Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Methyltransferase/helicase/RNA-directed RNA polymerase

Gene
N/A
Organism
Raspberry bushy dwarf virus (isolate Malling Jewel raspberry/R15) (RBDV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase replicates the viral genome.Curated

Catalytic activityi

ATP + H2O = ADP + phosphate.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methyltransferase/helicase/RNA-directed RNA polymerase (EC:2.1.1.-, EC:2.7.7.48, EC:3.6.4.13)
OrganismiRaspberry bushy dwarf virus (isolate Malling Jewel raspberry/R15) (RBDV)
Taxonomic identifieri652675 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageIdaeovirus
Virus hostiRubus idaeus (Raspberry) [TaxID: 32247]
Rubus occidentalis (Black raspberry) [TaxID: 75079]
Rubus ursinus (California blackberry) [TaxID: 75100]
Proteomesi
  • UP000001102 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004024731 – 1694Methyltransferase/helicase/RNA-directed RNA polymeraseAdd BLAST1694

Structurei

3D structure databases

ProteinModelPortaliQ05983.
SMRiQ05983.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini194 – 444Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST251
Domaini829 – 983(+)RNA virus helicase ATP-bindingAdd BLAST155
Domaini984 – 1145(+)RNA virus helicase C-terminalAdd BLAST162
Domaini1442 – 1558RdRp catalyticPROSITE-ProRule annotationAdd BLAST117

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG09000048.

