Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q05917 (HME2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein engrailed-2

Short name=Gg-En-2
Short name=Homeobox protein en-2
Gene names
Name:EN2
Synonyms:EN-2
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Nucleus.

Sequence similarities

Belongs to the engrailed homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence caution

The sequence AAA53437.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AAA53438.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Homeobox protein engrailed-2
PRO_0000196069

Regions

DNA binding200 – 25960Homeobox
Compositional bias98 – 1069Poly-Gly

Secondary structure

............ 289
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q05917 [UniParc].

Last modified September 5, 2012. Version 2.
Checksum: C5EF48F9F160AA2A

FASTA28930,507
        10         20         30         40         50         60 
MEEGGRSPRE EAAEPQESGG DAEPGGGRRA LLLPPGDPPH PHPHPHRITN FFIDNILRPE 

        70         80         90        100        110        120 
FGRRKEAGGT AGEPRRPGAE SRRSPAAAAP APGAPVPGGG GGGGGGSPGR GEGGPAALAL 

       130        140        150        160        170        180 
HGAAKKGGDP AALEAALKAR GLSGAELSVS SDSDSSQAGS NAGNQPMLWP AWVYCTRYSD 

       190        200        210        220        230        240 
RPSSGPRSRK PKKKNPNKED KRPRTAFTAE QLQRLKAEFQ TNRYLTEQRR QSLAQELGLN 

       250        260        270        280 
ESQIKIWFQN KRAKIKKATG SKNSLAVHLM AQGLYNHSTT AKDGKSDSE 

« Hide

References

[1]"Cloning and sequence comparison of the mouse, human, and chicken engrailed genes reveal potential functional domains and regulatory regions."
Logan C., Hanks M.C., Noble-Topham S., Nallainathan D., Provart N.J., Joyner A.L.
Dev. Genet. 13:345-358(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L12696 Genomic DNA. Translation: AAA53437.1. Sequence problems.
L12697 Genomic DNA. Translation: AAA53438.1. Sequence problems.
PIRF48423.
RefSeqNP_001254648.1. NM_001267719.1.
UniGeneGga.56328.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZOBNMR-A200-259[»]
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000038721; ENSGALP00000042412; ENSGALG00000023430.
GeneID100859435.
KEGGgga:100859435.

Phylogenomic databases

GeneTreeENSGT00750000117439.
HOVERGENHBG005975.
KOK09319.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR019549. Homeobox-engrailed_C-terminal.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
IPR000747. Homeodomain_engrailed.
IPR019737. Homoebox-engrailed_CS.
IPR000047. HTH_motif.
[Graphical view]
PfamPF10525. Engrail_1_C_sig. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00026. ENGRAILED.
PR00024. HOMEOBOX.
PR00031. HTHREPRESSR.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00033. ENGRAILED. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHME2_CHICK
AccessionPrimary (citable) accession number: Q05917
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 1994
Last sequence update: September 5, 2012
Last modified: April 16, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references