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Protein

Homeobox protein engrailed-2

Gene

EN2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi200 – 25960HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. axon guidance Source: UniProtKB
  2. hindbrain development Source: Ensembl
  3. midbrain development Source: Ensembl
  4. positive regulation of phosphorylation Source: UniProtKB
  5. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  6. positive regulation of translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein engrailed-2
Short name:
Gg-En-2
Short name:
Homeobox protein en-2
Gene namesi
Name:EN2
Synonyms:EN-2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. filopodium Source: UniProtKB
  2. growth cone Source: UniProtKB
  3. lamellipodium Source: UniProtKB
  4. neuron projection Source: UniProtKB
  5. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Homeobox protein engrailed-2PRO_0000196069Add
BLAST

Structurei

Secondary structure

1
289
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi203 – 2064Combined sources
Helixi209 – 22113Combined sources
Turni227 – 2293Combined sources
Helixi230 – 2367Combined sources
Helixi241 – 25212Combined sources
Beta strandi254 – 2563Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZOBNMR-A200-259[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi98 – 1069Poly-Gly

Sequence similaritiesi

Belongs to the engrailed homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

GeneTreeiENSGT00780000121984.
HOVERGENiHBG005975.
InParanoidiQ05917.
KOiK09319.
OMAiPHPHRIT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR019549. Homeobox-engrailed_C-terminal.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000747. Homeodomain_engrailed.
IPR019737. Homoebox-engrailed_CS.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF10525. Engrail_1_C_sig. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00026. ENGRAILED.
PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00033. ENGRAILED. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q05917-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEGGRSPRE EAAEPQESGG DAEPGGGRRA LLLPPGDPPH PHPHPHRITN
60 70 80 90 100
FFIDNILRPE FGRRKEAGGT AGEPRRPGAE SRRSPAAAAP APGAPVPGGG
110 120 130 140 150
GGGGGGSPGR GEGGPAALAL HGAAKKGGDP AALEAALKAR GLSGAELSVS
160 170 180 190 200
SDSDSSQAGS NAGNQPMLWP AWVYCTRYSD RPSSGPRSRK PKKKNPNKED
210 220 230 240 250
KRPRTAFTAE QLQRLKAEFQ TNRYLTEQRR QSLAQELGLN ESQIKIWFQN
260 270 280
KRAKIKKATG SKNSLAVHLM AQGLYNHSTT AKDGKSDSE
Length:289
Mass (Da):30,507
Last modified:September 5, 2012 - v2
Checksum:iC5EF48F9F160AA2A
GO

Sequence cautioni

The sequence AAA53437.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAA53438.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12696 Genomic DNA. Translation: AAA53437.1. Sequence problems.
L12697 Genomic DNA. Translation: AAA53438.1. Sequence problems.
PIRiF48423.
RefSeqiNP_001254648.1. NM_001267719.1.
UniGeneiGga.56328.

Genome annotation databases

EnsembliENSGALT00000038721; ENSGALP00000042412; ENSGALG00000023430.
GeneIDi100859435.
KEGGigga:100859435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12696 Genomic DNA. Translation: AAA53437.1. Sequence problems.
L12697 Genomic DNA. Translation: AAA53438.1. Sequence problems.
PIRiF48423.
RefSeqiNP_001254648.1. NM_001267719.1.
UniGeneiGga.56328.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZOBNMR-A200-259[»]
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000038721; ENSGALP00000042412; ENSGALG00000023430.
GeneIDi100859435.
KEGGigga:100859435.

Organism-specific databases

CTDi2020.

Phylogenomic databases

GeneTreeiENSGT00780000121984.
HOVERGENiHBG005975.
InParanoidiQ05917.
KOiK09319.
OMAiPHPHRIT.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR019549. Homeobox-engrailed_C-terminal.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000747. Homeodomain_engrailed.
IPR019737. Homoebox-engrailed_CS.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF10525. Engrail_1_C_sig. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00026. ENGRAILED.
PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00033. ENGRAILED. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions."
    Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., Provart N.J., Joyner A.L.
    Dev. Genet. 13:345-358(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHME2_CHICK
AccessioniPrimary (citable) accession number: Q05917
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: September 5, 2012
Last modified: March 4, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.