Q05972 (CH601_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
60 kDa chaperonin 1

Alternative name(s):
GroEL protein 1
Protein Cpn60 1

Gene names

Name:	groL1
Synonyms:	cpn60-1, groEL-1, groEL1
Ordered Locus Names:	slr2076

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis › Synechocystis sp. PCC 6803

Protein attributes

Sequence length	541 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions By similarity. HAMAP-Rule MF_00600
Subunit structure	Oligomer of 14 subunits composed of two stacked rings of 7 subunits By similarity.
Subcellular location	Cytoplasm HAMAP-Rule MF_00600.
Induction	By stress conditions e.g. heat shock. HAMAP-Rule MF_00600
Sequence similarities	Belongs to the chaperonin (HSP60) family.

Ontologies

Keywords
Biological process	Stress response
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	protein refolding Inferred from electronic annotation. Source: HAMAP response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
trxA	P52231	4	EBI-862119,EBI-862916

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1 Ref.3 Ref.4
	Chain	2 – 541	540	60 kDa chaperonin 1 HAMAP-Rule MF_00600		PRO_0000063575
Experimental info
	Sequence conflict	12	1	R → T AA sequence Ref.4
	Sequence conflict	91	1	A → D in BAA02180. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q05972 [UniParc]. Last modified January 23, 2007. Version 4. Checksum: 37E158A939CBFCB8	FASTA	541	57,653
	10 20 30 40 50 60 MAKSIIYNDE ARRALERGMD ILAEAVAVTL GPKGRNVVLE KKFGSPQIIN DGITIAKEIE 70 80 90 100 110 120 LEDHVENTGV SLIRQAASKT NDVAGDGTTT ATVLAHAIVK EGLRNVAAGA NPISLKRGID 130 140 150 160 170 180 KATDFLVARI KEHAQPVGDS KAIAQVGAIS AGNDEEVGQM IANAMDKVGQ EGVISLEEGK 190 200 210 220 230 240 SMTTELEITE GMRFDKGYIS PYFVTDAERM EAVLEDPRIL ITDKKINLVQ DLVPILEQVA 250 260 270 280 290 300 RQGKPLLIIA EDIEKEALAT LVVNRLRGVL NVAAVKAPGF GDRRKQMLED IATLTGGQVI 310 320 330 340 350 360 SEDAGLKLES ATVDSLGSAR RINITKDNTT IVAEGNEAAV KSRCEQIRRQ IEETDSSYDK 370 380 390 400 410 420 EKLQERLAKL AGGVAVIKVG AATETEMKDR KLRLEDAINA TKAAVEEGIV PGGGTTLAHL 430 440 450 460 470 480 APQLEDWATG NLKDEELTGA LIVARALPAP LKRIAENAGQ NGAVISERVK EKEFNVGYNA 490 500 510 520 530 540 ASLEYVDMLA AGIVDPAKVT RSALQNAASI AGMVLTTECI VVDKPEKEKA PAGAPGGDFD Y

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A second groEL-like gene, organized in a groESL operon is present in the genome of Synechocystis sp. PCC 6803." Lehel C., Los D.A., Wada H., Gyorgyei J., Horvath I., Kovacs E., Murata N., Vigh L. J. Biol. Chem. 268:1799-1804(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-26.
[2]	"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PCC 6803 / Kazusa.
[3]	"Towards a proteome project of cyanobacterium Synechocystis sp. strain PCC6803: linking 130 protein spots with their respective genes." Sazuka T., Ohara O. Electrophoresis 18:1252-1258(1997) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-21.
[4]	"Heat shock protein synthesis of the cyanobacterium Synechocystis PCC 6803: purification of the GroEL-related chaperonin." Lehel C., Wada H., Kovacs E., Toroek Z., Gombos Z., Horvath I., Murata N., Vigh L. Plant Mol. Biol. 18:327-336(1992) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-26.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D12677 Genomic DNA. Translation: BAA02180.1. BA000022 Genomic DNA. Translation: BAA17411.1.
PIR	B44425.
RefSeq	NP_440731.1. NC_000911.1. YP_005650790.1. NC_017277.1. YP_007450614.1. NC_020286.1.
3D structure databases
ProteinModelPortal	Q05972.
SMR	Q05972. Positions 2-527.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q05972. 2 interactions.
STRING	1148.slr2076.
Proteomic databases
PaxDb	Q05972.
PRIDE	Q05972.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAA17411; BAA17411; BAA17411.
GeneID	12254712. 14616264. 954034.
KEGG	syn:slr2076. syy:SYNGTS_0837.
PATRIC	23838680. VBISynSp132158_0907.
Phylogenomic databases
eggNOG	COG0459.
HOGENOM	HOG000076290.
KO	K04077.
OMA	DVKAGIN.
ProtClustDB	PRK00013.
Family and domain databases
HAMAP	MF_00600. CH60.
InterPro	IPR018370. Chaperonin_Cpn60_CS. IPR001844. Chaprnin_Cpn60. IPR002423. Cpn60/TCP-1. [Graphical view]
PANTHER	PTHR11353. PTHR11353. 1 hit.
Pfam	PF00118. Cpn60_TCP1. 1 hit. [Graphical view]
PRINTS	PR00298. CHAPERONIN60.
SUPFAM	SSF48592. GroEL-ATPase. 1 hit.
TIGRFAMs	TIGR02348. GroEL. 1 hit.
PROSITE	PS00296. CHAPERONINS_CPN60. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CH601_SYNY3

Accession

Primary (citable) accession number: Q05972
Secondary accession number(s): P73379

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 98 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program