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Q05AM4 (FAH2B_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fatty-acid amide hydrolase 2-B

EC=3.5.1.99
Gene names
Name:faah2b
ORF Names:zgc:153568
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Protein attributes

Sequence length526 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Anandamide + H2O = arachidonic acid + ethanolamine.

Oleamide + H2O = oleic acid + NH3.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the amidase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 526526Fatty-acid amide hydrolase 2-B
PRO_0000291995

Regions

Transmembrane12 – 3221Helical; Potential

Sites

Active site1281Charge relay system By similarity
Active site2031Charge relay system By similarity
Active site2271Acyl-ester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q05AM4 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: 271E1756BABDDA86

FASTA52657,026
        10         20         30         40         50         60 
MGLTLGERVQ HCLLVLVSGL FLALFRLLSP GTKRPKHLPP ITNPLLTLSA VQLAEKIRRG 

        70         80         90        100        110        120 
EVSSVEVVQA YIDRIQEVNP LLNALIKDRF SAALLEAARA DKLIKEENGG EEVLRNQFPL 

       130        140        150        160        170        180 
LGVPMSVKES FGLQGMPNSG GLKSRGKVLA SVDAPPVALL KRAGAIPLGV TNTSELCMWM 

       190        200        210        220        230        240 
ESNNHLYGIT SNPYNLERIC GGSSGGEGSI IGGGASVFGI GSDIGGSIRM PCFFNGIFGH 

       250        260        270        280        290        300 
KPSRGVVSND NQFPRCSGLQ NEYTGSGPMC RYAEDLLPLL KIMAGPTADK LTLSKAVDLK 

       310        320        330        340        350        360 
KLRFFTIVDD GGSPLTSPVD RQLVEVQKRV AARLEADLGV TVQEVNFPQL KYSYQIWDTF 

       370        380        390        400        410        420 
LALPDKDGKP PEAFVELMAD GGSVWPVWEL IKRIFGRSEH TVAAIGLALM ESSHSSKSSE 

       430        440        450        460        470        480 
FILKQKEDLQ REMEDLLGTD GVLLYPSHPL LAPKHHHPLF MPFNFSYTGI LNILGLPVTQ 

       490        500        510        520 
CPLGLSKERL PLGVQVVAGL CQDHLTLAMA LYLEKAFGGW VDPGVV 

« Hide

References

« Hide 'large scale' references
[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[2]"A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio)."
McPartland J.M., Glass M., Matias I., Norris R.W., Kilpatrick C.W.
Mol. Genet. Genomics 277:555-570(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION AS FAAH2B.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC124392 mRNA. Translation: AAI24393.1.
RefSeqNP_001070930.1. NM_001077462.1.
UniGeneDr.81626.

3D structure databases

ProteinModelPortalQ05AM4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000071507.

Proteomic databases

PRIDEQ05AM4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID768298.
KEGGdre:768298.

Organism-specific databases

CTD768298.
ZFINZDB-GENE-061027-358. faah2b.

Phylogenomic databases

eggNOGCOG0154.
HOGENOMHOG000116697.
HOVERGENHBG101001.
InParanoidQ05AM4.
PhylomeDBQ05AM4.

Family and domain databases

Gene3D3.90.1300.10. 1 hit.
InterProIPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
[Graphical view]
PANTHERPTHR11895. PTHR11895. 1 hit.
PfamPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMSSF75304. SSF75304. 1 hit.
PROSITEPS00571. AMIDASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20918561.
PROQ05AM4.

Entry information

Entry nameFAH2B_DANRE
AccessionPrimary (citable) accession number: Q05AM4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 14, 2006
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families