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Protein

Mitochondrial distribution and morphology protein 30

Gene

MDM30

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Recognizes FZO1 and regulates the amount of FZO1. Regulatory factor for the mitochondrial fusion machinery. Required for mitochondrial DNA maintenance.By similarity6 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • chronological cell aging Source: SGD
  • mitochondrial fusion Source: SGD
  • mitochondrion organization Source: SGD
  • protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: SGD
  • proteolysis involved in cellular protein catabolic process Source: SGD
  • regulation of mRNA export from nucleus Source: SGD
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: SGD

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-32437-MONOMER.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial distribution and morphology protein 30
Gene namesi
Name:MDM30
Ordered Locus Names:YLR368W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR368W.
SGDiS000004360. MDM30.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199691 – 598Mitochondrial distribution and morphology protein 30Add BLAST598

Proteomic databases

PRIDEiQ05930.

Interactioni

Subunit structurei

Interacts with SKP1. Component of the probable SCF(MDM30) complex containing CDC53, SKP1, RBX1 and MDM30. Interacts with SKP1 and FZO1.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31628. 76 interactors.
DIPiDIP-1239N.
IntActiQ05930. 13 interactors.
MINTiMINT-384045.
STRINGi4932.YLR368W.

Structurei

3D structure databases

ProteinModelPortaliQ05930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 59F-boxPROSITE-ProRule annotationAdd BLAST47

Phylogenomic databases

InParanoidiQ05930.
KOiK15070.
OMAiRESICEH.
OrthoDBiEOG092C3XON.

Family and domain databases

InterProiView protein in InterPro
IPR001810. F-box_dom.
IPR036047. F-box_dom_like.
PfamiView protein in Pfam
PF00646. F-box. 1 hit.
SMARTiView protein in SMART
SM00256. FBOX. 1 hit.
SUPFAMiSSF81383. SSF81383. 1 hit.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q05930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKRRNLFMV GSSFTIDHLP PEIWLCISKL VGTSDLHNLC LINRRLYLTI
60 70 80 90 100
TSDEIWKRRC YDRWINRESL DILTGNDYDS IPVSQWYSYY LRRAKWENKI
110 120 130 140 150
FCLLWGLTEE TNPQHFREKY LHILQFRHYK LATFLHRIIK QGYIPDKRPL
160 170 180 190 200
DLITYANYLL KNVRHKYVFP LFYPTNAAEL KNLNNMASRD AEMIYLRLSA
210 220 230 240 250
IDTSFDDLLD AREFILNGIC SDLLQKYKKI EEFLKLRPVT RVSKLISIST
260 270 280 290 300
DYLDCFTQPH DSVGQTNDRA TGRELHREDF MLLRVYSREG RGYKTIILAI
310 320 330 340 350
IQAITKRYNV DSYLARDHLV VSEPDFPDGR AFVTVNEDFQ PYIFDKEDLL
360 370 380 390 400
SVWSNNFHNA ENFESTVLPA LLEPISIQHL LTEFFRELLR CKPRPFEGYP
410 420 430 440 450
NRAHGLRDMF PYGKVEVPRD VTMYFAFIYD LFDGMFESGM TSLRGQMLRD
460 470 480 490 500
LLNYVNANNF GDLNIIIGQN ALKEPNDCWS NKRDYVLLDD NNKIGYFYTD
510 520 530 540 550
IETEDTLCAL NQYEVDGKVF ITTIDILGDI RVRLAEGLTP FQGDNDKLWE
560 570 580 590
SFSSVVPRTD WGLFFKGYDK ERRRMQLNPY IEEKLSNLAN DEQPLHNL
Length:598
Mass (Da):70,528
Last modified:November 1, 1996 - v1
Checksum:iCECDC2E2C7EDBB06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19103 Genomic DNA. Translation: AAB67566.1.
BK006945 Genomic DNA. Translation: DAA09671.1.
PIRiS51386.
RefSeqiNP_013472.3. NM_001182257.3.

Genome annotation databases

EnsemblFungiiYLR368W; YLR368W; YLR368W.
GeneIDi851083.
KEGGisce:YLR368W.

Similar proteinsi

Entry informationi

Entry nameiMDM30_YEAST
AccessioniPrimary (citable) accession number: Q05930
Secondary accession number(s): D6VZ05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names