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Q05A80

- CAPR2_MOUSE

UniProt

Q05A80 - CAPR2_MOUSE

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Protein

Caprin-2

Gene

Caprin2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.1 Publication

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of cell growth Source: UniProtKB
  2. negative regulation of translation Source: UniProtKB-KW
  3. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  4. positive regulation of dendrite morphogenesis Source: UniProtKB
  5. positive regulation of dendritic spine morphogenesis Source: UniProtKB
  6. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  7. positive regulation of protein binding Source: Ensembl
  8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Protein synthesis inhibitor

Keywords - Biological processi

Differentiation, Growth regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Caprin-2
Alternative name(s):
C1q domain-containing protein 1
Cytoplasmic activation/proliferation-associated protein 2
RNA granule protein 140
Gene namesi
Name:Caprin2Imported
Synonyms:C1qdc1Imported, Kiaa1873Imported, Rng140
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2448541. Caprin2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. centrosome Source: Ensembl
  2. cytoplasm Source: UniProtKB
  3. mitochondrion Source: UniProtKB
  4. nucleus Source: Ensembl
  5. receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10311031Caprin-2PRO_0000302083Add
BLAST

Proteomic databases

PaxDbiQ05A80.
PRIDEiQ05A80.

PTM databases

PhosphoSiteiQ05A80.

Expressioni

Tissue specificityi

Specifically expressed in brain (at protein level).1 Publication

Developmental stagei

Detected at E17.5 in brain (at protein level).1 Publication

Gene expression databases

BgeeiQ05A80.
CleanExiMM_CAPRIN2.
ExpressionAtlasiQ05A80. baseline and differential.
GenevestigatoriQ05A80.

Structurei

3D structure databases

ProteinModelPortaliQ05A80.
SMRiQ05A80. Positions 903-1029.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini897 – 1031135C1qPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the caprin family.Curated
Contains 1 C1q domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG41180.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000082543.
HOVERGENiHBG057777.
InParanoidiQ05A80.
OMAiAGWSDSS.
OrthoDBiEOG74XS5W.
TreeFamiTF329471.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR028816. Caprin.
IPR022070. Caprin-1_C.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PANTHERiPTHR22922. PTHR22922. 1 hit.
PfamiPF00386. C1q. 1 hit.
PF12287. Caprin-1_C. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q05A80-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSAKSQVNQ DQQGENQRAL SPLQSTLSSA ASPSQAYETY IDNGLICLKH
60 70 80 90 100
KIRNIEKKKL KLEDYKDRLK NGEQLNPDQL EAVEKYEEVL HNLEFAKELQ
110 120 130 140 150
KTFSALSQDL LKAQKKAQRR EHMLKLETEK KKLRTMLQIQ YVLQNLTQEH
160 170 180 190 200
VQKDFKGGLN GAMYLPSKEL DYLIKFSKLT CPERNESLSV EDQMEQSSLY
210 220 230 240 250
FWDLLEGSEK TVVGTTYKHV KDLLSKLLHS GYFESVPVLR NSKEKAEEVL
260 270 280 290 300
MQSEMKKQLL KSESIKESES LTELVQPEIQ PQEFLNRRYM TEVKFSRKQE
310 320 330 340 350
NVEQSWEADY ARKPSLLKCW NTLPEPDGQE KKKESLESWK SSLKTQEVSK
360 370 380 390 400
PVVSLVQGKL RPTLQEEQKQ QVPITPVSQW KPESPKSKVG SPQEEQNVQE
410 420 430 440 450
TPKPWVVQSQ KEQDPKKLPP GSWAVSVQSE QSGSRSWTTP VCREQASVQP
460 470 480 490 500
GTPVSWENNA ENQKHSLVPQ SQISLKSWGA ASAGLLPNGQ VLTRKLNVEP
510 520 530 540 550
KDVPKPLPQP IDSSSALPKD PVLRKEKLQD LMSQIQGTYN FMQESVLDFD
560 570 580 590 600
KPSSAIPSSQ PPSACPVSTV SAEQNLSNQS DFLQEPSQAS SPVTCSSNAC
610 620 630 640 650
LVTTDQASSG SETEFTTSET PEMVVSPCKP KPASALASPN PPLSKSFQLP
660 670 680 690 700
PASGSSEAIS TAPFQAMQTV FNVNAPLPPR KEQEMKEPPY SSGYNQNFTS
710 720 730 740 750
SSTQTVSQCQ LPAVHIDQTT QPPETGAGYH PDGTVQVSNG SLAFYPAPTS
760 770 780 790 800
MFPRPAQPFI SSRGTLRGCS HGGRLLMSSY QSPGGYKGFD SYRGLPSVSS
810 820 830 840 850
GNYSQLQLQA REYSGTAYSQ RDNFQQCYKR SGTSSGLQAN SRAGWSDSSQ
860 870 880 890 900
VSSPERDSET FNSGDSGLGD SRSMTPVDVP VTSPAAAILP VHIYPLPQQM
910 920 930 940 950
RVAFSAARTS NLAPGTLDQP IVFDLLLNNL GETFDLQLGR FNCPVNGTYV
960 970 980 990 1000
FIFHMLKLAV NVPLYVNLMK NEEVLVSAYA NDGAPDHETA SNHAVLQLLQ
1010 1020 1030
GDQIWLRLHR GAIYGSSWKY STFSGYLLYQ D

