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Q05A80

- CAPR2_MOUSE

UniProt

Q05A80 - CAPR2_MOUSE

Protein

Caprin-2

Gene

Caprin2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.1 Publication

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of cell growth Source: UniProtKB
    2. negative regulation of translation Source: UniProtKB-KW
    3. positive regulation of canonical Wnt signaling pathway Source: Ensembl
    4. positive regulation of dendrite morphogenesis Source: UniProtKB
    5. positive regulation of dendritic spine morphogenesis Source: UniProtKB
    6. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    7. positive regulation of protein binding Source: Ensembl
    8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl

    Keywords - Molecular functioni

    Protein synthesis inhibitor

    Keywords - Biological processi

    Differentiation, Growth regulation

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Caprin-2
    Alternative name(s):
    C1q domain-containing protein 1
    Cytoplasmic activation/proliferation-associated protein 2
    RNA granule protein 140
    Gene namesi
    Name:Caprin2Imported
    Synonyms:C1qdc1Imported, Kiaa1873Imported, Rng140
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:2448541. Caprin2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. mitochondrion Source: UniProtKB
    3. receptor complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10311031Caprin-2PRO_0000302083Add
    BLAST

    Proteomic databases

    PaxDbiQ05A80.
    PRIDEiQ05A80.

    PTM databases

    PhosphoSiteiQ05A80.

    Expressioni

    Tissue specificityi

    Specifically expressed in brain (at protein level).1 Publication

    Developmental stagei

    Detected at E17.5 in brain (at protein level).1 Publication

    Gene expression databases

    ArrayExpressiQ05A80.
    BgeeiQ05A80.
    CleanExiMM_CAPRIN2.
    GenevestigatoriQ05A80.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05A80.
    SMRiQ05A80. Positions 903-1029.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini897 – 1031135C1qPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the caprin family.Curated
    Contains 1 C1q domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG41180.
    GeneTreeiENSGT00730000110222.
    HOGENOMiHOG000082543.
    HOVERGENiHBG057777.
    InParanoidiQ05A80.
    OMAiAGWSDSS.
    OrthoDBiEOG74XS5W.
    TreeFamiTF329471.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR001073. C1q.
    IPR028816. Caprin.
    IPR022070. Caprin-1_C.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PANTHERiPTHR22922. PTHR22922. 1 hit.
    PfamiPF00386. C1q. 1 hit.
    PF12287. Caprin-1_C. 1 hit.
    [Graphical view]
    PRINTSiPR00007. COMPLEMNTC1Q.
    SMARTiSM00110. C1Q. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50871. C1Q. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q05A80-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSAKSQVNQ DQQGENQRAL SPLQSTLSSA ASPSQAYETY IDNGLICLKH     50
    KIRNIEKKKL KLEDYKDRLK NGEQLNPDQL EAVEKYEEVL HNLEFAKELQ 100
    KTFSALSQDL LKAQKKAQRR EHMLKLETEK KKLRTMLQIQ YVLQNLTQEH 150
    VQKDFKGGLN GAMYLPSKEL DYLIKFSKLT CPERNESLSV EDQMEQSSLY 200
    FWDLLEGSEK TVVGTTYKHV KDLLSKLLHS GYFESVPVLR NSKEKAEEVL 250
    MQSEMKKQLL KSESIKESES LTELVQPEIQ PQEFLNRRYM TEVKFSRKQE 300
    NVEQSWEADY ARKPSLLKCW NTLPEPDGQE KKKESLESWK SSLKTQEVSK 350
    PVVSLVQGKL RPTLQEEQKQ QVPITPVSQW KPESPKSKVG SPQEEQNVQE 400
    TPKPWVVQSQ KEQDPKKLPP GSWAVSVQSE QSGSRSWTTP VCREQASVQP 450
    GTPVSWENNA ENQKHSLVPQ SQISLKSWGA ASAGLLPNGQ VLTRKLNVEP 500
    KDVPKPLPQP IDSSSALPKD PVLRKEKLQD LMSQIQGTYN FMQESVLDFD 550
    KPSSAIPSSQ PPSACPVSTV SAEQNLSNQS DFLQEPSQAS SPVTCSSNAC 600
    LVTTDQASSG SETEFTTSET PEMVVSPCKP KPASALASPN PPLSKSFQLP 650
    PASGSSEAIS TAPFQAMQTV FNVNAPLPPR KEQEMKEPPY SSGYNQNFTS 700
    SSTQTVSQCQ LPAVHIDQTT QPPETGAGYH PDGTVQVSNG SLAFYPAPTS 750
    MFPRPAQPFI SSRGTLRGCS HGGRLLMSSY QSPGGYKGFD SYRGLPSVSS 800
    GNYSQLQLQA REYSGTAYSQ RDNFQQCYKR SGTSSGLQAN SRAGWSDSSQ 850
    VSSPERDSET FNSGDSGLGD SRSMTPVDVP VTSPAAAILP VHIYPLPQQM 900
    RVAFSAARTS NLAPGTLDQP IVFDLLLNNL GETFDLQLGR FNCPVNGTYV 950
    FIFHMLKLAV NVPLYVNLMK NEEVLVSAYA NDGAPDHETA SNHAVLQLLQ 1000
    GDQIWLRLHR GAIYGSSWKY STFSGYLLYQ D 1031

    Note: No experimental confirmation available.Curated

    Length:1,031
    Mass (Da):114,491
    Last modified:November 14, 2006 - v1
    Checksum:iDA2A62E64372F6A6
    GO
    Isoform 21 Publication (identifier: Q05A80-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         284-502: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:812
    Mass (Da):89,745
    Checksum:iC9E90D652EB98CC2
    GO

    Sequence cautioni

    The sequence BAC98270.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti843 – 8431Missing in BAC98270. (PubMed:14621295)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei284 – 502219Missing in isoform 2. 1 PublicationVSP_052540Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129460 mRNA. Translation: BAC98270.1. Different initiation.
    BC092093 mRNA. Translation: AAH92093.1.
    BC125373 mRNA. Translation: AAI25374.1.
    BC125375 mRNA. Translation: AAI25376.1.
    CCDSiCCDS39720.1. [Q05A80-1]
    RefSeqiNP_853519.2. NM_181541.3. [Q05A80-1]
    XP_006507102.1. XM_006507039.1. [Q05A80-1]
    XP_006507105.1. XM_006507042.1. [Q05A80-2]
    UniGeneiMm.150568.

    Genome annotation databases

    EnsembliENSMUST00000072324; ENSMUSP00000072165; ENSMUSG00000030309. [Q05A80-2]
    ENSMUST00000111569; ENSMUSP00000107195; ENSMUSG00000030309. [Q05A80-1]
    GeneIDi232560.
    KEGGimmu:232560.
    UCSCiuc009eto.1. mouse. [Q05A80-2]
    uc009etp.1. mouse. [Q05A80-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK129460 mRNA. Translation: BAC98270.1 . Different initiation.
    BC092093 mRNA. Translation: AAH92093.1 .
    BC125373 mRNA. Translation: AAI25374.1 .
    BC125375 mRNA. Translation: AAI25376.1 .
    CCDSi CCDS39720.1. [Q05A80-1 ]
    RefSeqi NP_853519.2. NM_181541.3. [Q05A80-1 ]
    XP_006507102.1. XM_006507039.1. [Q05A80-1 ]
    XP_006507105.1. XM_006507042.1. [Q05A80-2 ]
    UniGenei Mm.150568.

    3D structure databases

    ProteinModelPortali Q05A80.
    SMRi Q05A80. Positions 903-1029.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q05A80.

    Proteomic databases

    PaxDbi Q05A80.
    PRIDEi Q05A80.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000072324 ; ENSMUSP00000072165 ; ENSMUSG00000030309 . [Q05A80-2 ]
    ENSMUST00000111569 ; ENSMUSP00000107195 ; ENSMUSG00000030309 . [Q05A80-1 ]
    GeneIDi 232560.
    KEGGi mmu:232560.
    UCSCi uc009eto.1. mouse. [Q05A80-2 ]
    uc009etp.1. mouse. [Q05A80-1 ]

    Organism-specific databases

    CTDi 65981.
    MGIi MGI:2448541. Caprin2.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG41180.
    GeneTreei ENSGT00730000110222.
    HOGENOMi HOG000082543.
    HOVERGENi HBG057777.
    InParanoidi Q05A80.
    OMAi AGWSDSS.
    OrthoDBi EOG74XS5W.
    TreeFami TF329471.

    Miscellaneous databases

    NextBioi 381151.
    PROi Q05A80.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q05A80.
    Bgeei Q05A80.
    CleanExi MM_CAPRIN2.
    Genevestigatori Q05A80.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR001073. C1q.
    IPR028816. Caprin.
    IPR022070. Caprin-1_C.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    PANTHERi PTHR22922. PTHR22922. 1 hit.
    Pfami PF00386. C1q. 1 hit.
    PF12287. Caprin-1_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00007. COMPLEMNTC1Q.
    SMARTi SM00110. C1Q. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50871. C1Q. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Embryonic tailImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: BrainImported and Mammary tumorImported.
    3. "RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain."
      Shiina N., Tokunaga M.
      J. Biol. Chem. 285:24260-24269(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCAPR2_MOUSE
    AccessioniPrimary (citable) accession number: Q05A80
    Secondary accession number(s): Q58E31, Q6ZPG7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3