Dual specificity protein phosphatase 2

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Reviewed, UniProtKB/Swiss-Prot Q05923 (DUS2_HUMAN)

Last modified June 16, 2009. Version 98. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Dual specificity protein phosphatase 2
    EC=3.1.3.48
    EC=3.1.3.16
Alternative name(s):
    Dual specificity protein phosphatase PAC-1

Gene names

Name:	DUSP2
Synonyms:	PAC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2.
Catalytic activity	Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate. A phosphoprotein + H₂O = a protein + phosphate.
Subcellular location	Nucleus.
Tissue specificity	In hematopoietic tissues.
Induction	By mitogens.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 rhodanese domain. Contains 1 tyrosine-protein phosphatase domain.

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Ontologies

Keywords
Cellular component	Nucleus
Molecular function	Hydrolase Protein phosphatase
Technical term	3D-structure
Gene Ontology (GO)
Biological process	inactivation of MAPK activity Traceable author statement. Source: ProtInc protein amino acid dephosphorylation Traceable author statement. Source: ProtInc
Cellular component	nucleus Traceable author statement. Source: ProtInc
Molecular function	MAP kinase tyrosine/serine/threonine phosphatase activity Inferred from electronic annotation. Source: InterPro protein tyrosine phosphatase activity Ref.1 Traceable author statement. Source: ProtInc protein tyrosine/threonine phosphatase activity Traceable author statement. Source: ProtInc
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 314

314

Dual specificity protein phosphatase 2

PRO_0000094793

Regions

Domain

23 – 144

122

Rhodanese

Domain

237 – 302

Tyrosine-protein phosphatase

Sites

Active site

257

Phosphocysteine intermediate By similarity

Secondary structure

314

Helix Strand Turn

Details...

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Sequences

Sequence

Length

Mass (Da)

Tools

Q05923-1 [UniParc].

Last modified February 1, 1994. Version 1.
Checksum: FDD3543C6DE10CA5
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FASTA

314

34,400

        10         20         30         40         50         60 
MGLEAARELE CAALGTLLRD PREAERTLLL DCRPFLAFCR RHVRAARPVP WNALLRRRAR 

        70         80         90        100        110        120 
GPPAAVLACL LPDRALRTRL VRGELARAVV LDEGSASVAE LRPDSPAHVL LAALLHETRA 

       130        140        150        160        170        180 
GPTAVYFLRG GFDGFQGCCP DLCSEAPAPA LPPTGDKTSR SDSRAPVYDQ GGPVEILPYL 

       190        200        210        220        230        240 
FLGSCSHSSD LQGLQACGIT AVLNVSASCP NHFEGLFRYK SIPVEDNQMV EISAWFQEAI 

       250        260        270        280        290        300 
GFIDWVKNSG GRVLVHCQAG ISRSATICLA YLMQSRRVRL DEAFDFVKQR RGVISPNFSF 

       310 
MGQLLQFETQ VLCH

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PAC-1: a mitogen-induced nuclear protein tyrosine phosphatase." Rohan P., Davis P., Moskaluk C.A., Kearns M., Krutzsch H., Siebenlist U., Kelly K. Science 259:1763-1766(1993) [PubMed: 7681221] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Genomic organization and chromosomal localization of the DUSP2 gene, encoding a MAP kinase phosphatase, to human 2p11.2-q11." Yi H., Morton C.C., Weremowicz S., McBride O.W., Kelly K. Genomics 28:92-96(1995) [PubMed: 7590752] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: B-cell.
[4]	"Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP." Farooq A., Plotnikova O., Chaturvedi G., Yan S., Zeng L., Zhang Q., Zhou M.M. Structure 11:155-164(2003) [PubMed: 12575935] [Abstract] Cited for: STRUCTURE BY NMR OF 170-314.
+	Additional computationally mapped references.

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Cross-references

Sequence databases

L11329 mRNA. Translation: AAA50779.1.
U23853 Genomic DNA. Translation: AAA86112.1.
BC007771 mRNA. Translation: AAH07771.1.

IPI

IPI00016729.

PIR

A57126.

RefSeq

NP_004409.1.

UniGene

Hs.1183

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1M3G	NMR	-	A	170-314	[»]

ModBase

Search...

Proteomic databases

PRIDE

Q05923.

Genome annotation databases

Ensembl

ENSG00000158050. Homo sapiens. [Contig view]

GeneID

1844.

KEGG

hsa:1844.

Organism-specific databases

GeneCards

GC02M096230.

H-InvDB

HIX0002269.

HGNC

HGNC:3068. DUSP2.

MIM

603068. gene.

PharmGKB

PA27525.

GenAtlas

Search...

Phylogenomic databases

HOGENOM

Q05923.

HOVERGEN

Q05923.

OMA

Q05923. NQMVEIS.

Enzyme and pathway databases

BRENDA

3.1.3.16. 247.
3.1.3.48. 247.

Gene expression databases

ArrayExpress

Q05923.

Bgee

Q05923.

CleanEx

HS_DUSP2.

GermOnline

ENSG00000158050. Homo sapiens.

Family and domain databases

InterPro

IPR014393. Dual_MAP_Kinase_Phosphatase.
IPR008343. MAPK_phosph.
IPR001763. Rhodanese-like.
IPR000387. Tyr_Pase.
IPR016130. Tyr_Pase_AS.
IPR000340. Tyr_Pase_dual_specific.
[Graphical view]

Gene3D

G3DSA:3.40.250.10. Rhodanese-like. 1 hit.

Pfam

PF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]

PIRSF

PIRSF000939. MAPK_Ptase. 1 hit.

PRINTS

PR01764. MAPKPHPHTASE.

SMART

SM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]

PROSITE

PS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

7551.

SOURCE

Search...

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Entry information

Entry name

DUS2_HUMAN

Accession

Primary (citable) accession number: Q05923

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1994
Last sequence update:	February 1, 1994
Last modified:	June 16, 2009
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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