Reviewed,
UniProtKB/Swiss-Prot Q05972 (CH601_SYNY3)
Last modified
June 16, 2009.
Version 67.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: 60 kDa chaperonin 1 Alternative name(s): Protein Cpn60 1 groEL protein 1 | ||||||
| Gene names |
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| Organism | Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1148 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Cyanobacteria › Chroococcales › Synechocystis |
Protein attributes
| Sequence length | 541 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions By similarity. |
| Subunit structure | Oligomer of 14 subunits composed of two stacked rings of 7 subunits By similarity. |
| Subcellular location | |
| Induction | By stress conditions e.g. heat shock. HAMAP MF_00600 |
| Sequence similarities | Belongs to the chaperonin (HSP60) family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Stress response |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Chaperone |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | protein refolding Inferred from electronic annotation. Source: HAMAP response to stressInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP unfolded protein bindingInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.1 Ref.3 Ref.4 | ||||||
| Chain | 2 – 541 | 540 | 60 kDa chaperonin 1 HAMAP MF_00600 | PRO_0000063575 | |||||
Experimental info | |||||||||
| Sequence conflict | 12 | 1 | R → T AA sequence Ref.4 | ||||||
| Sequence conflict | 91 | 1 | A → D in BAA02180. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A second groEL-like gene, organized in a groESL operon is present in the genome of Synechocystis sp. PCC 6803." Lehel C., Los D.A., Wada H., Gyorgyei J., Horvath I., Kovacs E., Murata N., Vigh L. J. Biol. Chem. 268:1799-1804(1993) [PubMed: 8093614] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-26. |
| [2] | "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. Tabata S.DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "Towards a proteome project of cyanobacterium Synechocystis sp. strain PCC6803: linking 130 protein spots with their respective genes." Sazuka T., Ohara O. Electrophoresis 18:1252-1258(1997) [PubMed: 9298645] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-21. |
| [4] | "Heat shock protein synthesis of the cyanobacterium Synechocystis PCC 6803: purification of the GroEL-related chaperonin." Lehel C., Wada H., Kovacs E., Toroek Z., Gombos Z., Horvath I., Murata N., Vigh L. Plant Mol. Biol. 18:327-336(1992) [PubMed: 1346251] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-26. |
Cross-references
Sequence databases | |
|---|---|
| D12677 Genomic DNA. Translation: BAA02180.1. BA000022 Genomic DNA. Translation: BAA17411.1. | |
| PIR | B44425. |
| RefSeq | NP_440731.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1GRL based on UniProtKB P06139. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q05972. 2 interactions. |
Genome annotation databases | |
| GeneID | 954034. |
| GenomeReviews | Gene locus slr2076 in contig BA000022_GR. |
| KEGG | syn:slr2076. |
| NMPDR | fig|1148.1.peg.832. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q05972. |
| OMA | Q05972. ELETWAN. |
Enzyme and pathway databases | |
| BioCyc | SSP1148:SLR2076-MON. |
Family and domain databases | |
| HAMAP | MF_00600. [Tree] |
| InterPro | IPR018370. Chaperonin_Cpn60_CS. IPR001844. Chaprnin_Cpn60. IPR002423. Cpn60/TCP-1. [Graphical view] |
| PANTHER | PTHR11353. Cpn60/TCP-1. 1 hit. |
| Pfam | PF00118. Cpn60_TCP1. 1 hit. [Graphical view] |
| PRINTS | PR00298. CHAPERONIN60. |
| TIGRFAMs | TIGR02348. GroEL. 1 hit. |
| PROSITE | PS00296. CHAPERONINS_CPN60. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CH601_SYNY3 | ||||||||
| Accession | Primary (citable) accession number: Q05972 Secondary accession number(s): P73379 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |
| Synechocystis PCC 6803 Synechocystis (strain PCC 6803): entries and gene names |

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