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Q05AS8

- DVL2_XENTR

UniProt

Q05AS8 - DVL2_XENTR

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Protein
Segment polarity protein dishevelled homolog DVL-2
Gene
dvl2, dsh
Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta-catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin-related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along the A/P axis in a dose-dependent manner by activating several early patterning genes. In the PCP pathway, required at the cell membrane for PCP-mediated neural and mesodermal convergent extension during gastrulation and subsequent neural tube closure, acting to activate jnk. Also involved in blastopore closure and archenteron elongation during early, but not late, gastrulation. Associates with ephrin receptors and ligands and acts as part of a downstream PCP pathway to mediate ephrin-mediated cell repulsion via activation of rhoa. Required for efnb1/ephrin-B1-driven movement of non-retinal progenitor cells into the retina during eye field formation. Patterns the hindbrain. Required for ciliogenesis. Controls the docking of basal bodies to the apical plasma membrane; mediates the activation, but not localization of rhoa at the apical surface of ciliated cells during basal body docking. Furthermore, required for the association of basal bodies with membrane-bound vesicles and the vesicle-trafficking protein exoc4/sec8, and this association is in turn required for basal body docking. Once basal bodies are docked, required for the planar polarization of basal bodies that underlies ciliary beating and the directional fluid flow across ciliated epithelia By similarity.By similarity

GO - Molecular functioni

  1. ephrin receptor binding Source: UniProtKB
  2. signal transducer activity Source: InterPro
  3. syndecan binding Source: UniProtKB

GO - Biological processi

  1. Wnt signaling pathway Source: UniProtKB
  2. activation of Rho GTPase activity Source: UniProtKB
  3. anterior/posterior axis specification Source: UniProtKB
  4. ciliary basal body organization Source: UniProtKB
  5. cilium assembly Source: UniProtKB
  6. convergent extension Source: UniProtKB
  7. convergent extension involved in gastrulation Source: UniProtKB
  8. dorsal/ventral axis specification Source: UniProtKB
  9. ephrin receptor signaling pathway Source: UniProtKB
  10. establishment of planar polarity Source: UniProtKB
  11. establishment or maintenance of cell polarity Source: UniProtKB
  12. gastrulation with mouth forming second Source: UniProtKB
  13. intracellular signal transduction Source: InterPro
  14. neural tube closure Source: UniProtKB
  15. neurogenesis Source: UniProtKB
  16. protein homooligomerization Source: UniProtKB
  17. protein stabilization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Cilium biogenesis/degradation, Gastrulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-2
Short name:
Dishevelled-2
Alternative name(s):
DSH homolog 2
Gene namesi
Name:dvl2
Synonyms:dsh
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-1017461. dvl2.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmic vesicle By similarity. Cell projectioncilium By similarity. Nucleus By similarity. Cell membrane; Peripheral membrane protein By similarity
Note: Recruited from the cytoplasm to the cell membrane by frizzled proteins. Also relocated to the cell membrane by sdc4 and ephb1/ephrin-B1. Concentrated at the cell membrane in both ciliated and non-ciliated cells. Enriched at the apical surface of ciliated cells. Localized to the cilium rootlet By similarity.By similarity

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. ciliary rootlet Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. cytoplasmic membrane-bounded vesicle Source: UniProtKB
  5. cytoplasmic vesicle Source: UniProtKB
  6. nucleus Source: UniProtKB
  7. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 732732Segment polarity protein dishevelled homolog DVL-2
PRO_0000354665Add
BLAST

Post-translational modificationi

Phosphorylated. Phosphorylation is controlled by frizzled proteins, correlates with the onset of embryo dorsalizing events and is higher in the dorsal half of early cleavage embryos. Phosphorylated on tyrosine residues in response to association with efnb1/ephrin-B1 By similarity.By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Can form homomultimers. Interacts with prickle1. Interacts (via the PDZ domain) with ccdc88c/dal and dact1-B/dpr. Interacts (via the DIX domain) with ARP/Axin-related protein and dact1-A/frodo. Interacts with sdc4, possibly via fz7. Interacts directly (via the DEP domain) with efnb1/ephrin-B1. May interact indirectly with the phosphorylated ephrin receptors ephb1 and ephb2 via SH domain-containing adapters By similarity.By similarity

Protein-protein interaction databases

STRINGi8364.ENSXETP00000037494.

Structurei

3D structure databases

ProteinModelPortaliQ05AS8.
SMRiQ05AS8. Positions 248-336, 408-498.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8282DIX
Add
BLAST
Domaini250 – 33586PDZ
Add
BLAST
Domaini424 – 49875DEP
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi90 – 12738Pro-rich
Add
BLAST
Compositional biasi218 – 2236Poly-Arg
Compositional biasi637 – 70872Pro-rich
Add
BLAST

Domaini

The C-terminal region containing the DEP domain is required for membrane accumulation and phosphorylation. Wnt signaling and axis induction requires the DIX domain. The C-terminus contributes to the localization at the cilia base By similarity.

