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Protein

Nuclear transition protein 2

Gene

TNP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12ZincBy similarity1
Metal bindingi16ZincBy similarity1
Metal bindingi26ZincBy similarity1
Metal bindingi30ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transition protein 2
Short name:
TP-2
Short name:
TP2
Gene namesi
Name:TNP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000178279.3
HGNCiHGNC:11952 TNP2
MIMi190232 gene
neXtProtiNX_Q05952

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7142
OpenTargetsiENSG00000178279
PharmGKBiPA36641

Polymorphism and mutation databases

BioMutaiTNP2
DMDMi464818

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001914251 – 138Nuclear transition protein 2Add BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei133PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ05952
PRIDEiQ05952

PTM databases

iPTMnetiQ05952
PhosphoSitePlusiQ05952

Expressioni

Tissue specificityi

Expressed by spermatids (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000178279
CleanExiHS_TNP2
ExpressionAtlasiQ05952 baseline and differential
GenevisibleiQ05952 HS

Interactioni

Protein-protein interaction databases

BioGridi112996, 12 interactors
IntActiQ05952, 8 interactors
STRINGi9606.ENSP00000325738

Structurei

3D structure databases

ProteinModelPortaliQ05952
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi111 – 119Nuclear localization signalBy similarity9

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J2UZ Eukaryota
ENOG411196P LUCA
GeneTreeiENSGT00390000008176
HOGENOMiHOG000065922
HOVERGENiHBG004481
InParanoidiQ05952
KOiK19925
OMAiQQVYKTK
OrthoDBiEOG091G11O9
PhylomeDBiQ05952
TreeFamiTF338516

Family and domain databases

InterProiView protein in InterPro
IPR000678 TP2
PANTHERiPTHR17488 PTHR17488, 1 hit
PfamiView protein in Pfam
PF01254 TP2, 1 hit
PROSITEiView protein in PROSITE
PS00970 TP2_1, 1 hit
PS00971 TP2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q05952-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTQTHSLPI THTQLHSNSQ PQSRTCTRHC QTFSQSCRQS HRGSRSQSSS
60 70 80 90 100
QSPASHRNPT GAHSSSGHQS QSPNTSPPPK RHKKTMNSHH SPMRPTILHC
110 120 130
RCPKNRKNLE GKLKKKKMAK RIQQVYKTKT RSSGWKSN
Length:138
Mass (Da):15,641
Last modified:February 1, 1994 - v1
Checksum:i9D2A605556BF644E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052157131R → W. Corresponds to variant dbSNP:rs11640138Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L03378 Genomic DNA Translation: AAA61203.1
U15422 Genomic DNA Translation: AAC50488.1
X63758 mRNA Translation: CAA45290.1
X63759 mRNA Translation: CAA45291.1
Z46940 Genomic DNA Translation: CAA87067.1
AF215715 Genomic DNA Translation: AAF35854.1
CCDSiCCDS45410.1
PIRiA44477 BGHU2
RefSeqiNP_005416.1, NM_005425.4
UniGeneiHs.513349

Genome annotation databases

EnsembliENST00000312693; ENSP00000325738; ENSG00000178279
GeneIDi7142
KEGGihsa:7142

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSTP2_HUMAN
AccessioniPrimary (citable) accession number: Q05952
Secondary accession number(s): Q9NZB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: January 31, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health