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Protein

U3 small nucleolar RNA-associated protein 13

Gene

UTP13

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in nucleolar processing of pre-18S ribosomal RNA.1 Publication

GO - Molecular functioni

  • snoRNA binding Source: SGD

GO - Biological processi

  • endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Enzyme and pathway databases

BioCyciYEAST:G3O-32336-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
U3 small nucleolar RNA-associated protein 13
Short name:
U3 snoRNA-associated protein 13
Alternative name(s):
U three protein 13
Gene namesi
Name:UTP13
Ordered Locus Names:YLR222C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR222C.
SGDiS000004212. UTP13.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: SGD
  • Pwp2p-containing subcomplex of 90S preribosome Source: SGD
  • small-subunit processome Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 817817U3 small nucleolar RNA-associated protein 13PRO_0000051320Add
BLAST

Proteomic databases

MaxQBiQ05946.
PeptideAtlasiQ05946.

PTM databases

iPTMnetiQ05946.

Interactioni

Subunit structurei

Interacts with snoRNA U3. Interacts with MPP10. Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.1 Publication

Protein-protein interaction databases

BioGridi31489. 55 interactions.
DIPiDIP-4790N.
IntActiQ05946. 19 interactions.
MINTiMINT-501291.

Structurei

3D structure databases

ProteinModelPortaliQ05946.
SMRiQ05946. Positions 19-699.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati59 – 10042WD 1Add
BLAST
Repeati102 – 13938WD 2Add
BLAST
Repeati142 – 18746WD 3Add
BLAST
Repeati191 – 23343WD 4Add
BLAST
Repeati238 – 28043WD 5Add
BLAST
Repeati386 – 42540WD 6Add
BLAST
Repeati432 – 47645WD 7Add
BLAST
Repeati489 – 52840WD 8Add
BLAST
Repeati531 – 57242WD 9Add
BLAST
Repeati573 – 61442WD 10Add
BLAST
Repeati616 – 65439WD 11Add
BLAST
Repeati664 – 70542WD 12Add
BLAST

Sequence similaritiesi

Contains 12 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

GeneTreeiENSGT00840000129769.
HOGENOMiHOG000188765.
InParanoidiQ05946.
KOiK14555.
OMAiTHHFRGS.
OrthoDBiEOG7B05NN.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013934. SSU_processome_Utp13.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08625. Utp13. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLKTSYKGI SLNPIYAGSS AVATVSENGK ILATPVLDEI NIIDLTPGSR
60 70 80 90 100
KILHKISNED EQEITALKLT PDGQYLTYVS QAQLLKIFHL KTGKVVRSMK
110 120 130 140 150
ISSPSYILDA DSTSTLLAVG GTDGSIIVVD IENGYITHSF KGHGGTISSL
160 170 180 190 200
KFYGQLNSKI WLLASGDTNG MVKVWDLVKR KCLHTLQEHT SAVRGLDIIE
210 220 230 240 250
VPDNDEPSLN LLSGGRDDII NLWDFNMKKK CKLLKTLPVN QQVESCGFLK
260 270 280 290 300
DGDGKRIIYT AGGDAIFQLI DSESGSVLKR TNKPIEELFI IGVLPILSNS
310 320 330 340 350
QMFLVLSDQT LQLINVEEDL KNDEDTIQVT SSIAGNHGII ADMRYVGPEL
360 370 380 390 400
NKLALATNSP SLRIIPVPDL SGPEASLPLD VEIYEGHEDL LNSLDATEDG
410 420 430 440 450
LWIATASKDN TAIVWRYNEN SCKFDIYAKY IGHSAAVTAV GLPNIVSKGY
460 470 480 490 500
PEFLLTASND LTIKKWIIPK PTASMDVQII KVSEYTRHAH EKDINALSVS
510 520 530 540 550
PNDSIFATAS YDKTCKIWNL ENGELEATLA NHKRGLWDVS FCQYDKLLAT
560 570 580 590 600
SSGDKTVKIW SLDTFSVMKT LEGHTNAVQR CSFINKQKQL ISCGADGLIK
610 620 630 640 650
IWDCSSGECL KTLDGHNNRL WALSTMNDGD MIVSADADGV FQFWKDCTEQ
660 670 680 690 700
EIEEEQEKAK LQVEQEQSLQ NYMSKGDWTN AFLLAMTLDH PMRLFNVLKR
710 720 730 740 750
ALGESRSRQD TEEGKIEVIF NEELDQAISI LNDEQLILLM KRCRDWNTNA
760 770 780 790 800
KTHTIAQRTI RCILMHHNIA KLSEIPGMVK IVDAIIPYTQ RHFTRVDNLV
810
EQSYILDYAL VEMDKLF
Length:817
Mass (Da):91,032
Last modified:November 1, 1996 - v1
Checksum:iA3DEA4288917027D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19027 Genomic DNA. Translation: AAB67411.1.
BK006945 Genomic DNA. Translation: DAA09538.1.
PIRiS51445.
RefSeqiNP_013323.1. NM_001182109.1.

Genome annotation databases

EnsemblFungiiYLR222C; YLR222C; YLR222C.
GeneIDi850919.
KEGGisce:YLR222C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19027 Genomic DNA. Translation: AAB67411.1.
BK006945 Genomic DNA. Translation: DAA09538.1.
PIRiS51445.
RefSeqiNP_013323.1. NM_001182109.1.

3D structure databases

ProteinModelPortaliQ05946.
SMRiQ05946. Positions 19-699.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31489. 55 interactions.
DIPiDIP-4790N.
IntActiQ05946. 19 interactions.
MINTiMINT-501291.

PTM databases

iPTMnetiQ05946.

Proteomic databases

MaxQBiQ05946.
PeptideAtlasiQ05946.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR222C; YLR222C; YLR222C.
GeneIDi850919.
KEGGisce:YLR222C.

Organism-specific databases

EuPathDBiFungiDB:YLR222C.
SGDiS000004212. UTP13.

Phylogenomic databases

GeneTreeiENSGT00840000129769.
HOGENOMiHOG000188765.
InParanoidiQ05946.
KOiK14555.
OMAiTHHFRGS.
OrthoDBiEOG7B05NN.

Enzyme and pathway databases

BioCyciYEAST:G3O-32336-MONOMER.

Miscellaneous databases

NextBioi967338.
PROiQ05946.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR013934. SSU_processome_Utp13.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08625. Utp13. 1 hit.
PF00400. WD40. 7 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 11 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: FUNCTION, INTERACTION WITH MPP10 AND SNORNA U3, IDENTIFICATION IN SSU PROCESSOME BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
  4. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiUTP13_YEAST
AccessioniPrimary (citable) accession number: Q05946
Secondary accession number(s): D6VYM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 8070 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.