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Protein

Mitochondrial distribution and morphology protein 30

Gene

MDM30

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins (By similarity). Recognizes FZO1 and regulates the amount of FZO1. Regulatory factor for the mitochondrial fusion machinery. Required for mitochondrial DNA maintenance.By similarity6 Publications

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

  • chronological cell aging Source: SGD
  • mitochondrial fusion Source: SGD
  • mitochondrion organization Source: SGD
  • protein ubiquitination Source: UniProtKB-UniPathway
  • proteolysis involved in cellular protein catabolic process Source: SGD
  • regulation of mRNA export from nucleus Source: SGD
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: SGD
  • ubiquitin-dependent protein catabolic process Source: SGD

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

BioCyciYEAST:G3O-32437-MONOMER
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial distribution and morphology protein 30
Gene namesi
Name:MDM30
Ordered Locus Names:YLR368W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLR368W
SGDiS000004360 MDM30

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199691 – 598Mitochondrial distribution and morphology protein 30Add BLAST598

Proteomic databases

PaxDbiQ05930
PRIDEiQ05930

Interactioni

Subunit structurei

Interacts with SKP1. Component of the probable SCF(MDM30) complex containing CDC53, SKP1, RBX1 and MDM30. Interacts with SKP1 and FZO1.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi31628, 79 interactors
DIPiDIP-1239N
IntActiQ05930, 14 interactors
MINTiQ05930
STRINGi4932.YLR368W

Structurei

3D structure databases

ProteinModelPortaliQ05930
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 59F-boxPROSITE-ProRule annotationAdd BLAST47

Phylogenomic databases

InParanoidiQ05930
KOiK15070
OMAiRESICEH
OrthoDBiEOG092C3XON

Family and domain databases

InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
PfamiView protein in Pfam
PF00646 F-box, 1 hit
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SUPFAMiSSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q05930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKRRNLFMV GSSFTIDHLP PEIWLCISKL VGTSDLHNLC LINRRLYLTI
60 70 80 90 100
TSDEIWKRRC YDRWINRESL DILTGNDYDS IPVSQWYSYY LRRAKWENKI
110 120 130 140 150
FCLLWGLTEE TNPQHFREKY LHILQFRHYK LATFLHRIIK QGYIPDKRPL
160 170 180 190 200
DLITYANYLL KNVRHKYVFP LFYPTNAAEL KNLNNMASRD AEMIYLRLSA
210 220 230 240 250
IDTSFDDLLD AREFILNGIC SDLLQKYKKI EEFLKLRPVT RVSKLISIST
260 270 280 290 300
DYLDCFTQPH DSVGQTNDRA TGRELHREDF MLLRVYSREG RGYKTIILAI
310 320 330 340 350
IQAITKRYNV DSYLARDHLV VSEPDFPDGR AFVTVNEDFQ PYIFDKEDLL
360 370 380 390 400
SVWSNNFHNA ENFESTVLPA LLEPISIQHL LTEFFRELLR CKPRPFEGYP
410 420 430 440 450
NRAHGLRDMF PYGKVEVPRD VTMYFAFIYD LFDGMFESGM TSLRGQMLRD
460 470 480 490 500
LLNYVNANNF GDLNIIIGQN ALKEPNDCWS NKRDYVLLDD NNKIGYFYTD
510 520 530 540 550
IETEDTLCAL NQYEVDGKVF ITTIDILGDI RVRLAEGLTP FQGDNDKLWE
560 570 580 590
SFSSVVPRTD WGLFFKGYDK ERRRMQLNPY IEEKLSNLAN DEQPLHNL
Length:598
Mass (Da):70,528
Last modified:November 1, 1996 - v1
Checksum:iCECDC2E2C7EDBB06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19103 Genomic DNA Translation: AAB67566.1
BK006945 Genomic DNA Translation: DAA09671.1
PIRiS51386
RefSeqiNP_013472.3, NM_001182257.3

Genome annotation databases

EnsemblFungiiYLR368W; YLR368W; YLR368W
GeneIDi851083
KEGGisce:YLR368W

Similar proteinsi

Entry informationi

Entry nameiMDM30_YEAST
AccessioniPrimary (citable) accession number: Q05930
Secondary accession number(s): D6VZ05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health