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Q05918

- IPHP_NOSCO

UniProt

Q05918 - IPHP_NOSCO

Protein

Tyrosine-protein phosphatase

Gene

iphP

Organism
Nostoc commune
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 Feb 1995)
      Previous versions | rss
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    • Comment

    Functioni

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei182 – 1821Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Protein family/group databases

    PptaseDBiP3D040487.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein phosphatase (EC:3.1.3.48)
    Gene namesi
    Name:iphP
    Synonyms:iph
    OrganismiNostoc commune
    Taxonomic identifieri1178 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24241 PublicationAdd
    BLAST
    Chaini25 – 294270Tyrosine-protein phosphatasePRO_0000025473Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliQ05918.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR026893. Tyr/Ser_Pase_IphP-type.
    IPR016130. Tyr_Pase_AS.
    IPR025163. Tyr_Phosphatase_C_dom.
    [Graphical view]
    PfamiPF13350. Y_phosphatase3. 1 hit.
    PF13348. Y_phosphatase3C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q05918-1 [UniParc]FASTAAdd to Basket

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    MKTHHANLAL ALMLGLSSSA TAVAADAPQA VATKAAAPNV KPVAADAHGV    50
    IPDGAPGMCA RSPACRATAI PADAFVRTAD LGRLTDADRD ALAALGVKLD 100
    IDLRTADEEA QSPDLLARDD RFDYQRISLM GTEKMDLQKM MTSFPDSLGE 150
    AYVQWLGHSQ PQFKQVFQRI AAQQDGAVLF HCTAGKDRTG IIAGLLLDLA 200
    GVPKAEIVHN YAISAHYLEG QPKDSDERAD HGAGQAEPGD RPQDGGHGRY 250
    RAGQHGAVLA ALHSQYGGAE GYLKSIGVSE QEIQQLKVRL GQAG 294
    Length:294
    Mass (Da):31,005
    Last modified:February 1, 1995 - v1
    Checksum:i9E067BC99D7EF2B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11392 Genomic DNA. Translation: AAA25511.1.
    PIRiA46635.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L11392 Genomic DNA. Translation: AAA25511.1 .
    PIRi A46635.

    3D structure databases

    ProteinModelPortali Q05918.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    PptaseDBi P3D040487.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR026893. Tyr/Ser_Pase_IphP-type.
    IPR016130. Tyr_Pase_AS.
    IPR025163. Tyr_Phosphatase_C_dom.
    [Graphical view ]
    Pfami PF13350. Y_phosphatase3. 1 hit.
    PF13348. Y_phosphatase3C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A protein-tyrosine/serine phosphatase encoded by the genome of the cyanobacterium Nostoc commune UTEX 584."
      Potts M., Sun H., Mockaitis K., Kennelly P.J., Reed D., Tonks N.K.
      J. Biol. Chem. 268:7632-7635(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 25-37.
      Strain: UTEX 584.
    2. "Nostoc commune UTEX 584 gene expressing indole phosphate hydrolase activity in Escherichia coli."
      Xie W.-Q., Whitton B.A., Simon J.W., Jaeger K., Reed D., Potts M.
      J. Bacteriol. 171:708-713(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: UTEX 584.

    Entry informationi

    Entry nameiIPHP_NOSCO
    AccessioniPrimary (citable) accession number: Q05918
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1995
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3