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Q05AM4

- FAH2B_DANRE

UniProt

Q05AM4 - FAH2B_DANRE

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Protein

Fatty-acid amide hydrolase 2-B

Gene

faah2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Anandamide + H2O = arachidonic acid + ethanolamine.
Oleamide + H2O = oleic acid + NH3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281Charge relay systemBy similarity
Active sitei203 – 2031Charge relay systemBy similarity
Active sitei227 – 2271Acyl-ester intermediateBy similarity

GO - Molecular functioni

  1. carbon-nitrogen ligase activity, with glutamine as amido-N-donor Source: InterPro
  2. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty-acid amide hydrolase 2-B (EC:3.5.1.99)
Gene namesi
Name:faah2b
ORF Names:zgc:153568
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-061027-358. faah2b.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Fatty-acid amide hydrolase 2-BPRO_0000291995Add
BLAST

Proteomic databases

PRIDEiQ05AM4.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000071507.

Structurei

3D structure databases

ProteinModelPortaliQ05AM4.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the amidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0154.
HOGENOMiHOG000116697.
HOVERGENiHBG101001.
InParanoidiQ05AM4.
PhylomeDBiQ05AM4.

Family and domain databases

Gene3Di3.90.1300.10. 1 hit.
InterProiIPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
[Graphical view]
PANTHERiPTHR11895. PTHR11895. 1 hit.
PfamiPF01425. Amidase. 1 hit.
[Graphical view]
SUPFAMiSSF75304. SSF75304. 1 hit.
PROSITEiPS00571. AMIDASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05AM4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGLTLGERVQ HCLLVLVSGL FLALFRLLSP GTKRPKHLPP ITNPLLTLSA
60 70 80 90 100
VQLAEKIRRG EVSSVEVVQA YIDRIQEVNP LLNALIKDRF SAALLEAARA
110 120 130 140 150
DKLIKEENGG EEVLRNQFPL LGVPMSVKES FGLQGMPNSG GLKSRGKVLA
160 170 180 190 200
SVDAPPVALL KRAGAIPLGV TNTSELCMWM ESNNHLYGIT SNPYNLERIC
210 220 230 240 250
GGSSGGEGSI IGGGASVFGI GSDIGGSIRM PCFFNGIFGH KPSRGVVSND
260 270 280 290 300
NQFPRCSGLQ NEYTGSGPMC RYAEDLLPLL KIMAGPTADK LTLSKAVDLK
310 320 330 340 350
KLRFFTIVDD GGSPLTSPVD RQLVEVQKRV AARLEADLGV TVQEVNFPQL
360 370 380 390 400
KYSYQIWDTF LALPDKDGKP PEAFVELMAD GGSVWPVWEL IKRIFGRSEH
410 420 430 440 450
TVAAIGLALM ESSHSSKSSE FILKQKEDLQ REMEDLLGTD GVLLYPSHPL
460 470 480 490 500
LAPKHHHPLF MPFNFSYTGI LNILGLPVTQ CPLGLSKERL PLGVQVVAGL
510 520
CQDHLTLAMA LYLEKAFGGW VDPGVV
Length:526
Mass (Da):57,026
Last modified:November 14, 2006 - v1
Checksum:i271E1756BABDDA86
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC124392 mRNA. Translation: AAI24393.1.
RefSeqiNP_001070930.1. NM_001077462.1.
UniGeneiDr.81626.

Genome annotation databases

GeneIDi768298.
KEGGidre:768298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC124392 mRNA. Translation: AAI24393.1 .
RefSeqi NP_001070930.1. NM_001077462.1.
UniGenei Dr.81626.

3D structure databases

ProteinModelPortali Q05AM4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7955.ENSDARP00000071507.

Proteomic databases

PRIDEi Q05AM4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 768298.
KEGGi dre:768298.

Organism-specific databases

CTDi 768298.
ZFINi ZDB-GENE-061027-358. faah2b.

Phylogenomic databases

eggNOGi COG0154.
HOGENOMi HOG000116697.
HOVERGENi HBG101001.
InParanoidi Q05AM4.
PhylomeDBi Q05AM4.

Miscellaneous databases

NextBioi 20918561.
PROi Q05AM4.

Family and domain databases

Gene3Di 3.90.1300.10. 1 hit.
InterProi IPR000120. Amidase.
IPR020556. Amidase_CS.
IPR023631. Amidase_dom.
[Graphical view ]
PANTHERi PTHR11895. PTHR11895. 1 hit.
Pfami PF01425. Amidase. 1 hit.
[Graphical view ]
SUPFAMi SSF75304. SSF75304. 1 hit.
PROSITEi PS00571. AMIDASES. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  2. "A shifted repertoire of endocannabinoid genes in the zebrafish (Danio rerio)."
    McPartland J.M., Glass M., Matias I., Norris R.W., Kilpatrick C.W.
    Mol. Genet. Genomics 277:555-570(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION AS FAAH2B.

Entry informationi

Entry nameiFAH2B_DANRE
AccessioniPrimary (citable) accession number: Q05AM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 14, 2006
Last modified: October 1, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3