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Q05918

- IPHP_NOSCO

UniProt

Q05918 - IPHP_NOSCO

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Protein
Tyrosine-protein phosphatase
Gene
iphP, iph
Organism
Nostoc commune
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei182 – 1821Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Protein family/group databases

PptaseDBiP3D040487.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase (EC:3.1.3.48)
Gene namesi
Name:iphP
Synonyms:iph
OrganismiNostoc commune
Taxonomic identifieri1178 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaNostocalesNostocaceaeNostoc

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 Publication
Add
BLAST
Chaini25 – 294270Tyrosine-protein phosphatase
PRO_0000025473Add
BLAST

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliQ05918.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR026893. Tyr/Ser_Pase_IphP-type.
IPR016130. Tyr_Pase_AS.
IPR025163. Tyr_Phosphatase_C_dom.
[Graphical view]
PfamiPF13350. Y_phosphatase3. 1 hit.
PF13348. Y_phosphatase3C. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q05918-1 [UniParc]FASTAAdd to Basket

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MKTHHANLAL ALMLGLSSSA TAVAADAPQA VATKAAAPNV KPVAADAHGV    50
IPDGAPGMCA RSPACRATAI PADAFVRTAD LGRLTDADRD ALAALGVKLD 100
IDLRTADEEA QSPDLLARDD RFDYQRISLM GTEKMDLQKM MTSFPDSLGE 150
AYVQWLGHSQ PQFKQVFQRI AAQQDGAVLF HCTAGKDRTG IIAGLLLDLA 200
GVPKAEIVHN YAISAHYLEG QPKDSDERAD HGAGQAEPGD RPQDGGHGRY 250
RAGQHGAVLA ALHSQYGGAE GYLKSIGVSE QEIQQLKVRL GQAG 294
Length:294
Mass (Da):31,005
Last modified:February 1, 1995 - v1
Checksum:i9E067BC99D7EF2B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11392 Genomic DNA. Translation: AAA25511.1.
PIRiA46635.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L11392 Genomic DNA. Translation: AAA25511.1 .
PIRi A46635.

3D structure databases

ProteinModelPortali Q05918.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

PptaseDBi P3D040487.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR026893. Tyr/Ser_Pase_IphP-type.
IPR016130. Tyr_Pase_AS.
IPR025163. Tyr_Phosphatase_C_dom.
[Graphical view ]
Pfami PF13350. Y_phosphatase3. 1 hit.
PF13348. Y_phosphatase3C. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A protein-tyrosine/serine phosphatase encoded by the genome of the cyanobacterium Nostoc commune UTEX 584."
    Potts M., Sun H., Mockaitis K., Kennelly P.J., Reed D., Tonks N.K.
    J. Biol. Chem. 268:7632-7635(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 25-37.
    Strain: UTEX 584.
  2. "Nostoc commune UTEX 584 gene expressing indole phosphate hydrolase activity in Escherichia coli."
    Xie W.-Q., Whitton B.A., Simon J.W., Jaeger K., Reed D., Potts M.
    J. Bacteriol. 171:708-713(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: UTEX 584.

Entry informationi

Entry nameiIPHP_NOSCO
AccessioniPrimary (citable) accession number: Q05918
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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