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Protein

Nuclear transition protein 2

Gene

TNP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transition protein 2
Short name:
TP-2
Short name:
TP2
Gene namesi
Name:TNP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:11952. TNP2.

Subcellular locationi

  • Nucleusnucleolus By similarity
  • Chromosome By similarity

  • Note: Nuclear import is ATP-dependent and nucleolar localization requires the protein to be phosphorylated.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36641.

Polymorphism and mutation databases

BioMutaiTNP2.
DMDMi464818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Nuclear transition protein 2PRO_0000191425Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei133 – 1331PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ05952.
PeptideAtlasiQ05952.
PRIDEiQ05952.

PTM databases

iPTMnetiQ05952.
PhosphoSiteiQ05952.

Expressioni

Tissue specificityi

Expressed by spermatids (at protein level).1 Publication

Gene expression databases

BgeeiQ05952.
CleanExiHS_TNP2.
ExpressionAtlasiQ05952. baseline and differential.
GenevisibleiQ05952. HS.

Interactioni

Protein-protein interaction databases

BioGridi112996. 12 interactions.
STRINGi9606.ENSP00000325738.

Structurei

3D structure databases

ProteinModelPortaliQ05952.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J2UZ. Eukaryota.
ENOG411196P. LUCA.
HOGENOMiHOG000065922.
HOVERGENiHBG004481.
InParanoidiQ05952.
KOiK19925.
OMAiQQVYKTK.
OrthoDBiEOG7NPFX8.
PhylomeDBiQ05952.
TreeFamiTF338516.

Family and domain databases

InterProiIPR000678. TP2.
[Graphical view]
PANTHERiPTHR17488. PTHR17488. 1 hit.
PfamiPF01254. TP2. 1 hit.
[Graphical view]
PROSITEiPS00970. TP2_1. 1 hit.
PS00971. TP2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTQTHSLPI THTQLHSNSQ PQSRTCTRHC QTFSQSCRQS HRGSRSQSSS
60 70 80 90 100
QSPASHRNPT GAHSSSGHQS QSPNTSPPPK RHKKTMNSHH SPMRPTILHC
110 120 130
RCPKNRKNLE GKLKKKKMAK RIQQVYKTKT RSSGWKSN
Length:138
Mass (Da):15,641
Last modified:February 1, 1994 - v1
Checksum:i9D2A605556BF644E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti131 – 1311R → W.
Corresponds to variant rs11640138 [ dbSNP | Ensembl ].
VAR_052157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03378 Genomic DNA. Translation: AAA61203.1.
U15422 Genomic DNA. Translation: AAC50488.1.
X63758 mRNA. Translation: CAA45290.1.
X63759 mRNA. Translation: CAA45291.1.
Z46940 Genomic DNA. Translation: CAA87067.1.
AF215715 Genomic DNA. Translation: AAF35854.1.
CCDSiCCDS45410.1.
PIRiA44477. BGHU2.
RefSeqiNP_005416.1. NM_005425.4.
UniGeneiHs.513349.

Genome annotation databases

EnsembliENST00000312693; ENSP00000325738; ENSG00000178279.
GeneIDi7142.
KEGGihsa:7142.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03378 Genomic DNA. Translation: AAA61203.1.
U15422 Genomic DNA. Translation: AAC50488.1.
X63758 mRNA. Translation: CAA45290.1.
X63759 mRNA. Translation: CAA45291.1.
Z46940 Genomic DNA. Translation: CAA87067.1.
AF215715 Genomic DNA. Translation: AAF35854.1.
CCDSiCCDS45410.1.
PIRiA44477. BGHU2.
RefSeqiNP_005416.1. NM_005425.4.
UniGeneiHs.513349.

3D structure databases

ProteinModelPortaliQ05952.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112996. 12 interactions.
STRINGi9606.ENSP00000325738.

PTM databases

iPTMnetiQ05952.
PhosphoSiteiQ05952.

Polymorphism and mutation databases

BioMutaiTNP2.
DMDMi464818.

Proteomic databases

PaxDbiQ05952.
PeptideAtlasiQ05952.
PRIDEiQ05952.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312693; ENSP00000325738; ENSG00000178279.
GeneIDi7142.
KEGGihsa:7142.

Organism-specific databases

CTDi7142.
GeneCardsiTNP2.
HGNCiHGNC:11952. TNP2.
MIMi190232. gene.
neXtProtiNX_Q05952.
PharmGKBiPA36641.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2UZ. Eukaryota.
ENOG411196P. LUCA.
HOGENOMiHOG000065922.
HOVERGENiHBG004481.
InParanoidiQ05952.
KOiK19925.
OMAiQQVYKTK.
OrthoDBiEOG7NPFX8.
PhylomeDBiQ05952.
TreeFamiTF338516.

Miscellaneous databases

GeneWikiiTNP2.
GenomeRNAii7142.
PROiQ05952.
SOURCEiSearch...

Gene expression databases

BgeeiQ05952.
CleanExiHS_TNP2.
ExpressionAtlasiQ05952. baseline and differential.
GenevisibleiQ05952. HS.

Family and domain databases

InterProiIPR000678. TP2.
[Graphical view]
PANTHERiPTHR17488. PTHR17488. 1 hit.
PfamiPF01254. TP2. 1 hit.
[Graphical view]
PROSITEiPS00970. TP2_1. 1 hit.
PS00971. TP2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Linkage of human spermatid-specific basic nuclear protein genes. Definition and evolution of the P1-->P2-->TP2 locus."
    Nelson J.E., Krawetz S.A.
    J. Biol. Chem. 268:2932-2936(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Characterization of a human locus in transition."
    Nelson J.E., Krawetz S.A.
    J. Biol. Chem. 269:31067-31073(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The gene for human transition protein 2: nucleotide sequence, assignment to the protamine gene cluster, and evidence for its low expression."
    Schluter G., Kremling H., Engel W.
    Genomics 14:377-383(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  4. "Rapid evolution of male reproductive genes in the descent of man."
    Wyckoff G.J., Wang W., Wu C.-I.
    Nature 403:304-309(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-133.
  5. "Expression of mRNA and protein of nucleoproteins during human spermiogenesis."
    Steger K., Klonisch T., Gavenis K., Drabent B., Doenecke D., Bergmann M.
    Mol. Hum. Reprod. 4:939-945(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiSTP2_HUMAN
AccessioniPrimary (citable) accession number: Q05952
Secondary accession number(s): Q9NZB0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: July 6, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.