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Protein

Thiamine transporter

Gene

THI7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for intake of thiamine.

GO - Molecular functioni

  • 5-amino-1-ribofuranosylimidazole-4-carboxamide transporter activity Source: SGD
  • nucleobase transmembrane transporter activity Source: GO_Central
  • thiamine transmembrane transporter activity Source: SGD

GO - Biological processi

  • 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport Source: SGD
  • nucleobase transport Source: GO_Central
  • thiamine transport Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-32346-MONOMER.

Protein family/group databases

TCDBi2.A.39.4.1. the nucleobase:cation symporter-1 (ncs1) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine transporter
Gene namesi
Name:THI7
Synonyms:THI10
Ordered Locus Names:YLR237W
ORF Names:L8083.2
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR237W.
SGDiS000004227. THI7.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Topological domaini63 – 73ExtracellularSequence analysisAdd BLAST11
Transmembranei74 – 94HelicalSequence analysisAdd BLAST21
Topological domaini95 – 111CytoplasmicSequence analysisAdd BLAST17
Transmembranei112 – 132HelicalSequence analysisAdd BLAST21
Topological domaini133 – 173ExtracellularSequence analysisAdd BLAST41
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Topological domaini195 – 197CytoplasmicSequence analysis3
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 240ExtracellularSequence analysisAdd BLAST22
Transmembranei241 – 261HelicalSequence analysisAdd BLAST21
Topological domaini262 – 274CytoplasmicSequence analysisAdd BLAST13
Transmembranei275 – 295HelicalSequence analysisAdd BLAST21
Topological domaini296 – 332ExtracellularSequence analysisAdd BLAST37
Transmembranei333 – 353HelicalSequence analysisAdd BLAST21
Topological domaini354 – 371CytoplasmicSequence analysisAdd BLAST18
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Topological domaini393 – 394ExtracellularSequence analysis2
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 446CytoplasmicSequence analysisAdd BLAST31
Transmembranei447 – 467HelicalSequence analysisAdd BLAST21
Topological domaini468 – 483ExtracellularSequence analysisAdd BLAST16
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 598CytoplasmicSequence analysisAdd BLAST94

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001979261 – 598Thiamine transporterAdd BLAST598

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei560PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ05998.
PRIDEiQ05998.

PTM databases

iPTMnetiQ05998.

Interactioni

Protein-protein interaction databases

BioGridi31504. 42 interactors.
DIPiDIP-4784N.
IntActiQ05998. 2 interactors.
MINTiMINT-573771.

Structurei

3D structure databases

ProteinModelPortaliQ05998.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000065049.
HOGENOMiHOG000066000.
InParanoidiQ05998.
KOiK03457.
OMAiWFGSVSP.
OrthoDBiEOG092C1JZY.

Family and domain databases

InterProiIPR012681. NCS1.
IPR001248. Pur-cyt_permease.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q05998-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFGSKVSRA LRFLEIPVKD RASVSFLKNP DLQPIKSANQ TWGFWSNFAY
60 70 80 90 100
WGVMSFSVGT WMSASSALGV GLSYPETIGT FIVGDVLTII FTLANSCPGY
110 120 130 140 150
DWKVGFTLAQ RFVFGIYGSA FGIIIRILMS IVNYGSNAWV GGLCINMILD
160 170 180 190 200
SWSHHYLHLP NTLSSKVAMT TKELIGFIIF HVLTAFCYLM KPYHMNYILI
210 220 230 240 250
WSCVATFFSM LGMVIYLAKQ AHGVGELFTS TKSTATGSTK AWAWVYMISY
260 270 280 290 300
WFGSVSPGST NQSDYSRFGS SNWAIWAGTI CALLIPTTLI PVFGVIGAST
310 320 330 340 350
CDKLYGEQYW MPMDIFNHWL TTNYSAGARA GAFFCGLSFV LSQMSYTISN
360 370 380 390 400
CGFASGMDLA GLLPKYVDIK RGALFAACVS WACLPWNFYN SSSTFLTVMS
410 420 430 440 450
SFGVVMTPII SVMICDNFLI RKRQYSITNA FILKGEYYFT KGVNWRAIVA
460 470 480 490 500
WVCGMTPGLP GIAWEVNNDY FHNTGIVNFF YGDSFFSFLI SFFVYWGLCL
510 520 530 540 550
LFPFKITVKH DDKDYYGAFT DEEARKKGMV PYSEISEEEI RAYTLGEGYT
560 570 580 590
TGHEYRPEGS DDEIPELVKT SSENTNEFEI VHHKNNEKQS STASEKAA
Length:598
Mass (Da):66,904
Last modified:November 1, 1996 - v1
Checksum:i5160ADCAFC68A39E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19027 Genomic DNA. Translation: AAB67405.1.
D55634 Genomic DNA. Translation: BAA09504.1.
BK006945 Genomic DNA. Translation: DAA09551.1.
PIRiS51456.
RefSeqiNP_013338.1. NM_001182124.1.

Genome annotation databases

EnsemblFungiiYLR237W; YLR237W; YLR237W.
GeneIDi850938.
KEGGisce:YLR237W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19027 Genomic DNA. Translation: AAB67405.1.
D55634 Genomic DNA. Translation: BAA09504.1.
BK006945 Genomic DNA. Translation: DAA09551.1.
PIRiS51456.
RefSeqiNP_013338.1. NM_001182124.1.

3D structure databases

ProteinModelPortaliQ05998.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31504. 42 interactors.
DIPiDIP-4784N.
IntActiQ05998. 2 interactors.
MINTiMINT-573771.

Protein family/group databases

TCDBi2.A.39.4.1. the nucleobase:cation symporter-1 (ncs1) family.

PTM databases

iPTMnetiQ05998.

Proteomic databases

MaxQBiQ05998.
PRIDEiQ05998.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR237W; YLR237W; YLR237W.
GeneIDi850938.
KEGGisce:YLR237W.

Organism-specific databases

EuPathDBiFungiDB:YLR237W.
SGDiS000004227. THI7.

Phylogenomic databases

GeneTreeiENSGT00530000065049.
HOGENOMiHOG000066000.
InParanoidiQ05998.
KOiK03457.
OMAiWFGSVSP.
OrthoDBiEOG092C1JZY.

Enzyme and pathway databases

BioCyciYEAST:G3O-32346-MONOMER.

Miscellaneous databases

PROiQ05998.

Family and domain databases

InterProiIPR012681. NCS1.
IPR001248. Pur-cyt_permease.
[Graphical view]
PfamiPF02133. Transp_cyt_pur. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00800. ncs1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTHI7_YEAST
AccessioniPrimary (citable) accession number: Q05998
Secondary accession number(s): D6VYN5, P87335
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 3120 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.