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Protein

Tyrosine-protein phosphatase

Gene

iphP

Organism
Nostoc commune
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei182 – 1821Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase (EC:3.1.3.48)
Gene namesi
Name:iphP
Synonyms:iph
OrganismiNostoc commune
Taxonomic identifieri1178 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 294270Tyrosine-protein phosphatasePRO_0000025473Add
BLAST

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliQ05918.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR026893. Tyr/Ser_Pase_IphP-type.
IPR016130. Tyr_Pase_AS.
IPR025163. Tyr_Phosphatase_C_dom.
[Graphical view]
PfamiPF13350. Y_phosphatase3. 1 hit.
PF13348. Y_phosphatase3C. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05918-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTHHANLAL ALMLGLSSSA TAVAADAPQA VATKAAAPNV KPVAADAHGV
60 70 80 90 100
IPDGAPGMCA RSPACRATAI PADAFVRTAD LGRLTDADRD ALAALGVKLD
110 120 130 140 150
IDLRTADEEA QSPDLLARDD RFDYQRISLM GTEKMDLQKM MTSFPDSLGE
160 170 180 190 200
AYVQWLGHSQ PQFKQVFQRI AAQQDGAVLF HCTAGKDRTG IIAGLLLDLA
210 220 230 240 250
GVPKAEIVHN YAISAHYLEG QPKDSDERAD HGAGQAEPGD RPQDGGHGRY
260 270 280 290
RAGQHGAVLA ALHSQYGGAE GYLKSIGVSE QEIQQLKVRL GQAG
Length:294
Mass (Da):31,005
Last modified:February 1, 1995 - v1
Checksum:i9E067BC99D7EF2B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11392 Genomic DNA. Translation: AAA25511.1.
PIRiA46635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L11392 Genomic DNA. Translation: AAA25511.1.
PIRiA46635.

3D structure databases

ProteinModelPortaliQ05918.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR026893. Tyr/Ser_Pase_IphP-type.
IPR016130. Tyr_Pase_AS.
IPR025163. Tyr_Phosphatase_C_dom.
[Graphical view]
PfamiPF13350. Y_phosphatase3. 1 hit.
PF13348. Y_phosphatase3C. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A protein-tyrosine/serine phosphatase encoded by the genome of the cyanobacterium Nostoc commune UTEX 584."
    Potts M., Sun H., Mockaitis K., Kennelly P.J., Reed D., Tonks N.K.
    J. Biol. Chem. 268:7632-7635(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 25-37.
    Strain: UTEX 584.
  2. "Nostoc commune UTEX 584 gene expressing indole phosphate hydrolase activity in Escherichia coli."
    Xie W.-Q., Whitton B.A., Simon J.W., Jaeger K., Reed D., Potts M.
    J. Bacteriol. 171:708-713(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: UTEX 584.

Entry informationi

Entry nameiIPHP_NOSCO
AccessioniPrimary (citable) accession number: Q05918
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: March 4, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.