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Q05A80

- CAPR2_MOUSE

UniProt

Q05A80 - CAPR2_MOUSE

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Protein

Caprin-2

Gene
Caprin2, C1qdc1, Kiaa1873, Rng140
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons. Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation. May be involved in apoptosis.1 Publication

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of cell growth Source: UniProtKB
  2. negative regulation of translation Source: UniProtKB-KW
  3. positive regulation of canonical Wnt signaling pathway Source: Ensembl
  4. positive regulation of dendrite morphogenesis Source: UniProtKB
  5. positive regulation of dendritic spine morphogenesis Source: UniProtKB
  6. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
  7. positive regulation of protein binding Source: Ensembl
  8. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Protein synthesis inhibitor

Keywords - Biological processi

Differentiation, Growth regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Caprin-2
Alternative name(s):
C1q domain-containing protein 1
Cytoplasmic activation/proliferation-associated protein 2
RNA granule protein 140
Gene namesi
Name:Caprin2
Synonyms:C1qdc1, Kiaa1873, Rng140
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2448541. Caprin2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. mitochondrion Source: UniProtKB
  3. receptor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10311031Caprin-2PRO_0000302083Add
BLAST

Proteomic databases

PaxDbiQ05A80.
PRIDEiQ05A80.

PTM databases

PhosphoSiteiQ05A80.

Expressioni

Tissue specificityi

Specifically expressed in brain (at protein level).1 Publication

Developmental stagei

Detected at E17.5 in brain (at protein level).1 Publication

Gene expression databases

ArrayExpressiQ05A80.
BgeeiQ05A80.
CleanExiMM_CAPRIN2.
GenevestigatoriQ05A80.

Structurei

3D structure databases

ProteinModelPortaliQ05A80.
SMRiQ05A80. Positions 903-1029.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini897 – 1031135C1qAdd
BLAST

Sequence similaritiesi

Belongs to the caprin family.
Contains 1 C1q domain.

Phylogenomic databases

eggNOGiNOG41180.
GeneTreeiENSGT00730000110222.
HOGENOMiHOG000082543.
HOVERGENiHBG057777.
InParanoidiQ05A80.
OMAiAGWSDSS.
OrthoDBiEOG74XS5W.
TreeFamiTF329471.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR001073. C1q.
IPR028816. Caprin.
IPR022070. Caprin-1_C.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PANTHERiPTHR22922. PTHR22922. 1 hit.
PfamiPF00386. C1q. 1 hit.
PF12287. Caprin-1_C. 1 hit.
[Graphical view]
PRINTSiPR00007. COMPLEMNTC1Q.
SMARTiSM00110. C1Q. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50871. C1Q. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q05A80-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKSAKSQVNQ DQQGENQRAL SPLQSTLSSA ASPSQAYETY IDNGLICLKH     50
KIRNIEKKKL KLEDYKDRLK NGEQLNPDQL EAVEKYEEVL HNLEFAKELQ 100
KTFSALSQDL LKAQKKAQRR EHMLKLETEK KKLRTMLQIQ YVLQNLTQEH 150
VQKDFKGGLN GAMYLPSKEL DYLIKFSKLT CPERNESLSV EDQMEQSSLY 200
FWDLLEGSEK TVVGTTYKHV KDLLSKLLHS GYFESVPVLR NSKEKAEEVL 250
MQSEMKKQLL KSESIKESES LTELVQPEIQ PQEFLNRRYM TEVKFSRKQE 300
NVEQSWEADY ARKPSLLKCW NTLPEPDGQE KKKESLESWK SSLKTQEVSK 350
PVVSLVQGKL RPTLQEEQKQ QVPITPVSQW KPESPKSKVG SPQEEQNVQE 400
TPKPWVVQSQ KEQDPKKLPP GSWAVSVQSE QSGSRSWTTP VCREQASVQP 450
GTPVSWENNA ENQKHSLVPQ SQISLKSWGA ASAGLLPNGQ VLTRKLNVEP 500
KDVPKPLPQP IDSSSALPKD PVLRKEKLQD LMSQIQGTYN FMQESVLDFD 550
KPSSAIPSSQ PPSACPVSTV SAEQNLSNQS DFLQEPSQAS SPVTCSSNAC 600
LVTTDQASSG SETEFTTSET PEMVVSPCKP KPASALASPN PPLSKSFQLP 650
PASGSSEAIS TAPFQAMQTV FNVNAPLPPR KEQEMKEPPY SSGYNQNFTS 700
SSTQTVSQCQ LPAVHIDQTT QPPETGAGYH PDGTVQVSNG SLAFYPAPTS 750
MFPRPAQPFI SSRGTLRGCS HGGRLLMSSY QSPGGYKGFD SYRGLPSVSS 800
GNYSQLQLQA REYSGTAYSQ RDNFQQCYKR SGTSSGLQAN SRAGWSDSSQ 850
VSSPERDSET FNSGDSGLGD SRSMTPVDVP VTSPAAAILP VHIYPLPQQM 900
RVAFSAARTS NLAPGTLDQP IVFDLLLNNL GETFDLQLGR FNCPVNGTYV 950
FIFHMLKLAV NVPLYVNLMK NEEVLVSAYA NDGAPDHETA SNHAVLQLLQ 1000
GDQIWLRLHR GAIYGSSWKY STFSGYLLYQ D 1031

Note: No experimental confirmation available.

