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Protein

Dynein light chain 1, axonemal

Gene

Dnal1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain 1, axonemal
Gene namesi
Name:Dnal1
Synonyms:Dnalc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1921462. Dnal1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002811312 – 190Dynein light chain 1, axonemalAdd BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei56PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ05A62.
PaxDbiQ05A62.
PRIDEiQ05A62.

PTM databases

iPTMnetiQ05A62.
PhosphoSitePlusiQ05A62.

Expressioni

Tissue specificityi

Expressed in the respiratory epithelium of the upper airways and the ependymal cells lining the brain ventricles.1 Publication

Gene expression databases

BgeeiENSMUSG00000042523.
CleanExiMM_DNALC1.
ExpressionAtlasiQ05A62. baseline and differential.
GenevisibleiQ05A62. MM.

Interactioni

Subunit structurei

Interacts with DNAH5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi222746. 1 interactor.
STRINGi10090.ENSMUSP00000121038.

Structurei

3D structure databases

ProteinModelPortaliQ05A62.
SMRiQ05A62.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati49 – 70LRR 1Add BLAST22
Repeati71 – 92LRR 2Add BLAST22
Repeati94 – 115LRR 3Add BLAST22
Repeati116 – 137LRR 4Add BLAST22
Domaini150 – 190LRRCTAdd BLAST41

Sequence similaritiesi

Belongs to the dynein light chain LC1-type family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00390000016904.
HOGENOMiHOG000230603.
HOVERGENiHBG081457.
InParanoidiQ05A62.
KOiK10411.
OMAiLWISYNN.
OrthoDBiEOG091G0P8H.
PhylomeDBiQ05A62.
TreeFamiTF323974.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 4 hits.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q05A62-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKATTIKEA LSRWEEKTGQ KPSDAKEIKL YAQIPPIEKM DASLSTLGNC
60 70 80 90 100
EKLSLSTNCI EKIANLNGLK NLRILSLGRN NIKNLNGLEA VGETLEELWI
110 120 130 140 150
SYNFIEKLKG IHVMKKLKIL YMSNNLVKDW AEFLKLAELP CLEDLVFVGN
160 170 180 190
PLEEKHSAEG NWIDEATKRV PKLKKLDGTP VIKEDEEEES
Length:190
Mass (Da):21,465
Last modified:March 20, 2007 - v2
Checksum:i7052EB49CDCE4A0B
GO
Isoform 2 (identifier: Q05A62-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-14: Missing.
     15-15: E → M

Note: No experimental confirmation available.
Show »
Length:177
Mass (Da):20,010
Checksum:iDB170C2A3B075B4B
GO
Isoform 3 (identifier: Q05A62-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Show »
Length:151
Mass (Da):17,054
Checksum:iC239D4222AB5681A
GO

Sequence cautioni

The sequence AAI25395 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147F → L in BAB24259 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0239851 – 39Missing in isoform 3. 2 PublicationsAdd BLAST39
Alternative sequenceiVSP_0239842 – 14Missing in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_02398315E → M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005826 mRNA. Translation: BAB24259.1.
BC125392 mRNA. Translation: AAI25393.1.
BC125394 mRNA. Translation: AAI25395.2. Different initiation.
BG916281 mRNA. No translation available.
CCDSiCCDS26039.2. [Q05A62-1]
CCDS83987.1. [Q05A62-3]
RefSeqiNP_001333457.1. NM_001346528.1. [Q05A62-3]
NP_083097.2. NM_028821.3. [Q05A62-1]
UniGeneiMm.101525.

Genome annotation databases

EnsembliENSMUST00000046340; ENSMUSP00000037076; ENSMUSG00000042523. [Q05A62-3]
ENSMUST00000123491; ENSMUSP00000121038; ENSMUSG00000042523. [Q05A62-1]
GeneIDi105000.
KEGGimmu:105000.
UCSCiuc007oek.2. mouse. [Q05A62-1]
uc011yot.1. mouse. [Q05A62-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDNAL1_MOUSE
AccessioniPrimary (citable) accession number: Q05A62
Secondary accession number(s): A0JLX1, Q9DAH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: September 27, 2017
This is version 83 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families