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Protein

DC-STAMP domain-containing protein 1

Gene

Dcst1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri672 – 711RING-type; degenerateAdd BLAST40

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
DC-STAMP domain-containing protein 1
Gene namesi
Name:Dcst1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1925022. Dcst1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 46CytoplasmicSequence analysisAdd BLAST46
Transmembranei47 – 67HelicalSequence analysisAdd BLAST21
Topological domaini68 – 76ExtracellularSequence analysis9
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 107CytoplasmicSequence analysis10
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 394ExtracellularSequence analysisAdd BLAST266
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 489CytoplasmicSequence analysisAdd BLAST74
Transmembranei490 – 510HelicalSequence analysisAdd BLAST21
Topological domaini511 – 576ExtracellularSequence analysisAdd BLAST66
Transmembranei577 – 597HelicalSequence analysisAdd BLAST21
Topological domaini598 – 732CytoplasmicSequence analysisAdd BLAST135

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002788251 – 732DC-STAMP domain-containing protein 1Add BLAST732

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi184N-linked (GlcNAc...)Sequence analysis1
Glycosylationi217N-linked (GlcNAc...)Sequence analysis1
Glycosylationi346N-linked (GlcNAc...)Sequence analysis1
Glycosylationi374N-linked (GlcNAc...)Sequence analysis1
Glycosylationi551N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ059Y8.
PRIDEiQ059Y8.

PTM databases

PhosphoSitePlusiQ059Y8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000042672.
CleanExiMM_DCST1.
GenevisibleiQ059Y8. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065502.

Structurei

3D structure databases

ProteinModelPortaliQ059Y8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 RING-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri672 – 711RING-type; degenerateAdd BLAST40

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG3726. Eukaryota.
ENOG410ZWQR. LUCA.
GeneTreeiENSGT00730000110972.
HOGENOMiHOG000112180.
HOVERGENiHBG081422.
InParanoidiQ059Y8.
OMAiLMAKPFT.
OrthoDBiEOG091G0GX3.
TreeFamiTF318254.

Family and domain databases

InterProiIPR012858. DC_STAMP-like.
[Graphical view]
PfamiPF07782. DC_STAMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q059Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLSSTLHS LGIFEKISRI KEVLKNRLLD LTKRRDQARE QQRKRPHTII
60 70 80 90 100
QGLLLWSLPV SWIRFLWRQP GEFPVTAFLL GAGTGGLLAI GLFQLLVNPM
110 120 130 140 150
NIYEEQKVVA LYCLASLGAI GWGTSPHIRC ASLLLVPKML GKEGRLFVMG
160 170 180 190 200
YALAAIYSGP AANLRSNINE VIASLGCTVE LQINNTRSAW RVSTAPLRAV
210 220 230 240 250
FKGMVGSKDS LNKEIQNVST SFEEMDEQVK SDAGYSSEDW DKNRESTEMF
260 270 280 290 300
GTSRVRPYLS TQMVYELRTR LRCIHVVNKA ILSCYRWFDK KHKNCMRRIH
310 320 330 340 350
LPLFNNMICV PMKFKFLCNI AKVIEIWCYK RIPVEGNFGQ TYDSVNQSIH
360 370 380 390 400
GLSGEFSANI NLKEEKQSSM VGLNTTNWEH MGTEVRDYVR QQETYLQWAM
410 420 430 440 450
GLLHVLLSCT FLLVFHSAFS YMDHYNWDIR FDNIYISTYF CQIDARRKKL
460 470 480 490 500
GKQSLLPLRK AERKTVIFPF KATIQAWEMR YVIRELLETL PIVLLLLVLC
510 520 530 540 550
AIDWALYSVF DTIRQHSFVQ YSFRSSHKLE IKVEGDSILA KLLRKTIGAL
560 570 580 590 600
NTSSSTDVET NNMPCLPQPI SLNARDYFKA SLPTLLLVCL CLAQAFGYRL
610 620 630 640 650
RRVIAAFYFP KREKKRALFF YNEFLKKRSA FTKLRRAAIV RRANQQKAPP
660 670 680 690 700
HYLVEALYRR CPLLHRFMRQ RCVVCQAMET PDSYVCPTPD CKALYCRSCW
710 720 730
DDMQRLCPVC TPREELSSSA HSDSNDDAVY GD
Length:732
Mass (Da):84,332
Last modified:November 14, 2006 - v1
Checksum:i22AB2CD98AC17CD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125478 mRNA. Translation: AAI25479.1.
BC125480 mRNA. Translation: AAI25481.1.
CCDSiCCDS38490.1.
RefSeqiNP_084250.1. NM_029974.2.
UniGeneiMm.164013.

Genome annotation databases

EnsembliENSMUST00000070820; ENSMUSP00000065502; ENSMUSG00000042672.
GeneIDi77772.
KEGGimmu:77772.
UCSCiuc008pyy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125478 mRNA. Translation: AAI25479.1.
BC125480 mRNA. Translation: AAI25481.1.
CCDSiCCDS38490.1.
RefSeqiNP_084250.1. NM_029974.2.
UniGeneiMm.164013.

3D structure databases

ProteinModelPortaliQ059Y8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065502.

PTM databases

PhosphoSitePlusiQ059Y8.

Proteomic databases

PaxDbiQ059Y8.
PRIDEiQ059Y8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000070820; ENSMUSP00000065502; ENSMUSG00000042672.
GeneIDi77772.
KEGGimmu:77772.
UCSCiuc008pyy.1. mouse.

Organism-specific databases

CTDi149095.
MGIiMGI:1925022. Dcst1.

Phylogenomic databases

eggNOGiKOG3726. Eukaryota.
ENOG410ZWQR. LUCA.
GeneTreeiENSGT00730000110972.
HOGENOMiHOG000112180.
HOVERGENiHBG081422.
InParanoidiQ059Y8.
OMAiLMAKPFT.
OrthoDBiEOG091G0GX3.
TreeFamiTF318254.

Miscellaneous databases

PROiQ059Y8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042672.
CleanExiMM_DCST1.
GenevisibleiQ059Y8. MM.

Family and domain databases

InterProiIPR012858. DC_STAMP-like.
[Graphical view]
PfamiPF07782. DC_STAMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCST1_MOUSE
AccessioniPrimary (citable) accession number: Q059Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: November 14, 2006
Last modified: November 2, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.