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Q05A56

- HYAL4_MOUSE

UniProt

Q05A56 - HYAL4_MOUSE

Protein

Hyaluronidase-4

Gene

Hyal4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (14 Nov 2006)
      Previous versions | rss
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    Functioni

    Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide By similarity.By similarity

    Catalytic activityi

    Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei147 – 1471Proton donorBy similarity

    GO - Molecular functioni

    1. hyalurononglucosaminidase activity Source: MGI

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. chondroitin sulfate catabolic process Source: MGI

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Protein family/group databases

    CAZyiGH56. Glycoside Hydrolase Family 56.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronidase-4 (EC:3.2.1.35)
    Short name:
    Hyal-4
    Alternative name(s):
    Chondroitin sulfate endo-beta-N-acetylgalactosaminidase
    Chondroitin sulfate hydrolase
    Short name:
    CSHY
    Hyaluronoglucosaminidase-4
    Gene namesi
    Name:Hyal4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1924292. Hyal4.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 481481Hyaluronidase-4PRO_0000302000Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi59 ↔ 351By similarity
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi223 ↔ 237By similarity
    Glycosylationi232 – 2321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi343 – 3431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi376 ↔ 387By similarity
    Disulfide bondi381 ↔ 435By similarity
    Disulfide bondi437 ↔ 446By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ05A56.
    PRIDEiQ05A56.

    PTM databases

    PhosphoSiteiQ05A56.

    Expressioni

    Gene expression databases

    BgeeiQ05A56.
    CleanExiMM_HYAL4.
    GenevestigatoriQ05A56.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000031691.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05A56.
    SMRiQ05A56. Positions 39-446.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1111CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini33 – 455423ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini477 – 4815CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei12 – 3221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei456 – 47621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi459 – 4646Poly-Ser

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 56 family.Curated

    Keywords - Domaini

    EGF-like domain, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG77606.
    GeneTreeiENSGT00550000074476.
    HOGENOMiHOG000015133.
    HOVERGENiHBG052053.
    InParanoidiQ05A56.
    KOiK01197.
    OMAiWNTKDVY.
    OrthoDBiEOG74J97S.
    PhylomeDBiQ05A56.
    TreeFamiTF321598.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    [Graphical view]
    PANTHERiPTHR11769. PTHR11769. 1 hit.
    PfamiPF01630. Glyco_hydro_56. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
    PRINTSiPR00846. GLHYDRLASE56.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05A56-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQLLPEGQLR LCVFQPVHLT SGLLILFILK SISSLKPARL PVYQRKPFIA    50
    AWNAPTDLCL IKYNLTLNLK VFQMVGSPRL KDRGQNVVIF YANRLGYYPW 100
    YTSEGVPING GLPQNTSLQV HLKKAAQDIN YYIPSENFSG LAVIDWEYWR 150
    PQWARNWNTK DIYRQKSRTL ISDMKENISA ADIEYSAKAT FEKSAKAFME 200
    ETIKLGSKSR PKGLWGYYLY PDCHNYNVYA TNYTGSCPEE EVLRNNDLSW 250
    LWNSSTALYP AVSIRKSFAD SENTLHFSRF RVRESLRIST MTSQDYALPV 300
    FVYTQLGYKE EPLLFLSKQD LISTIGESAA LGAAGIVVWG DMNLTSSEEN 350
    CTKVNRFVNS DFGSYIINVT RAAEVCSRHL CKNNGRCVRK TWKAAHYLHL 400
    NPASYHIEAS EDGEFIVRGR ASDTDLAVMA ENFLCHCYEG YEGADCREMT 450
    EASGPSGLSL SSSSVITLCL LVLAGYQSIQ L 481
    Length:481
    Mass (Da):54,385
    Last modified:November 14, 2006 - v1
    Checksum:i388B46DDD9EFDB40
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti124 – 1263KAA → GAG in BAB29454. (PubMed:16141072)Curated
    Sequence conflicti316 – 3172LS → PF in BAB29454. (PubMed:16141072)Curated
    Sequence conflicti376 – 3761C → S in BAB29454. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014599 mRNA. Translation: BAB29454.1.
    BC125402 mRNA. Translation: AAI25403.1.
    BC132096 mRNA. Translation: AAI32097.1.
    CCDSiCCDS39441.1.
    RefSeqiNP_084124.1. NM_029848.1.
    UniGeneiMm.66017.

    Genome annotation databases

    EnsembliENSMUST00000031691; ENSMUSP00000031691; ENSMUSG00000029680.
    GeneIDi77042.
    KEGGimmu:77042.
    UCSCiuc009bbx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK014599 mRNA. Translation: BAB29454.1 .
    BC125402 mRNA. Translation: AAI25403.1 .
    BC132096 mRNA. Translation: AAI32097.1 .
    CCDSi CCDS39441.1.
    RefSeqi NP_084124.1. NM_029848.1.
    UniGenei Mm.66017.

    3D structure databases

    ProteinModelPortali Q05A56.
    SMRi Q05A56. Positions 39-446.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000031691.

    Protein family/group databases

    CAZyi GH56. Glycoside Hydrolase Family 56.

    PTM databases

    PhosphoSitei Q05A56.

    Proteomic databases

    PaxDbi Q05A56.
    PRIDEi Q05A56.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031691 ; ENSMUSP00000031691 ; ENSMUSG00000029680 .
    GeneIDi 77042.
    KEGGi mmu:77042.
    UCSCi uc009bbx.1. mouse.

    Organism-specific databases

    CTDi 23553.
    MGIi MGI:1924292. Hyal4.

    Phylogenomic databases

    eggNOGi NOG77606.
    GeneTreei ENSGT00550000074476.
    HOGENOMi HOG000015133.
    HOVERGENi HBG052053.
    InParanoidi Q05A56.
    KOi K01197.
    OMAi WNTKDVY.
    OrthoDBi EOG74J97S.
    PhylomeDBi Q05A56.
    TreeFami TF321598.

    Miscellaneous databases

    NextBioi 346362.
    PROi Q05A56.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q05A56.
    CleanExi MM_HYAL4.
    Genevestigatori Q05A56.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    [Graphical view ]
    PANTHERi PTHR11769. PTHR11769. 1 hit.
    Pfami PF01630. Glyco_hydro_56. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
    PRINTSi PR00846. GLHYDRLASE56.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Skin.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiHYAL4_MOUSE
    AccessioniPrimary (citable) accession number: Q05A56
    Secondary accession number(s): Q9D660
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: November 14, 2006
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3