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Protein

Caprin-2

Gene

Caprin2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (By similarity). Faciliates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (By similarity). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (PubMed:20516077). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (By similarity). May be involved in apoptosis (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi982Calcium 1; shared with neighboring subunitsBy similarity1
Metal bindingi988Calcium 2; shared with neighboring subunitsBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein synthesis inhibitor, RNA-binding
Biological processDifferentiation, Growth regulation
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Caprin-2
Alternative name(s):
C1q domain-containing protein 1
Cytoplasmic activation/proliferation-associated protein 2
RNA granule protein 140
Gene namesi
Name:Caprin2Imported
Synonyms:C1qdc1Imported, Kiaa1873Imported, Rng140
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:2448541. Caprin2.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell membrane; Peripheral membrane protein By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003020831 – 1031Caprin-2Add BLAST1031

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei852PhosphoserineCombined sources1
Modified residuei853PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ05A80.
PaxDbiQ05A80.
PRIDEiQ05A80.

PTM databases

iPTMnetiQ05A80.
PhosphoSitePlusiQ05A80.

Expressioni

Tissue specificityi

Specifically expressed in brain (at protein level).1 Publication

Developmental stagei

Detected at E17.5 in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000030309.
CleanExiMM_CAPRIN2.
ExpressionAtlasiQ05A80. baseline and differential.
GenevisibleiQ05A80. MM.

Interactioni

Subunit structurei

Homotrimer; via C1q domain. Found in a complex with LRP6, CCNY and CDK14 during G2/M stage; CAPRIN2 functions as a scaffold for the complex by binding to CCNY via its N terminus and to CDK14 via its C terminus. Interacts with LRP5. Interacts with LRP6.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107195.

Structurei

3D structure databases

ProteinModelPortaliQ05A80.
SMRiQ05A80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini897 – 1031C1qPROSITE-ProRule annotationAdd BLAST135

