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Q05972 (CH601_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
60 kDa chaperonin 1
Alternative name(s):
GroEL protein 1
Protein Cpn60 1
Gene names
Name:groL1
Synonyms:cpn60-1, groEL-1, groEL1
Ordered Locus Names:slr2076
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length541 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions By similarity. HAMAP-Rule MF_00600

Subunit structure

Oligomer of 14 subunits composed of two stacked rings of 7 subunits By similarity.

Subcellular location

Cytoplasm HAMAP-Rule MF_00600.

Induction

By stress conditions e.g. heat shock. HAMAP-Rule MF_00600

Sequence similarities

Belongs to the chaperonin (HSP60) family.

Ontologies

Keywords
   Biological processStress response
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processprotein refolding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

response to stress

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

protein binding

Inferred from physical interaction PubMed 14673118PubMed 17922517. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

trxAP522314EBI-862119,EBI-862916

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1 Ref.3 Ref.4
Chain2 – 54154060 kDa chaperonin 1 HAMAP-Rule MF_00600
PRO_0000063575

Experimental info

Sequence conflict121R → T AA sequence Ref.4
Sequence conflict911A → D in BAA02180. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q05972 [UniParc].

Last modified January 23, 2007. Version 4.
Checksum: 37E158A939CBFCB8

FASTA54157,653
        10         20         30         40         50         60 
MAKSIIYNDE ARRALERGMD ILAEAVAVTL GPKGRNVVLE KKFGSPQIIN DGITIAKEIE 

        70         80         90        100        110        120 
LEDHVENTGV SLIRQAASKT NDVAGDGTTT ATVLAHAIVK EGLRNVAAGA NPISLKRGID 

       130        140        150        160        170        180 
KATDFLVARI KEHAQPVGDS KAIAQVGAIS AGNDEEVGQM IANAMDKVGQ EGVISLEEGK 

       190        200        210        220        230        240 
SMTTELEITE GMRFDKGYIS PYFVTDAERM EAVLEDPRIL ITDKKINLVQ DLVPILEQVA 

       250        260        270        280        290        300 
RQGKPLLIIA EDIEKEALAT LVVNRLRGVL NVAAVKAPGF GDRRKQMLED IATLTGGQVI 

       310        320        330        340        350        360 
SEDAGLKLES ATVDSLGSAR RINITKDNTT IVAEGNEAAV KSRCEQIRRQ IEETDSSYDK 

       370        380        390        400        410        420 
EKLQERLAKL AGGVAVIKVG AATETEMKDR KLRLEDAINA TKAAVEEGIV PGGGTTLAHL 

       430        440        450        460        470        480 
APQLEDWATG NLKDEELTGA LIVARALPAP LKRIAENAGQ NGAVISERVK EKEFNVGYNA 

       490        500        510        520        530        540 
ASLEYVDMLA AGIVDPAKVT RSALQNAASI AGMVLTTECI VVDKPEKEKA PAGAPGGDFD 


Y 

« Hide

References

« Hide 'large scale' references
[1]"A second groEL-like gene, organized in a groESL operon is present in the genome of Synechocystis sp. PCC 6803."
Lehel C., Los D.A., Wada H., Gyorgyei J., Horvath I., Kovacs E., Murata N., Vigh L.
J. Biol. Chem. 268:1799-1804(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-26.
[2]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.
[3]"Towards a proteome project of cyanobacterium Synechocystis sp. strain PCC6803: linking 130 protein spots with their respective genes."
Sazuka T., Ohara O.
Electrophoresis 18:1252-1258(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-21.
[4]"Heat shock protein synthesis of the cyanobacterium Synechocystis PCC 6803: purification of the GroEL-related chaperonin."
Lehel C., Wada H., Kovacs E., Toroek Z., Gombos Z., Horvath I., Murata N., Vigh L.
Plant Mol. Biol. 18:327-336(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-26.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D12677 Genomic DNA. Translation: BAA02180.1.
BA000022 Genomic DNA. Translation: BAA17411.1.
PIRB44425.
RefSeqNP_440731.1. NC_000911.1.
YP_005650790.1. NC_017277.1.
YP_007450614.1. NC_020286.1.

3D structure databases

ProteinModelPortalQ05972.
SMRQ05972. Positions 2-527.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ05972. 2 interactions.
STRING1148.slr2076.

Proteomic databases

PaxDbQ05972.
PRIDEQ05972.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA17411; BAA17411; BAA17411.
GeneID954034.
KEGGsyn:slr2076.
syy:SYNGTS_0837.
syz:MYO_18420.
PATRIC23838680. VBISynSp132158_0907.

Phylogenomic databases

eggNOGCOG0459.
HOGENOMHOG000076290.
KOK04077.
OMAAMISANM.
OrthoDBEOG6JDWBZ.
PhylomeDBQ05972.

Family and domain databases

Gene3D1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPMF_00600. CH60.
InterProIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PANTHERPTHR11353. PTHR11353. 1 hit.
PfamPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSPR00298. CHAPERONIN60.
SUPFAMSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
TIGRFAMsTIGR02348. GroEL. 1 hit.
PROSITEPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCH601_SYNY3
AccessionPrimary (citable) accession number: Q05972
Secondary accession number(s): P73379
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 107 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families