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Q05A80 (CAPR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Caprin-2
Alternative name(s):
C1q domain-containing protein 1
Cytoplasmic activation/proliferation-associated protein 2
RNA granule protein 140
Gene names
Name:Caprin2
Synonyms:C1qdc1, Kiaa1873, Rng140
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1031 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis. Ref.3

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Specifically expressed in brain (at protein level). Ref.3

Developmental stage

Detected at E17.5 in brain (at protein level). Ref.3

Sequence similarities

Belongs to the caprin family.

Contains 1 C1q domain.

Sequence caution

The sequence BAC98270.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
   Biological processDifferentiation
Growth regulation
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
   LigandRNA-binding
   Molecular functionProtein synthesis inhibitor
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of cell growth

Inferred from sequence or structural similarity. Source: UniProtKB

negative regulation of translation

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of canonical Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of dendrite morphogenesis

Inferred from mutant phenotype Ref.3. Source: UniProtKB

positive regulation of dendritic spine morphogenesis

Inferred from mutant phenotype Ref.3. Source: UniProtKB

positive regulation of peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of protein binding

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

mitochondrion

Inferred from sequence or structural similarity. Source: UniProtKB

receptor complex

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 Ref.2 (identifier: Q05A80-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: No experimental confirmation available.
Isoform 2 Ref.1 (identifier: Q05A80-2)

The sequence of this isoform differs from the canonical sequence as follows:
     284-502: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10311031Caprin-2
PRO_0000302083

Regions

Domain897 – 1031135C1q

Natural variations

Alternative sequence284 – 502219Missing in isoform 2. Ref.1
VSP_052540

Experimental info

Sequence conflict8431Missing in BAC98270. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 14, 2006. Version 1.
Checksum: DA2A62E64372F6A6

FASTA1,031114,491
        10         20         30         40         50         60 
MKSAKSQVNQ DQQGENQRAL SPLQSTLSSA ASPSQAYETY IDNGLICLKH KIRNIEKKKL 

        70         80         90        100        110        120 
KLEDYKDRLK NGEQLNPDQL EAVEKYEEVL HNLEFAKELQ KTFSALSQDL LKAQKKAQRR 

       130        140        150        160        170        180 
EHMLKLETEK KKLRTMLQIQ YVLQNLTQEH VQKDFKGGLN GAMYLPSKEL DYLIKFSKLT 

       190        200        210        220        230        240 
CPERNESLSV EDQMEQSSLY FWDLLEGSEK TVVGTTYKHV KDLLSKLLHS GYFESVPVLR 

       250        260        270        280        290        300 
NSKEKAEEVL MQSEMKKQLL KSESIKESES LTELVQPEIQ PQEFLNRRYM TEVKFSRKQE 

       310        320        330        340        350        360 
NVEQSWEADY ARKPSLLKCW NTLPEPDGQE KKKESLESWK SSLKTQEVSK PVVSLVQGKL 

       370        380        390        400        410        420 
RPTLQEEQKQ QVPITPVSQW KPESPKSKVG SPQEEQNVQE TPKPWVVQSQ KEQDPKKLPP 

       430        440        450        460        470        480 
GSWAVSVQSE QSGSRSWTTP VCREQASVQP GTPVSWENNA ENQKHSLVPQ SQISLKSWGA 

       490        500        510        520        530        540 
ASAGLLPNGQ VLTRKLNVEP KDVPKPLPQP IDSSSALPKD PVLRKEKLQD LMSQIQGTYN 

       550        560        570        580        590        600 
FMQESVLDFD KPSSAIPSSQ PPSACPVSTV SAEQNLSNQS DFLQEPSQAS SPVTCSSNAC 

       610        620        630        640        650        660 
LVTTDQASSG SETEFTTSET PEMVVSPCKP KPASALASPN PPLSKSFQLP PASGSSEAIS 

       670        680        690        700        710        720 
TAPFQAMQTV FNVNAPLPPR KEQEMKEPPY SSGYNQNFTS SSTQTVSQCQ LPAVHIDQTT 

       730        740        750        760        770        780 
QPPETGAGYH PDGTVQVSNG SLAFYPAPTS MFPRPAQPFI SSRGTLRGCS HGGRLLMSSY 

       790        800        810        820        830        840 
QSPGGYKGFD SYRGLPSVSS GNYSQLQLQA REYSGTAYSQ RDNFQQCYKR SGTSSGLQAN 

       850        860        870        880        890        900 
SRAGWSDSSQ VSSPERDSET FNSGDSGLGD SRSMTPVDVP VTSPAAAILP VHIYPLPQQM 

       910        920        930        940        950        960 
RVAFSAARTS NLAPGTLDQP IVFDLLLNNL GETFDLQLGR FNCPVNGTYV FIFHMLKLAV 

       970        980        990       1000       1010       1020 
NVPLYVNLMK NEEVLVSAYA NDGAPDHETA SNHAVLQLLQ GDQIWLRLHR GAIYGSSWKY 

      1030 
STFSGYLLYQ D 

« Hide

Isoform 2 [UniParc].

Checksum: C9E90D652EB98CC2
Show »

FASTA81289,745

References

« Hide 'large scale' references
[1]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Embryonic tail.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Mammary tumor.
[3]"RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain."
Shiina N., Tokunaga M.
J. Biol. Chem. 285:24260-24269(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK129460 mRNA. Translation: BAC98270.1. Different initiation.
BC092093 mRNA. Translation: AAH92093.1.
BC125373 mRNA. Translation: AAI25374.1.
BC125375 mRNA. Translation: AAI25376.1.
CCDSCCDS39720.1. [Q05A80-1]
RefSeqNP_853519.2. NM_181541.3. [Q05A80-1]
XP_006507102.1. XM_006507039.1. [Q05A80-1]
XP_006507105.1. XM_006507042.1. [Q05A80-2]
UniGeneMm.150568.

3D structure databases

ProteinModelPortalQ05A80.
SMRQ05A80. Positions 903-1029.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ05A80.

Proteomic databases

PaxDbQ05A80.
PRIDEQ05A80.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000072324; ENSMUSP00000072165; ENSMUSG00000030309. [Q05A80-2]
ENSMUST00000111569; ENSMUSP00000107195; ENSMUSG00000030309. [Q05A80-1]
GeneID232560.
KEGGmmu:232560.
UCSCuc009eto.1. mouse. [Q05A80-2]
uc009etp.1. mouse. [Q05A80-1]

Organism-specific databases

CTD65981.
MGIMGI:2448541. Caprin2.
RougeSearch...

Phylogenomic databases

eggNOGNOG41180.
GeneTreeENSGT00730000110222.
HOGENOMHOG000082543.
HOVERGENHBG057777.
InParanoidQ05A80.
OMAAGWSDSS.
OrthoDBEOG74XS5W.
TreeFamTF329471.

Gene expression databases

ArrayExpressQ05A80.
BgeeQ05A80.
CleanExMM_CAPRIN2.
GenevestigatorQ05A80.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR001073. C1q.
IPR028816. Caprin.
IPR022070. Caprin-1_C.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PANTHERPTHR22922. PTHR22922. 1 hit.
PfamPF00386. C1q. 1 hit.
PF12287. Caprin-1_C. 1 hit.
[Graphical view]
PRINTSPR00007. COMPLEMNTC1Q.
SMARTSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50871. C1Q. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio381151.
PROQ05A80.
SOURCESearch...

Entry information

Entry nameCAPR2_MOUSE
AccessionPrimary (citable) accession number: Q05A80
Secondary accession number(s): Q58E31, Q6ZPG7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot