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Q05918 (IPHP_NOSCO) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tyrosine-protein phosphatase

EC=3.1.3.48
Gene names
Name:iphP
Synonyms:iph
OrganismNostoc commune
Taxonomic identifier1178 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subunit structure

Monomer.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family.

Ontologies

Keywords
   DomainSignal
   Molecular functionHydrolase
Protein phosphatase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Ref.1
Chain25 – 294270Tyrosine-protein phosphatase
PRO_0000025473

Sites

Active site1821Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q05918 [UniParc].

Last modified February 1, 1995. Version 1.
Checksum: 9E067BC99D7EF2B5

FASTA29431,005
        10         20         30         40         50         60 
MKTHHANLAL ALMLGLSSSA TAVAADAPQA VATKAAAPNV KPVAADAHGV IPDGAPGMCA 

        70         80         90        100        110        120 
RSPACRATAI PADAFVRTAD LGRLTDADRD ALAALGVKLD IDLRTADEEA QSPDLLARDD 

       130        140        150        160        170        180 
RFDYQRISLM GTEKMDLQKM MTSFPDSLGE AYVQWLGHSQ PQFKQVFQRI AAQQDGAVLF 

       190        200        210        220        230        240 
HCTAGKDRTG IIAGLLLDLA GVPKAEIVHN YAISAHYLEG QPKDSDERAD HGAGQAEPGD 

       250        260        270        280        290 
RPQDGGHGRY RAGQHGAVLA ALHSQYGGAE GYLKSIGVSE QEIQQLKVRL GQAG 

« Hide

References

[1]"A protein-tyrosine/serine phosphatase encoded by the genome of the cyanobacterium Nostoc commune UTEX 584."
Potts M., Sun H., Mockaitis K., Kennelly P.J., Reed D., Tonks N.K.
J. Biol. Chem. 268:7632-7635(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 25-37.
Strain: UTEX 584.
[2]"Nostoc commune UTEX 584 gene expressing indole phosphate hydrolase activity in Escherichia coli."
Xie W.-Q., Whitton B.A., Simon J.W., Jaeger K., Reed D., Potts M.
J. Bacteriol. 171:708-713(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: UTEX 584.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L11392 Genomic DNA. Translation: AAA25511.1.
PIRA46635.

3D structure databases

ProteinModelPortalQ05918.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

PptaseDBP3D040487.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR026893. Tyr/Ser_Pase_IphP-type.
IPR016130. Tyr_Pase_AS.
IPR025163. Tyr_Phosphatase_C_dom.
[Graphical view]
PfamPF13350. Y_phosphatase3. 1 hit.
PF13348. Y_phosphatase3C. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIPHP_NOSCO
AccessionPrimary (citable) accession number: Q05918
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families