Q05949 (BUR2_YEAST) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 85.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Protein BUR2 Alternative name(s): Bypass UAS requirement protein 2 Chromosome stability protein 4 | ||||||
| Gene names |
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| Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ||||||
| Taxonomic identifier | 559292 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces |
Protein attributes
| Sequence length | 395 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates 'Ser-120' of the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B, the localization of the PAF1 complex to the chromatin, and the silencing of telomeric-associated genes. Also required for histone H3 'Lys-4' trimethylation. May phosphorylate the 'Ser-5' of the RBP1 carboxy-terminal domain (CTD) repeats. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase. Also required for vegetative growth itself. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation. Ref.3 Ref.5 Ref.8 |
| Subunit structure | Belongs to the BUR kinase complex composed of SGV1/BUR1 and BUR2. Interacts with SGV1. Ref.5 |
| Subcellular location | |
| Miscellaneous | Present with 2910 molecules/cell in log phase SD medium. Ref.7 |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| SGV1 | P23293 | 6 | EBI-30948,EBI-17078 |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. Hoheisel J.D.Nature 387:87-90(1997) [PubMed: 9169871] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972. |
| [2] | Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c. |
| [3] | "Mutations that suppress the deletion of an upstream activating sequence in yeast: involvement of a protein kinase and histone H3 in repressing transcription in vivo." Prelich G., Winston F. Genetics 135:665-676(1993) [PubMed: 8293972] [Abstract] Cited for: FUNCTION. |
| [4] | "New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability." Ouspenski I.I., Elledge S.J., Brinkley B.R. Nucleic Acids Res. 27:3001-3008(1999) [PubMed: 10454593] [Abstract] Cited for: GENE NAME. |
| [5] | "BUR1 and BUR2 encode a divergent cyclin-dependent kinase-cyclin complex important for transcription in vivo." Yao S., Neiman A., Prelich G. Mol. Cell. Biol. 20:7080-7087(2000) [PubMed: 10982824] [Abstract] Cited for: INTERACTION WITH BUR1, FUNCTION. |
| [6] | "Global analysis of protein localization in budding yeast." Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W., Weissman J.S., O'Shea E.K. Nature 425:686-691(2003) [PubMed: 14562095] [Abstract] Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. |
| [7] | "Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed: 14562106] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS]. |
| [8] | "BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex." Laribee R.N., Krogan N.J., Xiao T., Shibata Y., Hughes T.R., Greenblatt J.F., Strahl B.D. Curr. Biol. 15:1487-1493(2005) [PubMed: 16040246] [Abstract] Cited for: FUNCTION. |
| [9] | "A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed: 18407956] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-24, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U19027 Genomic DNA. Translation: AAB67407.1. BK006945 Genomic DNA. Translation: DAA09542.1. |
| PIR | S51449. |
| RefSeq | NP_013327.1. NM_001182113.1. |
3D structure databases | |
| ProteinModelPortal | Q05949. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-4787N. |
| IntAct | Q05949. 4 interactions. |
| MINT | MINT-507428. |
| STRING | Q05949. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblFungi | YLR226W; YLR226W; YLR226W. |
| GeneID | 850923. |
| KEGG | sce:YLR226W. |
| NMPDR | fig|4932.3.peg.4338. |
Organism-specific databases | |
| CYGD | YLR226w. |
| SGD | S000004216. BUR2. |
Phylogenomic databases | |
| eggNOG | fuNOG08201. |
| HOGENOM | HBG202504. |
| OMA | MEKCLMY. |
| OrthoDB | EOG4BS0VM. |
Gene expression databases | |
| ArrayExpress | Q05949. |
| Genevestigator | Q05949. |
| GermOnline | YLR226W. Saccharomyces cerevisiae. |
Family and domain databases | |
| InterPro | IPR013763. Cyclin-like. [Graphical view] |
| Gene3D | G3DSA:1.10.472.10. Cyclin_related. 1 hit. |
| KO | K15563. |
| SUPFAM | SSF47954. Cyclin_like. 1 hit. |
| ProtoNet | Search... |
Other | |
| NextBio | 967350. |
Entry information
| Entry name | BUR2_YEAST | ||||||||
| Accession | Primary (citable) accession number: Q05949 Secondary accession number(s): D6VYM6 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| Yeast Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD |

Clusters with