Family and domain databases

InterProiView protein in InterPro
IPR027351. (+)RNA_virus_helicase_core_dom.
IPR002588. Alphavirus-like_MT_dom.
IPR027417. P-loop_NTPase.
IPR007094. RNA-dir_pol_PSvirus.
IPR001788. Tymovirus_RNA-dep_RNA_pol.
PfamiView protein in Pfam
PF00978. RdRP_2. 1 hit.
PF01443. Viral_helicase1. 1 hit.
PF01660. Vmethyltransf. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51743. ALPHAVIRUS_MT. 1 hit.
PS51657. PSRV_HELICASE. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q05983-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MECLDFSKLW FSTAAGLQQR CYYDCVAWEC LGDDDLQIFI SGLNRLIESV
60 70 80 90 100
AVSCTGDEDL DFVVDSCNEF VTGRDLKSFF AADLPVREVS SVGCISHFIP
110 120 130 140 150
GSVSGLNVSD LLDNQLYGCS VFSSDFESKL RDIRDAALSD AASGVSQLVS
160 170 180 190 200
CHFEKDVRHL LAENANSVKI PVPQKLSDDD MRILRDHFPR YELKFTQNVD
210 220 230 240 250
GPHNMAAAHR LLETHDLLSN FPADAPILDI GGNWFSHFRY GRSNVHSCCP
260 270 280 290 300
MLDLRDNERH THRLTMTESL MSSLRHRYAG TIDLDPDAHL SRKVSDSMKE
310 320 330 340 350
FYKRWAVHPK DLIRLYAGIR DGNSSLYCHH KFGVSWNDVL WESERNNCLT
360 370 380 390 400
VPEPECPFKA KYAIMVHSGY DLPLKELIGG MVQHGVVELH GTMIADPAML
410 420 430 440 450
VATSGYIPAL RCNWEKSKGQ IWFSFRDDST MGYRHDWEVY SKYLTSTVVS
460 470 480 490 500
CGKHFYVMER DKYRHGVLFY SIIKCSGSLR KGDHTFFHNA WFHEMYDKYI
510 520 530 540 550
MKVPLVKVKD LTGDEGSVEC SWREVVMSRK LVDRVIEVCL RGVKPINFGN
560 570 580 590 600
CDDAVHMDNL RIIQNHLLSH SQTLVLNGST IIREEAIPFK DFSPVSVTIY
610 620 630 640 650
FEILLTRYKE SLSLAWFHAG LGPDFKLGSW VSSLKRVFYR ILGFPANLLK
660 670 680 690 700
YVLNALFRCR DKVSDMEFVK PAVEKLTVLE NTYIGKSLMG DCPTLKEYDD
710 720 730 740 750
SAFFNILENV GNELFNNSST DSGKPETPEV TMTGNPNAVI AEAISYCRAE
760 770 780 790 800
VDRIGKKCER ILHAYQATGN CGGYLNDTDN VGVFDKMTSW VQKPKEFDHE
810 820 830 840 850
FGWDGSSFIK LSWFGKIPDF VGRYLVVTDG TRVTTNLKFS RQYATIPATV
860 870 880 890 900
TPTIKLVDGV TGCGKTTEIV RRYRPGILIL SVCKANVDEI RRKLAAVDSK
910 920 930 940 950
FIRTVDSYLL SPSVTGSCDE LFIDEYGLSH PGILLLAIHI SGIRKVTLFG
960 970 980 990 1000
DSEQIPFCNR LADFPLKYNS VEDVGLNFDR EIRSTTYRCP QDITLSLQKM
1010 1020 1030 1040 1050
YKTKPIKTVS TVESSITIKP IKSEFEIPLP NAFDGPVLYI CMTKHDESLL
1060 1070 1080 1090 1100
KLRWAKENIS SEVRTVHAAQ GLSYKNVVYF RLTRTDNDLY TKRKLPYHLV
1110 1120 1130 1140 1150
AISRHTDKIV YCTTKPEDSS DFSLSALKNT IKTSRDLTQE ASGSESSYAV
1160 1170 1180 1190 1200
VFESNSEVTA TKPEVCENVR KAAEMNFPVS SDALYQKEVP IYGAIPDPKG
1210 1220 1230 1240 1250
KASYNPGSVI RAIEELTPGN TSIDTDALDE LVEVGPMSLQ VGSIRWDVSK
1260 1270 1280 1290 1300
ISPRLFTNNK FAVPHLPTGA LLRRNTSSRQ VGLAIEKRNA NVMNSQKYFD
1310 1320 1330 1340 1350
LENLANKAVE RFFDFFIDME KFSKLPTGVL GSSAEQIQTY QNKTGNKVTD
1360 1370 1380 1390 1400
PVCVALSPIQ KYKHMIKRDV KFNLTDGAQS EYTKAATITY HQPEITQVAT
1410 1420 1430 1440 1450
AIFGQFKTRL LACRNKFLNI PLEHDNDLSG YLTKYHLGSE NNTFTEIDFS
1460 1470 1480 1490 1500
KFDKSQGEIH QLIQDLILIK FGCDPEFVAL WSTAHRSSSI FDQNVGIGFK
1510 1520 1530 1540 1550
TDFQRRTGDA FTFLGNSLVT AAMLAFVISD PDREKIRYML VGGDDSLICS
1560 1570 1580 1590 1600
YGPIQVPLEP LGDIFNMSCK LVQPACPYFA SRYLIRRGDE ILCVPDPYKL
1610 1620 1630 1640 1650
LVKLGRKDVP DNQASLCEIR TGLADSAKYI FDDIVKQKLA ILVQVRYNKA
1660 1670 1680 1690
APSLYDALCT VHWALSSNTN FSKFYTVTNT SNEVRRNRRG VKIT
Length:1,694
Mass (Da):191,100
Last modified:November 1, 1996 - v1
Checksum:i831A8BE8BDB4B382
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S51557 Genomic RNA. Translation: AAB24599.1.
PIRiJQ1896.
RefSeqiNP_620465.1. NC_003739.1.

Genome annotation databases

GeneIDi963857.
KEGGivg:963857.

Similar proteinsi

Entry informationi

Entry nameiRDRP_RBDVR
AccessioniPrimary (citable) accession number: Q05983
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 1, 1996
Last modified: May 10, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families