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Protein

Heat shock protein SSQ1, mitochondrial

Gene

SSQ1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a role in mitochondrial iron homeostasis. Appears to be involved in the processing of the intermediate form of the frataxin homolog YFH1. Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria.7 Publications

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • unfolded protein binding Source: SGD

GO - Biological processi

  • intracellular sequestering of iron ion Source: SGD
  • iron-sulfur cluster assembly Source: SGD
  • protein maturation Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:G3O-32438-MONOMER.
YEAST:G3O-32438-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein SSQ1, mitochondrial
Alternative name(s):
Stress-seventy subfamily Q protein 1
mtHSP70 homolog
Gene namesi
Name:SSQ1
Synonyms:SSC2
Ordered Locus Names:YLR369W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR369W.
SGDiS000004361. SSQ1.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial matrix Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi462 – 4621F → S: Decreased interaction with ISU1. 1 Publication
Mutagenesisi472 – 4721V → F: 10-fold decrease in interaction with ISU1. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 657Heat shock protein SSQ1, mitochondrialPRO_0000270557
Transit peptidei1 – ?Mitochondrion

Proteomic databases

MaxQBiQ05931.

PTM databases

iPTMnetiQ05931.

Interactioni

Subunit structurei

Interacts with the Fe/S cluster assembly protein ISU1 and MGE1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ISU1Q030204EBI-35227,EBI-29901

GO - Molecular functioni

  • unfolded protein binding Source: SGD

Protein-protein interaction databases

BioGridi31629. 21 interactions.
DIPiDIP-6407N.
IntActiQ05931. 3 interactions.
MINTiMINT-694730.

Structurei

3D structure databases

ProteinModelPortaliQ05931.
SMRiQ05931. Positions 29-614.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

GeneTreeiENSGT00780000122466.
HOGENOMiHOG000228135.
InParanoidiQ05931.
OMAiYIRDSND.
OrthoDBiEOG092C1VPN.

Family and domain databases

Gene3Di2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05931-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKSGRLNFL KLNINSRLLY STNPQLTKKV IGIDLGTTNS AVAYIRDSND
60 70 80 90 100
KKSATIIEND EGQRTTPSIV AFDVKSSPQN KDQMKTLVGM AAKRQNAINS
110 120 130 140 150
ENTFFATKRL IGRAFNDKEV QRDMAVMPYK IVKCESNGQA YLSTSNGLIQ
160 170 180 190 200
SPSQIASILL KYLKQTSEEY LGEKVNLAVI TVPAYFNDSQ RQATKDAGKL
210 220 230 240 250
AGLNVLRVIN EPTAAALSFG IDDKRNNGLI AVYDLGGGTF DISILDIEDG
260 270 280 290 300
VFEVRATNGD THLGGEDFDN VIVNYIIDTF IHENPEITRE EITKNRETMQ
310 320 330 340 350
RLKDVSERAK IDLSHVKKTF IELPFVYKSK HLRVPMTEEE LDNMTLSLIN
360 370 380 390 400
RTIPPVKQAL KDADIEPEDI DEVILVGGMT RMPKIRSVVK DLFGKSPNSS
410 420 430 440 450
VNPDETVALG AAIQGGILSG EIKNVLLLDV TPLTLGIETF GGAFSPLIPR
460 470 480 490 500
NTTVPVKKTE IFSTGVDGQA GVDIKVFQGE RGLVRNNKLI GDLKLTGITP
510 520 530 540 550
LPKGIPQIYV TFDIDADGII NVSAAEKSSG KQQSITVIPN SGLSEEEIAK
560 570 580 590 600
LIEEANANRA QDNLIRQRLE LISKADIMIS DTENLFKRYE KLISSEKEYS
610 620 630 640 650
NIVEDIKALR QAIKNFKANE NDMSIDVNGI KKATDALQGR ALKLFQSATK

NQQNQGK
Length:657
Mass (Da):72,365
Last modified:November 1, 1996 - v1
Checksum:iAC2DF42F3D623892
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19103 Genomic DNA. Translation: AAB67565.1.
BK006945 Genomic DNA. Translation: DAA09672.1.
PIRiS51387.
RefSeqiNP_013473.1. NM_001182258.1.

Genome annotation databases

EnsemblFungiiYLR369W; YLR369W; YLR369W.
GeneIDi851084.
KEGGisce:YLR369W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19103 Genomic DNA. Translation: AAB67565.1.
BK006945 Genomic DNA. Translation: DAA09672.1.
PIRiS51387.
RefSeqiNP_013473.1. NM_001182258.1.

3D structure databases

ProteinModelPortaliQ05931.
SMRiQ05931. Positions 29-614.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31629. 21 interactions.
DIPiDIP-6407N.
IntActiQ05931. 3 interactions.
MINTiMINT-694730.

PTM databases

iPTMnetiQ05931.

Proteomic databases

MaxQBiQ05931.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR369W; YLR369W; YLR369W.
GeneIDi851084.
KEGGisce:YLR369W.

Organism-specific databases

EuPathDBiFungiDB:YLR369W.
SGDiS000004361. SSQ1.

Phylogenomic databases

GeneTreeiENSGT00780000122466.
HOGENOMiHOG000228135.
InParanoidiQ05931.
OMAiYIRDSND.
OrthoDBiEOG092C1VPN.

Enzyme and pathway databases

BioCyciMetaCyc:G3O-32438-MONOMER.
YEAST:G3O-32438-MONOMER.

Miscellaneous databases

PROiQ05931.

Family and domain databases

Gene3Di2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029048. HSP70_C.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
SUPFAMiSSF100920. SSF100920. 1 hit.
SSF100934. SSF100934. 1 hit.
PROSITEiPS00297. HSP70_1. 1 hit.
PS00329. HSP70_2. 1 hit.
PS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP7Q_YEAST
AccessioniPrimary (citable) accession number: Q05931
Secondary accession number(s): D6VZ06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: November 1, 1996
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 5550 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.