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Q05925

- HME1_HUMAN

UniProt

Q05925 - HME1_HUMAN

Protein

Homeobox protein engrailed-1

Gene

EN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi303 – 36260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anatomical structure morphogenesis Source: ProtInc
    2. dorsal/ventral pattern formation Source: Ensembl
    3. embryonic forelimb morphogenesis Source: Ensembl
    4. hindbrain development Source: Ensembl
    5. midbrain development Source: Ensembl
    6. midbrain-hindbrain boundary development Source: Ensembl
    7. neuron development Source: Ensembl
    8. pigmentation Source: Ensembl
    9. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    10. proximal/distal pattern formation Source: Ensembl
    11. response to cocaine Source: Ensembl
    12. skeletal system development Source: ProtInc

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    SignaLinkiQ05925.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein engrailed-1
    Short name:
    Homeobox protein en-1
    Short name:
    Hu-En-1
    Gene namesi
    Name:EN1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:3342. EN1.

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA27779.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Homeobox protein engrailed-1PRO_0000196062Add
    BLAST

    Proteomic databases

    MaxQBiQ05925.
    PaxDbiQ05925.
    PRIDEiQ05925.

    PTM databases

    PhosphoSiteiQ05925.

    Expressioni

    Gene expression databases

    BgeeiQ05925.
    CleanExiHS_EN1.
    GenevestigatoriQ05925.

    Organism-specific databases

    HPAiCAB014884.

    Interactioni

    Protein-protein interaction databases

    BioGridi108334. 3 interactions.
    STRINGi9606.ENSP00000295206.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05925.
    SMRiQ05925. Positions 282-362.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi199 – 21820Poly-AlaAdd
    BLAST
    Compositional biasi224 – 2318Poly-Gly

    Sequence similaritiesi

    Belongs to the engrailed homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG238866.
    HOGENOMiHOG000247054.
    HOVERGENiHBG005975.
    InParanoidiQ05925.
    KOiK09319.
    OMAiNCGPPDG.
    OrthoDBiEOG7VTDN8.
    PhylomeDBiQ05925.
    TreeFamiTF106461.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR019549. Homeobox-engrailed_C-terminal.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000747. Homeodomain_engrailed.
    IPR019737. Homoebox-engrailed_CS.
    [Graphical view]
    PfamiPF10525. Engrail_1_C_sig. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00026. ENGRAILED.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00033. ENGRAILED. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05925-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEQQPEPKS QRDSALGAAA AATPGGLSLS LSPGASGSSG SGSDGDSVPV    50
    SPQPAPPSPP AAPCLPPLAH HPHLPPHPPP PPPQHLAAPA HQPQPAAQLH 100
    RTTNFFIDNI LRPDFGCKKE QPPPQLLVAA AARGGAGGGG RVERDRGQTA 150
    AGRDPVHPLG TRAPGAASLL CAPDANCGPP DGSQPAAAGA GASKAGNPAA 200
    AAAAAAAAVA AAAAAAAAKP SDTGGGGSGG GAGSPGAQGT KYPEHGNPAI 250
    LLMGSANGGP VVKTDSQQPL VWPAWVYCTR YSDRPSSGPR TRKLKKKKNE 300
    KEDKRPRTAF TAEQLQRLKA EFQANRYITE QRRQTLAQEL SLNESQIKIW 350
    FQNKRAKIKK ATGIKNGLAL HLMAQGLYNH STTTVQDKDE SE 392
    Length:392
    Mass (Da):40,115
    Last modified:November 25, 2008 - v3
    Checksum:iBDFE6279E9C27BFD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti18 – 181A → G in AAA53502. (PubMed:1363401)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12699, L12698 Genomic DNA. Translation: AAA53502.2.
    AC012665 Genomic DNA. Translation: AAX88967.1.
    CH471103 Genomic DNA. Translation: EAW95206.1.
    CCDSiCCDS2123.1.
    PIRiB48423.
    RefSeqiNP_001417.3. NM_001426.3.
    UniGeneiHs.271977.

    Genome annotation databases

    EnsembliENST00000295206; ENSP00000295206; ENSG00000163064.
    GeneIDi2019.
    KEGGihsa:2019.
    UCSCiuc002tlm.3. human.

    Polymorphism databases

    DMDMi215274149.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12699 , L12698 Genomic DNA. Translation: AAA53502.2 .
    AC012665 Genomic DNA. Translation: AAX88967.1 .
    CH471103 Genomic DNA. Translation: EAW95206.1 .
    CCDSi CCDS2123.1.
    PIRi B48423.
    RefSeqi NP_001417.3. NM_001426.3.
    UniGenei Hs.271977.

    3D structure databases

    ProteinModelPortali Q05925.
    SMRi Q05925. Positions 282-362.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108334. 3 interactions.
    STRINGi 9606.ENSP00000295206.

    PTM databases

    PhosphoSitei Q05925.

    Polymorphism databases

    DMDMi 215274149.

    Proteomic databases

    MaxQBi Q05925.
    PaxDbi Q05925.
    PRIDEi Q05925.

    Protocols and materials databases

    DNASUi 2019.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000295206 ; ENSP00000295206 ; ENSG00000163064 .
    GeneIDi 2019.
    KEGGi hsa:2019.
    UCSCi uc002tlm.3. human.

    Organism-specific databases

    CTDi 2019.
    GeneCardsi GC02M119694.
    HGNCi HGNC:3342. EN1.
    HPAi CAB014884.
    MIMi 131290. gene.
    neXtProti NX_Q05925.
    PharmGKBi PA27779.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238866.
    HOGENOMi HOG000247054.
    HOVERGENi HBG005975.
    InParanoidi Q05925.
    KOi K09319.
    OMAi NCGPPDG.
    OrthoDBi EOG7VTDN8.
    PhylomeDBi Q05925.
    TreeFami TF106461.

    Enzyme and pathway databases

    SignaLinki Q05925.

    Miscellaneous databases

    GeneWikii EN1_(gene).
    GenomeRNAii 2019.
    NextBioi 8181.
    PROi Q05925.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q05925.
    CleanExi HS_EN1.
    Genevestigatori Q05925.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR019549. Homeobox-engrailed_C-terminal.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000747. Homeodomain_engrailed.
    IPR019737. Homoebox-engrailed_CS.
    [Graphical view ]
    Pfami PF10525. Engrail_1_C_sig. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00026. ENGRAILED.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00033. ENGRAILED. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions."
      Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., Provart N.J., Joyner A.L.
      Dev. Genet. 13:345-358(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., Provart N.J., Joyner A.L.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 288.
    3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiHME1_HUMAN
    AccessioniPrimary (citable) accession number: Q05925
    Secondary accession number(s): Q4ZG44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 126 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3