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Q05925

- HME1_HUMAN

UniProt

Q05925 - HME1_HUMAN

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Protein

Homeobox protein engrailed-1

Gene

EN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi303 – 36260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. anatomical structure morphogenesis Source: ProtInc
  2. dorsal/ventral pattern formation Source: Ensembl
  3. embryonic forelimb morphogenesis Source: Ensembl
  4. hindbrain development Source: Ensembl
  5. midbrain development Source: Ensembl
  6. midbrain-hindbrain boundary development Source: Ensembl
  7. multicellular organism growth Source: Ensembl
  8. neuron development Source: Ensembl
  9. pigmentation Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. proximal/distal pattern formation Source: Ensembl
  12. response to cocaine Source: Ensembl
  13. skeletal system development Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

SignaLinkiQ05925.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein engrailed-1
Short name:
Homeobox protein en-1
Short name:
Hu-En-1
Gene namesi
Name:EN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:3342. EN1.

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: Ensembl
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA27779.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Homeobox protein engrailed-1PRO_0000196062Add
BLAST

Proteomic databases

MaxQBiQ05925.
PaxDbiQ05925.
PRIDEiQ05925.

PTM databases

PhosphoSiteiQ05925.

Expressioni

Gene expression databases

BgeeiQ05925.
CleanExiHS_EN1.
GenevestigatoriQ05925.

Organism-specific databases

HPAiCAB014884.

Interactioni

Protein-protein interaction databases

BioGridi108334. 3 interactions.
STRINGi9606.ENSP00000295206.

Structurei

3D structure databases

ProteinModelPortaliQ05925.
SMRiQ05925. Positions 282-362.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi199 – 21820Poly-AlaAdd
BLAST
Compositional biasi224 – 2318Poly-Gly

Sequence similaritiesi

Belongs to the engrailed homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG238866.
GeneTreeiENSGT00760000119211.
HOGENOMiHOG000247054.
HOVERGENiHBG005975.
InParanoidiQ05925.
KOiK09319.
OMAiNCGPPDG.
OrthoDBiEOG7VTDN8.
PhylomeDBiQ05925.
TreeFamiTF106461.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR019549. Homeobox-engrailed_C-terminal.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000747. Homeodomain_engrailed.
IPR019737. Homoebox-engrailed_CS.
[Graphical view]
PfamiPF10525. Engrail_1_C_sig. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00026. ENGRAILED.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00033. ENGRAILED. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05925-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEQQPEPKS QRDSALGAAA AATPGGLSLS LSPGASGSSG SGSDGDSVPV
60 70 80 90 100
SPQPAPPSPP AAPCLPPLAH HPHLPPHPPP PPPQHLAAPA HQPQPAAQLH
110 120 130 140 150
RTTNFFIDNI LRPDFGCKKE QPPPQLLVAA AARGGAGGGG RVERDRGQTA
160 170 180 190 200
AGRDPVHPLG TRAPGAASLL CAPDANCGPP DGSQPAAAGA GASKAGNPAA
210 220 230 240 250
AAAAAAAAVA AAAAAAAAKP SDTGGGGSGG GAGSPGAQGT KYPEHGNPAI
260 270 280 290 300
LLMGSANGGP VVKTDSQQPL VWPAWVYCTR YSDRPSSGPR TRKLKKKKNE
310 320 330 340 350
KEDKRPRTAF TAEQLQRLKA EFQANRYITE QRRQTLAQEL SLNESQIKIW
360 370 380 390
FQNKRAKIKK ATGIKNGLAL HLMAQGLYNH STTTVQDKDE SE
Length:392
Mass (Da):40,115
Last modified:November 25, 2008 - v3
Checksum:iBDFE6279E9C27BFD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181A → G in AAA53502. (PubMed:1363401)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12699, L12698 Genomic DNA. Translation: AAA53502.2.
AC012665 Genomic DNA. Translation: AAX88967.1.
CH471103 Genomic DNA. Translation: EAW95206.1.
CCDSiCCDS2123.1.
PIRiB48423.
RefSeqiNP_001417.3. NM_001426.3.
UniGeneiHs.271977.

Genome annotation databases

EnsembliENST00000295206; ENSP00000295206; ENSG00000163064.
GeneIDi2019.
KEGGihsa:2019.
UCSCiuc002tlm.3. human.

Polymorphism databases

DMDMi215274149.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L12699 , L12698 Genomic DNA. Translation: AAA53502.2 .
AC012665 Genomic DNA. Translation: AAX88967.1 .
CH471103 Genomic DNA. Translation: EAW95206.1 .
CCDSi CCDS2123.1.
PIRi B48423.
RefSeqi NP_001417.3. NM_001426.3.
UniGenei Hs.271977.

3D structure databases

ProteinModelPortali Q05925.
SMRi Q05925. Positions 282-362.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 108334. 3 interactions.
STRINGi 9606.ENSP00000295206.

PTM databases

PhosphoSitei Q05925.

Polymorphism databases

DMDMi 215274149.

Proteomic databases

MaxQBi Q05925.
PaxDbi Q05925.
PRIDEi Q05925.

Protocols and materials databases

DNASUi 2019.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000295206 ; ENSP00000295206 ; ENSG00000163064 .
GeneIDi 2019.
KEGGi hsa:2019.
UCSCi uc002tlm.3. human.

Organism-specific databases

CTDi 2019.
GeneCardsi GC02M119694.
HGNCi HGNC:3342. EN1.
HPAi CAB014884.
MIMi 131290. gene.
neXtProti NX_Q05925.
PharmGKBi PA27779.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG238866.
GeneTreei ENSGT00760000119211.
HOGENOMi HOG000247054.
HOVERGENi HBG005975.
InParanoidi Q05925.
KOi K09319.
OMAi NCGPPDG.
OrthoDBi EOG7VTDN8.
PhylomeDBi Q05925.
TreeFami TF106461.

Enzyme and pathway databases

SignaLinki Q05925.

Miscellaneous databases

GeneWikii EN1_(gene).
GenomeRNAii 2019.
NextBioi 8181.
PROi Q05925.
SOURCEi Search...

Gene expression databases

Bgeei Q05925.
CleanExi HS_EN1.
Genevestigatori Q05925.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR019549. Homeobox-engrailed_C-terminal.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000747. Homeodomain_engrailed.
IPR019737. Homoebox-engrailed_CS.
[Graphical view ]
Pfami PF10525. Engrail_1_C_sig. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00026. ENGRAILED.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00033. ENGRAILED. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions."
    Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., Provart N.J., Joyner A.L.
    Dev. Genet. 13:345-358(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., Provart N.J., Joyner A.L.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 288.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiHME1_HUMAN
AccessioniPrimary (citable) accession number: Q05925
Secondary accession number(s): Q4ZG44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3