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Protein

Dynein light chain 1, axonemal

Gene

Dnal1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 1, axonemal
Gene namesi
Name:Dnal1
Synonyms:Dnalc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1921462. Dnal1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 190189Dynein light chain 1, axonemalPRO_0000281131Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei56 – 561PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ05A62.
PaxDbiQ05A62.
PRIDEiQ05A62.

PTM databases

iPTMnetiQ05A62.
PhosphoSiteiQ05A62.

Expressioni

Tissue specificityi

Expressed in the respiratory epithelium of the upper airways and the ependymal cells lining the brain ventricles.1 Publication

Gene expression databases

BgeeiENSMUSG00000042523.
CleanExiMM_DNALC1.
ExpressionAtlasiQ05A62. baseline and differential.
GenevisibleiQ05A62. MM.

Interactioni

Subunit structurei

Interacts with DNAH5.By similarity

Protein-protein interaction databases

BioGridi222746. 1 interaction.
STRINGi10090.ENSMUSP00000121038.

Structurei

3D structure databases

ProteinModelPortaliQ05A62.
SMRiQ05A62. Positions 1-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati49 – 7022LRR 1Add
BLAST
Repeati71 – 9222LRR 2Add
BLAST
Repeati94 – 11522LRR 3Add
BLAST
Repeati116 – 13722LRR 4Add
BLAST
Domaini150 – 19041LRRCTAdd
BLAST

Sequence similaritiesi

Belongs to the dynein light chain LC1-type family.Curated
Contains 4 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00390000016904.
HOGENOMiHOG000230603.
HOVERGENiHBG081457.
InParanoidiQ05A62.
KOiK10411.
OMAiKWEEKNG.
OrthoDBiEOG091G0P8H.
PhylomeDBiQ05A62.
TreeFamiTF323974.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q05A62-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKATTIKEA LSRWEEKTGQ KPSDAKEIKL YAQIPPIEKM DASLSTLGNC
60 70 80 90 100
EKLSLSTNCI EKIANLNGLK NLRILSLGRN NIKNLNGLEA VGETLEELWI
110 120 130 140 150
SYNFIEKLKG IHVMKKLKIL YMSNNLVKDW AEFLKLAELP CLEDLVFVGN
160 170 180 190
PLEEKHSAEG NWIDEATKRV PKLKKLDGTP VIKEDEEEES
Length:190
Mass (Da):21,465
Last modified:March 20, 2007 - v2
Checksum:i7052EB49CDCE4A0B
GO
Isoform 2 (identifier: Q05A62-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-14: Missing.
     15-15: E → M

Note: No experimental confirmation available.
Show »
Length:177
Mass (Da):20,010
Checksum:iDB170C2A3B075B4B
GO
Isoform 3 (identifier: Q05A62-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Show »
Length:151
Mass (Da):17,054
Checksum:iC239D4222AB5681A
GO

Sequence cautioni

The sequence AAI25395 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti147 – 1471F → L in BAB24259 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3939Missing in isoform 3. 2 PublicationsVSP_023985Add
BLAST
Alternative sequencei2 – 1413Missing in isoform 2. 1 PublicationVSP_023984Add
BLAST
Alternative sequencei15 – 151E → M in isoform 2. 1 PublicationVSP_023983

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005826 mRNA. Translation: BAB24259.1.
BC125392 mRNA. Translation: AAI25393.1.
BC125394 mRNA. Translation: AAI25395.2. Different initiation.
BG916281 mRNA. No translation available.
CCDSiCCDS26039.2. [Q05A62-1]
RefSeqiNP_083097.2. NM_028821.3. [Q05A62-1]
XP_006515434.1. XM_006515371.2. [Q05A62-3]
UniGeneiMm.101525.

Genome annotation databases

EnsembliENSMUST00000046340; ENSMUSP00000037076; ENSMUSG00000042523. [Q05A62-3]
ENSMUST00000123491; ENSMUSP00000121038; ENSMUSG00000042523. [Q05A62-1]
GeneIDi105000.
KEGGimmu:105000.
UCSCiuc007oek.2. mouse. [Q05A62-1]
uc011yot.1. mouse. [Q05A62-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005826 mRNA. Translation: BAB24259.1.
BC125392 mRNA. Translation: AAI25393.1.
BC125394 mRNA. Translation: AAI25395.2. Different initiation.
BG916281 mRNA. No translation available.
CCDSiCCDS26039.2. [Q05A62-1]
RefSeqiNP_083097.2. NM_028821.3. [Q05A62-1]
XP_006515434.1. XM_006515371.2. [Q05A62-3]
UniGeneiMm.101525.

3D structure databases

ProteinModelPortaliQ05A62.
SMRiQ05A62. Positions 1-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi222746. 1 interaction.
STRINGi10090.ENSMUSP00000121038.

PTM databases

iPTMnetiQ05A62.
PhosphoSiteiQ05A62.

Proteomic databases

MaxQBiQ05A62.
PaxDbiQ05A62.
PRIDEiQ05A62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046340; ENSMUSP00000037076; ENSMUSG00000042523. [Q05A62-3]
ENSMUST00000123491; ENSMUSP00000121038; ENSMUSG00000042523. [Q05A62-1]
GeneIDi105000.
KEGGimmu:105000.
UCSCiuc007oek.2. mouse. [Q05A62-1]
uc011yot.1. mouse. [Q05A62-2]

Organism-specific databases

CTDi83544.
MGIiMGI:1921462. Dnal1.

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00390000016904.
HOGENOMiHOG000230603.
HOVERGENiHBG081457.
InParanoidiQ05A62.
KOiK10411.
OMAiKWEEKNG.
OrthoDBiEOG091G0P8H.
PhylomeDBiQ05A62.
TreeFamiTF323974.

Miscellaneous databases

PROiQ05A62.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042523.
CleanExiMM_DNALC1.
ExpressionAtlasiQ05A62. baseline and differential.
GenevisibleiQ05A62. MM.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAL1_MOUSE
AccessioniPrimary (citable) accession number: Q05A62
Secondary accession number(s): A0JLX1, Q9DAH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: September 7, 2016
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.