Domaini

The C1q domain is essential for the function in Wnt signaling.By similarity

Sequence similaritiesi

Belongs to the caprin family.Curated

Phylogenomic databases

eggNOGiENOG410IEA8. Eukaryota.
ENOG4110M5Q. LUCA.
GeneTreeiENSGT00760000119052.
HOGENOMiHOG000082543.
HOVERGENiHBG057777.
InParanoidiQ05A80.
KOiK18744.
OMAiAIYGSSW.
OrthoDBiEOG091G0UOF.
TreeFamiTF329471.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiView protein in InterPro
IPR001073. C1q_dom.
IPR028816. Caprin.
IPR022070. Caprin-1_C.
IPR008983. Tumour_necrosis_fac-like_dom.
PANTHERiPTHR22922. PTHR22922. 1 hit.
PfamiView protein in Pfam
PF00386. C1q. 1 hit.
PF12287. Caprin-1_C. 1 hit.
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiView protein in SMART
SM00110. C1Q. 1 hit.
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiView protein in PROSITE
PS50871. C1Q. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q05A80-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSAKSQVNQ DQQGENQRAL SPLQSTLSSA ASPSQAYETY IDNGLICLKH
60 70 80 90 100
KIRNIEKKKL KLEDYKDRLK NGEQLNPDQL EAVEKYEEVL HNLEFAKELQ
110 120 130 140 150
KTFSALSQDL LKAQKKAQRR EHMLKLETEK KKLRTMLQIQ YVLQNLTQEH
160 170 180 190 200
VQKDFKGGLN GAMYLPSKEL DYLIKFSKLT CPERNESLSV EDQMEQSSLY
210 220 230 240 250
FWDLLEGSEK TVVGTTYKHV KDLLSKLLHS GYFESVPVLR NSKEKAEEVL
260 270 280 290 300
MQSEMKKQLL KSESIKESES LTELVQPEIQ PQEFLNRRYM TEVKFSRKQE
310 320 330 340 350
NVEQSWEADY ARKPSLLKCW NTLPEPDGQE KKKESLESWK SSLKTQEVSK
360 370 380 390 400
PVVSLVQGKL RPTLQEEQKQ QVPITPVSQW KPESPKSKVG SPQEEQNVQE
410 420 430 440 450
TPKPWVVQSQ KEQDPKKLPP GSWAVSVQSE QSGSRSWTTP VCREQASVQP
460 470 480 490 500
GTPVSWENNA ENQKHSLVPQ SQISLKSWGA ASAGLLPNGQ VLTRKLNVEP
510 520 530 540 550
KDVPKPLPQP IDSSSALPKD PVLRKEKLQD LMSQIQGTYN FMQESVLDFD
560 570 580 590 600
KPSSAIPSSQ PPSACPVSTV SAEQNLSNQS DFLQEPSQAS SPVTCSSNAC
610 620 630 640 650
LVTTDQASSG SETEFTTSET PEMVVSPCKP KPASALASPN PPLSKSFQLP
660 670 680 690 700
PASGSSEAIS TAPFQAMQTV FNVNAPLPPR KEQEMKEPPY SSGYNQNFTS
710 720 730 740 750
SSTQTVSQCQ LPAVHIDQTT QPPETGAGYH PDGTVQVSNG SLAFYPAPTS
760 770 780 790 800
MFPRPAQPFI SSRGTLRGCS HGGRLLMSSY QSPGGYKGFD SYRGLPSVSS
810 820 830 840 850
GNYSQLQLQA REYSGTAYSQ RDNFQQCYKR SGTSSGLQAN SRAGWSDSSQ
860 870 880 890 900
VSSPERDSET FNSGDSGLGD SRSMTPVDVP VTSPAAAILP VHIYPLPQQM
910 920 930 940 950
RVAFSAARTS NLAPGTLDQP IVFDLLLNNL GETFDLQLGR FNCPVNGTYV
960 970 980 990 1000
FIFHMLKLAV NVPLYVNLMK NEEVLVSAYA NDGAPDHETA SNHAVLQLLQ
1010 1020 1030
GDQIWLRLHR GAIYGSSWKY STFSGYLLYQ D
Note: No experimental confirmation available.Curated
Length:1,031
Mass (Da):114,491
Last modified:November 14, 2006 - v1
Checksum:iDA2A62E64372F6A6
GO
Isoform 21 Publication (identifier: Q05A80-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-502: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:812
Mass (Da):89,745
Checksum:iC9E90D652EB98CC2
GO

Sequence cautioni

The sequence BAC98270 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti843Missing in BAC98270 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052540284 – 502Missing in isoform 2. 1 PublicationAdd BLAST219

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129460 mRNA. Translation: BAC98270.1. Different initiation.
BC092093 mRNA. Translation: AAH92093.1.
BC125373 mRNA. Translation: AAI25374.1.
BC125375 mRNA. Translation: AAI25376.1.
CCDSiCCDS39720.1. [Q05A80-1]
RefSeqiNP_001288280.1. NM_001301351.1.
NP_853519.2. NM_181541.4. [Q05A80-1]
XP_006507102.1. XM_006507039.3. [Q05A80-1]
XP_006507105.1. XM_006507042.3. [Q05A80-2]
XP_017177051.1. XM_017321562.1. [Q05A80-1]
UniGeneiMm.150568.
Mm.425358.

Genome annotation databases

EnsembliENSMUST00000072324; ENSMUSP00000072165; ENSMUSG00000030309. [Q05A80-2]
ENSMUST00000111569; ENSMUSP00000107195; ENSMUSG00000030309. [Q05A80-1]
GeneIDi232560.
KEGGimmu:232560.
UCSCiuc009eto.2. mouse. [Q05A80-2]
uc009etp.2. mouse. [Q05A80-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCAPR2_MOUSE
AccessioniPrimary (citable) accession number: Q05A80
Secondary accession number(s): Q58E31, Q6ZPG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: July 5, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families