Length:1,031
Mass (Da):114,491
Last modified:November 14, 2006 - v1
Checksum:iDA2A62E64372F6A6
GO
Isoform 21 Publication (identifier: Q05A80-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     284-502: Missing.

Note: No experimental confirmation available.

Show »
Length:812
Mass (Da):89,745
Checksum:iC9E90D652EB98CC2
GO

Sequence cautioni

The sequence BAC98270.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei284 – 502219Missing in isoform 2. 1 PublicationVSP_052540Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti843 – 8431Missing in BAC98270. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129460 mRNA. Translation: BAC98270.1. Different initiation.
BC092093 mRNA. Translation: AAH92093.1.
BC125373 mRNA. Translation: AAI25374.1.
BC125375 mRNA. Translation: AAI25376.1.
CCDSiCCDS39720.1. [Q05A80-1]
RefSeqiNP_853519.2. NM_181541.3. [Q05A80-1]
XP_006507102.1. XM_006507039.1. [Q05A80-1]
XP_006507105.1. XM_006507042.1. [Q05A80-2]
UniGeneiMm.150568.

Genome annotation databases

EnsembliENSMUST00000072324; ENSMUSP00000072165; ENSMUSG00000030309. [Q05A80-2]
ENSMUST00000111569; ENSMUSP00000107195; ENSMUSG00000030309. [Q05A80-1]
GeneIDi232560.
KEGGimmu:232560.
UCSCiuc009eto.1. mouse. [Q05A80-2]
uc009etp.1. mouse. [Q05A80-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK129460 mRNA. Translation: BAC98270.1 . Different initiation.
BC092093 mRNA. Translation: AAH92093.1 .
BC125373 mRNA. Translation: AAI25374.1 .
BC125375 mRNA. Translation: AAI25376.1 .
CCDSi CCDS39720.1. [Q05A80-1 ]
RefSeqi NP_853519.2. NM_181541.3. [Q05A80-1 ]
XP_006507102.1. XM_006507039.1. [Q05A80-1 ]
XP_006507105.1. XM_006507042.1. [Q05A80-2 ]
UniGenei Mm.150568.

3D structure databases

ProteinModelPortali Q05A80.
SMRi Q05A80. Positions 903-1029.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q05A80.

Proteomic databases

PaxDbi Q05A80.
PRIDEi Q05A80.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000072324 ; ENSMUSP00000072165 ; ENSMUSG00000030309 . [Q05A80-2 ]
ENSMUST00000111569 ; ENSMUSP00000107195 ; ENSMUSG00000030309 . [Q05A80-1 ]
GeneIDi 232560.
KEGGi mmu:232560.
UCSCi uc009eto.1. mouse. [Q05A80-2 ]
uc009etp.1. mouse. [Q05A80-1 ]

Organism-specific databases

CTDi 65981.
MGIi MGI:2448541. Caprin2.
Rougei Search...

Phylogenomic databases

eggNOGi NOG41180.
GeneTreei ENSGT00730000110222.
HOGENOMi HOG000082543.
HOVERGENi HBG057777.
InParanoidi Q05A80.
OMAi AGWSDSS.
OrthoDBi EOG74XS5W.
TreeFami TF329471.

Miscellaneous databases

NextBioi 381151.
PROi Q05A80.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q05A80.
Bgeei Q05A80.
CleanExi MM_CAPRIN2.
Genevestigatori Q05A80.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR001073. C1q.
IPR028816. Caprin.
IPR022070. Caprin-1_C.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
PANTHERi PTHR22922. PTHR22922. 1 hit.
Pfami PF00386. C1q. 1 hit.
PF12287. Caprin-1_C. 1 hit.
[Graphical view ]
PRINTSi PR00007. COMPLEMNTC1Q.
SMARTi SM00110. C1Q. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
PROSITEi PS50871. C1Q. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Embryonic tail.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Mammary tumor.
  3. "RNA granule protein 140 (RNG140), a paralog of RNG105 localized to distinct RNA granules in neuronal dendrites in the adult vertebrate brain."
    Shiina N., Tokunaga M.
    J. Biol. Chem. 285:24260-24269(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCAPR2_MOUSE
AccessioniPrimary (citable) accession number: Q05A80
Secondary accession number(s): Q58E31, Q6ZPG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: November 14, 2006
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi