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Protein

Segment polarity protein dishevelled homolog DVL-2

Gene

dvl2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta-catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin-related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along the A/P axis in a dose-dependent manner by activating several early patterning genes. In the PCP pathway, required at the cell membrane for PCP-mediated neural and mesodermal convergent extension during gastrulation and subsequent neural tube closure, acting to activate jnk. Also involved in blastopore closure and archenteron elongation during early, but not late, gastrulation. Associates with ephrin receptors and ligands and acts as part of a downstream PCP pathway to mediate ephrin-mediated cell repulsion via activation of rhoa. Required for efnb1/ephrin-B1-driven movement of non-retinal progenitor cells into the retina during eye field formation. Patterns the hindbrain. Required for ciliogenesis. Controls the docking of basal bodies to the apical plasma membrane; mediates the activation, but not localization of rhoa at the apical surface of ciliated cells during basal body docking. Furthermore, required for the association of basal bodies with membrane-bound vesicles and the vesicle-trafficking protein exoc4/sec8, and this association is in turn required for basal body docking. Once basal bodies are docked, required for the planar polarization of basal bodies that underlies ciliary beating and the directional fluid flow across ciliated epithelia (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processCilium biogenesis/degradation, Gastrulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Segment polarity protein dishevelled homolog DVL-2By similarity
Short name:
Dishevelled-2By similarity
Alternative name(s):
DSH homolog 2
Gene namesi
Name:dvl2Imported
Synonyms:dshBy similarity
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-1017461 dvl2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003546651 – 732Segment polarity protein dishevelled homolog DVL-2Add BLAST732

Post-translational modificationi

Phosphorylated. Phosphorylation is controlled by frizzled proteins, correlates with the onset of embryo dorsalizing events and is higher in the dorsal half of early cleavage embryos. Phosphorylated on tyrosine residues in response to association with efnb1/ephrin-B1 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ05AS8

Interactioni

Subunit structurei

Can form homomultimers. Interacts with prickle1. Interacts (via the PDZ domain) with ccdc88c/dal and dact1-B/dpr. Interacts (via the DIX domain) with ARP/Axin-related protein and dact1-A/frodo. Interacts with sdc4, possibly via fz7. Interacts directly (via the DEP domain) with efnb1/ephrin-B1. May interact indirectly with the phosphorylated ephrin receptors ephb1 and ephb2 via SH domain-containing adapters (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000037494

Structurei

3D structure databases

ProteinModelPortaliQ05AS8
SMRiQ05AS8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 82DIXPROSITE-ProRule annotationAdd BLAST82
Domaini250 – 335PDZPROSITE-ProRule annotationAdd BLAST86
Domaini424 – 498DEPPROSITE-ProRule annotationAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi90 – 127Pro-richSequence analysisAdd BLAST38
Compositional biasi218 – 223Poly-ArgSequence analysis6
Compositional biasi637 – 708Pro-richSequence analysisAdd BLAST72

Domaini

The C-terminal region containing the DEP domain is required for membrane accumulation and phosphorylation. Wnt signaling and axis induction requires the DIX domain. The C-terminus contributes to the localization at the cilia base (By similarity).By similarity

Sequence similaritiesi

Belongs to the DSH family.Sequence analysis

Phylogenomic databases

eggNOGiKOG3571 Eukaryota
ENOG410Y5G4 LUCA
HOGENOMiHOG000017084
HOVERGENiHBG005542
InParanoidiQ05AS8
KOiK02353

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.10.20.380, 1 hit
InterProiView protein in InterPro
IPR000591 DEP_dom
IPR024580 Dishevelled_C-dom
IPR008339 Dishevelled_fam
IPR003351 Dishevelled_protein_dom
IPR001158 DIX
IPR038207 DIX_dom_sf
IPR015506 Dsh/Dvl-rel
IPR008341 DVL2
IPR001478 PDZ
IPR036034 PDZ_sf
IPR029071 Ubiquitin-like_domsf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR10878 PTHR10878, 1 hit
PTHR10878:SF8 PTHR10878:SF8, 1 hit
PfamiView protein in Pfam
PF00610 DEP, 1 hit
PF02377 Dishevelled, 1 hit
PF00778 DIX, 1 hit
PF12316 Dsh_C, 1 hit
PF00595 PDZ, 1 hit
PRINTSiPR01760 DISHEVELLED
PR01762 DISHEVELLED2
SMARTiView protein in SMART
SM00021 DAX, 1 hit
SM00049 DEP, 1 hit
SM00228 PDZ, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF50156 SSF50156, 1 hit
SSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50186 DEP, 1 hit
PS50841 DIX, 1 hit
PS50106 PDZ, 1 hit

Sequencei

Sequence statusi: Complete.

Q05AS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAETKVIYHL DEEETPYLVK VPVPANEIRL RDFKAALGRG HAKYFFKAMD
60 70 80 90 100
QDFGVVKEEI SDDNAKLPCF NGRVVSWLVS SETSQTDSAP PAAEVRPDPP
110 120 130 140 150
PVPPPVPPPP AERTSGIGDS RPPSFHPNVS GSTEQLDQDN ESVISMRRDR
160 170 180 190 200
VRRRDSTEQG VARGVNGRAE RHLSGYESSS TLLTSEIETS ICDSEEDDAM
210 220 230 240 250
SRFSSSTEQS SASRLLKRHR RRRKQRPPRL ERTSSFSSVT DSTMSLNIIT
260 270 280 290 300
VTLNMEKYNF LGISIVGQSN ERGDGGIYIG SIMKGGAVAA DGRIEPGDML
310 320 330 340 350
LQVNDINFEN MSNDDAVRVL RDIVHKPGPI ILTVAKCWDP SPQGYFTLPR
360 370 380 390 400
NEPIQPIDPA AWVSHSAALS GSFPVYPGSA SMSSMTSSTS VTETELSHAL
410 420 430 440 450
PPVSLFSLSV HTDLASVAKV MASPESGLEV RDRMWLKITI PNAFLGSDMV
460 470 480 490 500
DWLYHHVEGF QDRREARKFA SNLLKAGLIR HTVNKITFSE QCYYIFGDLT
510 520 530 540 550
GCENYMANLS LNDNDGSSGA SDQDTLAPLP LPGASPWPLL PTFSYQYPAP
560 570 580 590 600
HPYSTQPPAY HELSSYSYGM GSAGSQHSEG SRSSGSNRSD GGRGTQKDER
610 620 630 640 650
SGVVGVGGGE SKSGSGSESE YSTRSSIRRI GGGEAGPPSE RSTSSRPPLH
660 670 680 690 700
HPPSVHSYAA PGVPLSYNPM MLMMMPPPPL PPPGACPPSS SVPPGAPPLV
710 720 730
RDLASVPPEL TASRQSFHMA MGNPSEFFVD VM
Length:732
Mass (Da):79,277
Last modified:November 14, 2006 - v1
Checksum:i2683B15F9FAA5841
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC123948 mRNA Translation: AAI23949.1
RefSeqiNP_001072660.1, NM_001079192.1
UniGeneiStr.16147

Genome annotation databases

GeneIDi780117
KEGGixtr:780117

Similar proteinsi

Entry informationi

Entry nameiDVL2_XENTR
AccessioniPrimary (citable) accession number: Q05AS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 14, 2006
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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