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Protein

Chaperone protein DnaK

Gene

dnaK

Organism
Brucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a chaperone.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperone protein DnaK
Alternative name(s):
HSP70
Heat shock 70 kDa protein
Heat shock protein 70
Gene namesi
Name:dnaK
Ordered Locus Names:BOV_2041
OrganismiBrucella ovis (strain ATCC 25840 / 63/290 / NCTC 10512)
Taxonomic identifieri444178 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000006383 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000784311 – 637Chaperone protein DnaKAdd BLAST637

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei198Phosphothreonine; by autocatalysisBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ05981.

Expressioni

Inductioni

By heat shock.

Structurei

3D structure databases

ProteinModelPortaliQ05981.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

HOGENOMiHOG000228136.
KOiK04043.
OMAiEKMAPPQ.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05981-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVIGIDLG TTNSCVAVMD GKNAKVIENA EGARTTPSII AFTDGDERLA
60 70 80 90 100
GQPAKRQAVT NPEGTLFAVK RLIGRRYDDP MVTKDKDLVP YKIVKGDNGD
110 120 130 140 150
AWVEVHGKKY SPSQISAMIL QKMKETAESY LGETVTQAVI TVPAYFNDAQ
160 170 180 190 200
RQATKDAGKI AGLEVLRIIN EPTAAALAYG LDKSEGKTIA VYDLGGGTFD
210 220 230 240 250
VSVLEIGDGV FEVKSTNGDT FLGGEDFDIR LVEYLVAEFK KESGIDLKND
260 270 280 290 300
KLALQRLKEA AEKAKIELSS SQQTEINLPF ITADQTGPKH LAIKLSRAKF
310 320 330 340 350
ESLVDDLVQR TVEPCKAALK DAGLKAGEID EVVLVGGMTR MPKIQEVVKA
360 370 380 390 400
FFGKEPHKGV NPDEVVAMGA AIQGGVLQGD VKDVLLLDVT PLSLGIETLG
410 420 430 440 450
GVFTRLIERN TTIPTKKSQT FSTAEDNQSA VTIRVFQGER EMAADNKLLG
460 470 480 490 500
QFDLVGIPPA PRGVPQIEVT FDIDANGIVN VSAKDKGTGK EHQIRIQASG
510 520 530 540 550
GLSDADIEKM VKDAEANAEA DKKRRESVEA KNQAESLVHS TEKSLAEYGD
560 570 580 590 600
KVSADDKKAI EDAIAALKTS LEGEDAEDIK AKTQALAEVS MKLGQAMYEA
610 620 630
AQAAEGAGAE GGEQASSSKD DVVDADYEEI DDNKKSS
Length:637
Mass (Da):68,194
Last modified:September 11, 2007 - v2
Checksum:iC659ABDE5529B91E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48 – 49RL → GV in AAC36132 (PubMed:1459952).Curated2
Sequence conflicti73I → L in AAC36132 (PubMed:1459952).Curated1
Sequence conflicti259E → D in AAC36132 (PubMed:1459952).Curated1
Sequence conflicti266I → T in AAC36132 (PubMed:1459952).Curated1
Sequence conflicti299 – 300KF → NV in AAC36132 (PubMed:1459952).Curated2
Sequence conflicti307 – 310LVQR → AVHA in AAC36132 (PubMed:1459952).Curated4
Sequence conflicti343K → E in AAC36132 (PubMed:1459952).Curated1
Sequence conflicti346 – 347EV → KC in AAC36132 (PubMed:1459952).Curated2
Sequence conflicti438 – 442GEREM → ASVKL in AAC36132 (PubMed:1459952).Curated5
Sequence conflicti465P → R in AAC36132 (PubMed:1459952).Curated1
Sequence conflicti486 – 489KGTG → GGVP in AAC36132 (PubMed:1459952).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95799 Genomic DNA. Translation: AAC36132.1.
CP000708 Genomic DNA. Translation: ABQ61277.1.
PIRiA47042.
RefSeqiWP_002969217.1. NC_009505.1.

Genome annotation databases

EnsemblBacteriaiABQ61277; ABQ61277; BOV_2041.
GeneIDi3788553.
KEGGibov:BOV_2041.
PATRICi17864232. VBIBruOvi136990_3487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M95799 Genomic DNA. Translation: AAC36132.1.
CP000708 Genomic DNA. Translation: ABQ61277.1.
PIRiA47042.
RefSeqiWP_002969217.1. NC_009505.1.

3D structure databases

ProteinModelPortaliQ05981.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ05981.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ61277; ABQ61277; BOV_2041.
GeneIDi3788553.
KEGGibov:BOV_2041.
PATRICi17864232. VBIBruOvi136990_3487.

Phylogenomic databases

HOGENOMiHOG000228136.
KOiK04043.
OMAiEKMAPPQ.

Miscellaneous databases

PROiQ05981.

Family and domain databases

Gene3Di1.20.1270.10. 1 hit.
2.60.34.10. 1 hit.
HAMAPiMF_00332. DnaK. 1 hit.
InterProiIPR012725. Chaperone_DnaK.
IPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
TIGRFAMsiTIGR02350. prok_dnaK. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDNAK_BRUO2
AccessioniPrimary (citable) accession number: Q05981
Secondary accession number(s): A5VT77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: September 11, 2007
Last modified: November 2, 2016
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.