Q05955 (ADY4_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Accumulates dyads protein 4

Gene names

Name:	ADY4
Ordered Locus Names:	YLR227C
ORF Names:	L8083.11

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in the pathway that organizes the shaping and sizing of the prospore membrane (PSM) during sporulation. May be required to stabilize the outer plaque of the spindle pole body (SPB). Ref.4
Subunit structure	Interacts with CNM67, SPO21/MPC70 and NUD1. Ref.4
Subcellular location	Cytoplasm › cytoskeleton › spindle pole body. Note: Localizes to the meiotic outer plaque of the SPB, at the end of the meiotic spindles. Ref.4
Developmental stage	Meiosis-specific Probable. Ref.4

Ontologies

Keywords
Biological process	Cell cycle Cell division Meiosis Sporulation
Cellular component	Cytoplasm Cytoskeleton Nucleus
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell division Inferred from electronic annotation. Source: UniProtKB-KW meiosis Inferred from electronic annotation. Source: UniProtKB-KW sporulation resulting in formation of a cellular spore Inferred from mutant phenotype Ref.3. Source: SGD
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW spindle pole body Inferred from direct assay. Source: SGD
Molecular function	structural molecule activity Inferred from mutant phenotype Ref.4. Source: SGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Accumulates dyads protein 4		PRO_0000064462

Sequences

	Sequence		Length	Mass (Da)
	Q05955 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 33A6E36B76181927	FASTA	493	57,833
	10 20 30 40 50 60 MNKDVDYQTF KKSLRKEFKK AVKTILNLQA YNGDLIRDFL ALYIPYHVVF YNLSIMKKGS 70 80 90 100 110 120 PLRIQTNNLL KEALAKILNF NLAMGPKHII KIMKKDKADP ETMNKLKLVL YIKLFQGVFG 130 140 150 160 170 180 HVDKNYNLAF QSFRWCLQFI AYSKRTRLFA SIADEQIGAF YELCELFISM LCCHCFLIDL 190 200 210 220 230 240 KENEALVGNN LKNFIKRQNP NYSHGFDLNE ETKSLQWHWS LDEVDVIEAL YCVAFDAMDK 250 260 270 280 290 300 ITLKFSKVNE NFVFSQFFQY CAEIEEMLAI LRGKIWECEC DVFGPRIGLL VDSNHMNETI 310 320 330 340 350 360 QKNILSITFK LKNDPQIICC LNKILEGLLL SSGVQFKVIQ FFYVLKLYYM QDNEYTFEAS 370 380 390 400 410 420 SEMDKLTIEC LCIIENIIDA CDNPDEVTDY QLPKVLLTAM EGKLLVAEKI SEDNDCSESL 430 440 450 460 470 480 DDYHPRTYQF RHPRIIIDKM KTKLKQKLRF DSPKDPETDD HWIEYWKYCY QDNIGNLPDI 490 LSRIYQTFTD PSN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D. Nature 387:87-90(1997) [PubMed: 9169871] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"A screen for genes required for meiosis and spore formation based on whole-genome expression." Rabitsch K.P., Toth A., Galova M., Schleiffer A., Schaffner G., Aigner E., Rupp C., Penkner A.M., Moreno-Borchart A.C., Primig M., Esposito R.E., Klein F., Knop M., Nasmyth K. Curr. Biol. 11:1001-1009(2001) [PubMed: 11470404] [Abstract] Cited for: IDENTIFICATION.
[4]	"Ady4p and Spo74p are components of the meiotic spindle pole body that promote growth of the prospore membrane in Saccharomyces cerevisiae." Nickas M.E., Schwartz C., Neiman A.M. Eukaryot. Cell 2:431-445(2003) [PubMed: 12796288] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, INTERACTION WITH CNM67; SPO21 AND NUD1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U19027 Genomic DNA. Translation: AAB67414.1. BK006945 Genomic DNA. Translation: DAA09543.1.
PIR	S51450.
RefSeq	NP_013328.1. NM_001182114.1.
3D structure databases
ProteinModelPortal	Q05955.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-4786N.
IntAct	Q05955. 6 interactions.
MINT	MINT-507610.
STRING	Q05955.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YLR227C; YLR227C; YLR227C.
GeneID	850924.
KEGG	sce:YLR227C.
NMPDR	fig|4932.3.peg.4339.
Organism-specific databases
CYGD	YLR227c.
SGD	S000004217. ADY4.
Phylogenomic databases
eggNOG	fuNOG13543.
OrthoDB	EOG4Q5D00.
Gene expression databases
ArrayExpress	Q05955.
Genevestigator	Q05955.
GermOnline	YLR227C. Saccharomyces cerevisiae.
Family and domain databases
ProtoNet	Search...
Other
NextBio	967353.

Entry information

Entry name

ADY4_YEAST

Accession

Primary (citable) accession number: Q05955
Secondary accession number(s): D6VYM7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program