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Q05AS8

- DVL2_XENTR

UniProt

Q05AS8 - DVL2_XENTR

Protein

Segment polarity protein dishevelled homolog DVL-2

Gene

dvl2

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Involved in at least 2 independent signaling cascades, controlling cell fate via canonical Wnt signaling and cell polarity via a planar cell polarity (PCP) cascade. Acts synergistically with dal/dapple-like to activate Wnt signaling, stabilizing ctnnb1/beta-catenin and leading to dorsal axis formation. Also prevents degradation of ctnnb1/beta-catenin by displacing gsk3 from a complex with ARP/Axin-related protein. Has an additional role in anterior-posterior (A/P) axis formation, specifying different neuroectodermal cell fates along the A/P axis in a dose-dependent manner by activating several early patterning genes. In the PCP pathway, required at the cell membrane for PCP-mediated neural and mesodermal convergent extension during gastrulation and subsequent neural tube closure, acting to activate jnk. Also involved in blastopore closure and archenteron elongation during early, but not late, gastrulation. Associates with ephrin receptors and ligands and acts as part of a downstream PCP pathway to mediate ephrin-mediated cell repulsion via activation of rhoa. Required for efnb1/ephrin-B1-driven movement of non-retinal progenitor cells into the retina during eye field formation. Patterns the hindbrain. Required for ciliogenesis. Controls the docking of basal bodies to the apical plasma membrane; mediates the activation, but not localization of rhoa at the apical surface of ciliated cells during basal body docking. Furthermore, required for the association of basal bodies with membrane-bound vesicles and the vesicle-trafficking protein exoc4/sec8, and this association is in turn required for basal body docking. Once basal bodies are docked, required for the planar polarization of basal bodies that underlies ciliary beating and the directional fluid flow across ciliated epithelia By similarity.By similarity

    GO - Molecular functioni

    1. ephrin receptor binding Source: UniProtKB
    2. signal transducer activity Source: InterPro
    3. syndecan binding Source: UniProtKB

    GO - Biological processi

    1. activation of Rho GTPase activity Source: UniProtKB
    2. anterior/posterior axis specification Source: UniProtKB
    3. ciliary basal body organization Source: UniProtKB
    4. cilium assembly Source: UniProtKB
    5. convergent extension Source: UniProtKB
    6. convergent extension involved in gastrulation Source: UniProtKB
    7. dorsal/ventral axis specification Source: UniProtKB
    8. ephrin receptor signaling pathway Source: UniProtKB
    9. establishment of planar polarity Source: UniProtKB
    10. establishment or maintenance of cell polarity Source: UniProtKB
    11. gastrulation with mouth forming second Source: UniProtKB
    12. intracellular signal transduction Source: InterPro
    13. neural tube closure Source: UniProtKB
    14. neurogenesis Source: UniProtKB
    15. protein homooligomerization Source: UniProtKB
    16. protein stabilization Source: UniProtKB
    17. Wnt signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Cilium biogenesis/degradation, Gastrulation, Wnt signaling pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Segment polarity protein dishevelled homolog DVL-2By similarity
    Short name:
    Dishevelled-2By similarity
    Alternative name(s):
    DSH homolog 2
    Gene namesi
    Name:dvl2Imported
    Synonyms:dshBy similarity
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-1017461. dvl2.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmic vesicle By similarity. Cell projectioncilium By similarity. Nucleus By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity
    Note: Recruited from the cytoplasm to the cell membrane by frizzled proteins. Also relocated to the cell membrane by sdc4 and ephb1/ephrin-B1. Concentrated at the cell membrane in both ciliated and non-ciliated cells. Enriched at the apical surface of ciliated cells. Localized to the cilium rootlet By similarity.By similarity

    GO - Cellular componenti

    1. cell surface Source: UniProtKB
    2. ciliary rootlet Source: UniProtKB
    3. cytoplasm Source: UniProtKB
    4. cytoplasmic membrane-bounded vesicle Source: UniProtKB
    5. cytoplasmic vesicle Source: UniProtKB
    6. nucleus Source: UniProtKB
    7. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 732732Segment polarity protein dishevelled homolog DVL-2PRO_0000354665Add
    BLAST

    Post-translational modificationi

    Phosphorylated. Phosphorylation is controlled by frizzled proteins, correlates with the onset of embryo dorsalizing events and is higher in the dorsal half of early cleavage embryos. Phosphorylated on tyrosine residues in response to association with efnb1/ephrin-B1 By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Can form homomultimers. Interacts with prickle1. Interacts (via the PDZ domain) with ccdc88c/dal and dact1-B/dpr. Interacts (via the DIX domain) with ARP/Axin-related protein and dact1-A/frodo. Interacts with sdc4, possibly via fz7. Interacts directly (via the DEP domain) with efnb1/ephrin-B1. May interact indirectly with the phosphorylated ephrin receptors ephb1 and ephb2 via SH domain-containing adapters By similarity.By similarity

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000037494.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05AS8.
    SMRiQ05AS8. Positions 248-336, 408-498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8282DIXPROSITE-ProRule annotationAdd
    BLAST
    Domaini250 – 33586PDZPROSITE-ProRule annotationAdd
    BLAST
    Domaini424 – 49875DEPPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi90 – 12738Pro-richSequence AnalysisAdd
    BLAST
    Compositional biasi218 – 2236Poly-ArgSequence Analysis
    Compositional biasi637 – 70872Pro-richSequence AnalysisAdd
    BLAST

