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Q05962 (ADT1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ADP/ATP translocase 1
Alternative name(s):
ADP,ATP carrier protein 1
Adenine nucleotide translocator 1
Short name=ANT 1
Solute carrier family 25 member 4
Gene names
Name:Slc25a4
Synonyms:Ant1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.

Subunit structure

Homodimer.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Tissue specificity

In heart, skeletal muscle and to a lesser extent, in brain and kidney.

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue By similarity.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 298297ADP/ATP translocase 1
PRO_0000090577

Regions

Transmembrane5 – 3935Helical; Name=1; By similarity
Transmembrane75 – 10026Helical; Name=2; By similarity
Transmembrane109 – 14335Helical; Name=3; By similarity
Transmembrane176 – 20227Helical; Name=4; By similarity
Transmembrane207 – 24135Helical; Name=5; By similarity
Transmembrane273 – 29826Helical; Name=6; By similarity
Repeat6 – 9893Solcar 1
Repeat111 – 20191Solcar 2
Repeat212 – 29786Solcar 3
Motif235 – 2406Substrate recognition By similarity

Sites

Binding site801Nucleotide By similarity

Amino acid modifications

Modified residue21N-acetylglycine Ref.2
Modified residue961N6-acetyllysine By similarity
Modified residue1261Phosphothreonine By similarity
Modified residue1271Phosphoserine By similarity
Modified residue1911Phosphotyrosine By similarity
Modified residue1951Phosphotyrosine By similarity
Cross-link10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q05962 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 66704FF78C6BC320

FASTA29832,989
        10         20         30         40         50         60 
MGDQALSFLK DFLAGGIAAA VSKTAVAPIE RVKLLLQVQH ASKQISAEKQ YKGIIDCVVR 

        70         80         90        100        110        120 
IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDRHKQFW RYFAGNLASG 

       130        140        150        160        170        180 
GAAGATSLCF VYPLDFARTR LAADVGKGSS QREFNGLGDC LTKIFKSDGL KGLYQGFSVS 

       190        200        210        220        230        240 
VQGIIIYRAA YFGVYDTAKG MLPDPKNVHI IVSWMIAQSV TAVAGLVSYP FDTVRRRMMM 

       250        260        270        280        290 
QSGRKGADIM YTGTVDCWRK IAKDEGRKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYV

« Hide

References

[1]"Isolation and characterization of cDNA clones and a genomic clone encoding rat mitochondrial adenine nucleotide translocator."
Shinohara Y., Kamida M., Yamazaki N., Terada H.
Biochim. Biophys. Acta 1152:192-196(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
Strain: Sprague-Dawley and Wistar.
Tissue: Heart and Liver.
[2]Bienvenut W.V., von Kriegsheim A.F., Kolch W.
Submitted (AUG-2006) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 2-31; 34-43; 73-80 AND 273-280, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT GLY-2, MASS SPECTROMETRY.
Tissue: Pheochromocytoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X61667 Genomic DNA. Translation: CAA43842.1.
D12770 mRNA. Translation: BAA02237.1.
IPIIPI00231927.
PIRI60173.
RefSeqNP_445967.1. NM_053515.1.
UniGeneRn.4092.

3D structure databases

ProteinModelPortalQ05962.
SMRQ05962. Positions 3-294.
ModBaseSearch...

Protein-protein interaction databases

IntActQ05962. 2 interactions.
MINTMINT-118747.
STRING10116.ENSRNOP00000014704.

PTM databases

PhosphoSiteQ05962.

Proteomic databases

PaxDbQ05962.
PRIDEQ05962.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID85333.
KEGGrno:85333.

Organism-specific databases

CTD291.
RGD620352. Slc25a4.

Phylogenomic databases

eggNOGNOG238123.
HOGENOMHOG000165727.
HOVERGENHBG108348.
InParanoidQ05962.
KOK05863.
OrthoDBEOG49CQ86.

Gene expression databases

ArrayExpressQ05962.
GenevestigatorQ05962.
GermOnlineENSRNOG00000010830. Rattus norvegicus.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMSSF103506. Mitoch_carrier. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio617472.

Entry information

Entry nameADT1_RAT
AccessionPrimary (citable) accession number: Q05962
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: January 23, 2007
Last modified: April 3, 2013
This is version 105 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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