Sequence similaritiesi

Belongs to the DSH family.
Contains 1 DEP domain.
Contains 1 DIX domain.
Contains 1 PDZ (DHR) domain.

Phylogenomic databases

eggNOGiNOG322275.
HOGENOMiHOG000017084.
HOVERGENiHBG005542.
KOiK02353.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProiIPR000591. DEP_dom.
IPR008341. Dishevelled_2.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10878. PTHR10878. 1 hit.
PTHR10878:SF8. PTHR10878:SF8. 1 hit.
PfamiPF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view]
PRINTSiPR01760. DISHEVELLED.
PR01762. DISHEVELLED2.
SMARTiSM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05AS8-1 [UniParc]FASTAAdd to Basket

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MAETKVIYHL DEEETPYLVK VPVPANEIRL RDFKAALGRG HAKYFFKAMD    50
QDFGVVKEEI SDDNAKLPCF NGRVVSWLVS SETSQTDSAP PAAEVRPDPP 100
PVPPPVPPPP AERTSGIGDS RPPSFHPNVS GSTEQLDQDN ESVISMRRDR 150
VRRRDSTEQG VARGVNGRAE RHLSGYESSS TLLTSEIETS ICDSEEDDAM 200
SRFSSSTEQS SASRLLKRHR RRRKQRPPRL ERTSSFSSVT DSTMSLNIIT 250
VTLNMEKYNF LGISIVGQSN ERGDGGIYIG SIMKGGAVAA DGRIEPGDML 300
LQVNDINFEN MSNDDAVRVL RDIVHKPGPI ILTVAKCWDP SPQGYFTLPR 350
NEPIQPIDPA AWVSHSAALS GSFPVYPGSA SMSSMTSSTS VTETELSHAL 400
PPVSLFSLSV HTDLASVAKV MASPESGLEV RDRMWLKITI PNAFLGSDMV 450
DWLYHHVEGF QDRREARKFA SNLLKAGLIR HTVNKITFSE QCYYIFGDLT 500
GCENYMANLS LNDNDGSSGA SDQDTLAPLP LPGASPWPLL PTFSYQYPAP 550
HPYSTQPPAY HELSSYSYGM GSAGSQHSEG SRSSGSNRSD GGRGTQKDER 600
SGVVGVGGGE SKSGSGSESE YSTRSSIRRI GGGEAGPPSE RSTSSRPPLH 650
HPPSVHSYAA PGVPLSYNPM MLMMMPPPPL PPPGACPPSS SVPPGAPPLV 700
RDLASVPPEL TASRQSFHMA MGNPSEFFVD VM 732
Length:732
Mass (Da):79,277
Last modified:November 14, 2006 - v1
Checksum:i2683B15F9FAA5841
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC123948 mRNA. Translation: AAI23949.1.
RefSeqiNP_001072660.1. NM_001079192.1.
UniGeneiStr.16147.

Genome annotation databases

GeneIDi780117.
KEGGixtr:780117.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC123948 mRNA. Translation: AAI23949.1 .
RefSeqi NP_001072660.1. NM_001079192.1.
UniGenei Str.16147.

3D structure databases

ProteinModelPortali Q05AS8.
SMRi Q05AS8. Positions 248-336, 408-498.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000037494.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 780117.
KEGGi xtr:780117.

Organism-specific databases

CTDi 1856.
Xenbasei XB-GENE-1017461. dvl2.

Phylogenomic databases

eggNOGi NOG322275.
HOGENOMi HOG000017084.
HOVERGENi HBG005542.
KOi K02353.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
2.30.42.10. 1 hit.
InterProi IPR000591. DEP_dom.
IPR008341. Dishevelled_2.
IPR024580. Dishevelled_C-dom.
IPR008339. Dishevelled_fam.
IPR003351. Dishevelled_protein_dom.
IPR001158. DIX.
IPR015506. Dsh/Dvl-rel.
IPR001478. PDZ.
IPR029071. Ubiquitin-rel_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10878. PTHR10878. 1 hit.
PTHR10878:SF8. PTHR10878:SF8. 1 hit.
Pfami PF00610. DEP. 1 hit.
PF02377. Dishevelled. 1 hit.
PF00778. DIX. 1 hit.
PF12316. Dsh_C. 1 hit.
PF00595. PDZ. 1 hit.
[Graphical view ]
PRINTSi PR01760. DISHEVELLED.
PR01762. DISHEVELLED2.
SMARTi SM00021. DAX. 1 hit.
SM00049. DEP. 1 hit.
SM00228. PDZ. 1 hit.
[Graphical view ]
SUPFAMi SSF50156. SSF50156. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50186. DEP. 1 hit.
PS50841. DIX. 1 hit.
PS50106. PDZ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiDVL2_XENTR
AccessioniPrimary (citable) accession number: Q05AS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 14, 2006
Last modified: June 11, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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