ID   A0A2R8QT05_DANRE        Unreviewed;       418 AA.
AC   A0A2R8QT05; B2GQL7; Q05AJ3;
DT   03-AUG-2022, integrated into UniProtKB/TrEMBL.
DT   03-AUG-2022, sequence version 1.
DT   27-MAR-2024, entry version 10.
DE   SubName: Full=GATA-binding protein 1 {ECO:0000313|EMBL:AAI24484.1, ECO:0000313|Ensembl:ENSDARP00000002330};
DE   SubName: Full=Gata1 protein {ECO:0000313|EMBL:AAI64788.1};
GN   Name=gata1a {ECO:0000313|Ensembl:ENSDARP00000002330,
GN   ECO:0000313|ZFIN:ZDB-GENE-980526-268};
GN   Synonyms=gata1 {ECO:0000313|EMBL:AAI24484.1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI24484.1};
RN   [1] {ECO:0000313|EMBL:AAI24484.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescue {ECO:0000313|EMBL:AAI64788.1}, and Whole
RC   {ECO:0000313|EMBL:AAI24484.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000002330}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000002330};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000002330}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000002330};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RG   Genome Reference Consortium Zebrafish;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA   Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA   Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA   Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA   Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA   Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA   Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA   Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA   Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA   Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA   Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA   Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA   Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA   Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA   Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA   Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA   Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA   Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA   Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA   Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA   Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA   Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000156542}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000156542};
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; CR932000; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC124483; AAI24484.1; -; mRNA.
DR   EMBL; BC164788; AAI64788.1; -; mRNA.
DR   RefSeq; NP_571309.1; NM_131234.1.
DR   STRING; 7955.ENSDARP00000002330; -.
DR   PaxDb; 7955-ENSDARP00000098204; -.
DR   Ensembl; ENSDART00000013714.9; ENSDARP00000002330.7; ENSDARG00000013477.9.
DR   Ensembl; ENSDART00000190542.1; ENSDARP00000156542.1; ENSDARG00000117116.1.
DR   GeneID; 30481; -.
DR   KEGG; dre:30481; -.
DR   AGR; ZFIN:ZDB-GENE-980526-268; -.
DR   CTD; 30481; -.
DR   ZFIN; ZDB-GENE-980526-268; gata1a.
DR   eggNOG; KOG1601; Eukaryota.
DR   HOGENOM; CLU_027524_1_1_1; -.
DR   OMA; EQSHWAS; -.
DR   OrthoDB; 685518at2759; -.
DR   TreeFam; TF315391; -.
DR   Reactome; R-DRE-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR   Reactome; R-DRE-8939236; RUNX1 regulates transcription of genes involved in differentiation of HSCs.
DR   Reactome; R-DRE-983231; Factors involved in megakaryocyte development and platelet production.
DR   Bgee; ENSDARG00000013477; Expressed in spleen and 17 other cell types or tissues.
DR   GO; GO:0005634; C:nucleus; IC:ZFIN.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:ZFIN.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0003690; F:double-stranded DNA binding; IDA:ZFIN.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:ZFIN.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR   GO; GO:0043009; P:chordate embryonic development; IMP:ZFIN.
DR   GO; GO:0035162; P:embryonic hemopoiesis; IMP:ZFIN.
DR   GO; GO:0048821; P:erythrocyte development; IMP:ZFIN.
DR   GO; GO:0030218; P:erythrocyte differentiation; IMP:ZFIN.
DR   GO; GO:0030225; P:macrophage differentiation; IMP:ZFIN.
DR   GO; GO:0030224; P:monocyte differentiation; IMP:ZFIN.
DR   GO; GO:0030099; P:myeloid cell differentiation; IGI:ZFIN.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IMP:ZFIN.
DR   GO; GO:0010629; P:negative regulation of gene expression; IMP:ZFIN.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0030223; P:neutrophil differentiation; IMP:ZFIN.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:ZFIN.
DR   GO; GO:0060215; P:primitive hemopoiesis; IMP:ZFIN.
DR   GO; GO:0045637; P:regulation of myeloid cell differentiation; IMP:ZFIN.
DR   GO; GO:0010725; P:regulation of primitive erythrocyte differentiation; IGI:ZFIN.
DR   CDD; cd00202; ZnF_GATA; 2.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 2.
DR   InterPro; IPR016374; TF_GATA-2/3.
DR   InterPro; IPR039355; Transcription_factor_GATA.
DR   InterPro; IPR000679; Znf_GATA.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   PANTHER; PTHR10071:SF336; GATA BINDING PROTEIN 1A; 1.
DR   PANTHER; PTHR10071; TRANSCRIPTION FACTOR GATA FAMILY MEMBER; 1.
DR   Pfam; PF00320; GATA; 2.
DR   PIRSF; PIRSF003027; TF_GATA-1/2/3; 2.
DR   PRINTS; PR00619; GATAZNFINGER.
DR   SMART; SM00401; ZnF_GATA; 2.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR   PROSITE; PS00344; GATA_ZN_FINGER_1; 2.
DR   PROSITE; PS50114; GATA_ZN_FINGER_2; 2.
PE   2: Evidence at transcript level;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00094}.
FT   DOMAIN          232..287
FT                   /note="GATA-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50114"
FT   DOMAIN          286..339
FT                   /note="GATA-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50114"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          124..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          341..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..138
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   418 AA;  45665 MW;  EF3004D9010BC203 CRC64;
     MENSSEPSRW VSPGLLSPDP LVNYTTDSGL LPPVDVDEPF YSSSETDLLP SYYSTSVQSR
     ASSSYRHSPV RQVYSSQSIL GNIQWLDNSA GHSLNSPYNP TSTVWSSSPF AKTPLHSHTS
     TSIYQNTATP SFTSPKEGFP SPSRDGKDSP RLQEVLKAER LSPMSGSGSS FLNLSSATGG
     VYGPSPHMLS PYGSYMSTSQ DYSSAALYST GGPWMSPSSY SPKLRNKMRL SPPEARECVN
     CGATATPLWR RDGTGHYLCN ACGLYHKMNG QNRPLIRPKK RLIVSKRAGT QCANCHTSTT
     TLWRRNASGE PVCNACGLYF KLHNVNRPLT MKKDGIQTRN RKVSNRNKKG KKNAASEVYP
     DMSHMAPPDE HVGAYSLNPG PLLSYSHPAH LLPTSTLHSS TTLPYTHHPN SGMMPTLV
//