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Protein

RNA-binding E3 ubiquitin-protein ligase MEX3C

Gene

Mex3c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri601 – 64141RING-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • chondrocyte hypertrophy Source: MGI
  • energy homeostasis Source: MGI
  • mitophagy in response to mitochondrial depolarization Source: MGI
  • regulation of fat cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding E3 ubiquitin-protein ligase MEX3C (EC:6.3.2.-)
Alternative name(s):
RING finger and KH domain-containing protein 2
Gene namesi
Name:Mex3c
Synonyms:Rkhd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2652843. Mex3c.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 652652RNA-binding E3 ubiquitin-protein ligase MEX3CPRO_0000278783Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ05A36.
PaxDbiQ05A36.
PRIDEiQ05A36.

PTM databases

iPTMnetiQ05A36.
PhosphoSiteiQ05A36.

Expressioni

Gene expression databases

BgeeiQ05A36.
CleanExiMM_MEX3C.
GenevisibleiQ05A36. MM.

Interactioni

Subunit structurei

Interacts with USP7, which antagonizes the ability to degrade mRNA.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089463.

Structurei

3D structure databases

ProteinModelPortaliQ05A36.
SMRiQ05A36. Positions 319-389, 600-646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 28662KH 1PROSITE-ProRule annotationAdd
BLAST
Domaini319 – 38062KH 2PROSITE-ProRule annotationAdd
BLAST

Domaini

Binds RNA through its KH domains.By similarity

Sequence similaritiesi

Contains 2 KH domains.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri601 – 64141RING-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2113. Eukaryota.
ENOG410Y337. LUCA.
GeneTreeiENSGT00390000018714.
HOGENOMiHOG000236282.
HOVERGENiHBG071698.
InParanoidiQ05A36.
KOiK15686.
OMAiRNKNGPT.
OrthoDBiEOG7D85WG.
PhylomeDBiQ05A36.
TreeFamiTF315107.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00013. KH_1. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiPS50084. KH_TYPE_1. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05A36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSGSSAALA LALAAAPAPL PQPPPLPPPP PAGGPELEGD GLLLRERLAA
60 70 80 90 100
LGLDDPSPAE PGAPALRAAA VAAAAAAQCQ ARRATGLAPE EPGRLATSET
110 120 130 140 150
AELELEVDEE EGEEAELDGE LLEEEELEEA EEEDRPSLLL LSPPAATASQ
160 170 180 190 200
TQPIPGGPLG SVLLPAAGFD AREAAAAGVL YGGDDAQGMM AAMLSHAYGP
210 220 230 240 250
GGGGAAAAAL NGEQAALLRR KSVNTTECVP VPSSEHVAEI VGRQGCKIKA
260 270 280 290 300
LRAKTNTYIK TPVRGEEPIF VVTGRKEDVA MAKREILSAA EHFSMIRASR
310 320 330 340 350
NKNGPALGGL SCSPNLPGQT TVQVRVPYRV VGLVVGPKGA TIKRIQQQTH
360 370 380 390 400
TYIVTPSRDK EPVFEVTGMP ENVDRAREEI EMHIAMRTGN YIELNEENDF
410 420 430 440 450
HYNGTDVSFE GGTLGSAWLS SNPVPPSRAR MMSNYRNDSS SSLGSGSTDS
460 470 480 490 500
YFGSNRLADF SPTSPFSTGN FWFGDTLPSV GSEDLTVDSP AFDSLPTSAQ
510 520 530 540 550
TIWTPFEPVN PLSGFGSDPS GNMKTQRRGS QPSTPRLSPT FPESIEHPLA
560 570 580 590 600
RRVRSDPPST GNHVGLPIYI PAFSNGTNSY SSSNGGSTSS SPPESRRKHD
610 620 630 640 650
CVICFENEVI AALVPCGHNL FCMECANKIC EKRTPSCPVC QTAVTQAIQI

HS
Length:652
Mass (Da):68,574
Last modified:March 20, 2007 - v2
Checksum:i74CF20585E55FB9C
GO

Sequence cautioni

The sequence AAI25428.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134447 Genomic DNA. No translation available.
BC108422 mRNA. Translation: AAI08423.1.
BC125427 mRNA. Translation: AAI25428.1. Different initiation.
CCDSiCCDS50318.1.
RefSeqiNP_001034303.3. NM_001039214.4.
UniGeneiMm.24131.
Mm.436942.

Genome annotation databases

EnsembliENSMUST00000091852; ENSMUSP00000089463; ENSMUSG00000037253.
GeneIDi240396.
KEGGimmu:240396.
UCSCiuc008fot.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC134447 Genomic DNA. No translation available.
BC108422 mRNA. Translation: AAI08423.1.
BC125427 mRNA. Translation: AAI25428.1. Different initiation.
CCDSiCCDS50318.1.
RefSeqiNP_001034303.3. NM_001039214.4.
UniGeneiMm.24131.
Mm.436942.

3D structure databases

ProteinModelPortaliQ05A36.
SMRiQ05A36. Positions 319-389, 600-646.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089463.

PTM databases

iPTMnetiQ05A36.
PhosphoSiteiQ05A36.

Proteomic databases

MaxQBiQ05A36.
PaxDbiQ05A36.
PRIDEiQ05A36.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091852; ENSMUSP00000089463; ENSMUSG00000037253.
GeneIDi240396.
KEGGimmu:240396.
UCSCiuc008fot.2. mouse.

Organism-specific databases

CTDi51320.
MGIiMGI:2652843. Mex3c.

Phylogenomic databases

eggNOGiKOG2113. Eukaryota.
ENOG410Y337. LUCA.
GeneTreeiENSGT00390000018714.
HOGENOMiHOG000236282.
HOVERGENiHBG071698.
InParanoidiQ05A36.
KOiK15686.
OMAiRNKNGPT.
OrthoDBiEOG7D85WG.
PhylomeDBiQ05A36.
TreeFamiTF315107.

Miscellaneous databases

ChiTaRSiMex3c. mouse.
PROiQ05A36.
SOURCEiSearch...

Gene expression databases

BgeeiQ05A36.
CleanExiMM_MEX3C.
GenevisibleiQ05A36. MM.

Family and domain databases

Gene3Di3.30.1370.10. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00013. KH_1. 2 hits.
[Graphical view]
SMARTiSM00322. KH. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 2 hits.
PROSITEiPS50084. KH_TYPE_1. 2 hits.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 128-652.
    Tissue: Brain.

Entry informationi

Entry nameiMEX3C_MOUSE
AccessioniPrimary (citable) accession number: Q05A36
Secondary accession number(s): Q2VPQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 20, 2007
Last modified: June 8, 2016
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.