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Protein

Probetacellulin

Gene

Btc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor, Mitogen

Enzyme and pathway databases

ReactomeiR-MMU-1227986. Signaling by ERBB2.
R-MMU-1236394. Signaling by ERBB4.
R-MMU-1250196. SHC1 events in ERBB2 signaling.
R-MMU-1250342. PI3K events in ERBB4 signaling.
R-MMU-1250347. SHC1 events in ERBB4 signaling.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-1963640. GRB2 events in ERBB2 signaling.
R-MMU-1963642. PI3K events in ERBB2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6785631. ERBB2 Regulates Cell Motility.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-8847993. ERBB2 Activates PTK6 Signaling.
R-MMU-8863795. Downregulation of ERBB2 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Probetacellulin
Cleaved into the following chain:
Betacellulin
Short name:
BTC
Gene namesi
Name:Btc
Synonyms:Bcn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:99439. Btc.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 118ExtracellularSequence analysisAdd BLAST87
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 177CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

  • extracellular space Source: GO_Central
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 311 PublicationAdd BLAST31
ChainiPRO_000030068632 – 177ProbetacellulinAdd BLAST146
ChainiPRO_000000749232 – 111BetacellulinAdd BLAST80
PropeptideiPRO_0000007493112 – 177Removed in mature formAdd BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Glycosylationi42N-linked (GlcNAc...)Sequence analysis1
Glycosylationi52N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi69 ↔ 82PROSITE-ProRule annotation
Disulfide bondi77 ↔ 93PROSITE-ProRule annotation
Disulfide bondi95 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ05928.
PeptideAtlasiQ05928.
PRIDEiQ05928.

PTM databases

iPTMnetiQ05928.
PhosphoSitePlusiQ05928.

Miscellaneous databases

PMAP-CutDBQ05928.

Expressioni

Tissue specificityi

Found in several mouse tissues including kidney, uterus and liver, as well as in beta tumor cell line and MCF-7 cells. It is not detected in the brain.

Gene expression databases

BgeeiENSMUSG00000082361.
ExpressionAtlasiQ05928. baseline and differential.
GenevisibleiQ05928. MM.

Interactioni

Subunit structurei

Monomer. Interacts with EGFR and ERBB4.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198395. 2 interactors.
STRINGi10090.ENSMUSP00000112765.

Structurei

3D structure databases

ProteinModelPortaliQ05928.
SMRiQ05928.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 105EGF-likePROSITE-ProRule annotationAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi146 – 153Arg/Lys-rich (basic)8

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWUI. Eukaryota.
ENOG41126JP. LUCA.
GeneTreeiENSGT00730000110951.
HOGENOMiHOG000237352.
HOVERGENiHBG004905.
InParanoidiQ05928.
KOiK09783.
OMAiIGARCER.
OrthoDBiEOG091G0RK4.
PhylomeDBiQ05928.
TreeFamiTF332938.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
PfamiPF00008. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPTAPGSSV SSLPLLLVLA LGLAILHCVV ADGNTTRTPE TNGSLCGAPG
60 70 80 90 100
ENCTGTTPRQ KVKTHFSRCP KQYKHYCIHG RCRFVVDEQT PSCICEKGYF
110 120 130 140 150
GARCERVDLF YLQQDRGQIL VVCLIVVMVV FIILVIGVCT CCHPLRKHRK
160 170
KKKEEKMETL DKDKTPISED IQETNIA
Length:177
Mass (Da):19,664
Last modified:February 1, 1994 - v1
Checksum:i066BB34F0E13F82B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08394 mRNA. Translation: AAA40511.1.
AK076272 mRNA. Translation: BAC36281.1.
CCDSiCCDS19422.1.
PIRiA37408.
RefSeqiNP_031594.1. NM_007568.5.
UniGeneiMm.2024.

Genome annotation databases

EnsembliENSMUST00000121044; ENSMUSP00000112765; ENSMUSG00000082361.
GeneIDi12223.
KEGGimmu:12223.
UCSCiuc008ybv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08394 mRNA. Translation: AAA40511.1.
AK076272 mRNA. Translation: BAC36281.1.
CCDSiCCDS19422.1.
PIRiA37408.
RefSeqiNP_031594.1. NM_007568.5.
UniGeneiMm.2024.

3D structure databases

ProteinModelPortaliQ05928.
SMRiQ05928.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198395. 2 interactors.
STRINGi10090.ENSMUSP00000112765.

PTM databases

iPTMnetiQ05928.
PhosphoSitePlusiQ05928.

Proteomic databases

PaxDbiQ05928.
PeptideAtlasiQ05928.
PRIDEiQ05928.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000121044; ENSMUSP00000112765; ENSMUSG00000082361.
GeneIDi12223.
KEGGimmu:12223.
UCSCiuc008ybv.2. mouse.

Organism-specific databases

CTDi685.
MGIiMGI:99439. Btc.

Phylogenomic databases

eggNOGiENOG410IWUI. Eukaryota.
ENOG41126JP. LUCA.
GeneTreeiENSGT00730000110951.
HOGENOMiHOG000237352.
HOVERGENiHBG004905.
InParanoidiQ05928.
KOiK09783.
OMAiIGARCER.
OrthoDBiEOG091G0RK4.
PhylomeDBiQ05928.
TreeFamiTF332938.

Enzyme and pathway databases

ReactomeiR-MMU-1227986. Signaling by ERBB2.
R-MMU-1236394. Signaling by ERBB4.
R-MMU-1250196. SHC1 events in ERBB2 signaling.
R-MMU-1250342. PI3K events in ERBB4 signaling.
R-MMU-1250347. SHC1 events in ERBB4 signaling.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-1963640. GRB2 events in ERBB2 signaling.
R-MMU-1963642. PI3K events in ERBB2 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6785631. ERBB2 Regulates Cell Motility.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-MMU-8847993. ERBB2 Activates PTK6 Signaling.
R-MMU-8863795. Downregulation of ERBB2 signaling.

Miscellaneous databases

PMAP-CutDBQ05928.
PROiQ05928.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000082361.
ExpressionAtlasiQ05928. baseline and differential.
GenevisibleiQ05928. MM.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
PfamiPF00008. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBTC_MOUSE
AccessioniPrimary (citable) accession number: Q05928
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: February 1, 1994
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.