Note: No experimental confirmation available.Curated

Length:1,031
Mass (Da):114,491
Last modified:November 14, 2006 - v1
Checksum:iDA2A62E64372F6A6
GO
Isoform 21 Publication (identifier: Q05A80-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-502: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:812
Mass (Da):89,745
Checksum:iC9E90D652EB98CC2
GO

Sequence cautioni

The sequence BAC98270.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti843 – 8431Missing in BAC98270. (PubMed:14621295)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei284 – 502219Missing in isoform 2. 1 PublicationVSP_052540Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129460 mRNA. Translation: BAC98270.1. Different initiation.
BC092093 mRNA. Translation: AAH92093.1.
BC125373 mRNA. Translation: AAI25374.1.
BC125375 mRNA. Translation: AAI25376.1.
CCDSiCCDS39720.1. [Q05A80-1]
RefSeqiNP_853519.2. NM_181541.4. [Q05A80-1]
XP_006507102.1. XM_006507039.1. [Q05A80-1]
XP_006507105.1. XM_006507042.1. [Q05A80-2]
UniGeneiMm.150568.

Genome annotation databases

EnsembliENSMUST00000072324; ENSMUSP00000072165; ENSMUSG00000030309. [Q05A80-2]
ENSMUST00000111569; ENSMUSP00000107195; ENSMUSG00000030309. [Q05A80-1]
GeneIDi232560.
KEGGimmu:232560.
UCSCiuc009eto.1. mouse. [Q05A80-2]
uc009etp.1. mouse. [Q05A80-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129460 mRNA. Translation: BAC98270.1 . Different initiation.
BC092093 mRNA. Translation: AAH92093.1 .
BC125373 mRNA. Translation: AAI25374.1 .
BC125375 mRNA. Translation: AAI25376.1 .
CCDSi CCDS39720.1. [Q05A80-1 ]
RefSeqi NP_853519.2. NM_181541.4. [Q05A80-1 ]
XP_006507102.1. XM_006507039.1. [Q05A80-1 ]
XP_006507105.1. XM_006507042.1. [Q05A80-2 ]
UniGenei Mm.150568.

3D structure databases

ProteinModelPortali Q05A80.
SMRi Q05A80. Positions 903-1029.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q05A80.

Proteomic databases

PaxDbi Q05A80.
PRIDEi Q05A80.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072324 ; ENSMUSP00000072165 ; ENSMUSG00000030309 . [Q05A80-2 ]
ENSMUST00000111569 ; ENSMUSP00000107195 ; ENSMUSG00000030309 . [Q05A80-1 ]
GeneIDi 232560.
KEGGi mmu:232560.
UCSCi uc009eto.1. mouse. [Q05A80-2 ]
uc009etp.1. mouse. [Q05A80-1 ]

Organism-specific databases

CTDi 65981.
MGIi MGI:2448541. Caprin2.
Rougei Search...

Phylogenomic databases

eggNOGi NOG41180.
GeneTreei ENSGT00760000119052.
HOGENOMi HOG000082543.
HOVERGENi HBG057777.
InParanoidi Q05A80.
OMAi AGWSDSS.
OrthoDBi EOG74XS5W.
TreeFami TF329471.

Miscellaneous databases

NextBioi 381151.
PROi Q05A80.
SOURCEi Search...

Gene expression databases

Bgeei Q05A80.
CleanExi MM_CAPRIN2.
ExpressionAtlasi Q05A80. baseline and differential.
Genevestigatori Q05A80.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR001073. C1q.
IPR028816. Caprin.
IPR022070. Caprin-1_C.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
PANTHERi PTHR22922. PTHR22922. 1 hit.
Pfami PF00386. C1q. 1 hit.
PF12287. Caprin-1_C. 1 hit.
[Graphical view ]
PRINTSi PR00007. COMPLEMNTC1Q.
SMARTi SM00110. C1Q. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS50871. C1Q. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryonic tailImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: BrainImported and Mammary tumorImported.
  3. "RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain."
    Shiina N., Tokunaga M.
    J. Biol. Chem. 285:24260-24269(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCAPR2_MOUSE
AccessioniPrimary (citable) accession number: Q05A80
Secondary accession number(s): Q58E31, Q6ZPG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3