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Q05AM4

- FAH2B_DANRE

UniProt

Q05AM4 - FAH2B_DANRE

Protein

Fatty-acid amide hydrolase 2-B

Gene

faah2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Anandamide + H2O = arachidonic acid + ethanolamine.
    Oleamide + H2O = oleic acid + NH3.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei128 – 1281Charge relay systemBy similarity
    Active sitei203 – 2031Charge relay systemBy similarity
    Active sitei227 – 2271Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. carbon-nitrogen ligase activity, with glutamine as amido-N-donor Source: InterPro
    2. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fatty-acid amide hydrolase 2-B (EC:3.5.1.99)
    Gene namesi
    Name:faah2b
    ORF Names:zgc:153568
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-061027-358. faah2b.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 526526Fatty-acid amide hydrolase 2-BPRO_0000291995Add
    BLAST

    Proteomic databases

    PRIDEiQ05AM4.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000071507.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05AM4.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the amidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0154.
    HOGENOMiHOG000116697.
    HOVERGENiHBG101001.
    InParanoidiQ05AM4.
    PhylomeDBiQ05AM4.

    Family and domain databases

    Gene3Di3.90.1300.10. 1 hit.
    InterProiIPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    [Graphical view]
    PANTHERiPTHR11895. PTHR11895. 1 hit.
    PfamiPF01425. Amidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF75304. SSF75304. 1 hit.
    PROSITEiPS00571. AMIDASES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05AM4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLTLGERVQ HCLLVLVSGL FLALFRLLSP GTKRPKHLPP ITNPLLTLSA    50
    VQLAEKIRRG EVSSVEVVQA YIDRIQEVNP LLNALIKDRF SAALLEAARA 100
    DKLIKEENGG EEVLRNQFPL LGVPMSVKES FGLQGMPNSG GLKSRGKVLA 150
    SVDAPPVALL KRAGAIPLGV TNTSELCMWM ESNNHLYGIT SNPYNLERIC 200
    GGSSGGEGSI IGGGASVFGI GSDIGGSIRM PCFFNGIFGH KPSRGVVSND 250
    NQFPRCSGLQ NEYTGSGPMC RYAEDLLPLL KIMAGPTADK LTLSKAVDLK 300
    KLRFFTIVDD GGSPLTSPVD RQLVEVQKRV AARLEADLGV TVQEVNFPQL 350
    KYSYQIWDTF LALPDKDGKP PEAFVELMAD GGSVWPVWEL IKRIFGRSEH 400
    TVAAIGLALM ESSHSSKSSE FILKQKEDLQ REMEDLLGTD GVLLYPSHPL 450
    LAPKHHHPLF MPFNFSYTGI LNILGLPVTQ CPLGLSKERL PLGVQVVAGL 500
    CQDHLTLAMA LYLEKAFGGW VDPGVV 526
    Length:526
    Mass (Da):57,026
    Last modified:November 14, 2006 - v1
    Checksum:i271E1756BABDDA86
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC124392 mRNA. Translation: AAI24393.1.
    RefSeqiNP_001070930.1. NM_001077462.1.
    UniGeneiDr.81626.

    Genome annotation databases

    GeneIDi768298.
    KEGGidre:768298.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC124392 mRNA. Translation: AAI24393.1 .
    RefSeqi NP_001070930.1. NM_001077462.1.
    UniGenei Dr.81626.

    3D structure databases

    ProteinModelPortali Q05AM4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000071507.

    Proteomic databases

    PRIDEi Q05AM4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 768298.
    KEGGi dre:768298.

    Organism-specific databases

    CTDi 768298.
    ZFINi ZDB-GENE-061027-358. faah2b.

    Phylogenomic databases

    eggNOGi COG0154.
    HOGENOMi HOG000116697.
    HOVERGENi HBG101001.
    InParanoidi Q05AM4.
    PhylomeDBi Q05AM4.

    Miscellaneous databases

    NextBioi 20918561.
    PROi Q05AM4.

    Family and domain databases

    Gene3Di 3.90.1300.10. 1 hit.
    InterProi IPR000120. Amidase.
    IPR020556. Amidase_CS.
    IPR023631. Amidase_dom.
    [Graphical view ]
    PANTHERi PTHR11895. PTHR11895. 1 hit.
    Pfami PF01425. Amidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF75304. SSF75304. 1 hit.
    PROSITEi PS00571. AMIDASES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Zebrafish Gene Collection (ZGC) project
      Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    2. "A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio)."
      McPartland J.M., Glass M., Matias I., Norris R.W., Kilpatrick C.W.
      Mol. Genet. Genomics 277:555-570(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION AS FAAH2B.

    Entry informationi

    Entry nameiFAH2B_DANRE
    AccessioniPrimary (citable) accession number: Q05AM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3