Q05AS8 (DVL2_XENTR) Reviewed, UniProtKB/Swiss-Prot
Last modified June 11, 2014. Version 56. History...
Names and origin
|Protein names||Recommended name:|
Segment polarity protein dishevelled homolog DVL-2
DSH homolog 2
|Organism||Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) [Reference proteome]|
|Taxonomic identifier||8364 [NCBI]|
|Taxonomic lineage||Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana|
|Sequence length||732 AA.|
|Protein existence||Evidence at transcript level|
General annotation (Comments)
Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta-catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin-related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along the A/P axis in a dose-dependent manner by activating several early patterning genes. In the PCP pathway, required at the cell membrane for PCP-mediated neural and mesodermal convergent extension during gastrulation and subsequent neural tube closure, acting to activate jnk. Also involved in blastopore closure and archenteron elongation during early, but not late, gastrulation. Associates with ephrin receptors and ligands and acts as part of a downstream PCP pathway to mediate ephrin-mediated cell repulsion via activation of rhoa. Required for efnb1/ephrin-B1-driven movement of non-retinal progenitor cells into the retina during eye field formation. Patterns the hindbrain. Required for ciliogenesis. Controls the docking of basal bodies to the apical plasma membrane; mediates the activation, but not localization of rhoa at the apical surface of ciliated cells during basal body docking. Furthermore, required for the association of basal bodies with membrane-bound vesicles and the vesicle-trafficking protein exoc4/sec8, and this association is in turn required for basal body docking. Once basal bodies are docked, required for the planar polarization of basal bodies that underlies ciliary beating and the directional fluid flow across ciliated epithelia By similarity. UniProtKB P51142
Can form homomultimers. Interacts with prickle1. Interacts (via the PDZ domain) with ccdc88c/dal and dact1-B/dpr. Interacts (via the DIX domain) with ARP/Axin-related protein and dact1-A/frodo. Interacts with sdc4, possibly via fz7. Interacts directly (via the DEP domain) with efnb1/ephrin-B1. May interact indirectly with the phosphorylated ephrin receptors ephb1 and ephb2 via SH domain-containing adapters By similarity. UniProtKB P51142
Cytoplasm By similarity. Cytoplasmic vesicle By similarity. Cell projection › cilium By similarity. Nucleus By similarity. Cell membrane; Peripheral membrane protein By similarity. Note: Recruited from the cytoplasm to the cell membrane by frizzled proteins. Also relocated to the cell membrane by sdc4 and ephb1/ephrin-B1. Concentrated at the cell membrane in both ciliated and non-ciliated cells. Enriched at the apical surface of ciliated cells. Localized to the cilium rootlet By similarity. UniProtKB P51142
The C-terminal region containing the DEP domain is required for membrane accumulation and phosphorylation. Wnt signaling and axis induction requires the DIX domain. The C-terminus contributes to the localization at the cilia base By similarity.
Phosphorylated. Phosphorylation is controlled by frizzled proteins, correlates with the onset of embryo dorsalizing events and is higher in the dorsal half of early cleavage embryos. Phosphorylated on tyrosine residues in response to association with efnb1/ephrin-B1 By similarity. UniProtKB P51142
Belongs to the DSH family.
Contains 1 DEP domain.
Contains 1 DIX domain.
Contains 1 PDZ (DHR) domain.
Sequence annotation (Features)
|Feature key||Position(s)||Length||Description||Graphical view||Feature identifier|
|Chain||1 – 732||732||Segment polarity protein dishevelled homolog DVL-2||PRO_0000354665|
|Domain||1 – 82||82||DIX|
|Domain||250 – 335||86||PDZ|
|Domain||424 – 498||75||DEP|
|Compositional bias||90 – 127||38||Pro-rich|
|Compositional bias||218 – 223||6||Poly-Arg|
|Compositional bias||637 – 708||72||Pro-rich|
|BC123948 mRNA. Translation: AAI23949.1.|
|RefSeq||NP_001072660.1. NM_001079192.1. |
3D structure databases
|SMR||Q05AS8. Positions 248-336, 408-498. |
Protein-protein interaction databases
Protocols and materials databases
Genome annotation databases
|Xenbase||XB-GENE-1017461. dvl2. |
Family and domain databases
|Gene3D||126.96.36.199. 1 hit. |
188.8.131.52. 1 hit.
|InterPro||IPR000591. DEP_dom. |
|PANTHER||PTHR10878. PTHR10878. 1 hit. |
PTHR10878:SF8. PTHR10878:SF8. 1 hit.
|Pfam||PF00610. DEP. 1 hit. |
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
|PRINTS||PR01760. DISHEVELLED. |
|SMART||SM00021. DAX. 1 hit. |
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
|SUPFAM||SSF50156. SSF50156. 1 hit. |
SSF54236. SSF54236. 1 hit.
|PROSITE||PS50186. DEP. 1 hit. |
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
|Accession||Primary (citable) accession number: Q05AS8|
|Entry status||Reviewed (UniProtKB/Swiss-Prot)|
|Annotation program||Chordata Protein Annotation Program|
Index of protein domains and families