Reviewed,
UniProtKB/Swiss-Prot Q05979 (KYNU_YEAST)
Last modified
November 25, 2008.
Version 66.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Kynureninase EC=3.7.1.3 Alternative name(s): L-kynurenine hydrolase | ||||||
| Gene names |
| ||||||
| Organism | Saccharomyces cerevisiae (Baker's yeast) [Complete proteome] | ||||||
| Taxonomic identifier | 4932 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 453 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic (AA) and 3-hydroxyanthranilic acids (3-OHAA), respectively. |
| Catalytic activity | L-kynurenine + H(2)O = anthranilate + L-alanine. L-3-hydroxykynurenine + H(2)O = 3-hydroxyanthranilate + L-alanine. |
| Cofactor | Pyridoxal phosphate By similarity. |
| Pathway | Cofactor biosynthesis; NAD(+) biosynthesis; pyridine-2,3-dicarboxylate from L-kynurenine: step 2/3. |
| Subcellular location | |
| Miscellaneous | Present with 3060 molecules/cell in log phase SD medium. |
| Sequence similarities | Belongs to the kynureninase family. |
Ontologies
Keywords | |
|---|---|
| Biological process | Pyridine nucleotide biosynthesis |
| Cellular component | Cytoplasm Nucleus |
| Ligand | Pyridoxal phosphate |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| Biological process | de novo NAD biosynthetic process from tryptophan Ref.2 Inferred from genetic interaction. Source: SGD tryptophan catabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Ref.3 Inferred from electronic annotation. Source: InterPro nucleus Ref.3Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | kynureninase activity Ref.2 Inferred from electronic annotation. Source: InterPro protein bindingInferred from physical interaction. Source: IntAct pyridoxal phosphate bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| P43582 | 1 | EBI-10016,EBI-22766 | ||
| ESS1 | P22696 | 1 | EBI-10016,EBI-6679 | |
| PRP40 | P33203 | 1 | EBI-10016,EBI-701 | |
| RSP5 | P39940 | 1 | EBI-10016,EBI-16219 | |
| SSM4 | P40318 | 1 | EBI-10016,EBI-18208 | |
| URN1 | Q06525 | 1 | EBI-10016,EBI-35138 |
Sequence annotation (Features)
Sequences
| ||||||||||||||||||
References
Cross-references
Sequence databases | |
|---|---|
| U19027 Genomic DNA. Translation: AAB67417.1. | |
| PIR | S51453. |
| RefSeq | NP_013332.1. |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:6518N. |
| IntAct | Q05979. |
Proteomic databases | |
| PeptideAtlas | Q05979. |
Genome annotation databases | |
| Ensembl | YLR231C. Saccharomyces cerevisiae. [Contig view] |
| GeneID | 850933. |
| GenomeReviews | Gene locus YLR231C in contig Y13138_GR. |
| KEGG | sce:YLR231C. |
| NMPDR | fig|4932.3.peg.4345. |
Organism-specific databases | |
| CYGD | YLR231c. |
| SGD | S000004221. BNA5. |
| Yeast-GFP | Search... |
Phylogenomic databases | |
| HOGENOM | Q05979. |
Enzyme and pathway databases | |
| BioCyc | MetaCyc:MON-8163. |
Gene expression databases | |
| GermOnline | YLR231C. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR010111. Kynureninase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view] |
| Gene3D | G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. |
| PANTHER | PTHR14084. Kynureninase. 1 hit. |
| TIGRFAMs | TIGR01814. kynureninase. 1 hit. |
| ProtoNet | Search... |
Other Resources | |
| LinkHub | Q05979. |
| NextBio | 967372. |
Entry information
| Entry name | KYNU_YEAST | ||||||||
| Accession | Primary (citable) accession number: Q05979 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |

Clusters with


