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Q05917

- HME2_CHICK

UniProt

Q05917 - HME2_CHICK

Protein

Homeobox protein engrailed-2

Gene

EN2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (05 Sep 2012)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi200 – 25960HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. axon guidance Source: UniProtKB
    2. hindbrain development Source: Ensembl
    3. midbrain development Source: Ensembl
    4. positive regulation of phosphorylation Source: UniProtKB
    5. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    6. positive regulation of translation Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein engrailed-2
    Short name:
    Gg-En-2
    Short name:
    Homeobox protein en-2
    Gene namesi
    Name:EN2
    Synonyms:EN-2
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. filopodium Source: UniProtKB
    2. growth cone Source: UniProtKB
    3. lamellipodium Source: UniProtKB
    4. neuron projection Source: UniProtKB
    5. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Homeobox protein engrailed-2PRO_0000196069Add
    BLAST

    Structurei

    Secondary structure

    1
    289
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi203 – 2064
    Helixi209 – 22113
    Turni227 – 2293
    Helixi230 – 2367
    Helixi241 – 25212
    Beta strandi254 – 2563

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZOBNMR-A200-259[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi98 – 1069Poly-Gly

    Sequence similaritiesi

    Belongs to the engrailed homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    GeneTreeiENSGT00750000117439.
    HOVERGENiHBG005975.
    KOiK09319.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR019549. Homeobox-engrailed_C-terminal.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000747. Homeodomain_engrailed.
    IPR019737. Homoebox-engrailed_CS.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF10525. Engrail_1_C_sig. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00026. ENGRAILED.
    PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00033. ENGRAILED. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q05917-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEGGRSPRE EAAEPQESGG DAEPGGGRRA LLLPPGDPPH PHPHPHRITN    50
    FFIDNILRPE FGRRKEAGGT AGEPRRPGAE SRRSPAAAAP APGAPVPGGG 100
    GGGGGGSPGR GEGGPAALAL HGAAKKGGDP AALEAALKAR GLSGAELSVS 150
    SDSDSSQAGS NAGNQPMLWP AWVYCTRYSD RPSSGPRSRK PKKKNPNKED 200
    KRPRTAFTAE QLQRLKAEFQ TNRYLTEQRR QSLAQELGLN ESQIKIWFQN 250
    KRAKIKKATG SKNSLAVHLM AQGLYNHSTT AKDGKSDSE 289
    Length:289
    Mass (Da):30,507
    Last modified:September 5, 2012 - v2
    Checksum:iC5EF48F9F160AA2A
    GO

    Sequence cautioni

    The sequence AAA53437.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence AAA53438.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12696 Genomic DNA. Translation: AAA53437.1. Sequence problems.
    L12697 Genomic DNA. Translation: AAA53438.1. Sequence problems.
    PIRiF48423.
    RefSeqiNP_001254648.1. NM_001267719.1.
    UniGeneiGga.56328.

    Genome annotation databases

    EnsembliENSGALT00000038721; ENSGALP00000042412; ENSGALG00000023430.
    GeneIDi100859435.
    KEGGigga:100859435.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L12696 Genomic DNA. Translation: AAA53437.1 . Sequence problems.
    L12697 Genomic DNA. Translation: AAA53438.1 . Sequence problems.
    PIRi F48423.
    RefSeqi NP_001254648.1. NM_001267719.1.
    UniGenei Gga.56328.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZOB NMR - A 200-259 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000038721 ; ENSGALP00000042412 ; ENSGALG00000023430 .
    GeneIDi 100859435.
    KEGGi gga:100859435.

    Phylogenomic databases

    GeneTreei ENSGT00750000117439.
    HOVERGENi HBG005975.
    KOi K09319.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR019549. Homeobox-engrailed_C-terminal.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    IPR000747. Homeodomain_engrailed.
    IPR019737. Homoebox-engrailed_CS.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF10525. Engrail_1_C_sig. 1 hit.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00026. ENGRAILED.
    PR00024. HOMEOBOX.
    PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00033. ENGRAILED. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions."
      Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., Provart N.J., Joyner A.L.
      Dev. Genet. 13:345-358(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHME2_CHICK
    AccessioniPrimary (citable) accession number: Q05917
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 1994
    Last sequence update: September 5, 2012
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3