    Domaini

    The C-terminal region containing the DEP domain is required for membrane accumulation and phosphorylation. Wnt signaling and axis induction requires the DIX domain. The C-terminus contributes to the localization at the cilia base By similarity.By similarity

    Sequence similaritiesi

    Belongs to the DSH family.Sequence Analysis
    Contains 1 DEP domain.PROSITE-ProRule annotation
    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 PDZ (DHR) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG322275.
    HOGENOMiHOG000017084.
    HOVERGENiHBG005542.
    KOiK02353.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProiIPR000591. DEP_dom.
    IPR008341. Dishevelled_2.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF8. PTHR10878:SF8. 1 hit.
    PfamiPF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view]
    PRINTSiPR01760. DISHEVELLED.
    PR01762. DISHEVELLED2.
    SMARTiSM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05AS8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAETKVIYHL DEEETPYLVK VPVPANEIRL RDFKAALGRG HAKYFFKAMD    50
    QDFGVVKEEI SDDNAKLPCF NGRVVSWLVS SETSQTDSAP PAAEVRPDPP 100
    PVPPPVPPPP AERTSGIGDS RPPSFHPNVS GSTEQLDQDN ESVISMRRDR 150
    VRRRDSTEQG VARGVNGRAE RHLSGYESSS TLLTSEIETS ICDSEEDDAM 200
    SRFSSSTEQS SASRLLKRHR RRRKQRPPRL ERTSSFSSVT DSTMSLNIIT 250
    VTLNMEKYNF LGISIVGQSN ERGDGGIYIG SIMKGGAVAA DGRIEPGDML 300
    LQVNDINFEN MSNDDAVRVL RDIVHKPGPI ILTVAKCWDP SPQGYFTLPR 350
    NEPIQPIDPA AWVSHSAALS GSFPVYPGSA SMSSMTSSTS VTETELSHAL 400
    PPVSLFSLSV HTDLASVAKV MASPESGLEV RDRMWLKITI PNAFLGSDMV 450
    DWLYHHVEGF QDRREARKFA SNLLKAGLIR HTVNKITFSE QCYYIFGDLT 500
    GCENYMANLS LNDNDGSSGA SDQDTLAPLP LPGASPWPLL PTFSYQYPAP 550
    HPYSTQPPAY HELSSYSYGM GSAGSQHSEG SRSSGSNRSD GGRGTQKDER 600
    SGVVGVGGGE SKSGSGSESE YSTRSSIRRI GGGEAGPPSE RSTSSRPPLH 650
    HPPSVHSYAA PGVPLSYNPM MLMMMPPPPL PPPGACPPSS SVPPGAPPLV 700
    RDLASVPPEL TASRQSFHMA MGNPSEFFVD VM 732
    Length:732
    Mass (Da):79,277
    Last modified:November 14, 2006 - v1
    Checksum:i2683B15F9FAA5841
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC123948 mRNA. Translation: AAI23949.1.
    RefSeqiNP_001072660.1. NM_001079192.1.
    UniGeneiStr.16147.

    Genome annotation databases

    GeneIDi780117.
    KEGGixtr:780117.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC123948 mRNA. Translation: AAI23949.1 .
    RefSeqi NP_001072660.1. NM_001079192.1.
    UniGenei Str.16147.

    3D structure databases

    ProteinModelPortali Q05AS8.
    SMRi Q05AS8. Positions 248-336, 408-498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000037494.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 780117.
    KEGGi xtr:780117.

    Organism-specific databases

    CTDi 1856.
    Xenbasei XB-GENE-1017461. dvl2.

    Phylogenomic databases

    eggNOGi NOG322275.
    HOGENOMi HOG000017084.
    HOVERGENi HBG005542.
    KOi K02353.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.30.42.10. 1 hit.
    InterProi IPR000591. DEP_dom.
    IPR008341. Dishevelled_2.
    IPR024580. Dishevelled_C-dom.
    IPR008339. Dishevelled_fam.
    IPR003351. Dishevelled_protein_dom.
    IPR001158. DIX.
    IPR015506. Dsh/Dvl-rel.
    IPR001478. PDZ.
    IPR029071. Ubiquitin-rel_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10878. PTHR10878. 1 hit.
    PTHR10878:SF8. PTHR10878:SF8. 1 hit.
    Pfami PF00610. DEP. 1 hit.
    PF02377. Dishevelled. 1 hit.
    PF00778. DIX. 1 hit.
    PF12316. Dsh_C. 1 hit.
    PF00595. PDZ. 1 hit.
    [Graphical view ]
    PRINTSi PR01760. DISHEVELLED.
    PR01762. DISHEVELLED2.
    SMARTi SM00021. DAX. 1 hit.
    SM00049. DEP. 1 hit.
    SM00228. PDZ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50156. SSF50156. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50186. DEP. 1 hit.
    PS50841. DIX. 1 hit.
    PS50106. PDZ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: TestisImported.

    Entry informationi

    Entry nameiDVL2_XENTR
    AccessioniPrimary (citable) accession number: Q05AS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2008
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3