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Protein

60 kDa chaperonin 1

Gene

groL1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
60 kDa chaperonin 1UniRule annotation
Alternative name(s):
GroEL protein 1UniRule annotation
Protein Cpn60 1UniRule annotation
Gene namesi
Name:groL1UniRule annotation
Synonyms:cpn60-1, groEL-1UniRule annotation, groEL1UniRule annotation
Ordered Locus Names:slr2076
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 54154060 kDa chaperonin 1PRO_0000063575Add
BLAST

Proteomic databases

PaxDbiQ05972.
PRIDEiQ05972.

Expressioni

Inductioni

By stress conditions e.g. heat shock.

Interactioni

Subunit structurei

Oligomer of 14 subunits composed of two stacked rings of 7 subunits.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
trxAP522314EBI-862119,EBI-862916

Protein-protein interaction databases

IntActiQ05972. 2 interactions.
STRINGi1148.SYNGTS_0837.

Structurei

3D structure databases

ProteinModelPortaliQ05972.
SMRiQ05972. Positions 2-527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0459.
HOGENOMiHOG000076290.
InParanoidiQ05972.
KOiK04077.
OMAiTTECIVA.
OrthoDBiEOG6JDWBZ.
PhylomeDBiQ05972.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSIIYNDE ARRALERGMD ILAEAVAVTL GPKGRNVVLE KKFGSPQIIN
60 70 80 90 100
DGITIAKEIE LEDHVENTGV SLIRQAASKT NDVAGDGTTT ATVLAHAIVK
110 120 130 140 150
EGLRNVAAGA NPISLKRGID KATDFLVARI KEHAQPVGDS KAIAQVGAIS
160 170 180 190 200
AGNDEEVGQM IANAMDKVGQ EGVISLEEGK SMTTELEITE GMRFDKGYIS
210 220 230 240 250
PYFVTDAERM EAVLEDPRIL ITDKKINLVQ DLVPILEQVA RQGKPLLIIA
260 270 280 290 300
EDIEKEALAT LVVNRLRGVL NVAAVKAPGF GDRRKQMLED IATLTGGQVI
310 320 330 340 350
SEDAGLKLES ATVDSLGSAR RINITKDNTT IVAEGNEAAV KSRCEQIRRQ
360 370 380 390 400
IEETDSSYDK EKLQERLAKL AGGVAVIKVG AATETEMKDR KLRLEDAINA
410 420 430 440 450
TKAAVEEGIV PGGGTTLAHL APQLEDWATG NLKDEELTGA LIVARALPAP
460 470 480 490 500
LKRIAENAGQ NGAVISERVK EKEFNVGYNA ASLEYVDMLA AGIVDPAKVT
510 520 530 540
RSALQNAASI AGMVLTTECI VVDKPEKEKA PAGAPGGDFD Y
Length:541
Mass (Da):57,653
Last modified:January 23, 2007 - v4
Checksum:i37E158A939CBFCB8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti12 – 121R → T AA sequence (PubMed:1346251).Curated
Sequence conflicti91 – 911A → D in BAA02180 (PubMed:8093614).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12677 Genomic DNA. Translation: BAA02180.1.
BA000022 Genomic DNA. Translation: BAA17411.1.
PIRiB44425.
RefSeqiYP_005650790.1. NC_017277.1.
YP_007450614.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA17411; BAA17411; BAA17411.
KEGGisyn:slr2076.
PATRICi23838680. VBISynSp132158_0907.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12677 Genomic DNA. Translation: BAA02180.1.
BA000022 Genomic DNA. Translation: BAA17411.1.
PIRiB44425.
RefSeqiYP_005650790.1. NC_017277.1.
YP_007450614.1. NC_020286.1.

3D structure databases

ProteinModelPortaliQ05972.
SMRiQ05972. Positions 2-527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ05972. 2 interactions.
STRINGi1148.SYNGTS_0837.

Proteomic databases

PaxDbiQ05972.
PRIDEiQ05972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA17411; BAA17411; BAA17411.
KEGGisyn:slr2076.
PATRICi23838680. VBISynSp132158_0907.

Phylogenomic databases

eggNOGiCOG0459.
HOGENOMiHOG000076290.
InParanoidiQ05972.
KOiK04077.
OMAiTTECIVA.
OrthoDBiEOG6JDWBZ.
PhylomeDBiQ05972.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60.
InterProiIPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
[Graphical view]
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiPS00296. CHAPERONINS_CPN60. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A second groEL-like gene, organized in a groESL operon is present in the genome of Synechocystis sp. PCC 6803."
    Lehel C., Los D.A., Wada H., Gyorgyei J., Horvath I., Kovacs E., Murata N., Vigh L.
    J. Biol. Chem. 268:1799-1804(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-26.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  3. "Towards a proteome project of cyanobacterium Synechocystis sp. strain PCC6803: linking 130 protein spots with their respective genes."
    Sazuka T., Ohara O.
    Electrophoresis 18:1252-1258(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-21.
  4. "Heat shock protein synthesis of the cyanobacterium Synechocystis PCC 6803: purification of the GroEL-related chaperonin."
    Lehel C., Wada H., Kovacs E., Toroek Z., Gombos Z., Horvath I., Murata N., Vigh L.
    Plant Mol. Biol. 18:327-336(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-26.

Entry informationi

Entry nameiCH601_SYNY3
AccessioniPrimary (citable) accession number: Q05972
Secondary accession number(s): P73379
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: June 24, 2015
This is version 114 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.