ID HME2_CHICK Reviewed; 289 AA. AC Q05917; DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot. DT 05-SEP-2012, sequence version 2. DT 24-JAN-2024, entry version 137. DE RecName: Full=Homeobox protein engrailed-2; DE Short=Gg-En-2; DE Short=Homeobox protein en-2; GN Name=EN2; Synonyms=EN-2; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; OC Phasianinae; Gallus. OX NCBI_TaxID=9031; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=1363401; DOI=10.1002/dvg.1020130505; RA Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., Provart N.J., RA Joyner A.L.; RT "Cloning and sequence comparison of the mouse, human, and chicken engrailed RT genes reveal potential functional domains and regulatory regions."; RL Dev. Genet. 13:345-358(1992). CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- SIMILARITY: Belongs to the engrailed homeobox family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAA53437.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC Sequence=AAA53438.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; L12696; AAA53437.1; ALT_SEQ; Genomic_DNA. DR EMBL; L12697; AAA53438.1; ALT_SEQ; Genomic_DNA. DR PIR; F48423; F48423. DR RefSeq; NP_001254648.1; NM_001267719.1. DR PDB; 3ZOB; NMR; -; A=200-259. DR PDBsum; 3ZOB; -. DR AlphaFoldDB; Q05917; -. DR BMRB; Q05917; -. DR SMR; Q05917; -. DR STRING; 9031.ENSGALP00000045557; -. DR PaxDb; 9031-ENSGALP00000042412; -. DR Ensembl; ENSGALT00000075534; ENSGALP00000045557; ENSGALG00000041295. DR Ensembl; ENSGALT00010060632.1; ENSGALP00010037391.1; ENSGALG00010024838.1. DR Ensembl; ENSGALT00015057330; ENSGALP00015034812; ENSGALG00015023455. DR GeneID; 100859435; -. DR KEGG; gga:100859435; -. DR CTD; 2020; -. DR VEuPathDB; HostDB:geneid_100859435; -. DR eggNOG; KOG0493; Eukaryota. DR GeneTree; ENSGT00940000159935; -. DR HOGENOM; CLU_051739_2_0_1; -. DR InParanoid; Q05917; -. DR OMA; GESGDQC; -. DR OrthoDB; 2897502at2759; -. DR PRO; PR:Q05917; -. DR Proteomes; UP000000539; Chromosome 2. DR Bgee; ENSGALG00000041295; Expressed in cerebellum and 1 other cell type or tissue. DR ExpressionAtlas; Q05917; baseline. DR GO; GO:0001650; C:fibrillar center; IEA:Ensembl. DR GO; GO:0030175; C:filopodium; IDA:UniProtKB. DR GO; GO:0030426; C:growth cone; IDA:UniProtKB. DR GO; GO:0030027; C:lamellipodium; IDA:UniProtKB. DR GO; GO:0043005; C:neuron projection; IDA:UniProtKB. DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central. DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0007411; P:axon guidance; IDA:UniProtKB. DR GO; GO:0071542; P:dopaminergic neuron differentiation; IEA:Ensembl. DR GO; GO:1990403; P:embryonic brain development; IEA:Ensembl. DR GO; GO:0030902; P:hindbrain development; IEA:Ensembl. DR GO; GO:0030901; P:midbrain development; IEA:Ensembl. DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl. DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central. DR GO; GO:0042327; P:positive regulation of phosphorylation; IDA:UniProtKB. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0045727; P:positive regulation of translation; IDA:UniProtKB. DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central. DR CDD; cd00086; homeodomain; 1. DR DisProt; DP01779; -. DR Gene3D; 1.10.10.60; Homeodomain-like; 1. DR InterPro; IPR019549; Homeobox-engrailed_C-terminal. DR InterPro; IPR009057; Homeobox-like_sf. DR InterPro; IPR017970; Homeobox_CS. DR InterPro; IPR001356; Homeobox_dom. DR InterPro; IPR000747; Homeobox_engrailed. DR InterPro; IPR020479; Homeobox_metazoa. DR InterPro; IPR019737; Homoebox-engrailed_CS. DR InterPro; IPR000047; HTH_motif. DR PANTHER; PTHR24341; HOMEOBOX PROTEIN ENGRAILED; 1. DR PANTHER; PTHR24341:SF5; HOMEOBOX PROTEIN ENGRAILED-2; 1. DR Pfam; PF10525; Engrail_1_C_sig; 1. DR Pfam; PF00046; Homeodomain; 1. DR PRINTS; PR00026; ENGRAILED. DR PRINTS; PR00024; HOMEOBOX. DR PRINTS; PR00031; HTHREPRESSR. DR SMART; SM00389; HOX; 1. DR SUPFAM; SSF46689; Homeodomain-like; 1. DR PROSITE; PS00033; ENGRAILED; 1. DR PROSITE; PS00027; HOMEOBOX_1; 1. DR PROSITE; PS50071; HOMEOBOX_2; 1. PE 1: Evidence at protein level; KW 3D-structure; Developmental protein; DNA-binding; Homeobox; Nucleus; KW Reference proteome. FT CHAIN 1..289 FT /note="Homeobox protein engrailed-2" FT /id="PRO_0000196069" FT DNA_BIND 200..259 FT /note="Homeobox" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108" FT REGION 1..166 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 179..206 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1..16 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 58..80 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 146..164 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT STRAND 203..206 FT /evidence="ECO:0007829|PDB:3ZOB" FT HELIX 209..221 FT /evidence="ECO:0007829|PDB:3ZOB" FT TURN 227..229 FT /evidence="ECO:0007829|PDB:3ZOB" FT HELIX 230..236 FT /evidence="ECO:0007829|PDB:3ZOB" FT HELIX 241..252 FT /evidence="ECO:0007829|PDB:3ZOB" FT STRAND 254..256 FT /evidence="ECO:0007829|PDB:3ZOB" SQ SEQUENCE 289 AA; 30507 MW; C5EF48F9F160AA2A CRC64; MEEGGRSPRE EAAEPQESGG DAEPGGGRRA LLLPPGDPPH PHPHPHRITN FFIDNILRPE FGRRKEAGGT AGEPRRPGAE SRRSPAAAAP APGAPVPGGG GGGGGGSPGR GEGGPAALAL HGAAKKGGDP AALEAALKAR GLSGAELSVS SDSDSSQAGS NAGNQPMLWP AWVYCTRYSD RPSSGPRSRK PKKKNPNKED KRPRTAFTAE QLQRLKAEFQ TNRYLTEQRR QSLAQELGLN ESQIKIWFQN KRAKIKKATG SKNSLAVHLM AQGLYNHSTT AKDGKSDSE //