.1. NM_001079600.1.
UniGeneiBt.4011.

Genome annotation databases

EnsembliENSBTAT00000021482; ENSBTAP00000021482; ENSBTAG00000016139.
GeneIDi520173.
KEGGibta:520173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC122849 mRNA. Translation: AAI22850.1.
RefSeqiNP_001073068.1. NM_001079600.1.
UniGeneiBt.4011.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021482.

Proteomic databases

PaxDbiQ05B45.
PRIDEiQ05B45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000021482; ENSBTAP00000021482; ENSBTAG00000016139.
GeneIDi520173.
KEGGibta:520173.

Organism-specific databases

CTDi83862.

Phylogenomic databases

eggNOGiKOG4758. Eukaryota.
ENOG410XT6G. LUCA.
GeneTreeiENSGT00390000007848.
HOGENOMiHOG000267032.
HOVERGENiHBG108532.
InParanoidiQ05B45.
OMAiSEWQASI.
OrthoDBiEOG091G0BVA.
TreeFamiTF313552.

Gene expression databases

BgeeiENSBTAG00000016139.

Family and domain databases

InterProiIPR012926. TMPIT.
[Graphical view]
PANTHERiPTHR21433. PTHR21433. 1 hit.
PfamiPF07851. TMPIT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiT120A_BOVIN
AccessioniPrimary (citable) accession number: Q05B45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 14, 2006
Last modified: September 7, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.