Q05918 (IPHP_NOSCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tyrosine-protein phosphatase
EC=3.1.3.48

Gene names

Name:	iphP
Synonyms:	iph

Organism

Nostoc commune

Taxonomic identifier

1178 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Cyanobacteria › Nostocales › Nostocaceae › Nostoc

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subunit structure	Monomer.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family.

Ontologies

Keywords
Domain	Signal
Molecular function	Hydrolase Protein phosphatase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Ref.1
	Chain	25 – 294	270	Tyrosine-protein phosphatase		PRO_0000025473
Sites
	Active site	182	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q05918 [UniParc]. Last modified February 1, 1995. Version 1. Checksum: 9E067BC99D7EF2B5	FASTA	294	31,005
	10 20 30 40 50 60 MKTHHANLAL ALMLGLSSSA TAVAADAPQA VATKAAAPNV KPVAADAHGV IPDGAPGMCA 70 80 90 100 110 120 RSPACRATAI PADAFVRTAD LGRLTDADRD ALAALGVKLD IDLRTADEEA QSPDLLARDD 130 140 150 160 170 180 RFDYQRISLM GTEKMDLQKM MTSFPDSLGE AYVQWLGHSQ PQFKQVFQRI AAQQDGAVLF 190 200 210 220 230 240 HCTAGKDRTG IIAGLLLDLA GVPKAEIVHN YAISAHYLEG QPKDSDERAD HGAGQAEPGD 250 260 270 280 290 RPQDGGHGRY RAGQHGAVLA ALHSQYGGAE GYLKSIGVSE QEIQQLKVRL GQAG

References

[1]	"A protein-tyrosine/serine phosphatase encoded by the genome of the cyanobacterium Nostoc commune UTEX 584." Potts M., Sun H., Mockaitis K., Kennelly P.J., Reed D., Tonks N.K. J. Biol. Chem. 268:7632-7635(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 25-37. Strain: UTEX 584.
[2]	"Nostoc commune UTEX 584 gene expressing indole phosphate hydrolase activity in Escherichia coli." Xie W.-Q., Whitton B.A., Simon J.W., Jaeger K., Reed D., Potts M. J. Bacteriol. 171:708-713(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: UTEX 584.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L11392 Genomic DNA. Translation: AAA25511.1.
PIR	A46635.
3D structure databases
ProteinModelPortal	Q05918.
ModBase	Search...
Protein family/group databases
PptaseDB	P3D040487.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR000387. Tyr/Dual-sp_Pase. IPR026893. Tyr/Ser_Pase_IphP-type. IPR016130. Tyr_Pase_AS. IPR025163. Tyr_Phosphatase_C_dom. [Graphical view]
Pfam	PF13350. Y_phosphatase3. 1 hit. PF13348. Y_phosphatase3C. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IPHP_NOSCO

Accession

Primary (citable) accession number: Q05918

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 1995
Last sequence update:	February 1, 1995
Last modified:	April 3, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program